Bisabolol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    515-69-5

    Molecular formula
    C15H26O

    SMILES
    CC1=CC[C@@H](CC1)[C@@](C)(CCC=C(C)C)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

    Retention indicies (RI)

    • DB5: 1684.43
    • Carbowax: 2218.71

  • Odor profile

    Floral 85.46%
    Sweet 63.07%
    Fruity 62.64%
    Rose 49.08%
    Woody 48.9%
    Citrus 47.54%
    Balsamic 46.01%
    Fresh 44.95%
    Tropical 39.39%
    Herbal 38.76%

    Scent© AI

  • Properties

    XLogP3-AA
    3.8

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    292°C

    Flash point est.
    119.29 ˚C

    Solubility expt.

    • Practically insoluble or insoluble in water
    • Slightly soluble (in ethanol)

  • Synonyms

    • alpha-Bisabolol
    • Bisabolol
    • 515-69-5
    • (+)-alpha-Bisabolol
    • 23178-88-3
    • (2R)-6-methyl-2-[(1R)-4-methylcyclohex-3-en-1-yl]hept-5-en-2-ol
    • D-alpha-Bisabolol
    • (+)-(1'R,2R)-alpha-Bisabolol
    • MFCD03846910
    • Dragosantol
    • Camilol
    • Anymol
    • (AlphaR,1R)-Alpha-Bisabolol
    • 36HQN158VC
    • CHEMBL1171719
    • DTXSID5045964
    • Hydagen B
    • 105S6I733Z
    • (2R)-6-Methyl-2-(4-methyl-3-cyclohexenyl)-5-heptene-2-ol
    • (R)-6-Methyl-2-((R)-4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol
    • 5-HEPTEN-2-OL, 6-METHYL-2-(4-METHYL-3-CYCLOHEXEN-1-YL)-
    • alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol
    • 3-Cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (R*,R*)-
    • DTXCID3025964
    • rel-(R)-6-Methyl-2-((R)-4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol
    • dl-.alpha.-Bisabolol
    • 6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol
    • BISABOLOL, ALPHA
    • CAS-515-69-5
    • BISABOLOL, .ALPHA.
    • RACEMIC ALFA-BISABOLOL
    • alpha-Bisabolol, (+)-
    • UNII-36HQN158VC
    • BISABOLA-1,12-DIEN-8-OL
    • UNII-105S6I733Z
    • alpha-Bisabolol (+)-form [MI]
    • NCGC00095252-01
    • 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-penten-1-yl)-, (alphaR,1R)-rel-
    • (+)-a-Bisabolol
    • EINECS 208-205-9
    • EINECS 246-973-7
    • +/-alpha-Bisabolol
    • (+)-.alpha.-Bisabolol
    • BISABOLOL [WHO-DD]
    • 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-penten-1-yl)-, (alphaR,1R)-
    • D-.ALPHA.-BISABOLOL
    • SCHEMBL24988
    • (+)-6R,7R-alpha-Bisabolol
    • .alpha.,4-Dimethyl-.alpha.-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol
    • .ALPHA.-BISABOLOL [MI]
    • BISABOLOL, (+/-)-
    • (R*,R*)-.alpha.,4-Dimethyl-.alpha.-(4-methyl-3-pentenyl)-3-cyclohexene-1-methanol
    • (R*,R*)-.alpha.,4-Dimethyl-.alpha.-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
    • CHEBI:192031
    • ALPHA-BISABOLOL, (+-)-
    • 3-Cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-penten-1-yl)-, (.alpha.R,1R)-rel-
    • (+/-)-.ALPHA.-BISABOLOL
    • .ALPHA.-BISABOLOL, (+)-
    • Tox21_111490
    • BDBM50284328
    • s6136
    • AKOS015969722
    • Tox21_111490_1
    • .ALPHA.-BISABOLOL, (+/-)-
    • (R*,R*)-alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
    • NCGC00095252-05
    • 25428-43-7
    • ( inverted exclamation markA)-|A-Bisabolol
    • .ALPHA.-BISABOLOL (+)-FORM [MI]
    • 1ST158680
    • HY-121222
    • (+)-(1'R,2R)-.ALPHA.-BISABOLOL
    • CS-0081254
    • 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-
    • (R*,R*)-(1)-alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol
    • 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (alphaR,1R)-rel-
    • 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (R*,R*)-
    • alpha,4-Dimethyl-alpha-(4-methyl-3-penten-1-yl)-(alphaR,1R)-3-Cyclohexene-1-methanol
    • 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL- 3-PENTEN-1-YL)-, (.ALPHA.R,1R)-REL-
    • 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL- 3-PENTENYL)-, (.THETA.,.THETA.)-(+/-)-
    • 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL- 3-PENTENYL)-, (R*,R*)-
    • 3-CYCLOHEXENE-1-METHANOL, .ALPHA.,4-DIMETHYL-.ALPHA.-(4-METHYL-3-PENTEN-1-YL)-, (.ALPHA.R,1R)-
    • 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, (theta,theta)-(+/-)-

