Globulol

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  • Identifiers

    CAS number
    489-41-8

    Molecular formula
    C15H26O

    SMILES
    C[C@@H]1CC[C@@H]2[C@@H]1[C@H]3[C@H](C3(C)C)CC[C@@]2(C)O

    Retention indicies (RI)

    • DB5: 1589.71
    • Carbowax: 2081.43

  • Odor profile

    Woody 74.61%
    Herbal 66.98%
    Sweet 63.98%
    Fruity 59.44%
    Spicy 52.78%
    Earthy 52.63%
    Balsamic 50.26%
    Mint 47.84%
    Green 47.15%
    Camphoreous 46.2%

    Scent© AI

  • Properties

    XLogP3-AA
    3.7

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    303°C

    Flash point est.
    94.82 ˚C

  • Synonyms

    • Globulol
    • (-)-Globulol
    • 489-41-8
    • UNII-G66H9XM0JK
    • G66H9XM0JK
    • EINECS 207-696-7
    • NSC 152470
    • GLOBULOL, (-)-
    • NSC-152470
    • (1aR,4R,4aR,7R,7aS,7bS)-1,1,4,7-tetramethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol
    • (1AR-(1aalpha,4alpha,4aalpha,7alpha,7abeta,7balpha))-decahydro-1,1,4,7-tetramethyl-1H-cycloprop(e)azulen-4-ol
    • (1AR-(1A.ALPHA.,4.ALPHA.,4A.ALPHA.,7.ALPHA.,7A.BETA.,7B.ALPHA.))-DECAHYDRO-1,1,4,7-TETRAMETHYL-1H-CYCLOPROP(E)AZULEN-4-OL
    • [1aR-(1aalpha,4alpha,4aalpha,7alpha,7abeta,7balpha)]-decahydro-1,1,4,7-tetramethyl-1H-cycloprop[e]azulen-4-ol
    • 1H-CYCLOPROP(E)AZULEN-4-OL, DECAHYDRO-1,1,4,7-TETRAMETHYL-, (1AR,4R,4AR,7R,7AS,7BS)-
    • 1H-CYCLOPROP(E)AZULEN-4-OL, DECAHYDRO-1,1,4,7-TETRAMETHYL-, (1AR-(1A.ALPHA.,4.ALPHA.,4A.ALPHA.,7.ALPHA.,7A.BETA.,7B.ALPHA.))-
    • (.+/-.)-Globulol
    • 1H-Cycloprop[e]azulen-4-ol, decahydro-1,1,4,7-tetramethyl-, [1aR-(1a.alpha.,4.alpha.,4a.alpha.,7.alpha.,7a.beta.,7b.alpha.)]-
    • (+/-)-Globulol
    • SCHEMBL60792
    • CHEMBL2171207
    • AYXPYQRXGNDJFU-QTPLKFIXSA-N
    • CHEBI:167415
    • DTXSID801318741
    • 1,1,4,7-Tetramethyldecahydro-1H-cyclopropa[e]azulen-4-ol, (1a.alpha.,4.alpha.,4a.alpha.,7.alpha.,7a.beta.,7b.alpha.)-
    • HY-N8389
    • MFCD00042615
    • AKOS040760425
    • 1H-Cycloprop(e)azulen-4-ol, decahydro-1,1,4,7-tetramethyl-, (1aR-(1aalpha,4alpha,4aalpha,7alpha,7abeta,7balpha))-
    • CS-0143849
    • NS00042446
    • H27817
    • (-)-Globulol, >=98.5% (sum of enantiomers, GC)
    • Q27278826
    • 1,1,4,7-Tetramethyldecahydro-1H-cyclopropa(e)azulen-4-ol, (1aalpha,4alpha,4aalpha,7alpha,7abeta,7balpha)-

