Myristic Acid

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  • Identifiers

    CAS number
    544-63-8

    Molecular formula
    C14H28O2

    SMILES
    CCCCCCCCCCCCCC(=O)O

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1773.0
    • Carbowax: 2688.43

  • Odor profile

    Fatty 82.79%
    Waxy 80.69%
    Oily 45.7%
    Dairy 38.94%
    Creamy 37.87%
    Milky 32.43%
    Soapy 31.38%
    Citrus 29.65%
    Coconut 29.1%
    Cheesy 28.21%

    Scent© AI

    Odor threshold

    • Odor Threshold Low: 10.0 [mmHg]. Odor threshold (detection) from HSDB
    • Aroma threshold values: Detection: 10 ppm

  • Properties

    XLogP3-AA
    5.3

    pKa est.
    7.2 (neutral)

    Molecular weight
    228.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 129 °F (NTP, 1992)
    • 53.9 °C

    Boiling point

    • 482.9 °F at 100 mmHg (NTP, 1992)
    • 326.2 °C

    Flash point est.
    160.26 ˚C

    Flash point expt.

    • greater than 235 °F (NTP, 1992)

    Solubility expt.

    • less than 1 mg/mL at 64 °F (NTP, 1992)
    • Sol in absolute alcohol, methanol, ether, petroleum ether, benzene, chloroform
    • Slightly soluble in ethyl ether; soluble in ethanol, acetone, chloroform, methanol; very soluble in benzene
    • In water, 22 mg/L at 30 °C
    • 0.00107 mg/mL
    • practically insoluble in water; soluble in alcohol, chloroform, ether

  • Synonyms

    • Tetradecanoic acid
    • MYRISTIC ACID
    • 544-63-8
    • n-Tetradecanoic acid
    • n-Tetradecan-1-oic acid
    • n-Tetradecoic acid
    • Crodacid
    • 1-Tridecanecarboxylic acid
    • Hydrofol acid 1495
    • Myristinsaeure
    • Univol U 316S
    • Emery 655
    • Myristate
    • tetradecoic acid
    • Hystrene 9014
    • Myristic acid, pure
    • FEMA No. 2764
    • Myristic acid (natural)
    • acide tetradecanoique
    • NSC 5028
    • CCRIS 4724
    • HSDB 5686
    • Philacid 1400
    • C14:0
    • Prifac 2942
    • CH3-[CH2]12-COOH
    • CHEBI:28875
    • AI3-15381
    • NSC-5028
    • 1-tetradecanecarboxylic acid
    • EINECS 208-875-2
    • PHILACID-1400
    • UNII-0I3V7S25AW
    • PRIFRAC-2942
    • BRN 0508624
    • 0I3V7S25AW
    • DTXSID6021666
    • Edenor C 14
    • Acid, Myristic
    • MFCD00002744
    • CHEMBL111077
    • DTXCID501666
    • MYRISTIC-14-13C ACID
    • NSC5028
    • 4-02-00-01126 (Beilstein Handbook Reference)
    • FA 14:0
    • MyristicAcid-13C14
    • MYRISTIC ACID (II)
    • MYRISTIC ACID [II]
    • 32112-52-0
    • MYRISTIC ACID (MART.)
    • MYRISTIC ACID [MART.]
    • MYRISTIC ACID (USP-RS)
    • MYRISTIC ACID [USP-RS]
    • CH3-(CH2)12-COOH
    • CAS-544-63-8
    • Acid, Tetradecanoic
    • Myristic acid [NF]
    • 62217-70-3
    • myristoate
    • myristoic acid
    • n-Tetradecanoate
    • Tetradecanoicacid
    • 3usx
    • Myristic acid pure
    • fatty acid 14:0
    • Hystrene 9514
    • TETRADECANSAEURE
    • 1-Tridecanecarboxylate
    • ACIDO MYNISTICO
    • Myristic acid, 95%
    • Myristic acid, natural
    • tridecanecarboxylic acid
    • Myristic acid (8CI)
    • Myristic Acid, Reagent
    • 3v2n
    • 3w9k
    • Myristic acid, puriss.
    • Univol U 3165
    • Myristic acid, ?99%
    • Myristic acid (Standard)
    • Tetradecanoic acid (9CI)
    • bmse000737
    • Epitope ID:176772
    • MYRISTIC ACID [MI]
    • SCHEMBL6374
    • MYRISTIC ACID [FCC]
    • MYRISTIC ACID [FHFI]
    • MYRISTIC ACID [HSDB]
    • MLS002152942
    • WLN: QV13
    • Tetradecanoic (Myristic) acid
    • GTPL2806
    • HY-N2041R
    • NAA 104
    • NAA 142
    • IS_D27-TETRADECANOIC ACID
    • HMS3039E15
    • HMS3648O20
    • Myristic acid, analytical standard
    • HY-N2041
    • EINECS 250-924-5
    • Myristic acid, >=98.0% (GC)
    • Tox21_201852
    • Tox21_302781
    • BDBM50147581
    • LMFA01010014
    • s5617
    • STL185697
    • Myristic acid, >=95%, FCC, FG
    • Myristic acid, Sigma Grade, >=99%
    • AKOS009156714
    • CCG-266785
    • DB08231
    • DS-3833
    • FM62595
    • NSC 122834
    • NCGC00091068-01
    • NCGC00091068-02
    • NCGC00091068-03
    • NCGC00256547-01
    • NCGC00259401-01
    • AC-34674
    • BP-27915
    • SMR001224536
    • CS-0018531
    • M0476
    • NS00010444

