trans,trans-Farnesol

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  • Identifiers

    CAS number
    4602-84-0

    Molecular formula
    C15H26O

    SMILES
    CC(=CCC/C(=C/CC/C(=C/CO)/C)/C)C

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1723.0
    • Carbowax: 2299.67

  • Odor profile

    Floral 90.45%
    Rose 65.81%
    Waxy 64.52%
    Sweet 60.12%
    Citrus 50.64%
    Green 48.91%
    Fruity 48.09%
    Fresh 47.42%
    Balsamic 46.27%
    Muguet 42.06%

    Scent© AI

  • Properties

    XLogP3-AA
    4.8

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • < 25 °C

    Boiling point

    • 283.00 to 284.00 °C. @ 760.00 mm Hg

    Flash point est.
    136.37 ˚C

  • Synonyms

    • farnesol
    • trans,trans-Farnesol
    • 106-28-5
    • (E,E)-Farnesol
    • (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
    • 4602-84-0
    • trans-Farnesol
    • (2E,6E)-Farnesol
    • 2-trans,6-trans-Farnesol
    • All-trans-Farnesol
    • Farnesyl alcohol
    • 3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
    • Inhibitor A2
    • FCI 119a
    • 2,6-Di-trans-Farnesol
    • (E)-farnesol
    • 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-
    • HSDB 445
    • 2,6,10-dodecatrien-1-ol, 3,7,11-trimethyl-, (2E,6E)-
    • 2E,6E-farnesol
    • 3,7,11-trimethyldodeca-2,6,10-trien-1-ol
    • 3,7,11-Trimethyl-2,6,10-dodecatrienol
    • (E,?E)?-?Farnesol
    • CHEBI:16619
    • X23PI60R17
    • (2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
    • Trimethyl dodecatrienol
    • 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl-, (E,E)-
    • EINECS 225-004-1
    • UNII-EB41QIU6JL
    • MFCD00002918
    • NSC 60597
    • EPA Pesticide Chemical Code 128911
    • Nikkosome
    • (2-trans,6-trans)-farnesol
    • AI3-44561
    • (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
    • trans,trans-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
    • FEMA No. 2478
    • CIS-TRANS-FARNESOL
    • EB41QIU6JL
    • FEMA 2478
    • DTXCID80196591
    • transfarnesol
    • UNII-X23PI60R17
    • trans- farnesol
    • trans,trans-Farnesol; trans-Farnesol
    • .beta.-Farnesol
    • E,E-farnesol
    • all-trans farnesol
    • (E,E)farnesol
    • FOF
    • trans,trans farnesol
    • (E,)-arnesol
    • Farnesol (6CI)
    • (E,E,)-farnesol
    • Farnesol (Standard)
    • Farnesol, 95%
    • trans, trans-Farnesol
    • ALL-E-FARNESOL
    • Farnesol (2E,6E)
    • Farnesol, (E,E)-
    • Farnesol, trans, trans
    • ST072172
    • 2E,6E-Farnesyl alcohol
    • Spectrum5_002027
    • trans,trans-alpha-farnesol
    • trans,trans-Farnesol, 96%
    • trans,trans-Farnesol, 97%
    • SCHEMBL58068
    • 2-trans-S-6-trans-farnesol
    • BSPBio_002660
    • Farnesol, analytical standard
    • CHEMBL25308
    • SPECTRUM1501022
    • (E)-.BETA.-FARNESOL
    • HY-Y0248AR
    • DTXSID2040789
    • (E,E)-2,6-FARNESOL
    • BDBM11021
    • CHEBI:26199
    • CHEBI:28600
    • FARNESOL, (2E,6E)-
    • HY-Y0248A
    • BCP22704
    • HY-Y0248
    • Tox21_302034
    • AC-422
    • BBL027412
    • CCG-38862
    • s4941
    • STL372743
    • AKOS004907430
    • LMPR0103010001
    • NCGC00095654-01
    • NCGC00095654-02
    • NCGC00095654-03
    • NCGC00095654-04
    • NCGC00095654-05
    • NCGC00255293-01
    • trans,trans-Farnesol, analytical standard
    • AS-16107
    • DA-63376
    • LS-14447
    • CAS-4602-84-0
    • FARNESOL TRANS,TRANS-FARNESOL [MI]
    • CS-0008518
    • CS-0031456
    • FEMA NO. 2478, (2E,6E)-
    • NS00007807
    • T0608
    • C01126
    • EN300-1692687
    • Q420449
    • BRD-K24656285-001-01-0
    • (2E, 6E)-3,7,11-trimethyl2,6,10-dodecatrien-1-ol
    • (E,E,)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
    • F1905-7040
    • Z2315575130
    • (2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trien-1-ol
    • (E,E)-3,7,11-TRIMETHYL-2,6,10-DODECATNEN-1-OL
    • 2,6,10-Dodecatrien-1-ol, 3,7,11-trimethyl- (8CI,9CI)
    • A2865747-EC66-4B9C-A593-0A066A438904
    • (2-trans,6-trans)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol
    • 3,7,11-TRIMETHYLDODECA-2-TRANS,6-TRANS,10-TRIEN-1-OL
    • InChI=1/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11
    • trans,trans-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol, (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol

  • Applications

    Farnesol (CAS 4602-84-0) is a naturally occurring sesquiterpene alcohol found in jasmine, orange, lemon and many other essential oils; industrially it is widely used as a fragrance modifier and fixative in fine perfumes, imparting warm, sweet, slightly fruity nuances to eau de toilette, scented soaps, nail lacquers and deodorants, while acting as an emollient, sebum regulator, antibacterial, antifungal and deodorizing agent in skin-care, anti-acne and anti-aging cosmetics; in pharmaceuticals, farnesol is being explored as a quorum-sensing modulator that suppresses biofilm formation by Candida albicans, supporting treatments for fungal infections, periodontitis and dermatitis; in the food-flavour industry it is employed at trace levels to reinforce citrus, peach and strawberry notes; in agriculture, farnesol functions as a pheromone for drosophila and pink bollworm, enabling biological traps or mating disruption strategies for pest control; finally, it serves as an intermediate for the synthesis of vitamin K2, coenzyme Q10 and various high-value terpenoids, highlighting the molecule’s multifaceted potential across specialty chemicals, functional foods and modern cosmeceuticals.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 589.99
    methanol 313.58
    isopropanol 467.1
    water 0.06
    ethyl acetate 448.5
    n-propanol 466.84
    acetone 269.13
    n-butanol 567.9
    acetonitrile 148.96
    DMF 114.22
    toluene 195.66
    isobutanol 285.96
    1,4-dioxane 938.53
    methyl acetate 224.77
    THF 1268.53
    2-butanone 340.02
    n-pentanol 383.19
    sec-butanol 432.9
    n-hexane 250.19
    ethylene glycol 15.9
    NMP 118.23
    cyclohexane 311.35
    DMSO 196.82
    n-butyl acetate 441.74
    n-octanol 159.08
    chloroform 548.9
    n-propyl acetate 294.68
    acetic acid 118.8
    dichloromethane 400.61
    cyclohexanone 421.5
    propylene glycol 72.04
    isopropyl acetate 287.81
    DMAc 171.47
    2-ethoxyethanol 368.93
    isopentanol 399.66
    n-heptane 213.29
    ethyl formate 128.9
    1,2-dichloroethane 303.29
    n-hexanol 546.98
    2-methoxyethanol 418.43
    isobutyl acetate 205.39
    tetrachloromethane 110.75
    n-pentyl acetate 219.53
    transcutol 1278.27
    n-heptanol 205.26
    ethylbenzene 132.1
    MIBK 254.0
    2-propoxyethanol 525.23
    tert-butanol 595.01
    MTBE 738.93
    2-butoxyethanol 295.94
    propionic acid 109.68
    o-xylene 118.89
    formic acid 21.11
    diethyl ether 1050.92
    m-xylene 141.76
    p-xylene 140.26
    chlorobenzene 139.51
    dimethyl carbonate 34.6
    n-octane 49.25
    formamide 32.37
    cyclopentanone 296.67
    2-pentanone 390.06
    anisole 221.38
    cyclopentyl methyl ether 493.26
    gamma-butyrolactone 215.93
    1-methoxy-2-propanol 384.5
    pyridine 344.33
    3-pentanone 233.26
    furfural 185.39
    n-dodecane 21.6
    diethylene glycol 160.15
    diisopropyl ether 277.51
    tert-amyl alcohol 469.61
    acetylacetone 212.45
    n-hexadecane 25.27
    acetophenone 150.29
    methyl propionate 181.93
    isopentyl acetate 374.95
    trichloroethylene 393.38
    n-nonanol 155.52
    cyclohexanol 362.89
    benzyl alcohol 131.59
    2-ethylhexanol 342.96
    isooctanol 167.63
    dipropyl ether 773.56
    1,2-dichlorobenzene 125.47
    ethyl lactate 86.12
    propylene carbonate 147.27
    n-methylformamide 57.96
    2-pentanol 409.65
    n-pentane 204.54
    1-propoxy-2-propanol 504.44
    1-methoxy-2-propyl acetate 334.82
    2-(2-methoxypropoxy) propanol 260.73
    mesitylene 102.84
    ε-caprolactone 346.76
    p-cymene 111.42
    epichlorohydrin 408.11
    1,1,1-trichloroethane 308.37
    2-aminoethanol 80.41
    morpholine-4-carbaldehyde 257.08
    sulfolane 206.78
    2,2,4-trimethylpentane 68.42
    2-methyltetrahydrofuran 873.45
    n-hexyl acetate 281.64
    isooctane 59.09
    2-(2-butoxyethoxy)ethanol 403.13
