alpha-Eudesmol

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  • Identifiers

    CAS number
    473-16-5

    Molecular formula
    C15H26O

    SMILES
    CC1=CCC[C@]2([C@H]1C[C@@H](CC2)C(C)(C)O)C

    Retention indicies (RI)

    • DB5: 1652.86
    • Carbowax: 2227.71

  • Odor profile

    Woody 80.3%
    Sweet 64.49%
    Floral 44.84%
    Spicy 44.21%
    Balsamic 40.07%
    Amber 40.02%
    Dry 39.05%
    Pine 35.64%
    Earthy 34.37%
    Citrus 34.17%

    Scent© AI

  • Properties

    XLogP3-AA
    3.5

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    301°C

    Flash point est.
    118.06 ˚C

  • Synonyms

    • alpha-Eudesmol
    • 473-16-5
    • eudesm-3-en-11-ol
    • SZ9QGL7BOX
    • UNII-SZ9QGL7BOX
    • (-)-|A-Eudesmol
    • CHEBI:10278
    • 2-Naphthalenemethanol, 1,2,3,4,4a,5,6,8a-octahydro-alpha,alpha,4a,8-tetramethyl-, (2R,4aR,8aR)-
    • (2R,4aR,8aR)-1,2,3,4,4a,5,6,8a-octahydro-alpha,alpha,4a,8-tetramethyl-2-naphthalenemethanol
    • 2-((2R,4AR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl)propan-2-ol
    • 2-[(2R,4aR,8aR)-4a,8-dimethyl-2,3,4,5,6,8a-hexahydro-1H-naphthalen-2-yl]propan-2-ol
    • 2-Naphthalenemethanol, 1,2,3,4,4a,5,6,8a-octahydro-.alpha.,.alpha.,4a,8-tetramethyl-, (2R,4aR,8aR)-
    • 2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]propan-2-ol
    • 1,2,3,4,4a,5,6,8a-octahydro-alpha,alpha,4a,8-tetramethyl-(2R-(2alpha,4aalpha,8abeta))-2-naphthalenemethanol
    • alpha-SELINENOL
    • (-)-a-Eudesmol; a-Selinenol; Eudesm-3-en-11-ol; [2R-(2a,4aa,8ass)]-1,2,3,4,4a,5,6,8a-Octahydro-a,a,4a,8-tetramethyl-2-naphthalenemethanol; 1,2ss,3,4,4a,5,6,8ass-Octahydro-a,a,4aa,8-tetramethyl-2-naphthalenemethanol; (2R,4aR,8aR)-1,2,3,4,4a,5,6,8a-Octahydro-a,a,4a,8-tetramethyl-2-naphthalenemethanol
    • (-)-alpha-EUDESMOL
    • .ALPHA.-SELINENOL
    • SCHEMBL1251075
    • (-)-.ALPHA.-EUDESMOL
    • CHEMBL3120654
    • DTXSID20883392
    • FCSRUSQUAVXUKK-VNHYZAJKSA-N
    • HY-165292
    • CS-1099832
    • C09663
    • Q27108609
    • 2-NAPHTHALENEMETHANOL, 1,2.BETA.,3,4,4A,5,6,8A.BETA.-OCTAHYDRO-.ALPHA.,.ALPHA.,4A.ALPHA.,8-TETRAMETHYL-
    • 2-NAPHTHALENEMETHANOL, 1,2beta,3,4,4A,5,6,8Abeta-OCTAHYDRO-alpha,alpha,4Aalpha,8-TETRAMETHYL-

