germacrene D-4-ol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    198991-79-6

    Molecular formula
    C15H26O

    SMILES
    C/C/1=C\CCC(/C=C/C(CC1)C(C)C)(C)O

    Retention indicies (RI)

    • DB5: 1579.14
    • Carbowax: 2009.0

  • Odor profile

    Fragrance
    Herbal 73.42%
    Floral 62.31%
    Woody 56.24%
    Spicy 50.03%
    Fresh 46.4%
    Citrus 45.79%
    Mint 40.53%
    Lemon 37.36%
    Earthy 35.7%
    Terpenic 34.93%

     

    Flavor
    Woody 45.77%
    Herb 41.02%
    Herbal 37.02%
    Minty 35.1%
    Spice 33.68%
    Mint 32.59%
    Wood 28.81%
    Medicinal 23.58%
    Must 23.16%
    Camphor 22.88%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.8

    pKa est.
    9.18 (weak base)

    Molecular weight
    222.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    284°C

    Flash point

    • 119.22 ˚C est.

  • Synonyms

    • Germacrene D-4-ol
    • Germacren D-4-ol
    • germacrene-D-4-ol
    • (2E,7E)-1,7-dimethyl-4-propan-2-ylcyclodeca-2,7-dien-1-ol
    • CHEBI:141218
    • Germacra-1(10),5-dien-4-ol
    • (2E,4S,7E)-4-Isopropyl-1,7-dimethylcyclodeca-2,7-dienol
    • (2E,7E)-1,7-dimethyl-4-(propan-2-yl)cyclodeca-2,7-dien-1-ol
    • 2,7-Cyclodecadien-1-ol, 1,7-dimethyl-4-(1-methylethyl)-, (2E,4S,7E)-
    • RHCTXHCNRLCYBN-XEUZVJIISA-N
    • Hydroxy-1,7-dimethyl-4-isopropyl-2,7-cyclodecadiene
    • Q67879906
    • 198991-79-6