    sec-butyl acetate 252.5
    tert-butyl acetate 326.53
    decalin 90.93
    glycerin 68.15
    diglyme 684.96
    acrylic acid 50.69
    isopropyl myristate 121.96
    n-butyric acid 324.0
    acetyl acetate 152.1
    di(2-ethylhexyl) phthalate 90.23
    ethyl propionate 227.86
    nitromethane 120.91
    1,2-diethoxyethane 704.59
    benzonitrile 131.22
    trioctyl phosphate 67.61
    1-bromopropane 398.7
    gamma-valerolactone 418.03
    n-decanol 110.16
    triethyl phosphate 122.62
    4-methyl-2-pentanol 208.29
    propionitrile 190.3
    vinylene carbonate 105.72
    1,1,2-trichlorotrifluoroethane 182.13
    DMS 113.08
    cumene 101.51
    2-octanol 130.03
    2-hexanone 329.53
    octyl acetate 136.99
    limonene 201.35
    1,2-dimethoxyethane 747.3
    ethyl orthosilicate 153.68
    tributyl phosphate 87.84
    diacetone alcohol 274.07
    N,N-dimethylaniline 145.97
    acrylonitrile 105.09
    aniline 174.25
    1,3-propanediol 187.18
    bromobenzene 149.18
    dibromomethane 353.07
    1,1,2,2-tetrachloroethane 396.37
    2-methyl-cyclohexyl acetate 256.5
    tetrabutyl urea 101.64
    diisobutyl methanol 190.66
    2-phenylethanol 189.81
    styrene 135.46
    dioctyl adipate 158.13
    dimethyl sulfate 41.17
    ethyl butyrate 377.74
    methyl lactate 57.98
    butyl lactate 138.57
    diethyl carbonate 186.61
    propanediol butyl ether 186.86
    triethyl orthoformate 292.36
    p-tert-butyltoluene 115.14
    methyl 4-tert-butylbenzoate 171.51
    morpholine 1162.49
    tert-butylamine 482.36
    n-dodecanol 83.07
    dimethoxymethane 241.68
    ethylene carbonate 114.56
    cyrene 142.94
    2-ethoxyethyl acetate 274.77
    2-ethylhexyl acetate 314.31
    1,2,4-trichlorobenzene 137.74
    4-methylpyridine 305.89
    dibutyl ether 394.31
    2,6-dimethyl-4-heptanol 190.66
    DEF 270.86
    dimethyl isosorbide 381.62
    tetrachloroethylene 242.63
    eugenol 147.47
    triacetin 191.68
    span 80 249.85
    1,4-butanediol 60.75
    1,1-dichloroethane 320.45
    2-methyl-1-pentanol 297.06
    methyl formate 34.79
    2-methyl-1-butanol 339.37
    n-decane 48.76
    butyronitrile 342.76
    3,7-dimethyl-1-octanol 174.54
    1-chlorooctane 138.66
    1-chlorotetradecane 49.13
    n-nonane 52.13
    undecane 30.19
    tert-butylcyclohexane 89.39
    cyclooctane 101.28
    cyclopentanol 225.46
    tetrahydropyran 1376.34
    tert-amyl methyl ether 469.95
    2,5,8-trioxanonane 416.47
    1-hexene 496.8
    2-isopropoxyethanol 280.76
    2,2,2-trifluoroethanol 21.09
    methyl butyrate 288.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
Restriction / Specification
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0.21 % Category 7A
Rinse-off products applied to the hair with some hand contact
 2.4 %
Category 2
Products applied to the axillae
 0.062 % Category 7B
Leave-on products applied to the hair with some hand contact
 2.4 %
Category 3
Products applied to the face/body using fingertips
 1.2 % Category 8
Products with significant anogenital exposure
 0.12 %
Category 4
Products related to fine fragrance
 1.2 % Category 9
Products with body and hand exposure, primarily rinse off
 2.3 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 0.29 % Category 10A
Household care products with mostly hand contact
 8.1 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 0.29 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 8.1 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0.29 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 4.5 %
Category 5D
Baby Creams, baby Oils and baby talc
 0.29 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 4.5 %
Category 6
Products with oral and lip exposure
 0.68 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Specification
Farnesol should only be used as a fragrance ingredient if it contains a minimum of 96% of farnesol isomers as determined by GLC.