  • Applications

    alpha-Eudesmol (CAS 473-16-5) is a woody, warm sesquiterpene alcohol used primarily as a fragrance ingredient and fixative in fine perfumery, soaps, shampoos, skin-care products, candles, and household cleaners, valued for its woody–earthy, sandalwood-like note; it is also employed as an intermediate/chiral scaffold for synthesizing sesquiterpene derivatives, as an analytical reference standard for essential-oil GC–MS profiling, and as a preclinical research probe with reported anti-inflammatory, antimicrobial, antioxidant, insect-repellent/termiticidal, and sensory neuroactive (ion-channel/TRP) properties, suggesting potential roles in cosmeceuticals, preservation of natural materials, and eco-friendly pest management, provided appropriate safety assessment (e.g., IFRA, irritation/sensitization) and local regulations are observed.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 327.69
    methanol 299.74
    isopropanol 262.68
    water 0.75
    ethyl acetate 389.12
    n-propanol 278.4
    acetone 393.81
    n-butanol 301.16
    acetonitrile 311.07
    DMF 394.15
    toluene 440.3
    isobutanol 185.37
    1,4-dioxane 1139.03
    methyl acetate 320.01
    THF 1393.82
    2-butanone 358.81
    n-pentanol 133.76
    sec-butanol 172.33
    n-hexane 38.86
    ethylene glycol 24.06
    NMP 284.18
    cyclohexane 132.38
    DMSO 193.64
    n-butyl acetate 412.54
    n-octanol 150.48
    chloroform 809.94
    n-propyl acetate 186.36
    acetic acid 147.24
    dichloromethane 590.91
    cyclohexanone 494.11
    propylene glycol 54.12
    isopropyl acetate 273.47
    DMAc 306.56
    2-ethoxyethanol 172.68
    isopentanol 235.06
    n-heptane 65.16
    ethyl formate 194.56
    1,2-dichloroethane 311.06
    n-hexanol 359.68
    2-methoxyethanol 364.3
    isobutyl acetate 165.15
    tetrachloromethane 132.97
    n-pentyl acetate 217.04
    transcutol 1285.64
    n-heptanol 164.61
    ethylbenzene 145.14
    MIBK 218.36
    2-propoxyethanol 498.8
    tert-butanol 295.09
    MTBE 369.54
    2-butoxyethanol 272.66
    propionic acid 138.74
    o-xylene 190.06
    formic acid 44.66
    diethyl ether 460.17
    m-xylene 264.29
    p-xylene 193.21
    chlorobenzene 337.07
    dimethyl carbonate 126.3
    n-octane 20.91
    formamide 91.12
    cyclopentanone 539.86
    2-pentanone 321.61
    anisole 287.47
    cyclopentyl methyl ether 483.39
    gamma-butyrolactone 494.69
    1-methoxy-2-propanol 324.61
    pyridine 595.2
    3-pentanone 241.34
    furfural 408.66
    n-dodecane 15.55
    diethylene glycol 221.03
    diisopropyl ether 152.56
    tert-amyl alcohol 174.98
    acetylacetone 336.19
    n-hexadecane 18.55
    acetophenone 204.24
    methyl propionate 267.93
    isopentyl acetate 375.65
    trichloroethylene 582.86
    n-nonanol 140.68
    cyclohexanol 242.74
    benzyl alcohol 167.24
    2-ethylhexanol 207.5
    isooctanol 126.42
    dipropyl ether 348.14
    1,2-dichlorobenzene 258.64
    ethyl lactate 82.15
    propylene carbonate 273.51
    n-methylformamide 176.2
    2-pentanol 162.34
    n-pentane 54.93
    1-propoxy-2-propanol 388.87
    1-methoxy-2-propyl acetate 444.36
    2-(2-methoxypropoxy) propanol 287.78
    mesitylene 161.12
    ε-caprolactone 400.47
    p-cymene 130.63
    epichlorohydrin 556.58
    1,1,1-trichloroethane 349.95
    2-aminoethanol 83.4
    morpholine-4-carbaldehyde 522.57
    sulfolane 315.72
    2,2,4-trimethylpentane 27.86
    2-methyltetrahydrofuran 724.67
