2,3-Dimethyl Pyrazine Aroma Chemical
CAS# 5910-89-4
Nutty, Roasted, Cocoa, Musty, Hazelnut
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2,3-Dimethyl Pyrazine is a nature-identical and synthetic ingredient that plays a key role in recreating culinary-style aromas. In nature, this compound is formed through the Maillard reaction during heating and is found abundantly in roasted coffee, cocoa, and toasted nuts. Its successful isolation and synthesis in the mid-20th century helped perfumers solve the challenge of creating realistic roasted notes. Physically, it is a clear to pale yellow liquid belonging to the food-like olfactory group and the roasted aroma family.
Description
The scent of 2,3-Dimethyl Pyrazine reveals an intense character of roasted nuts, dark chocolate, coffee grounds, blended with subtle earthy and baked potato nuances. Functioning from the top note to the heart note, and serving as both an enhancer and a modifier, this material has explosive odor strength, piercing diffusion, and a persistence ranging from several hours up to 24 hours on a blotter. In fragrance compositions, it helps construct coffee, hazelnut, and caramel notes while also providing warmth and a vivid “burnt” effect. Perfumers often pair it with Vanillin, coffee extract, patchouli, and sandalwood to create complete gourmand accords. Because its odor is extremely powerful and can easily disrupt the overall balance, it must be diluted in safe solvents such as DPG, TEC, or IPM at very low concentrations such as 1%, 0.1%, or 0.01% for easier dosage control.
Applications
In terms of applications, this material is used mainly in food flavorings, fine fragrance, scented candles, and home fragrance products with pastry or coffee shop themes, but it is less common in soap or skincare cosmetics. 2,3-Dimethyl Pyrazine is considered safe and is not subject to strict IFRA restrictions, allowing flexible use, although in practice only trace levels from 0.001% to 0.05% are needed. Users do not need to be concerned about phototoxicity or European allergen labeling requirements. However, it should be stored tightly closed in a cool, dry place to prevent evaporation and quality loss. Many niche coffee-themed fragrances by Montale or Kilian bear the imprint of this type of material. Finally, the value of this ingredient was affirmed in Perfume and Flavor Chemicals, where expert Steffen Arctander described pyrazine derivatives as possessing extremely powerful roasted, nutty, and cocoa-like odors. He emphasized their enormous diffusive strength, the need for extremely low dosage, and their importance in recreating artificial coffee and cocoa notes.
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Technical standards
Technical standards
Solubility @25˚C
Solubility @25˚C
| Solvent | Solubility (g/L) |
|---|---|
| ethanol | 110.58 |
| methanol | 236.9 |
| isopropanol | 62.62 |
| water | 13.27 |
| ethyl acetate | 66.31 |
| n-propanol | 90.9 |
| acetone | 70.0 |
| n-butanol | 73.62 |
| acetonitrile | 89.3 |
| DMF | 157.18 |
| toluene | 60.45 |
| isobutanol | 63.66 |
| 1,4-dioxane | 111.1 |
| methyl acetate | 78.91 |
| THF | 183.17 |
| 2-butanone | 89.71 |
| n-pentanol | 55.25 |
| sec-butanol | 64.56 |
| n-hexane | 21.82 |
| ethylene glycol | 29.33 |
| NMP | 242.58 |
| cyclohexane | 22.47 |
| DMSO | 147.9 |
| n-butyl acetate | 49.34 |
| n-octanol | 18.03 |
| chloroform | 399.49 |
| n-propyl acetate | 34.33 |
| acetic acid | 86.45 |
| dichloromethane | 394.16 |
| cyclohexanone | 121.0 |
| propylene glycol | 24.41 |
| isopropyl acetate | 34.37 |
