Isoisopulegol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    18674-65-2

    Retention indicies (RI)

    • DB5: 1156.0

  • Properties

  • Applications

    (+)-Isoisopulegone (CAS 18674-65-2) is an enantiopure monoterpene ketone used mainly as a chiral building block and precursor in terpenoid synthesis (e.g., selective conversion to menthone/menthol, isomenthone, or piperitone derivatives via hydrogenation, isomerization, and redox steps), as a model substrate to probe mint biosynthetic pathways and the selectivity of reductases/isomerases, as an intermediate and note-modifier in fragrance/flavor R&D with minty–herbal–camphoraceous character (typically for experimental evaluation rather than direct consumer use due to safety and regulatory considerations), as an analytical reference for GC/GC–MS/olfactometry, and as a starting point to assemble stereodefined organic motifs (terpene-derived ligands/auxiliaries) or heterocycles via Michael additions, cycloadditions, and other enone transformations.

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IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Citronella java (China) 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 0.29%
Citronella java (Argentina) 2 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 0.41%
Citronella java (S. America) 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 0.34%
Citronella java 3 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 0.22%
Citronella ceylon 5 8000-29-1 Cymbopogon nardus (L.) Rendle, fam. Poaceae (Gramineae) 0.87%
Eucalyptus citriodora (Spain) 8000-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 17.25%
Eucalyptus brassiana Eucalyptus brassiana S.T. Blake, fam. Myrtaceae 0.34%
Eucalyptus citriodora (Burundi) 8000-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 0.7%
Cornmint (Mentha arvensis) (Brazil) 1 68917-18-0 Mentha arvensis (L.) var. piperascens Malinv., fam. Lamiaceae (Labiatae) 0.16%
Cornmint (Mentha arvensis) (Japan) 1 68917-18-0 Mentha arvensis (L.) var. piperascens Malinv., fam. Lamiaceae (Labiatae) 0.25%
Cornmint (Mentha arvensis) (China) 1 68917-18-0 Mentha arvensis (L.) var. piperascens Malinv., fam. Lamiaceae (Labiatae) 0.8%
Peppermint (USA) 4 8006-90-4 Mentha piperita L. cultivar Kennewick, fam. Lamiaceae (Labiatae) 0.79%
Peppermint (USA) 5 8006-90-4 Mentha piperita L. cultivar Michigan, fam. Lamiaceae (Labiatae) 0.78%
Peppermint (Bulgaria) 1 8006-90-4 Mentha piperita L., fam. Lamiaceae (Labiatae) 0.61%
Lime (Mexican, West Indian, Key) leaf 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 0.01%
Rough lemon leaf (USA) 2 Citrus jambhiri Lush., fam. Rutaceae 0.6%
Meyer lemon leaf (USA) Citrus limon x Citrus sinensis, fam. Rutaceae 0.16%
Lemon leaf (petitgrain) (Italy) 4 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.01%
Eucalyptus citriodora (Australia) 8008-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 8.51%
Peppermint 5a 8006-90-4 Mentha piperita L. cultivar Kennewick, fam. Lamiaceae (Labiatae) 0.79%
Peppermint 5b 8006-90-4 Mentha piperita L. cultivar Michigan, fam. Lamiaceae (Labiatae) 0.78%
Peppermint 5c 8006-90-4 Mentha piperita L. cultivar Mitcham, fam. Lamiaceae (Labiatae) 0.61%
Litsea cubeba (India) 2a stem 68555-99-2 Litsea cubeba (Lour.) Pers. (L. citrata Blume), fam. Lauraceae 1.05%
Litsea cubeba (India) 2c fruit 68555-99-2 Litsea cubeba (Lour.) Pers. (L. citrata Blume), fam. Lauraceae 0.7%
Eucalyptus citriodora (Bangladesh) 8000-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 4.13%
Rosemary (Brazil) 2 8000-25-7 Rosmarinus officinalis L., fam. Lamiaceae (Labiatae) 0.05%
Eucalyptus citriodora 1a 8008-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 0.42%
Eucalyptus citriodora 1b 8008-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 8.51%
Leptospermum petersonii Leptospermum petersonii (syn. L. citratum), fam. Myrtaceae 1.0%
Niaouli (India) Melaleuca quinquenervia (Cav.) S.T. Blake, fam. Myrtaceae 0.2%
Hedychium coronarium rhizome (Mauritius) Hedychium coronarium Koenig, fam. Zingiberaceae 1.1%