beta-Bisabolol

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  • Identifiers

    CAS number
    15352-77-9

    Molecular formula
    C15H26O

    SMILES
    CC1=CC[C@@](CC1)([C@@H](C)CCC=C(C)C)O

    Safety labels

    Environmental Hazard
    Environmental

    Retention indicies (RI)

    • DB5: 1670.0
    • Carbowax: 2045.4

  • Odor profile

    Floral 72.97%
    Sweet 60.98%
    Citrus 58.57%
    Fresh 53.83%
    Herbal 50.19%
    Lemon 46.81%
    Spicy 38.76%
    Woody 38.54%
    Clean 35.44%
    Lily 35.25%

    Scent© AI

  • Properties

    XLogP3-AA
    4.0

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point

    • 305.00 to 307.00 °C. @ 760.00 mm Hg

    Flash point est.
    122.56 ˚C

  • Synonyms

    • beta-Bisabolol
    • 15352-77-9
    • b-Bisabolol
    • LP618AV2EA
    • UNII-LP618AV2EA
    • .beta.-Bisabolol
    • 3-Cyclohexen-1-ol, 1-(1,5-dimethyl-4-hexenyl)-4-methyl-, (S-(R*,R*))-
    • BETA-BISABOLOL (USP-RS)
    • BETA-BISABOLOL [USP-RS]
    • (1S)-4-METHYL-1-[(2S)-6-METHYLHEPT-5-EN-2-YL]CYCLOHEX-3-EN-1-OL
    • 3-CYCLOHEXEN-1-OL, 1-((1S)-1,5-DIMETHYL-4-HEXEN-1-YL)-4-METHYL-, (1S)-
    • 3-CYCLOHEXEN-1-OL, 1-((1S)-1,5-DIMETHYL-4-HEXENYL)-4-METHYL-, (1S)-
    • beta -bisabolol
    • 3-Cyclohexen-1-ol, 1-[(1S)-1,5-dimethyl-4-hexen-1-yl]-4-methyl-, (1S)-
    • 1-(1,5-Dimethyl-4-hexenyl)-4-methyl-3-cyclohexen-1-ol #
    • SCHEMBL17627680
    • WTVHAMTYZJGJLJ-LSDHHAIUSA-N
    • DTXSID601034686
    • 3-Cyclohexen-1-ol, 1-(1,5-dimethyl-4-hexenyl)-4-methyl- (8CI)
    • (1S)-1-[(1S)-1,5-Dimethyl-4-hexen-1-yl]-4-methyl-3-cyclohexen-1-ol
    • 1-[(1S)-1,5-Dimethyl-4-hexen-1-yl]-4-methyl-(1S)-3-Cyclohexen-1-ol