| DMAc | 181.76 |
| 2-ethoxyethanol | 71.58 |
| isopentanol | 52.28 |
| n-heptane | 14.24 |
| ethyl formate | 77.58 |
| 1,2-dichloroethane | 180.63 |
| n-hexanol | 41.99 |
| 2-methoxyethanol | 133.25 |
| isobutyl acetate | 22.94 |
| tetrachloromethane | 111.87 |
| n-pentyl acetate | 36.93 |
| transcutol | 123.94 |
| n-heptanol | 23.96 |
| ethylbenzene | 28.63 |
| MIBK | 32.11 |
| 2-propoxyethanol | 72.69 |
| tert-butanol | 56.29 |
| MTBE | 60.54 |
| 2-butoxyethanol | 45.17 |
| propionic acid | 78.52 |
| o-xylene | 47.94 |
| formic acid | 98.27 |
| diethyl ether | 83.69 |
| m-xylene | 33.93 |
| p-xylene | 44.93 |
| chlorobenzene | 99.16 |
| dimethyl carbonate | 23.75 |
| n-octane | 6.08 |
| formamide | 128.81 |
| cyclopentanone | 154.5 |
| 2-pentanone | 59.09 |
| anisole | 52.48 |
| cyclopentyl methyl ether | 87.93 |
| gamma-butyrolactone | 180.54 |
| 1-methoxy-2-propanol | 70.3 |
| pyridine | 148.57 |
| 3-pentanone | 66.58 |
| furfural | 203.73 |
| n-dodecane | 3.74 |
| diethylene glycol | 48.71 |
| diisopropyl ether | 20.69 |
| tert-amyl alcohol | 61.66 |
| acetylacetone | 48.36 |
| n-hexadecane | 4.18 |
| acetophenone | 49.63 |
| methyl propionate | 63.78 |
| isopentyl acetate | 45.12 |
| trichloroethylene | 296.35 |
| n-nonanol | 17.84 |
| cyclohexanol | 52.95 |
| benzyl alcohol | 49.02 |
| 2-ethylhexanol | 29.59 |
| isooctanol | 20.13 |
| dipropyl ether | 42.78 |
| 1,2-dichlorobenzene | 100.99 |
| ethyl lactate | 20.5 |
| propylene carbonate | 88.17 |
| n-methylformamide | 132.53 |
| 2-pentanol | 41.29 |
| n-pentane | 21.32 |
| 1-propoxy-2-propanol | 47.06 |
| 1-methoxy-2-propyl acetate | 44.84 |
| 2-(2-methoxypropoxy) propanol | 38.34 |
| mesitylene | 21.49 |
| ε-caprolactone | 106.58 |
| p-cymene | 24.32 |
| epichlorohydrin | 203.6 |
| 1,1,1-trichloroethane | 178.37 |
| 2-aminoethanol | 60.84 |
| morpholine-4-carbaldehyde | 152.94 |
| sulfolane | 215.26 |
| 2,2,4-trimethylpentane | 11.37 |
| 2-methyltetrahydrofuran | 147.41 |
| n-hexyl acetate | 37.9 |
| isooctane | 5.26 |
| 2-(2-butoxyethoxy)ethanol | 45.88 |
| sec-butyl acetate | 23.6 |
| tert-butyl acetate | 33.17 |
| decalin | 12.59 |
| glycerin | 37.1 |
| diglyme | 102.14 |
| acrylic acid | 73.57 |
| isopropyl myristate | 17.9 |
| n-butyric acid | 85.32 |
| acetyl acetate | 40.19 |
| di(2-ethylhexyl) phthalate | 21.98 |
| ethyl propionate | 36.51 |
| nitromethane | 144.46 |
| 1,2-diethoxyethane | 64.57 |
| benzonitrile | 73.04 |
| trioctyl phosphate | 14.12 |
| 1-bromopropane | 128.69 |
| gamma-valerolactone | 177.27 |
| n-decanol | 13.47 |
| triethyl phosphate | 29.48 |
| 4-methyl-2-pentanol | 20.28 |
| propionitrile | 95.34 |
| vinylene carbonate | 90.5 |
| 1,1,2-trichlorotrifluoroethane | 136.14 |
| DMS | 39.7 |
| cumene | 23.64 |
| 2-octanol | 16.61 |
| 2-hexanone | 41.32 |
| octyl acetate | 21.49 |
| limonene | 32.47 |
| 1,2-dimethoxyethane | 103.98 |
| ethyl orthosilicate | 30.38 |
| tributyl phosphate | 21.09 |
| diacetone alcohol | 36.91 |
| N,N-dimethylaniline | 44.07 |
| acrylonitrile | 107.39 |
| aniline | 79.77 |
| 1,3-propanediol | 69.9 |
| bromobenzene | 98.92 |
| dibromomethane | 261.84 |
| 1,1,2,2-tetrachloroethane | 244.83 |
| 2-methyl-cyclohexyl acetate | 36.91 |
| tetrabutyl urea | 27.7 |
| diisobutyl methanol | 17.47 |
| 2-phenylethanol | 40.66 |
| styrene | 35.56 |
| dioctyl adipate | 25.14 |
| dimethyl sulfate | 51.44 |
| ethyl butyrate | 42.75 |
| methyl lactate | 30.82 |
| butyl lactate | 25.24 |
| diethyl carbonate | 33.04 |
| propanediol butyl ether | 24.52 |
| triethyl orthoformate | 37.5 |
| p-tert-butyltoluene | 22.73 |