  • Applications

    Myristic acid (C14H28O2, also known as tetradecanoic acid, CAS 544-63-8) is a medium-chain saturated fatty acid widely employed in cosmetics and personal-care formulations as a surfactant, thickener, emulsifier and stabilizer in soaps, creams and shaving foams; in food technology as a flavoring compound, structuring fat and aroma carrier; in pharmaceuticals as an excipient, liposome component, drug-delivery matrix and microencapsulation coating; in industry for lubricants, biodegradable hydraulic fluids, synthetic esters, candle waxes, rust inhibitors and metalworking additives; in agriculture as a solvent, emulsifier and spreading adjuvant; it is also used as an analytical standard, precursor for myristate esters in perfumery, flavorings, plastics and rubber, and as a biochemical tool for studying protein myristoylation.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 514.22
    methanol 401.39
    isopropanol 641.89
    water 0.01
    ethyl acetate 483.84
    n-propanol 479.44
    acetone 555.22
    n-butanol 494.95
    acetonitrile 154.59
    DMF 840.82
    toluene 166.94
    isobutanol 476.24
    1,4-dioxane 550.9
    methyl acetate 270.79
    THF 1904.75
    2-butanone 595.08
    n-pentanol 447.68
    sec-butanol 524.08
    n-hexane 321.1
    ethylene glycol 23.83
    NMP 873.0
    cyclohexane 296.71
    DMSO 1238.08
    n-butyl acetate 778.7
    n-octanol 234.33
    chloroform 674.98
    n-propyl acetate 652.4
    acetic acid 184.64
    dichloromethane 689.94
    cyclohexanone 1216.74
    propylene glycol 105.69
    isopropyl acetate 531.08
    DMAc 678.28
    2-ethoxyethanol 510.3
    isopentanol 596.7
    n-heptane 149.07
    ethyl formate 221.66
    1,2-dichloroethane 697.53
    n-hexanol 459.15
    2-methoxyethanol 632.25
    isobutyl acetate 473.87
    tetrachloromethane 180.86
    n-pentyl acetate 616.95
    transcutol 1578.65
    n-heptanol 257.11
    ethylbenzene 160.15
    MIBK 601.19
    2-propoxyethanol 652.04
    tert-butanol 887.04
    MTBE 881.81
    2-butoxyethanol 489.48
    propionic acid 255.91
    o-xylene 153.24
    formic acid 31.79
    diethyl ether 680.13
    m-xylene 172.38
    p-xylene 214.41
    chlorobenzene 259.69
    dimethyl carbonate 82.91
    n-octane 50.9
    formamide 66.77
    cyclopentanone 1261.28
    2-pentanone 730.3
    anisole 297.1
    cyclopentyl methyl ether 977.0
    gamma-butyrolactone 969.62
    1-methoxy-2-propanol 744.58
    pyridine 478.76
    3-pentanone 413.11
    furfural 593.29
    n-dodecane 24.92
    diethylene glycol 250.57
    diisopropyl ether 308.42
    tert-amyl alcohol 732.54
    acetylacetone 586.62
    n-hexadecane 30.25
    acetophenone 324.6
    methyl propionate 343.33
    isopentyl acetate 745.17
    trichloroethylene 859.6
    n-nonanol 217.28
    cyclohexanol 637.86
    benzyl alcohol 226.1
    2-ethylhexanol 378.22
    isooctanol 270.32
    dipropyl ether 714.08
    1,2-dichlorobenzene 292.53
    ethyl lactate 207.01
    propylene carbonate 517.01
    n-methylformamide 257.0
    2-pentanol 488.22
    n-pentane 139.41
    1-propoxy-2-propanol 684.3
    1-methoxy-2-propyl acetate 572.98
    2-(2-methoxypropoxy) propanol 355.42
    mesitylene 142.97
    ε-caprolactone 876.43
    p-cymene 130.07
    epichlorohydrin 1028.94
    1,1,1-trichloroethane 613.81
    2-aminoethanol 142.03
    morpholine-4-carbaldehyde 697.39
    sulfolane 1575.17
    2,2,4-trimethylpentane 68.15
