Dimethyl Disulfide

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  • Identifiers

    CAS number
    624-92-0

    Molecular formula
    C2H6S2

    SMILES
    CSSC

    Safety labels

    Flammable
    Flammable

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

    Retention indicies (RI)

    • DB5: 742.0
    • Carbowax: 1080.75

  • Odor profile

    Sulfurous 88.78%
    Onion 81.63%
    Garlic 75.98%
    Alliaceous 69.47%
    Vegetable 66.37%
    Savory 52.81%
    Meaty 50.52%
    Cabbage 50.04%
    Cooked 49.92%
    Green 46.9%

    Scent© AI

    Odor threshold

    • Odor Threshold Low: 0.00078 [mmHg]. Odor Threshold High: 0.0036 [mmHg]. Odor threshold (detection) from CHEMINFO
    • 0.029 mg/cu m (recognition in air)
    • 0.003-0.014 mg/cu m (detection in air)
    • 3X10-3 ppm in water

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    8.45 (weak base)

    Molecular weight
    94.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -120.5 °F (NTP, 1992)
    • -84.67 °C
    • -85 °C
    • -120.5 °F

    Boiling point

    • 229.5 °F at 760 mmHg (NTP, 1992)
    • 109.72 °C
    • 109.00 to 110.00 °C. @ 760.00 mm Hg
    • 110 °C
    • 229.5 °F

    Flash point est.
    10.26 ˚C

    Flash point expt.

    • 76 °F (NTP, 1992)
    • 24 °C (closed cup)
    • 10 °C c.c.
    • 76 °F

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • Insoluble in water
    • Miscible with ethanol, ethyl ether
    • Completely miscible with most organic solvents
    • Very slightly soluble in water; soluble in alcohol and oils
    • 3 mg/mL at 25 °C
    • Solubility in water, g/l at 20 °C: 2.5 (poor)
    • very slightly soluble in water; soluble in alcohol and oils

  • Synonyms

    • Dimethyl disulfide
    • 624-92-0
    • METHYL DISULFIDE
    • Dimethyldisulfide
    • Dimethyl disulphide
    • DMDS
    • Disulfide, dimethyl
    • (Methyldisulfanyl)methane
    • 2,3-Dithiabutane
    • Methyldisulfide
    • Methyldithiomethane
    • (Methyldithio)methane
    • Sulfa-hitech
    • dimethyldisulphide
    • Methyldisulfanylmethane
    • FEMA No. 3536
    • NSC 9370
    • CCRIS 2939
    • HSDB 6400
    • EINECS 210-871-0
    • MFCD00008561
    • UNII-3P8D642K5E
    • CHEBI:4608
    • 1,2-Dimethyldisulfane
    • AI3-25305
    • 3P8D642K5E
    • NSC-9370
    • DTXSID4025117
    • (CH3S)2
    • EC 210-871-0
    • Dimethyl-d6 disulfide
    • Paladin
    • UN2381
    • dimethydisulfide
    • methyl disulphide
    • Dimethyl disulfane
    • Disulfide dimethyl
    • MeS-SMe
    • Disulfide, dimethyl-
    • methyldisulfanyl methane
    • Dimethyl disulfide, 99%
    • (Methyldisulfanyl)methane #
    • Dimethyl disulfide, >=99%
    • WLN: 1SS1
    • DTXCID805117
    • METHYL DISULFIDE [HSDB]
    • CHEMBL1347061
    • Dimethyl disulfide, >=99.0%
    • DIMETHYL DISULFIDE [FHFI]
    • NSC9370
    • BDBM233038
    • Dimethyl disulfide, >=98%, FG
    • EINECS 272-923-9
    • Tox21_201525
    • MSK001203
    • AKOS009157459
    • Dimethyl disulfide, analytical standard
    • UN 2381
    • NCGC00091798-01
    • NCGC00091798-02
    • NCGC00259075-01
    • CAS-624-92-0
    • Dimethyl disulfide, natural, >=98%, FG
    • D0714
    • Dimethyl disulfide, purum, >=98.0% (GC)
    • NS00001484
    • EN300-36043
    • InChI=1/C2H6S2/c1-3-4-2/h1-2H
    • C08371
    • E78981
    • A833808
    • Dimethyl disulfide [UN2381] [Flammable liquid]
    • Q419800
    • F0001-1676
    • 210-871-0