Botanical

Name CAS Botanical Proportion
Ageratum conyzoides (Vietnam) 85480-32-6 Ageratum conyzoides L., fam. Asteraceae (Compositae) 0.2%
Artemisia monosperma Artemisia monosperma Del., fam. Asteraceae (Compositae) 0.1%
Asafoetida (Pakistan) 1a 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 0.1%
Boldo leaf Boldea fragrans Juss. (Peumus boldus Mol.) 0.4%
Ylang Ylang (Fiji) 68606-83-7 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 21.0%
Cardamom seed 1 8000-66-6 Elettaria cardamomum (L.) Maton, fam. Zingiberaceae 0.05%
Cardamom (Costa Rica) 8000-66-6 Elettaria cardamomum (L.) Maton, fam. Zingiberaceae 0.01%
Cardamom (Reunion) 8000-66-6 Elettaria cardamomum (L.) Maton, var. alpha-minor, fam. Zingiberaceae 0.1%
Cassia, branch & leaf (Australia) 8007-80-5 Cinnamomum cassia Blume, fam. Lauraceae 0.01%
Cassia, bark (Australia) 8007-80-5 Cinnamomum cassia Blume, fam. Lauraceae 0.01%
Cassia, leaf (Australia) 8007-80-5 Cinnamomum cassia Blume, fam. Lauraceae 0.08%
Chamomile, german (Argentina) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 1.93%
Citronella java 1 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 0.6%
Cymbopogon distans 1 (Himalaya) Cymbopogon distans (Steud.) Wats. (Chemotype 1), fam. Poaceae (Gramineae) 5.1%
Cymbopogon distans 2 (Himalaya) Cymbopogon distans (Steud.) Wats. (Chemotype 2), fam. Poaceae (Gramineae) 0.3%
Cymbopogon jwarancusa (India) Cymbopogon jwarancusa (Jones) Schult., fam. Poaceae (Gramineae) 0.3%
Davana (India) 1 8016-03-3 Artemisia pallens Wall. ex DC., fam. Asteraceae (Compositae) 0.05%
Ginger (Sri Lanka) 1 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 2.8%
Ginger (Sri Lanka) 2 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 1.2%
Ginger (Sri Lanka) 3 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 2.0%
Ginger (Sri Lanka) 4 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 1.6%
Mullilam Zanthoxylum rhetsa D.C. syn. Z. limonella (Dennst.) Alston, fam. Rutaceae 0.5%
Neroli bigarade (bitter orange flower) Spain 2 8016-38-4 Citrus aurantium L., ssp. amara Engl., fam. Rutaceae 1.0%
Ocimum basilicum, Methyl cinnamate type III Ocimum basilicum L. (Chemotype III), fam. Lamiaceae (Labiatae) 2.93%
Ocimum basilicum, Methyl cinnamate type I Ocimum basilicum L. (Chemotype I), fam. Lamiaceae (Labiatae) 1.69%