  • Applications

    beta-Bisabolol (CAS 15352-77-9) is a sesquiterpene alcohol widely used in cosmetics, dermocosmetics, and perfumery for its soothing, anti-irritant, redness-reducing, and mild antimicrobial/antioxidant benefits; it is commonly incorporated into barrier-repair creams and serums, gentle cleansers, baby care, after-sun, deodorants, and scalp-care products to enhance comfort and reduce stinging, and into toothpastes and mouthwashes to calm gingival tissues; in fragrances and fragranced goods it adds a soft sweet–herbal nuance and serves as a fixative that smooths the olfactive profile, while potentially enhancing percutaneous delivery of actives such as panthenol, niacinamide, or retinoids to optimize formulation performance; from a formulation standpoint it is oil-soluble, stable across typical cosmetic pH, and used at about 0.05–1.0%, aligning with clean/sustainable sourcing when produced from natural or synthetic routes, and compliant with contemporary safety guidelines when used at appropriate levels.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 710.82
    methanol 391.16
    isopropanol 706.24
    water 0.12
    ethyl acetate 1260.02
    n-propanol 650.38
    acetone 544.9
    n-butanol 796.9
    acetonitrile 385.1
    DMF 369.39
    toluene 824.79
    isobutanol 426.75
    1,4-dioxane 1731.43
    methyl acetate 678.9
    THF 1968.0
    2-butanone 840.1
    n-pentanol 454.64
    sec-butanol 629.21
    n-hexane 331.87
    ethylene glycol 24.34
    NMP 225.37
    cyclohexane 383.25
    DMSO 284.56
    n-butyl acetate 1125.64
    n-octanol 317.16
    chloroform 1494.76
    n-propyl acetate 598.35
    acetic acid 202.62
    dichloromethane 960.7
    cyclohexanone 758.7
    propylene glycol 80.01
    isopropyl acetate 911.96
    DMAc 517.83
    2-ethoxyethanol 489.67
    isopentanol 736.21
    n-heptane 195.52
    ethyl formate 310.42
    1,2-dichloroethane 669.27
    n-hexanol 929.82
    2-methoxyethanol 665.14
    isobutyl acetate 478.12
    tetrachloromethane 271.66
    n-pentyl acetate 541.6
    transcutol 3151.06
    n-heptanol 349.44
    ethylbenzene 417.45
    MIBK 604.66
    2-propoxyethanol 946.71
    tert-butanol 982.49
    MTBE 1945.26
    2-butoxyethanol 563.47
    propionic acid 213.82
    o-xylene 405.37
    formic acid 38.42
    diethyl ether 1930.52
    m-xylene 503.45
    p-xylene 430.82
    chlorobenzene 485.67
    dimethyl carbonate 147.83
    n-octane 64.92
    formamide 74.47
    cyclopentanone 550.6
    2-pentanone 803.65
    anisole 687.18
    cyclopentyl methyl ether 877.12
    gamma-butyrolactone 455.3
    1-methoxy-2-propanol 699.94
    pyridine 912.61
    3-pentanone 592.77
    furfural 448.52
    n-dodecane 38.69
    diethylene glycol 308.51
    diisopropyl ether 645.06
    tert-amyl alcohol 768.86
    acetylacetone 621.48
    n-hexadecane 46.19
    acetophenone 412.82
    methyl propionate 543.92
    isopentyl acetate 1031.23
    trichloroethylene 1044.46
    n-nonanol 307.22
    cyclohexanol 494.73
    benzyl alcohol 308.47
    2-ethylhexanol 574.69
    isooctanol 301.24
    dipropyl ether 1065.56
    1,2-dichlorobenzene 413.0
    ethyl lactate 167.91