  • Applications

    Bisabolol (CAS 515-69-5), also known as alpha-bisabolol/levomenol, is a sesquiterpene alcohol from German chamomile and the candeia tree valued for soothing, anti-inflammatory and anti-irritant effects, enabling broad use in cosmetics and dermocosmetics: it reduces UV-induced erythema and stinging from acids, retinoids or shaving; supports barrier repair, sensitive-skin routines, acne and post-blemish care; calms itch and flaking in scalp/body products; provides mild antibacterial/antifungal benefits useful in oral care, deodorants and aftershaves; enhances penetration of co-actives and acts as a fragrance note/fixative with a soft sweet woody-floral odor; typically used at 0.1–1% in creams, serums, gels, cleansers, sunscreens, makeup and baby care, and appears in topical therapeutics to mitigate mild inflammation and aid re-epithelialization; it is compatible with emulsions, anhydrous systems and surfactant bases and remains stable across typical cosmetic pH, making it a popular soothing booster to improve formula tolerance.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1075.02
    methanol 606.33
    isopropanol 870.56
    water 0.24
    ethyl acetate 1211.98
    n-propanol 720.87
    acetone 651.78
    n-butanol 884.47
    acetonitrile 409.15
    DMF 353.23
    toluene 655.12
    isobutanol 481.98
    1,4-dioxane 2053.23
    methyl acetate 626.77
    THF 2628.43
    2-butanone 742.97
    n-pentanol 499.17
    sec-butanol 627.78
    n-hexane 235.15
    ethylene glycol 30.07
    NMP 288.14
    cyclohexane 421.04
    DMSO 319.34
    n-butyl acetate 1076.36
    n-octanol 384.0
    chloroform 1362.19
    n-propyl acetate 546.04
    acetic acid 301.72
    dichloromethane 1008.09
    cyclohexanone 837.94
    propylene glycol 96.02
    isopropyl acetate 845.27
    DMAc 450.12
    2-ethoxyethanol 513.31
    isopentanol 759.1
    n-heptane 245.44
    ethyl formate 351.86
    1,2-dichloroethane 614.57
    n-hexanol 981.08
    2-methoxyethanol 828.46
    isobutyl acetate 414.35
    tetrachloromethane 216.57
    n-pentyl acetate 508.49
    transcutol 3199.18
    n-heptanol 400.93
    ethylbenzene 298.22
    MIBK 577.11
    2-propoxyethanol 1100.14
    tert-butanol 1043.46
    MTBE 1586.38
    2-butoxyethanol 586.16
    propionic acid 247.32
    o-xylene 312.94
    formic acid 58.35
    diethyl ether 1823.61
    m-xylene 417.36
    p-xylene 349.21
    chlorobenzene 440.4
    dimethyl carbonate 141.42
    n-octane 75.17
    formamide 101.21
    cyclopentanone 666.97
    2-pentanone 811.34
    anisole 537.24
    cyclopentyl methyl ether 1023.87
    gamma-butyrolactone 565.88
    1-methoxy-2-propanol 757.32
    pyridine 905.18
    3-pentanone 507.94
    furfural 482.2
    n-dodecane 52.58
    diethylene glycol 373.14
    diisopropyl ether 609.0
    tert-amyl alcohol 680.51
    acetylacetone 647.0
    n-hexadecane 60.22
    acetophenone 335.57
    methyl propionate 512.86
    isopentyl acetate 1002.42
    trichloroethylene 908.25
    n-nonanol 362.73
    cyclohexanol 605.63
    benzyl alcohol 271.74
    2-ethylhexanol 578.21
    isooctanol 317.8
    dipropyl ether 1122.95
    1,2-dichlorobenzene 357.45