Ocimum basilicum, Methyl cinnamate type II Ocimum basilicum L. (Chemotype II), fam. Lamiaceae (Labiatae) 1.6%
Orange, bitter (Spain) 1 72968-50-4 Citrus aurantium L., ssp. amara Engl., fam. Rutaceae 0.02%
Orange, bitter (Spain) 2 72968-50-4 Citrus aurantium L., ssp. amara Engl., fam. Rutaceae 0.02%
Palmarosa (India) 5 8014-19-5 Cymbopogon martini (Roxb.) Wats, var. martini, fam. Poaceae (Gramineae) 0.22%
Bitter orange leaf (Petitgrain) (Spain) 1 8014-17-3 Citrus aurantium L., ssp. amara Engl., fam. Rutaceae 0.1%
Rose (Turkey) 6 8007-01-0 Rosa damascena Mill., fam. Rosaceae 0.15%
Santolina canescens Santolina rosmarinifolia (L.) ssp. canescens (Lag.) Nyman, fam. Asteraceae 3.2%
Santolina pectina Santolina pectina Lag., fam. Asteraceae (Compositae) 2.4%
Ylang Ylang (China) 1 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 4.75%
Ginger (Japan) 2 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 0.1%
Ambrette seed (China) 8015-62-1 Hibiscus abelmoschus L. (Abelmoschus moschatus Moench), fam. Malvaceae 0.19%
Narcissus poeticus absolute 8023-75-4 Narcissus poeticus L., fam. Amaryllidaceae 0.1%
Citronella ceylon 1 8000-29-1 Cymbopogon nardus (L.) Rendle, fam. Poaceae (Gramineae) 0.01%
Lemongrass (Nigeria) 8007-02-1 Cymbopogon citratus (DC) Stapf (C. flexuosus), fam. Poaceae (Gramineae) 2.4%
Cumin (India) 1 8014-30-9 Cuminum cyminum L., fam. Apiaceae (Umbelliferae) 2.98%
Lemongrass (India) 1 8007-02-1 Cymbopogon citratus (DC) Stapf (C. flexuosus), fam. Poaceae (Gramineae) 9.4%
Jasmine oil (Turkey) 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 0.04%
Jasmine absolute (Turkey) 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 0.93%
Jasmine absolute (France) 2 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 1.0%
Jasmine absolute (Italy) 2 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 1.0%
Jasmine absolute (India) 1 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 1.0%
Jasmine absolute (Morocco) 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 1.0%
Jasmine absolute (Egypt) 2 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 1.0%
Osmanthus concentrate 1 (Sukhumi-Abkhasia) 68917-05-5 Osmanthus fragrans (Thunb.) Lour., fam. Oleaceae 6.0%
Osmanthus concentrate 2 (Sukhumi-Abkhasia) 68917-05-5 Osmanthus fragrans (Thunb.) Lour., fam. Oleaceae 0.18%