    2-methyltetrahydrofuran 1285.62
    n-hexyl acetate 628.12
    isooctane 61.48
    2-(2-butoxyethoxy)ethanol 551.85
    sec-butyl acetate 523.57
    tert-butyl acetate 726.69
    decalin 116.9
    glycerin 122.61
    diglyme 981.05
    acrylic acid 127.58
    isopropyl myristate 234.69
    n-butyric acid 640.54
    acetyl acetate 221.83
    di(2-ethylhexyl) phthalate 162.11
    ethyl propionate 483.89
    nitromethane 324.57
    1,2-diethoxyethane 748.45
    benzonitrile 257.83
    trioctyl phosphate 146.96
    1-bromopropane 613.52
    gamma-valerolactone 1254.69
    n-decanol 151.52
    triethyl phosphate 218.35
    4-methyl-2-pentanol 330.66
    propionitrile 244.74
    vinylene carbonate 311.47
    1,1,2-trichlorotrifluoroethane 582.94
    DMS 245.21
    cumene 135.61
    2-octanol 223.99
    2-hexanone 718.29
    octyl acetate 267.43
    limonene 260.89
    1,2-dimethoxyethane 960.24
    ethyl orthosilicate 234.82
    tributyl phosphate 196.06
    diacetone alcohol 686.96
    N,N-dimethylaniline 242.47
    acrylonitrile 204.71
    aniline 216.34
    1,3-propanediol 282.86
    bromobenzene 294.32
    dibromomethane 573.82
    1,1,2,2-tetrachloroethane 972.8
    2-methyl-cyclohexyl acetate 454.89
    tetrabutyl urea 267.17
    diisobutyl methanol 247.46
    2-phenylethanol 256.87
    styrene 184.58
    dioctyl adipate 317.08
    dimethyl sulfate 207.1
    ethyl butyrate 560.09
    methyl lactate 164.3
    butyl lactate 387.39
    diethyl carbonate 260.75
    propanediol butyl ether 380.51
    triethyl orthoformate 397.78
    p-tert-butyltoluene 135.63
    methyl 4-tert-butylbenzoate 342.16
    morpholine 1024.41
    tert-butylamine 636.06
    n-dodecanol 111.38
    dimethoxymethane 498.71
    ethylene carbonate 309.29
    cyrene 319.66
    2-ethoxyethyl acetate 501.89
    2-ethylhexyl acetate 600.82
    1,2,4-trichlorobenzene 330.61
    4-methylpyridine 494.38
    dibutyl ether 570.71
    2,6-dimethyl-4-heptanol 247.46
    DEF 738.03
    dimethyl isosorbide 683.52
    tetrachloroethylene 579.36
    eugenol 288.28
    triacetin 439.78
    span 80 382.8
    1,4-butanediol 115.71
    1,1-dichloroethane 612.47
    2-methyl-1-pentanol 414.36
    methyl formate 117.49
    2-methyl-1-butanol 478.87
    n-decane 58.66
    butyronitrile 415.17
    3,7-dimethyl-1-octanol 284.8
    1-chlorooctane 245.02
    1-chlorotetradecane 76.03
    n-nonane 63.99
    undecane 35.97
    tert-butylcyclohexane 109.99
    cyclooctane 84.66
    cyclopentanol 686.72
    tetrahydropyran 1227.56
    tert-amyl methyl ether 617.58
    2,5,8-trioxanonane 591.15
    1-hexene 622.41
    2-isopropoxyethanol 474.04
    2,2,2-trifluoroethanol 57.16
    methyl butyrate 695.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Genet absolute 1 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 2.5%
Osmanthus absolute 68917-05-5 Osmanthus fragrans (Thunb.) Lour., fam. Oleaceae 1.0%
Asafoetida (Pakistan) 1b 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 21.23%
Melittis melissophyllum Melittis melissophylum L., ssp. albida Guss, fam. Lamiaceae (Labiatae) 0.54%
Hedychium coronarium flower (Japan) Hedychium coronarium Koenig, fam. Zingiberaceae 0.01%
Guava fruit (Nigeria) 91770-12-6 Psidium guajava L., fam. Myrtaceae 5.17%
Orris butter 8002-73-1 Iris florentina L., fam. Iridaceae 85.0%
Osmanthus concentrate 1 (Sukhumi-Abkhasia) 68917-05-5 Osmanthus fragrans (Thunb.) Lour., fam. Oleaceae 0.07%