  • Applications

    Dimethyl disulfide (DMDS, CAS 624-92-0) is a garlic-odored sulfur compound widely applied as a sulfiding and presulfiding agent for hydroprocessing catalysts in petroleum refining, a pre-plant soil fumigant that controls nematodes, fungi and weeds as a replacement for methyl bromide, a savory onion-garlic flavor additive for foods, seasonings and tobacco, an intermediate for producing methanesulfonyl chloride, agrochemicals and pharmaceuticals, a vulcanization accelerator in rubber, an oilfield treatment and corrosion-inhibiting additive, a solvent for desulfurization and coal liquefaction, and a calibration standard for gas-leak detection, thanks to its high volatility, good solvency and ability to deliver highly reactive sulfur economically.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 64.77
    methanol 55.86
    isopropanol 60.9
    water 0.84
    ethyl acetate 253.99
    n-propanol 73.51
    acetone 187.19
    n-butanol 80.94
    acetonitrile 179.43
    DMF 213.14
    toluene 194.25
    isobutanol 56.37
    1,4-dioxane 374.16
    methyl acetate 251.61
    THF 462.86
    2-butanone 212.22
    n-pentanol 59.55
    sec-butanol 84.21
    n-hexane 45.07
    ethylene glycol 19.94
    NMP 344.14
    cyclohexane 110.16
    DMSO 177.76
    n-butyl acetate 225.6
    n-octanol 83.38
    chloroform 804.04
    n-propyl acetate 156.5
    acetic acid 147.14
    dichloromethane 503.65
    cyclohexanone 320.14
    propylene glycol 33.74
    isopropyl acetate 163.43
    DMAc 243.57
    2-ethoxyethanol 114.62
    isopentanol 66.37
    n-heptane 89.93
    ethyl formate 136.7
    1,2-dichloroethane 271.49
    n-hexanol 96.13
    2-methoxyethanol 151.09
    isobutyl acetate 92.66
    tetrachloromethane 243.52
    n-pentyl acetate 164.66
    transcutol 383.74
    n-heptanol 88.21
    ethylbenzene 100.19
    MIBK 110.2
    2-propoxyethanol 153.41
    tert-butanol 101.31
    MTBE 138.0
    2-butoxyethanol 142.35
    propionic acid 138.81
    o-xylene 141.95
    formic acid 37.45
    diethyl ether 186.97
    m-xylene 124.45
    p-xylene 126.81
    chlorobenzene 252.91
    dimethyl carbonate 100.15
    n-octane 36.51
    formamide 77.44
    cyclopentanone 408.61
    2-pentanone 175.29
    anisole 200.89
    cyclopentyl methyl ether 253.97
    gamma-butyrolactone 461.95
    1-methoxy-2-propanol 136.95
    pyridine 376.13
    3-pentanone 181.4
    furfural 438.49
    n-dodecane 22.43
    diethylene glycol 85.14
    diisopropyl ether 86.37
    tert-amyl alcohol 112.22
    acetylacetone 228.85
    n-hexadecane 25.9
    acetophenone 186.61
    methyl propionate 196.17
    isopentyl acetate 172.81
    trichloroethylene 669.76
    n-nonanol 83.48
    cyclohexanol 125.51
    benzyl alcohol 112.8
    2-ethylhexanol 102.18
    isooctanol 75.17
    dipropyl ether 199.15
    1,2-dichlorobenzene 269.78
    ethyl lactate 76.82
    propylene carbonate 284.47
    n-methylformamide 112.23
    2-pentanol 76.46
    n-pentane 46.14
    1-propoxy-2-propanol 163.54
    1-methoxy-2-propyl acetate 202.49
    2-(2-methoxypropoxy) propanol 132.04
    mesitylene 94.47
    ε-caprolactone 312.08
    p-cymene 111.78
    epichlorohydrin 406.72
    1,1,1-trichloroethane 481.08
    2-aminoethanol 41.95
    morpholine-4-carbaldehyde 325.64
    sulfolane 416.82
    2,2,4-trimethylpentane 29.2
    2-methyltetrahydrofuran 345.36
    n-hexyl acetate 171.0
    isooctane 22.14
    2-(2-butoxyethoxy)ethanol 173.7
    sec-butyl acetate 122.14
    tert-butyl acetate 193.04
    decalin 50.82
    glycerin 53.62
    diglyme 378.22
    acrylic acid 132.85
    isopropyl myristate 93.08
    n-butyric acid 175.29
    acetyl acetate 223.02
    di(2-ethylhexyl) phthalate 72.4