    ethyl lactate 158.5
    propylene carbonate 414.32
    n-methylformamide 160.82
    2-pentanol 632.3
    n-pentane 230.38
    1-propoxy-2-propanol 912.08
    1-methoxy-2-propyl acetate 984.82
    2-(2-methoxypropoxy) propanol 609.78
    mesitylene 280.21
    ε-caprolactone 767.79
    p-cymene 239.5
    epichlorohydrin 904.46
    1,1,1-trichloroethane 673.87
    2-aminoethanol 139.57
    morpholine-4-carbaldehyde 731.76
    sulfolane 414.7
    2,2,4-trimethylpentane 99.33
    2-methyltetrahydrofuran 1733.33
    n-hexyl acetate 761.36
    isooctane 102.31
    2-(2-butoxyethoxy)ethanol 984.19
    sec-butyl acetate 473.21
    tert-butyl acetate 877.52
    decalin 144.0
    glycerin 126.43
    diglyme 1560.55
    acrylic acid 129.8
    isopropyl myristate 317.84
    n-butyric acid 726.67
    acetyl acetate 545.81
    di(2-ethylhexyl) phthalate 246.79
    ethyl propionate 459.57
    nitromethane 362.94
    1,2-diethoxyethane 1638.51
    benzonitrile 375.28
    trioctyl phosphate 172.46
    1-bromopropane 668.99
    gamma-valerolactone 977.3
    n-decanol 261.12
    triethyl phosphate 238.81
    4-methyl-2-pentanol 418.85
    propionitrile 472.56
    vinylene carbonate 355.68
    1,1,2-trichlorotrifluoroethane 359.6
    DMS 361.94
    cumene 205.59
    2-octanol 259.49
    2-hexanone 530.79
    octyl acetate 369.03
    limonene 384.73
    1,2-dimethoxyethane 1178.27
    ethyl orthosilicate 271.66
    tributyl phosphate 212.46
    diacetone alcohol 602.07
    N,N-dimethylaniline 320.03
    acrylonitrile 311.31
    aniline 497.58
    1,3-propanediol 390.19
    bromobenzene 502.1
    dibromomethane 768.17
    1,1,2,2-tetrachloroethane 807.28
    2-methyl-cyclohexyl acetate 494.62
    tetrabutyl urea 256.94
    diisobutyl methanol 336.49
    2-phenylethanol 465.48
    styrene 339.89
    dioctyl adipate 394.62
    dimethyl sulfate 143.21
    ethyl butyrate 729.92
    methyl lactate 159.84
    butyl lactate 299.94
    diethyl carbonate 411.75
    propanediol butyl ether 430.14
    triethyl orthoformate 516.69
    p-tert-butyltoluene 264.06
    methyl 4-tert-butylbenzoate 410.41
    morpholine 2082.86
    tert-butylamine 809.4
    n-dodecanol 195.88
    dimethoxymethane 688.7
    ethylene carbonate 354.24
    cyrene 273.73
    2-ethoxyethyl acetate 702.52
    2-ethylhexyl acetate 775.18
    1,2,4-trichlorobenzene 381.28
    4-methylpyridine 871.27
    dibutyl ether 792.42
    2,6-dimethyl-4-heptanol 336.49
    DEF 601.99
    dimethyl isosorbide 866.78
    tetrachloroethylene 487.52
    eugenol 336.25
    triacetin 515.95
    span 80 559.54
    1,4-butanediol 90.45
    1,1-dichloroethane 719.58
    2-methyl-1-pentanol 454.97
    methyl formate 110.79
    2-methyl-1-butanol 563.51
    n-decane 101.04
    butyronitrile 728.23
    3,7-dimethyl-1-octanol 434.31
    1-chlorooctane 293.51
    1-chlorotetradecane 118.41
    n-nonane 101.04
    undecane 70.12
    tert-butylcyclohexane 146.49
    cyclooctane 155.29
    cyclopentanol 399.2
    tetrahydropyran 2327.64
    tert-amyl methyl ether 819.7
    2,5,8-trioxanonane 1003.88
    1-hexene 578.7
    2-isopropoxyethanol 413.4
    2,2,2-trifluoroethanol 60.58
    methyl butyrate 547.81