Osmanthus concentrate 2 (Sukhumi-Abkhasia) 68917-05-5 Osmanthus fragrans (Thunb.) Lour., fam. Oleaceae 0.03%
Rhus coriaria Rhus coriaria L., fam. Anarcadiaceae 0.5%
Genet absolute 2 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 3.5%
Cinnamomum parthenoxylon (Vietnam) 1a Cinnamomum parthenoxylon (Jack) Nees, fam. Lauraceae 0.9%
Cinnamomum parthenoxylon (Vietnam) 1b Cinnamomum parthenoxylon (Jack) Nees, fam. Lauraceae 0.5%
Geum montanum root Geum montanum L., fam. Rosaceae 0.25%
Zingiber zerumbet (Vietnam) 2c flower Zingiber zerumbet (L.) Sm., fam. Zingiberaceae 0.2%
Ageratum houstonianum (India) Ageratum houstonianum Mill., fam. Asteraceae (Compositae) 0.01%
Fagraea berteriana flower Fagraea berteriana A. Gray ex Benth., fam. Potaliaceae 3.48%
Averrhoa bilimbi fruit (Malaysia) Averrhoa bilimbi L., fam. Oxalidaceae 1.7%
Rhubarb root Rheum palmatum L., fam. Polygonaceae 2.1%
Coriander fruit (Cuba) 8008-32-4 Coriandrum sativum L., fam. Apiaceae (Umbelliferae) 0.57%
Zizyphus jujuba fruit (Malaysia) Zizyphus jujuba Mill. var. inermis, fam. Rhamnaceae 1.38%
Sideritis condensata Sideritis condensata Boiss. et Heldr., fam. Lamiaceae (Labiatae) 1.3%
Jasmine rose absolute (India) Gardenia jasminoides Ellis, fam. Rubiaceae 1.22%
Acacia confusa flower (China) Acacia confusa Merr., fam. Mimosaceae (Leguminosae) 0.26%
Nutmeg (India) 6 8008-45-5 Myristica fragrans Houtt., fam. Myristicaceae 0.01%
Tamarind 3 fruit Tamarindus indica L., fam. Leguminosae 0.6%
Pennyroyal (Cuba) 8013-99-8 Mentha pulegium L., fam. Lamiaceae (Labiatae) 0.56%
Rue (Cuba) 8014-29-7 Ruta graveolens L., fam. Rutaceae 0.29%
Teucrium divaricatum (Greece) Teucrium divaricatum Heldr. ssp. divaricatum, fam. Lamiaceae (Labiatae) 1.15%
Pelargonium sidoides Pelargonium sidoides DC., fam. Geraniaceae 0.1%
Phaeomeria speciosa Phaeomeria speciosa Koord., (Etlingera elatior (Jack) R.M. Smith), Zingib. 0.14%
Colocasia esculenta (Taro) Colocasia esculenta (L.) Schott, fam. Araceae 1.4%
Datura flower headspace (Japan) Datura candida (Pers.), fam. Solanaceae 3.6%
Mango (India) 1a cv. Langra 90063-86-8 Mangifera indica L. cv. Langra, fam. Anacardiaceae 2.0%
Mango (India) 1b cv. Bombay 90063-86-8 Mangifera indica L. cv. Bombay, fam. Anacardiaceae 0.3%
Mango (India) 1c cv. Desi 90063-86-8 Mangifera indica L. cv. Desi, fam. Anacardiaceae 0.4%
Couroupita guianensis flower (Brazil) Couroupita guainensis Auble., fam. Lecythidaceae 0.4%
Bacuri fruit (Brazil) Platonia insignis M., fam. Guttiferae 1.5%
Genipap fruit (Brazil) Genipa americana L., fam. Rubiaceae 1.2%
Guava fruit (Cuba) 91770-12-6 Psidium guajava L., fam. Myrtaceae 2.0%
Rollinia mucosa fruit Rollinia mucosa (Jacq.) Baill, fam. Annonaceae 0.8%
Lemon balm (Slovak Republic) 8014-71-9 Melissa officinalis L., fam. Lamiaceae (Labiatae) 0.8%
Nutmeg (West Indies) 4 8008-45-5 Myristica fragrans Houtt., fam. Myristicaceae 4.0%
Grapefruit (Japan) 2 8016-20-4 Citrus paradisi Macfayden, fam. Rutaceae 0.03%
Tejpat leaf Cinnamomum tamala (Ham.) Nees et Eberm., fam. Lauraceae 0.2%
Lantana camara (India) 1b flower 90046-17-6 Lantana camara L., fam. Verbenaceae 1.4%
Helichrysum litoreum (Italy) 1a flower Helichrysum litoreum Guss., fam. Asteraceae (Compositae) 1.8%
Helichrysum litoreum (Italy) 1b stem Helichrysum litoreum Guss., fam. Asteraceae (Compositae) 0.05%
Oregano, spanish (Israel) 4 8007-11-2 Coridothymus capitatus Rchb. (Thymus capitatus Hoffm. et Link.), Lamiaceae 0.1%
Cordia nitida fruit Cordia nitida Vahl., fam. Borraginaceae 0.5%