    ethyl propionate 162.99
    nitromethane 315.05
    1,2-diethoxyethane 234.55
    benzonitrile 214.58
    trioctyl phosphate 54.84
    1-bromopropane 184.59
    gamma-valerolactone 413.68
    n-decanol 62.19
    triethyl phosphate 112.15
    4-methyl-2-pentanol 50.44
    propionitrile 162.83
    vinylene carbonate 288.16
    1,1,2-trichlorotrifluoroethane 334.65
    DMS 145.71
    cumene 72.52
    2-octanol 67.3
    2-hexanone 140.01
    octyl acetate 110.87
    limonene 167.9
    1,2-dimethoxyethane 231.28
    ethyl orthosilicate 113.05
    tributyl phosphate 66.28
    diacetone alcohol 158.18
    N,N-dimethylaniline 127.8
    acrylonitrile 195.03
    aniline 169.27
    1,3-propanediol 60.45
    bromobenzene 289.53
    dibromomethane 360.3
    1,1,2,2-tetrachloroethane 530.66
    2-methyl-cyclohexyl acetate 162.89
    tetrabutyl urea 83.33
    diisobutyl methanol 78.96
    2-phenylethanol 136.03
    styrene 130.24
    dioctyl adipate 116.96
    dimethyl sulfate 149.43
    ethyl butyrate 223.07
    methyl lactate 89.13
    butyl lactate 115.81
    diethyl carbonate 154.43
    propanediol butyl ether 94.76
    triethyl orthoformate 173.47
    p-tert-butyltoluene 112.24
    methyl 4-tert-butylbenzoate 179.06
    morpholine 332.64
    tert-butylamine 79.44
    n-dodecanol 50.57
    dimethoxymethane 163.64
    ethylene carbonate 222.49
    cyrene 149.0
    2-ethoxyethyl acetate 193.56
    2-ethylhexyl acetate 166.07
    1,2,4-trichlorobenzene 318.78
    4-methylpyridine 298.83
    dibutyl ether 158.57
    2,6-dimethyl-4-heptanol 78.96
    DEF 206.59
    dimethyl isosorbide 281.14
    tetrachloroethylene 392.67
    eugenol 150.08
    triacetin 195.69
    span 80 145.24
    1,4-butanediol 29.67
    1,1-dichloroethane 310.51
    2-methyl-1-pentanol 60.03
    methyl formate 105.22
    2-methyl-1-butanol 71.78
    n-decane 39.24
    butyronitrile 146.42
    3,7-dimethyl-1-octanol 82.73
    1-chlorooctane 103.5
    1-chlorotetradecane 45.14
    n-nonane 40.84
    undecane 28.32
    tert-butylcyclohexane 42.83
    cyclooctane 57.18
    cyclopentanol 132.24
    tetrahydropyran 331.91
    tert-amyl methyl ether 142.31
    2,5,8-trioxanonane 255.15
    1-hexene 84.34
    2-isopropoxyethanol 95.4
    2,2,2-trifluoroethanol 93.03
    methyl butyrate 187.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Onion (shallot) 8002-72-0 Allium cepa L., Aggregatum g., fam. Liliaceae 0.85%
Onion, welsh 8002-72-0 Allium fistulosum L. var. Maichuon, fam. Liliaceae 0.78%
Scallion Allium fistulosum L. var. Caespitosum, fam. Liliaceae 0.24%
Garlic 2 8008-99-9 Allium sativum L., fam. Liliaceae 0.5%
Lavender (France) 6 8000-28-0 Lavandula angustifolia Mill., fam. Lamiaceae (Labiatae) 0.01%
Garlic (China) Allium sativum L., fam. Liliaceae 0.01%
Truffle, white (Italy) Tuber magnatum Pico, fam. Ascomycetae 2.5%
Allium macrochatum (Turkey) Allium macrochaetum Boiss. et Hausskn., fam. Liliaceae 0.06%
Nira (Brazil) Allium tuberosum Rottl., fam. Liliaceae 5.3%
Chicory root, roasted 1b 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.03%
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 3.1%
Carob bean powder 2a raw 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.01%
Carob bean powder 2b roasted 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 1.1%
Truffle, Asian Tuber indicum Cooke et Mass. (T. himalayense Zhang-Minter),fam.Ascomycetae 0.5%
Pineapple pulp Ananas comosus (L.) Merr., fam. Bromeliaceae 0.12%
Scallion (Cuba) Allium fistulosum L., fam. Liliaceae 0.3%
Asafoetida (Pakistan) 2 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 0.01%
Asafoetida headspace 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 0.11%