  • Applications

    germacrene D-4-ol (CAS 198991-79-6) is a sesquiterpenoid alcohol found in several essential oils. In industry it is used primarily as a fragrance ingredient, contributing a warm, woody note in perfumery and cosmetic formulations. It may be employed as an odorant or aroma contributor in flavor applications where permitted by regulations. It can function as an intermediate in the synthesis of other sesquiterpenes and fragrance compounds in industrial manufacturing. It is also used in household products such as scented cleaners and air fresheners as part of the fragrance system. Additionally, it is of interest as a starting point for developing related terpenoid derivatives.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 427.57
    methanol 271.51
    isopropanol 363.26
    water 0.21
    ethyl acetate 312.72
    n-propanol 327.96
    acetone 270.12
    n-butanol 371.51
    acetonitrile 145.21
    DMF 184.48
    toluene 243.76
    isobutanol 234.53
    1,4-dioxane 734.02
    methyl acetate 216.8
    THF 1157.88
    2-butanone 309.41
    n-pentanol 230.13
    sec-butanol 276.59
    n-hexane 83.09
    ethylene glycol 24.58
    NMP 170.46
    cyclohexane 153.87
    DMSO 211.57
    n-butyl acetate 403.21
    n-octanol 212.61
    chloroform 576.86
    n-propyl acetate 194.07
    acetic acid 126.7
    dichloromethane 410.47
    cyclohexanone 372.73
    propylene glycol 78.98
    isopropyl acetate 237.01
    DMAc 208.37
    2-ethoxyethanol 208.67
    isopentanol 311.32
    n-heptane 114.53
    ethyl formate 128.97
    1,2-dichloroethane 234.59
    n-hexanol 454.14
    2-methoxyethanol 338.83
    isobutyl acetate 167.93
    tetrachloromethane 95.5
    n-pentyl acetate 210.26
    transcutol 1027.83
    n-heptanol 209.28
    ethylbenzene 133.34
    MIBK 209.57
    2-propoxyethanol 450.68
    tert-butanol 433.46
    MTBE 429.57
    2-butoxyethanol 283.5
    propionic acid 114.69
    o-xylene 137.41
    formic acid 24.8
    diethyl ether 456.96
    m-xylene 174.86
    p-xylene 162.98
    chlorobenzene 186.13
    dimethyl carbonate 56.35
    n-octane 37.48
    formamide 41.01
    cyclopentanone 352.72
    2-pentanone 297.61
    anisole 222.37
    cyclopentyl methyl ether 386.04
    gamma-butyrolactone 264.61
    1-methoxy-2-propanol 344.13
    pyridine 353.01
    3-pentanone 181.24
    furfural 233.8
    n-dodecane 27.87
    diethylene glycol 191.53
    diisopropyl ether 158.36
    tert-amyl alcohol 298.86
    acetylacetone 227.87
    n-hexadecane 31.72
    acetophenone 166.46
    methyl propionate 172.41
    isopentyl acetate 364.59
    trichloroethylene 377.09
    n-nonanol 190.7
    cyclohexanol 271.96
    benzyl alcohol 152.38
    2-ethylhexanol 273.18
    isooctanol 170.55
    dipropyl ether 386.32
    1,2-dichlorobenzene 147.4
    ethyl lactate 81.73
    propylene carbonate 195.3
    n-methylformamide 74.84
    2-pentanol 245.61
    n-pentane 88.95
    1-propoxy-2-propanol 407.46
    1-methoxy-2-propyl acetate 337.86
    2-(2-methoxypropoxy) propanol 281.41
    mesitylene 115.73
    ε-caprolactone 310.2
    p-cymene 130.58
    epichlorohydrin 381.05
    1,1,1-trichloroethane 264.28
    2-aminoethanol 85.92
    morpholine-4-carbaldehyde 296.01
    sulfolane 234.27
    2,2,4-trimethylpentane 42.2
    2-methyltetrahydrofuran 690.76
    n-hexyl acetate 317.28
    isooctane 41.74
    2-(2-butoxyethoxy)ethanol 390.8
    sec-butyl acetate 166.21
    tert-butyl acetate 265.06
    decalin 59.28
    glycerin 90.65
    diglyme 569.53
    acrylic acid 65.5
    isopropyl myristate 151.43
    n-butyric acid 266.22
    acetyl acetate 161.34
    di(2-ethylhexyl) phthalate 137.61
    ethyl propionate 152.14
    nitromethane 141.01
    1,2-diethoxyethane 451.24
    benzonitrile 189.52
    trioctyl phosphate 102.92
    1-bromopropane 277.17
    gamma-valerolactone 437.23
    n-decanol 144.94
    triethyl phosphate 104.03
    4-methyl-2-pentanol 168.97
    propionitrile 186.68
    vinylene carbonate 154.84
    1,1,2-trichlorotrifluoroethane 181.07
    DMS 152.69
    cumene 98.57
    2-octanol 140.72
    2-hexanone 213.6
    octyl acetate 178.97
    limonene 193.89
    1,2-dimethoxyethane 442.83
    ethyl orthosilicate 115.79
    tributyl phosphate 112.48
    diacetone alcohol 254.92
    N,N-dimethylaniline 147.83
    acrylonitrile 137.02
    aniline 205.25
    1,3-propanediol 177.64
    bromobenzene 208.36
    dibromomethane 327.74
    1,1,2,2-tetrachloroethane 334.97
    2-methyl-cyclohexyl acetate 221.01
    tetrabutyl urea 136.87
    diisobutyl methanol 166.55
    2-phenylethanol 227.36
    styrene 150.95
    dioctyl adipate 185.03
    dimethyl sulfate 64.53
    ethyl butyrate 245.55
    methyl lactate 79.59
    butyl lactate 162.74
    diethyl carbonate 139.69
    propanediol butyl ether 262.34
    triethyl orthoformate 191.12
    p-tert-butyltoluene 141.8