    Scent© AI

1 4

IFRA standard 51

Recommendation
Restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0.42 % Category 7A
Rinse-off products applied to the hair with some hand contact
 3 %
Category 2
Products applied to the axillae
 0.13 % Category 7B
Leave-on products applied to the hair with some hand contact
 3 %
Category 3
Products applied to the face/body using fingertips
 2.5 % Category 8
Products with significant anogenital exposure
 0.2 %
Category 4
Products related to fine fragrance
 2.4 % Category 9
Products with body and hand exposure, primarily rinse off
 4.6 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 0.6 % Category 10A
Household care products with mostly hand contact
 4.6 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 0.6 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 17 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0.6 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 0.2 %
Category 5D
Baby Creams, baby Oils and baby talc
 0.2 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 0.2 %
Category 6
Products with oral and lip exposure
 1.4 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Aristolochia asclepiadifolia root Aristolochia asclepiadifolia, fam. Aristolochiaceae 0.9%
Basil (Nigeria) 2 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 1.48%
Bergamot (Italy) 3 8007-75-8 Citrus bergamia Risso et Poiteau, fam. Rutaceae 0.01%
Carrot seed (France) 1 8015-88-1 Daucus carota L., fam. Apiaceae (Umbelliferae) 0.11%
Cedrela odorata Cedrela odorata L., fam. Meliaceae 0.1%
Chamomile, german (Bulgaria) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 9.55%
Chamomile, german (Hungary) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 10.0%
Cymbopogon distans 1 (Himalaya) Cymbopogon distans (Steud.) Wats. (Chemotype 1), fam. Poaceae (Gramineae) 3.0%
Cymbopogon distans 4 (Himalaya) Cymbopogon distans (Steud.) Wats. (Chemotype 4), fam. Poaceae (Gramineae) 1.8%
Spike lavender (Spain) 3 8016-78-2 Lavandula latifolia Medikus (L. spica D.C.), fam. Lamiaceae (Labiatae) 0.01%
Juniper branch 8012-91-7 Juniperus communis L., fam. Cupressaceae 0.2%
Lavandula dentata (Chemotype A) Lavandula dentata L. (Chemotype A), fam. Lamiaceae (Labiatae) 0.2%
Lavandula dentata (Chemotype B) Lavandula dentata L. (Chemotype B), fam. Lamiaceae (Labiatae) 0.3%
Lavandula multifida Lavandula multifida L., fam. Lamiaceae (Labiatae) 20.8%
Lavandula viridis Lavandula viridis L., fam. Lamiaceae (Labiatae) 0.2%
Sideritis granatensis Sideritis granatensis (Pau) Rivas-Goday, fam. Lamiaceae (Labiatae) 1.0%
Wormwood (Mugwort) 1 8008-93-3 Artemisia absinthium L., fam. Asteraceae (Compositae) 1.0%
Thymus riatarum Thymus riatarum Humbert et Maire, fam. Lamiaceae (Labiatae) 0.1%