| methyl 4-tert-butylbenzoate | 42.62 |
| morpholine | 132.69 |
| tert-butylamine | 43.51 |
| n-dodecanol | 10.7 |
| dimethoxymethane | 76.79 |
| ethylene carbonate | 72.13 |
| cyrene | 44.2 |
| 2-ethoxyethyl acetate | 50.68 |
| 2-ethylhexyl acetate | 41.29 |
| 1,2,4-trichlorobenzene | 116.03 |
| 4-methylpyridine | 137.64 |
| dibutyl ether | 31.36 |
| 2,6-dimethyl-4-heptanol | 17.47 |
| DEF | 89.06 |
| dimethyl isosorbide | 87.26 |
| tetrachloroethylene | 195.45 |
| eugenol | 38.14 |
| triacetin | 37.59 |
| span 80 | 28.81 |
| 1,4-butanediol | 28.59 |
| 1,1-dichloroethane | 176.15 |
| 2-methyl-1-pentanol | 46.94 |
| methyl formate | 82.73 |
| 2-methyl-1-butanol | 61.12 |
| n-decane | 6.13 |
| butyronitrile | 85.49 |
| 3,7-dimethyl-1-octanol | 19.78 |
| 1-chlorooctane | 18.64 |
| 1-chlorotetradecane | 8.76 |
| n-nonane | 6.05 |
| undecane | 4.6 |
| tert-butylcyclohexane | 11.36 |
| cyclooctane | 8.59 |
| cyclopentanol | 75.48 |
| tetrahydropyran | 101.14 |
| tert-amyl methyl ether | 57.95 |
| 2,5,8-trioxanonane | 73.96 |
| 1-hexene | 42.12 |
| 2-isopropoxyethanol | 41.55 |
| 2,2,2-trifluoroethanol | 55.95 |
| methyl butyrate | 47.43 |
Scent© AI

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CAS NUMBER
5910-89-4
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FAMILIES
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BRAND
Scent.vn
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EVAPORATION RATE
Very fast
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Odor impact
High est.
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FLASH POINT
60.96 ˚C est.
Olfactory Pyramid
Notes
| Nutty |
| Roasted |
| Cocoa |
| Musty |
| Hazelnut |
| Maximum acceptable concentrations in the finished product (%) | |||
|---|---|---|---|
|
Category 1
Products applied to the lips
|
No restriction |
Category 7A
Rinse-off products applied to the hair with some hand contact
|
No restriction |
|
Category 2
Products applied to the axillae
|
No restriction |
Category 7B
Leave-on products applied to the hair with some hand contact
|
No restriction |
|
Category 3
Products applied to the face/body using fingertips
|
No restriction |
Category 8
Products with significant anogenital exposure
|
No restriction |
|
Category 4
Products related to fine fragrance
|
No restriction |
Category 9
Products with body and hand exposure, primarily rinse off
|
No restriction |
|
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
|
No restriction |
Category 10A
Household care products with mostly hand contact
|
No restriction |
|
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
|
No restriction |
Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
|
No restriction |
|
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
|
No restriction |
Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
|
No restriction |
|
Category 5D
Baby Creams, baby Oils and baby talc
|
No restriction |
Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
|
No restriction |
|
Category 6
Products with oral and lip exposure
|
No restriction |
Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
|
No restriction |
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Certificates of Quality
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Certificate of Analysis (COA)
Provides information on the physical and chemical properties of the product.Download -
IFRA Certificate of Conformity
Sets safety standards and guidelines for the product in manufacturing.Download -
Safety Data Sheet (SDS)
Provides important safety guidelines for transporting, storing, and using the product.Download