    propylene carbonate 345.15
    n-methylformamide 154.89
    2-pentanol 650.02
    n-pentane 260.93
    1-propoxy-2-propanol 856.56
    1-methoxy-2-propyl acetate 934.97
    2-(2-methoxypropoxy) propanol 613.51
    mesitylene 339.45
    ε-caprolactone 719.61
    p-cymene 264.18
    epichlorohydrin 876.11
    1,1,1-trichloroethane 822.64
    2-aminoethanol 112.75
    morpholine-4-carbaldehyde 594.05
    sulfolane 349.48
    2,2,4-trimethylpentane 124.91
    2-methyltetrahydrofuran 1393.64
    n-hexyl acetate 779.89
    isooctane 122.03
    2-(2-butoxyethoxy)ethanol 927.02
    sec-butyl acetate 600.25
    tert-butyl acetate 972.01
    decalin 163.11
    glycerin 93.12
    diglyme 1556.41
    acrylic acid 111.37
    isopropyl myristate 320.61
    n-butyric acid 595.13
    acetyl acetate 497.83
    di(2-ethylhexyl) phthalate 237.41
    ethyl propionate 532.5
    nitromethane 287.18
    1,2-diethoxyethane 1642.88
    benzonitrile 394.28
    trioctyl phosphate 160.06
    1-bromopropane 793.11
    gamma-valerolactone 831.28
    n-decanol 219.65
    triethyl phosphate 249.17
    4-methyl-2-pentanol 438.27
    propionitrile 537.02
    vinylene carbonate 305.78
    1,1,2-trichlorotrifluoroethane 368.43
    DMS 400.13
    cumene 282.92
    2-octanol 237.65
    2-hexanone 629.19
    octyl acetate 362.35
    limonene 392.2
    1,2-dimethoxyethane 1170.73
    ethyl orthosilicate 284.77
    tributyl phosphate 210.72
    diacetone alcohol 611.36
    N,N-dimethylaniline 408.33
    acrylonitrile 357.39
    aniline 509.38
    1,3-propanediol 293.67
    bromobenzene 580.43
    dibromomethane 785.19
    1,1,2,2-tetrachloroethane 952.93
    2-methyl-cyclohexyl acetate 495.25
    tetrabutyl urea 241.23
    diisobutyl methanol 343.81
    2-phenylethanol 489.73
    styrene 472.98
    dioctyl adipate 380.18
    dimethyl sulfate 144.69
    ethyl butyrate 735.42
    methyl lactate 155.54
    butyl lactate 308.72
    diethyl carbonate 416.59
    propanediol butyl ether 393.31
    triethyl orthoformate 533.47
    p-tert-butyltoluene 289.13
    methyl 4-tert-butylbenzoate 461.16
    morpholine 1786.43
    tert-butylamine 834.34
    n-dodecanol 166.78
    dimethoxymethane 625.03
    ethylene carbonate 319.09
    cyrene 257.78
    2-ethoxyethyl acetate 750.27
    2-ethylhexyl acetate 830.04
    1,2,4-trichlorobenzene 448.38
    4-methylpyridine 961.33
    dibutyl ether 786.87
    2,6-dimethyl-4-heptanol 343.81
    DEF 643.11
    dimethyl isosorbide 782.26
    tetrachloroethylene 567.38
    eugenol 375.9
    triacetin 543.31
    span 80 485.68
    1,4-butanediol 79.51
    1,1-dichloroethane 795.13
    2-methyl-1-pentanol 481.9
    methyl formate 93.4
    2-methyl-1-butanol 572.96
    n-decane 81.45
    butyronitrile 718.31
    3,7-dimethyl-1-octanol 436.34
    1-chlorooctane 270.84
    1-chlorotetradecane 103.5
    n-nonane 79.27
    undecane 53.39
    tert-butylcyclohexane 172.0
    cyclooctane 147.92
    cyclopentanol 309.99
    tetrahydropyran 1977.32
    tert-amyl methyl ether 1000.47
    2,5,8-trioxanonane 958.53
    1-hexene 748.25
    2-isopropoxyethanol 430.84
    2,2,2-trifluoroethanol 47.98
    methyl butyrate 594.66