    n-hexyl acetate 314.77
    isooctane 27.77
    2-(2-butoxyethoxy)ethanol 396.04
    sec-butyl acetate 155.2
    tert-butyl acetate 298.13
    decalin 43.15
    glycerin 73.37
    diglyme 713.74
    acrylic acid 101.07
    isopropyl myristate 135.73
    n-butyric acid 270.84
    acetyl acetate 250.09
    di(2-ethylhexyl) phthalate 132.79
    ethyl propionate 170.49
    nitromethane 297.77
    1,2-diethoxyethane 505.88
    benzonitrile 287.13
    trioctyl phosphate 91.04
    1-bromopropane 260.28
    gamma-valerolactone 718.24
    n-decanol 101.13
    triethyl phosphate 119.03
    4-methyl-2-pentanol 119.8
    propionitrile 315.68
    vinylene carbonate 301.64
    1,1,2-trichlorotrifluoroethane 236.4
    DMS 216.99
    cumene 97.37
    2-octanol 97.69
    2-hexanone 188.69
    octyl acetate 162.18
    limonene 172.99
    1,2-dimethoxyethane 436.16
    ethyl orthosilicate 126.76
    tributyl phosphate 107.54
    diacetone alcohol 240.73
    N,N-dimethylaniline 170.4
    acrylonitrile 285.16
    aniline 324.35
    1,3-propanediol 164.96
    bromobenzene 374.43
    dibromomethane 394.81
    1,1,2,2-tetrachloroethane 437.9
    2-methyl-cyclohexyl acetate 221.9
    tetrabutyl urea 129.69
    diisobutyl methanol 129.25
    2-phenylethanol 259.5
    styrene 175.67
    dioctyl adipate 175.19
    dimethyl sulfate 125.83
    ethyl butyrate 262.87
    methyl lactate 110.43
    butyl lactate 162.69
    diethyl carbonate 171.59
    propanediol butyl ether 216.7
    triethyl orthoformate 210.79
    p-tert-butyltoluene 141.23
    methyl 4-tert-butylbenzoate 228.23
    morpholine 1017.78
    tert-butylamine 233.25
    n-dodecanol 76.57
    dimethoxymethane 461.33
    ethylene carbonate 257.06
    cyrene 180.94
    2-ethoxyethyl acetate 317.97
    2-ethylhexyl acetate 302.91
    1,2,4-trichlorobenzene 291.25
    4-methylpyridine 559.47
    dibutyl ether 216.5
    2,6-dimethyl-4-heptanol 129.25
    DEF 277.88
    dimethyl isosorbide 495.56
    tetrachloroethylene 274.69
    eugenol 204.05
    triacetin 272.24
    span 80 256.23
    1,4-butanediol 41.19
    1,1-dichloroethane 351.12
    2-methyl-1-pentanol 123.35
    methyl formate 130.75
    2-methyl-1-butanol 182.77
    n-decane 30.24
    butyronitrile 361.92
    3,7-dimethyl-1-octanol 158.07
    1-chlorooctane 105.54
    1-chlorotetradecane 42.81
    n-nonane 28.18
    undecane 20.95
    tert-butylcyclohexane 40.51
    cyclooctane 48.79
    cyclopentanol 211.61
    tetrahydropyran 981.88
    tert-amyl methyl ether 211.65
    2,5,8-trioxanonane 470.25
    1-hexene 111.97
    2-isopropoxyethanol 142.8
    2,2,2-trifluoroethanol 54.09
    methyl butyrate 195.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Artemisia nilagirica (vulgaris) (India) 1 Artemisia nilagirica (C.B. Clarks) Pamp. (A. vulgaris Hook f.), Asteraceae 1.62%
Galbanum 2 9000-24-2 Ferula galbaniflua Boiss. et Buhse, fam. Apiaceae (Umbelliferae) 0.5%
Ginger (India) 1 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 0.1%
Hinoki leaf Chamaecyparis obtusa (Sieb. et Zucc.) Endl., fam. Cupressaceae 5.39%
Schinus molle 68917-52-2 Schinus molle L., fam. Anarcadiaceae 0.3%
Yuzu (Japan) 2 Citrus junos Sieb. ex Tanaka, fam. Rutaceae 0.03%
Schinus molle berry 68917-52-2 Schinus molle L., fam. Anarcadiaceae 0.1%
Schinus molle leaf 68917-52-2 Schinus molle L., fam. Anarcadiaceae 0.01%
Eucalyptus viminalis (Uruguay) Eucalyptus viminalis Labill., fam. Myrtaceae 6.1%
