Bisabolol (unknown isomer), CAS 26560-22-5, is a sesquiterpene alcohol sourced from chamomile or candeia wood (Vanillosmopsis) and/or produced synthetically, widely used in cosmetics, personal care, and topical pharmaceuticals for soothing, anti-inflammatory, and anti-irritant benefits; it reduces erythema and stinging, supports barrier recovery, calms post-sun/post-shave discomfort, and mitigates irritation from acids/retinoids; it shows mild antibacterial/antifungal activity (useful in acne care, deodorants, and intimate hygiene) and its soft chamomile-like scent also serves as a fragrance component; it can act as a penetration enhancer for certain actives and improves sensorial feel and perceived formulation stability; because this CAS does not specify the isomer, materials may be mixed/racemic, so odor, optical rotation, and some bioactivity may differ from natural (−)-α-bisabolol, though the formulation roles remain broadly similar; common uses include sensitive-skin creams, barrier-repair serums, after-sun/after-shave products, oral-care gels/toothpastes for gum comfort, lip care, hair/scalp care, baby care, cosmeceuticals targeting mild dermatitis/erythema, and soft fragrances; it is generally compatible over pH ~4–8, reasonably heat/light stable, blends well with emollients, esters, and silicones; typical use levels are ~0.05–1% (up to ~2% for soothing-focused products), and it is broadly permitted under global cosmetic regulations with a favorable safety profile.