  • Applications

    Globulol (CAS 489-41-8) is a natural sesquiterpenoid alcohol found in many essential oils (notably Eucalyptus globulus) and is used mainly as a fragrance ingredient with woody–earthy–balsamic nuances and fixative behavior due to its low volatility in fine fragrances, cosmetics, candles, and personal care products; in flavor applications it may be employed at trace levels to modulate herbal/eucalyptaceous notes, though use is constrained by local safety regulations; in analytics and quality control, globulol serves as a reference standard and chemotaxonomic marker for profiling and quantifying essential oils by GC–MS; in R&D it provides an eudesmane scaffold for chemical modification, semisynthesis, and structure–odor studies, and has been investigated in vitro for antimicrobial/antifungal, antioxidant, and insect-repellent activities, suggesting potential as a natural additive, preservative booster, or eco‑friendly crop‑protection lead, subject to toxicological, stability, and regulatory evaluation.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 335.89
    methanol 248.05
    isopropanol 435.04
    water 1.08
    ethyl acetate 321.23
    n-propanol 350.14
    acetone 531.11
    n-butanol 317.06
    acetonitrile 309.82
    DMF 503.84
    toluene 300.45
    isobutanol 282.09
    1,4-dioxane 765.5
    methyl acetate 326.21
    THF 1606.29
    2-butanone 422.14
    n-pentanol 160.12
    sec-butanol 257.71
    n-hexane 31.93
    ethylene glycol 71.8
    NMP 310.94
    cyclohexane 84.7
    DMSO 337.58
    n-butyl acetate 281.17
    n-octanol 149.66
    chloroform 774.42
    n-propyl acetate 196.39
    acetic acid 151.7
    dichloromethane 561.26
    cyclohexanone 564.82
    propylene glycol 136.36
    isopropyl acetate 292.98
    DMAc 310.52
    2-ethoxyethanol 221.51
    isopentanol 272.41
    n-heptane 46.14
    ethyl formate 218.59
    1,2-dichloroethane 334.73
    n-hexanol 287.54
    2-methoxyethanol 409.17
    isobutyl acetate 188.66
    tetrachloromethane 145.28
    n-pentyl acetate 205.16
    transcutol 449.87
    n-heptanol 157.62
    ethylbenzene 140.96
    MIBK 291.35
    2-propoxyethanol 434.81
    tert-butanol 395.42
    MTBE 424.96
    2-butoxyethanol 258.29
    propionic acid 177.07
    o-xylene 170.41
    formic acid 46.0
    diethyl ether 385.3
    m-xylene 212.74
    p-xylene 187.25
    chlorobenzene 268.17
    dimethyl carbonate 154.24
    n-octane 22.36
    formamide 80.94
    cyclopentanone 791.68
    2-pentanone 382.39
    anisole 241.83
    cyclopentyl methyl ether 448.0
    gamma-butyrolactone 670.16
    1-methoxy-2-propanol 403.36
    pyridine 481.04
    3-pentanone 258.15
    furfural 410.81
    n-dodecane 19.97
    diethylene glycol 272.33
    diisopropyl ether 145.99
    tert-amyl alcohol 234.46
    acetylacetone 407.42
    n-hexadecane 23.45
    acetophenone 208.7
    methyl propionate 268.98
    isopentyl acetate 299.69
    trichloroethylene 539.81
    n-nonanol 134.28
    cyclohexanol 278.15
    benzyl alcohol 184.0
    2-ethylhexanol 155.07
    isooctanol 132.39
    dipropyl ether 207.09
    1,2-dichlorobenzene 217.61
    ethyl lactate 124.42
    propylene carbonate 330.99
    n-methylformamide 227.79
    2-pentanol 224.16
    n-pentane 47.75
    1-propoxy-2-propanol 311.84
    1-methoxy-2-propyl acetate 343.3
    2-(2-methoxypropoxy) propanol 207.81
    mesitylene 143.94
    ε-caprolactone 414.71
    p-cymene 117.03
    epichlorohydrin 657.19
    1,1,1-trichloroethane 365.04
    2-aminoethanol 155.26