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Ayou Aydendron barbeyana Mez. (Nectandra globosa Mez.), fam. Lauraceae 8.3%
Bergamot (Italy) 3 8007-75-8 Citrus bergamia Risso et Poiteau, fam. Rutaceae 0.01%
Cedrela odorata Cedrela odorata L., fam. Meliaceae 0.53%
Cymbopogon distans 2 (Himalaya) Cymbopogon distans (Steud.) Wats. (Chemotype 2), fam. Poaceae (Gramineae) 0.5%
Ginger (Vietnam) 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 0.59%
Helichrysum italicum (Yugoslavia) 8023-95-8 Helichrysum italicum (Roth) G. Don (H. angustifolium D.C.), fam.Asteraceae 0.1%
Etrog, leaf Citrus medica L., cultivar ethrog Engl., fam. Rutaceae 0.05%
Etrog, peel Citrus medica L., cultivar ethrog Engl., fam. Rutaceae 0.01%
Cascarilla 2 8007-06-5 Croton eluteria Bennett, fam. Euphorbiaceae 0.02%
Sandalwood, indian (India) 2 8006-87-9 Santalum album L., fam. Santalaceae 0.64%
Ginger (Japan) 2 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 0.2%
Turmeric (Indonesia) 8024-37-1 Curcuma longa L. (C. domestica Val.), fam. Zingiberaceae 0.3%
Pepper, black 3 8006-82-4 Piper nigrum L., fam. Piperaceae 0.01%
Pepper, black (India) 1 8006-82-4 Piper nigrum L., fam. Piperaceae 0.15%
Laurel leaf (China) 8006-78-8 Laurus nobilis L., fam. Lauraceae 1.0%
Lavandin (France) (Grosso) 2 8022-15-9 Lavandula x hybrida Rev. (L. x intermedia Emeric ex Loiesleur), Lamiaceae 0.4%
Lavandin (France) (Abrialis) 2 8022-15-9 Lavandula x hybrida Rev. (L. x intermedia Emeric ex Loiseleur), Lamiaceae 0.24%
Spike lavender 8016-78-2 Lavandula latifolia Medikus (L. spica D.C.), fam. Lamiaceae (Labiatae) 0.02%
Copaiba (Colombia) 8001-61-4 Copaifera officinalis L., fam. Legumiosae (Papilionaceae) 1.06%
Lemon (Uruguay) 2 84929-31-7 Citrus limon (L.) Burm. f., cultivar Vernia, fam. Rutaceae 0.02%
Lemon (Uruguay) 3 84929-31-7 Citrus limon (L.) Burm. f., cultivar Eureka, fam. Rutaceae 0.03%
Lemon (Uruguay) 4 84929-31-7 Citrus limon (L.) Burm. f., cultivar Mesaro, fam. Rutaceae 0.03%
Lemon (Uruguay) 5 84929-31-7 Citrus limon (L.) Burm. f., cultivar Lisbon, fam. Rutaceae 0.03%
Lemon (Uruguay) 7 84929-31-7 Citrus limon (L.) Burm. f., cultivar Vila, fam. Rutaceae 0.02%
Lemon (Italy-Sicily) 10 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.02%
Phoebe 1 Phoebe porosa Mez. (syn. Oreodaphne porosa Nees et Mart.), fam. Lauraceae 2.9%
Phoebe 2 Phoebe porsa Mez. (syn. Oreodaphne prosa Nees & Mart.), fam. Lauraceae 2.55%
Teucrium heterophyllum (Madeira) Teucrium heterophyllum L'Her. (T. canariensis), fam. Lamiaceae (Labiatae) 0.45%
Boronia megastigma 91771-36-7 Boronia megastigma Nees., fam. Rutaceae 0.1%
Pepper, black (India) 3 8006-82-4 Piper nigrum L., fam. Piperaceae 0.2%
Aegle marmelos leaf (India) 1 Aegle marmelos (L.) Correa, fam. Rutaceae 1.5%
Santolina chamaecyparisus ssp. squarrosa Santolina chamaecyparisus L. ssp. squarrosa, fam. Asteraceae (Compositae) 0.05%
Lemon (Uruguay) 8a 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.02%
Lemon (Uruguay) 8b 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.02%
Pelargonium sidoides Pelargonium sidoides DC., fam. Geraniaceae 0.5%
Cabore (Brazil) Micrastur ruficolis, fam. Leguminosae (so-called: officially unknown) 0.01%
Piper guineense (Cameroon) 1a Piper guineense Schum. et Thom., fam. Piperaceae 1.0%
Chamomile, german (Greece) 1a 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 1.1%
Chamomile, german (Greece) 1b 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 1.4%
Canella winterana (Cuba) 2 Canella winterana (L.) Gaertn., fam. Canellaceae 3.1%
Fitzroya cupressoides Fitzroya cupressoides (Mol.) Johnston, fam. Cupressaceae 0.7%
Curcuma aromatica (India) 2a leaf Curcuma aromatica Salisb., fam. Zingiberaceae 0.1%
Curcuma aromatica (India) 2b rhizome Curcuma aromatica Salisb., fam. Zingiberaceae 0.05%
Eugenia ovalifolia leaf Eugenia ovalifolia Camb., fam. Myrtaceae 1.6%
Rollinia mucosa fruit Rollinia mucosa (Jacq.) Baill, fam. Annonaceae 0.1%
Cassia, leaf (China) 4b 8007-80-5 Cinnamomum cassia Blume, fam. Lauraceae 0.01%
Turmeric (China) 2 8024-37-1 Curcuma longa L. (C. domestica Val.), fam. Zingiberaceae 0.3%
Sandalwood, australian (Australia) Santalum spicatum L., fam. Santalaceae 3.0%
Sandalwood, queenslandian (Australia) Santalum lanceolatum L., fam. Santalaceae 2.0%
Turmeric (India) 5a rhizome 8024-37-1 Curcuma longa L., cv. Roma (C. domestica Val.), fam. Zingiberaceae 1.0%