Cajuput (Vietnam) 2 8008-98-8 Melaleuca cajuputi Powell, var. cajuputi, fam. Myrtaceae 0.7%
Eucalyptus brassiana Eucalyptus brassiana S.T. Blake, fam. Myrtaceae 0.06%
Juniperus martinezii Juniperus martinezii Perez de la Rosa, fam. Cupressaceae 0.3%
Juniperus flaccida var. flaccida Juniperus flaccida Schlecht, var. flaccida, fam. Cupressaceae 0.7%
Swangi (Citrus hystrix) peel (Thailand) 2c Citrus hystrix DC (Swangi), fam. Rutaceae 0.01%
Guava fruit (Nigeria) 91770-12-6 Psidium guajava L., fam. Myrtaceae 0.46%
Schinus latifolius Schinus latifolius Engl., fam. Anarcadiaceae 0.5%
Clary sage leaf 8016-63-5 Salvia sclarea L., fam. Lamiaceae (Labiatae) 0.01%
Amyris 2 8015-65-4 Amyris balsamifera L., fam. Rutaceae 4.8%
Eucalyptus globulus (Burundi) 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 1.7%
Eucalyptus maidenii (Burundi) Eucalyptus maidenii F. Muell., fam. Myrtaceae 0.8%
Blumea brevipes Blumea brevipes (Oliv. & Hiern) Willd., fam. Asteraceae (Compositae) 0.3%
Magnolia sprengeri (China) Magnolia sprengeri Pamp., fam. Magnoliaceae 4.62%
Celery seed (India) 4 8015-90-5 Apium graveolens L., fam. Apiaceae (Umbelliferae) 0.9%
Salvia cryptantha (Turkey) Salvia cryptantha Montbret et Aucher ex Benth., fam. Lamiaceae (Labiatae) 0.5%
Juniperus rigida (Japan) 2 Juniperus rigida Mig., fam. Cupressaceae 0.05%
Guarea cedrata bark Guarea cedrata (A. Chev.) Pellegr., fam. Meliaceae 2.3%
Phoebe 2 Phoebe porsa Mez. (syn. Oreodaphne prosa Nees & Mart.), fam. Lauraceae 5.3%
Mentha diemenica (Australia) Mentha diemenica Sprengel, fam. Lamiaceae (Labiatae) 0.12%
Sassafras root wood (USA) 1b 8006-80-2 Sassafras albidum (Nutt.) Nees, fam. Lauraceae 0.4%
Cedarleaf (Canada) 5 wood Thuja occidentalis L., fam. Taxodiaceae 4.95%
Pepper, black (India) 2 8006-82-4 Piper nigrum L., fam. Piperaceae 0.1%
Pepper, green (India) 8006-82-4 Piper nigrum L., fam. Piperaceae 0.1%
Alpinia speciosa leaf (Egypt) Alipinia speciosa (J.C. Wendl.) K. Schum., fam. Zingiberaceae 0.3%
Alpinia speciosa rhizome (Egypt) Alpinia speciosa (J.C. Wendl.) K.Schum., fam. Zingiberaceae 0.5%
Alpinia speciosa stem (Egypt) Alpinia speciosa (J.C. Wendl.) K.Schum., fam. Zingiberaceae 0.1%
Uromyrtus australis (Australia) Uromyrtus australis A.J. Scott, fam. Myrtaceae 8.42%
Annona squamosa root Annona squamosa L., fam. Annonaceae (sweetsop or custard apple) 2.42%
St. John's wort (India) 84082-80-4 Hypericum perforatum L., fam. Guttiferae (Hypericaceae) 0.5%
Pepper, black (India) 3 8006-82-4 Piper nigrum L., fam. Piperaceae 0.05%
Xylopia aethiopica fruit (Benin) 2 Xylopia aethiopica (Dunal) A. Richard, fam. Annonaceae 0.05%
Xylopia aethiopica leaf (Benin) Xylopia aethiopica (Dunal) A. Richard, fam. Annonaceae 1.3%
Thymus funkii Thymus funkii Cosson, fam. Lamiaceae (Labiatae) 0.1%
Leptospermum javanicum (Malaysia) Leptospermum javanicum Blume, fam. Myrtaceae 3.5%
Citronella java (Cuba) 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Graminae) 2.64%
Rose headspace 2 8007-01-0 Rosa damascena Mill., cv. rose de resht, fam. Rosaceae 0.2%
Mentha citrata (Bergamot mint) (France) 68917-15-7 Mentha citrata Ehrh., fam. Lamiaceae (Labiatae) 0.5%
Citronella java (Ghana) 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 0.3%
Helichrysum italicum 1a 8023-95-8 Helichrysum italicum (Roth) G. Don ssp. italicum, fam. Asteraceae 0.2%
Clary sage (Italy) 1 8016-63-5 Salvia sclarea L., fam. Lamiaceae (Labiatae) 0.13%
Eucalyptus macathurii Ecalyptus macathurii Dean & Maiden, fam. Myrtaceae 4.9%