    morpholine-4-carbaldehyde 419.53
    sulfolane 544.12
    2,2,4-trimethylpentane 27.88
    2-methyltetrahydrofuran 661.06
    n-hexyl acetate 285.18
    isooctane 33.38
    2-(2-butoxyethoxy)ethanol 266.92
    sec-butyl acetate 167.38
    tert-butyl acetate 312.74
    decalin 39.33
    glycerin 153.56
    diglyme 471.08
    acrylic acid 149.42
    isopropyl myristate 128.23
    n-butyric acid 268.13
    acetyl acetate 221.98
    di(2-ethylhexyl) phthalate 123.19
    ethyl propionate 183.85
    nitromethane 309.13
    1,2-diethoxyethane 236.17
    benzonitrile 256.54
    trioctyl phosphate 104.2
    1-bromopropane 281.89
    gamma-valerolactone 749.55
    n-decanol 102.2
    triethyl phosphate 108.07
    4-methyl-2-pentanol 165.34
    propionitrile 337.9
    vinylene carbonate 308.32
    1,1,2-trichlorotrifluoroethane 327.26
    DMS 196.67
    cumene 103.97
    2-octanol 116.12
    2-hexanone 209.71
    octyl acetate 153.25
    limonene 144.69
    1,2-dimethoxyethane 419.75
    ethyl orthosilicate 105.32
    tributyl phosphate 105.28
    diacetone alcohol 283.26
    N,N-dimethylaniline 158.59
    acrylonitrile 323.37
    aniline 244.42
    1,3-propanediol 239.05
    bromobenzene 289.75
    dibromomethane 407.94
    1,1,2,2-tetrachloroethane 451.8
    2-methyl-cyclohexyl acetate 198.51
    tetrabutyl urea 127.73
    diisobutyl methanol 124.32
    2-phenylethanol 249.9
    styrene 152.89
    dioctyl adipate 148.11
    dimethyl sulfate 181.94
    ethyl butyrate 198.67
    methyl lactate 160.48
    butyl lactate 171.6
    diethyl carbonate 139.11
    propanediol butyl ether 221.66
    triethyl orthoformate 157.73
    p-tert-butyltoluene 123.85
    methyl 4-tert-butylbenzoate 213.25
    morpholine 684.09
    tert-butylamine 264.36
    n-dodecanol 80.67
    dimethoxymethane 476.59
    ethylene carbonate 281.42
    cyrene 200.93
    2-ethoxyethyl acetate 257.28
    2-ethylhexyl acetate 231.44
    1,2,4-trichlorobenzene 247.26
    4-methylpyridine 437.46
    dibutyl ether 163.94
    2,6-dimethyl-4-heptanol 124.32
    DEF 261.17
    dimethyl isosorbide 353.96
    tetrachloroethylene 295.9
    eugenol 187.49
    triacetin 229.17
    span 80 201.05
    1,4-butanediol 99.1
    1,1-dichloroethane 408.15
    2-methyl-1-pentanol 138.65
    methyl formate 201.12
    2-methyl-1-butanol 217.22
    n-decane 34.28
    butyronitrile 345.93
    3,7-dimethyl-1-octanol 150.2
    1-chlorooctane 109.47
    1-chlorotetradecane 45.48
    n-nonane 31.94
    undecane 25.61
    tert-butylcyclohexane 39.1
    cyclooctane 34.0
    cyclopentanol 343.49
    tetrahydropyran 730.05
    tert-amyl methyl ether 222.78
    2,5,8-trioxanonane 297.58
    1-hexene 101.07
    2-isopropoxyethanol 189.3
    2,2,2-trifluoroethanol 84.04
    methyl butyrate 217.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Eucalyptus cloeziana leaf (Chemotype 1) Eucalyptus cloeziana F. Muell., fam. Myrtaeceae 2.49%
Eucalyptus globulus (Morocco) 1 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 6.3%
Eucalyptus globulus (Spain) 1 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 0.47%
Eugenia javanica Eugenia javanica Lamk., fam. Myrtaceae 0.2%
Hedeoma mandoniana Hedeoma mandoniana Wedd, fam. Lamiaceae (Labiatae) 0.49%
Hyptis pectinata Hyptis pectinata (L.) Poit., fam. Lamiaceae (Labiatae) 0.05%
Minthostachys andina Minthostachys andina (Brett) Epling, fam. Lamiaceae (Labiatae) 0.75%
Pimento (Allspice) 2 8006-77-7 Pimenta dioica (L.) Merr. (P. officinalis Lindl.), fam. Myrtaceae 0.11%