Populus deltoides Populus deltoides Bartr. (P. deltoides Marsh.), fam. Salicaceae 26.0%
Lemon (USA-California) 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.04%
Lemon (Italy-Sicily) 8 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.04%
Cordia cylindrostachya Cordia cylidrostachya Roem & Schult., fam. Boraginaceae 0.1%
Cascarilla 2 8007-06-5 Croton eluteria Bennett, fam. Euphorbiaceae 0.02%
Lippia alba (S. America) Lippia alba (Mill.) N.E. Brown (Cidreira), fam. Verbenaceae 0.4%
Sandalwood, indian (India) 2 8006-87-9 Santalum album L., fam. Santalaceae 0.26%
Santolina chamaecyparisus (Egypt) 84961-58-0 Santolina chamaecyparisus L., fam. Asteraceae (Compositae) 2.1%
Carrot seed (France) 4 8015-88-1 Daucus carota L., fam. Apiaceae (Umbelliferae) 0.17%
Wormwood (Mugwort) (Italy) 1 8008-93-3 Artemisia absinthium L., fam. Asteraceae (Compositae) 2.0%
Artemisia molinieri Artemisia molinieri Quezel, Barbero et R. Loisel, fam. Asteraceae (Compos) 0.28%
Sederitis dichotoma (Turkey) Sideritis dichotoma Huter, fam. Lamiaceae (Labiatae) 3.94%
Laser tribolum (Turkey) Laser tribolum (L.) Borkh. (Laserpitium t.L., Siler t.Crantz),fam.Apiaceae 0.02%
Curcuma xanthorrhiza (Indonesia) Curcuma xanthorrhiza Roxb., fam. Zingiberaceae 0.8%
Curcuma aromatica (Indonesia) Curcuma aromatica Salisb., fam. Zingiberaceae 0.7%
Curcuma heyneana (Indonesia) Curcuma heyneana Val., fam. Zingiberaceae 0.01%
Pepper, black 3 8006-82-4 Piper nigrum L., fam. Piperaceae 0.1%
Rosemary (France) 1 8000-25-7 Rosmarinus officinalis L., fam. Lamiaceae (Labiatae) 0.1%
Chamomile, german (Brazil) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 13.15%
Chamomile, german (Germany) 1 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 0.51%
Lemon (Japan) 4 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.01%
Artemisia atrovirens (China) Artemisia atrovirens Hand.-Mazz., fam. Asteraceae (Compositae) 0.98%
Artemisia desertorum (China) Artemisia desertorum Spreng., fam. Asteraceae (Compositae) 55.53%
Artemisia speciosa (China) Artemisia speciosa (Pamp.) Ling et Y.R. Ling, fam. Asteraceae (Compositae) 0.25%
Abies nephrolepsis (China) Abies nephrolepsis (Trautr.) Maxim., fam. Pinaceae 0.91%
Heteromorpha trifoliata Heteromorpha trifoliata (Wendl.) Eckl. & Zey., fam.Apiaceae (Umbelliferae) 0.3%
Eucalyptus globulus (Portugal) 1 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 0.4%
Ylang Ylang (Colombia) 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 0.1%
Lemon (Uruguay) 6 84929-31-7 Citrus limon (L.) Burm. f., cultivar Ferres, fam. Rutaceae 0.02%
Phoebe 1 Phoebe porosa Mez. (syn. Oreodaphne porosa Nees et Mart.), fam. Lauraceae 3.6%
Phoebe 2 Phoebe porsa Mez. (syn. Oreodaphne prosa Nees & Mart.), fam. Lauraceae 3.4%
Lemon (Italy-Sardinia) 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.04%