Eucalyptus paniculata (Uruguay) Eucalyptus paniculata Sm., fam. Myrtaceae 0.6%
Eucalyptus melliodora (Uruguay) Eucalyptus melliodora Cumn., fam. Myrtaceae 1.9%
Eucalyptus botryoides (Uruguay) Eucalyptus botryoides Sm., fam. Myrtaceae 2.0%
Eucalyptus grandis (Uruguay) Eucalyptus grandis W. Hill ex Maiden, fam. Myrtaceae 0.9%
Eucalyptus sideroxylon (Uruguay) Eucalyptus sideroxylon Sm., fam. Myrtaceae 2.7%
Eucalyptus longifolia (Uruguay) Eucalyptus longifolia Link & Otto, fam. Myrtaceae 3.2%
Eucalyptus amplifolia (Uruguay) Eucalyptus amplifolia Naud., fam. Myrtaceae 4.4%
Eucalyptus affinis (Uruguay) Eucalyptus affinis Deane & Maiden, fam. Myrtaceae 0.9%
Eucalyptus brassiana Eucalyptus brassiana S.T. Blake, fam. Myrtaceae 2.9%
Guava leaf 1 91770-12-6 Psidium guajava L., fam. Myrtaceae 6.8%
Micromyrtus striata Micromyrtus striata J.W. Green (M. ciliata (Sm) Druce), fam. Myrtaceae 2.4%
Eucalyptus pellita Eucalyptus pellita Benth., fam. Myrtaceae 0.1%
Lepechinia urbanii Lepechinia urbanii (Briq.) Epling, fam. Lamiaceae (Labiatae) 0.21%
Tea Tree (Australia) 7 68647-73-4 Melaleuca alternifolia (Maiden et Betche) Cheel, fam. Myrtaceae 0.2%
Tea Tree (Australia) 8 68647-73-4 Melaleuca alternifolia (Maiden et Betche) Cheel, fam. Myrtaceae 1.55%
Eucalyptus globulus (Morocco) 2 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 1.3%
Eucalyptus camaldulensis (Morocco) 2 Eucalyptus camaldulensis Dehn., fam. Myrtaceae 0.4%
Eucalyptus dealbata (Morocco) Eucalyptus dealbata A. Cunn. ex Schau, fam. Myrtaceae 1.2%
Idiospermum australiense Idiospermum australiense (Diels) S.T. Blake, fam. Idiospermaceae 4.7%
Eucalyptus camaldulensis (Morocco) 3 Eucalyptus camaldulensis Dehn., fam. Myrtaceae 1.46%
Eucalyptus camaldulensis (Morocco) 1 Eucalyptus camaldulensis Dehn., fam. Myrtaceae 4.66%
Eucalyptus globulus (Burundi) 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 1.3%
Eucalyptus camaldulensis (Burundi) Eucalyptus camaldulensis Dehn., fam. Myrtaceae 0.2%
Eucalyptus grandis (Burundi) Eucalyptus grandis W. Hill ex Maiden, fam. Myrtaceae 0.2%
Eucalyptus maidenii (Burundi) Eucalyptus maidenii F. Muell., fam. Myrtaceae 0.7%
Yuzu (Japan) 3 Citrus junos Sieb. ex Tanaka, fam. Rutaceae 0.01%
Vassoura (Brazil) 2 Baccharis dracunculifolia DC., fam. Asteraceae (Compositae) 3.19%
Vassoura (Uruguay) Baccharis dracunculifolia DC., fam. Asteraceae (Compositae) 14.0%
Ylang Ylang (China) 2b 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 0.12%
Hyptis suaveolens Hyptis suaveolens (L.) Poit., fam. Lamiaceae (Labiatae) 0.03%
Eucalyptus globulus (Algeria) 1 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 0.8%
Eucalyptus globulus (Portugal) 1 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 2.0%
Lepechinia floribunda Lepechinia floribunda (Benth.) Epl. (Salvia morada), fam. Lamiaceae 0.3%
Cinnamomum parthenoxylon (Vietnam) 1a Cinnamomum parthenoxylon (Jack) Nees, fam. Lauraceae 2.2%
Guarea cedrata bark Guarea cedrata (A. Chev.) Pellegr., fam. Meliaceae 11.1%
Triphasia trifolia Mauritius Triphasia trifolia (Burm. f.), fam. Rutaceae 2.2%
Eucalyptus kirtoniana Eucalyptus kirtoniana F. Muel., fam. Myrtaceae 0.6%
Machilus bombycina Machilus bombicyna King, fam. Lauraceae 0.5%
Sideritis lycia (Turkey) Sideritis lycia Boiss. et Heldr., fam. Lamiaceae (Labiatae) 0.5%
Geum montanum root Geum montanum L., fam. Rosaceae 0.17%
Sage, dalmatian (Italy) 5 8022-56-8 Salvia officinalis L. var. angustifolia Ten., fam. Lamiaceae (Labiatae) 2.12%
Mentha diemenica (Australia) Mentha diemenica Sprengel, fam. Lamiaceae (Labiatae) 0.25%