    methyl 4-tert-butylbenzoate 193.04
    morpholine 769.4
    tert-butylamine 329.63
    n-dodecanol 116.57
    dimethoxymethane 257.03
    ethylene carbonate 146.25
    cyrene 168.86
    2-ethoxyethyl acetate 257.88
    2-ethylhexyl acetate 301.77
    1,2,4-trichlorobenzene 173.19
    4-methylpyridine 352.87
    dibutyl ether 268.84
    2,6-dimethyl-4-heptanol 166.55
    DEF 210.0
    dimethyl isosorbide 414.12
    tetrachloroethylene 197.0
    eugenol 175.5
    triacetin 222.19
    span 80 290.18
    1,4-butanediol 60.08
    1,1-dichloroethane 281.37
    2-methyl-1-pentanol 208.93
    methyl formate 54.03
    2-methyl-1-butanol 244.6
    n-decane 50.59
    butyronitrile 281.11
    3,7-dimethyl-1-octanol 215.27
    1-chlorooctane 133.06
    1-chlorotetradecane 61.52
    n-nonane 49.96
    undecane 35.45
    tert-butylcyclohexane 59.8
    cyclooctane 58.74
    cyclopentanol 230.37
    tetrahydropyran 881.77
    tert-amyl methyl ether 262.81
    2,5,8-trioxanonane 406.5
    1-hexene 213.79
    2-isopropoxyethanol 177.35
    2,2,2-trifluoroethanol 27.04
    methyl butyrate 189.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Teucrium abutiloides (Madeira) Teucrium abutiloides L'Her., fam. Lamiaceae (Labiatae) 1.8%
Daniellia oliveri Daniellia oliveri (Rolfe) Hutch & Dalz., fam. Caesalpiniaceae 1.6%
Juniperus rigida (Japan) 2 Juniperus rigida Mig., fam. Cupressaceae 0.05%
Teucrium heterophyllum (Madeira) Teucrium heterophyllum L'Her. (T. canariensis), fam. Lamiaceae (Labiatae) 0.01%
Cinnamon fruit (India) 1 8007-80-5 Cinnamomum zeylanicum Blume (C. verum L. Presl), fam. Lauraceae 0.3%
Citronella java (Ghana) 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 3.0%
Laurel leaf (France) 3 8006-78-8 Laurus nobilis L., fam. Lauraceae 0.9%
Laurel stem bark (France) Laurus nobilis L., fam. Lauraceae 0.1%
Laurel flower (France) Laurus nobilis L., fam. Lauraceae 10.1%
Laurel stem wood (France) Laurus nobilis L., fam. Lauraceae 0.4%
Pistacia lentiscus (Spain) 2 whole plant 90082-83-0 Pistacia lentiscus L., fam. Anarcadiaceae 3.5%
Grapefruit (Cuba), cold-pressed 8016-20-4 Citrus paradisi Macfayden, fam. Rutaceae 0.01%
Eugenia nitida (Brazil) Eugenia nitida Camb., fam. Myrtaceae 9.8%
Mandarin (Uruguay) 3 8008-31-9 Citrus deliciosa Tenore cv. Nova (C. reticulata Blanco), fam. Rutaceae 0.01%
Juniper leaf (Sweden) 8012-91-7 Juniperus communis L., fam. Cupressaceae 0.8%
Cubeb (India) 8007-87-2 Piper cubeba L., fam. Piperaceae 0.77%
Eucalyptus citriodora (Rwanda) 8008-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 0.15%
Guarea macrophylla ssp. tuberculata leaf Guarea macrophylla Vahl. ssp. tuberculata Vellozo, fam. Meliaceae 1.6%
Salvia pomifera Salvia pomifera L. ssp. calycina (Sm.) Hayek, fam. Lamiaceae (Labiatae) 0.01%
Mikania cordata leaf Mikania cordata (Burm.f.) B.L. Robinson var. cordata, fam. Asteraceae 0.3%
Lemongrass (Ivory Coast) 1 8007-02-1 Cymbopogon citratus (DC) Stapf (C. flexuosus), fam. Poaceae (Gramineae) 0.15%
Aristolochia odoratissima Aristolochia odoratissima L., fam. Aristolochaceae 0.6%
Pinus pumila 2 Pinus pumila (Pall.) Regel, fam. Pinaceae 0.8%
Zanthoxylum hyemale Zanthoxylum hyemale A. St. Hil. (Fagara hyemalis Engl.), fam. Rutaceae 5.2%
Inula verbascifolia ssp. parnassica Inula verbascifolia Hausskn., ssp. parnassia Tutin, fam. Asteraceae 0.01%
Eupatorium ballotaefolium Eupatorium ballotaefolium H.B.K., fam. Asteraceae (Compositae) 0.6%
Carrot umbel (Poland) 8015-88-1 Daucus carota L. ssp. carota, fam. Apiaceae (Umbelliferae) 0.01%
Tanacetum balsamita Tanacetum balsamita L., fam. Asteraceae (Compositae) 0.4%
Citronella java (Brazil) 2 8000-29-1 Cymbopogon winterianus Jowitt., fam. Poaceae (Gramineae) 1.7%
Lantana indica leaf (India) Lantana indica Roxb., fam. Verbenaceae 0.3%
Pinus sylvestris 8 8023-99-2 Pinus sylvestris L. (Scotch pine), fam. Pinaceae 4.0%
Pinus sylvestris (Lithuania) 8023-99-2 Pinus sylvestris L. (Scotch pine), fam. Pinaceae 5.0%
Teucrium montanum (Serbia/Montenegro) Teucrium montanum L., fam. Lamiaceae (Labiatae) 1.4%
Teucrium scordium (Serbia/Montenegro) 90131-54-7 Teucrium scordium L., fam. Lamiaceae (Labiatae) 0.5%
Teucrium stocksianum (United Arab Emirates) Teucrium stocksianum Boiss., fam. Lamiaceae (Labiatae) 3.5%
Cymbopogon validus (Zimbabwe) Cymbopogon validus (Stapf) Stapf ex Burtt Davy, fam. Poaceae (Gramineae) 2.7%
Satureja boliviana (Argentina) Satureja boliviana Briq. (Micromeria boliviana Benth.), fam. Lamiaceae 0.3%
Argyranthemum adauctum ssp. adauctum Argyranthemum adauctum ssp.adauctum Humphries, fam.Asteraceae (Compositae) 0.8%
Micromeria graeca (Greece) Micromeria graeca (L.) Bentham et Reichenb., fam. Lamiaceae (Labiatae) 0.02%
Oregano, greek (Italy) 3 84012-24-8 Origanum vulgare L., fam. Lamiaceae (Labiatae) 0.35%
Oregano, greek (Italy) 2 84012-24-8 Origanum vulgare L. ssp hirtum (Link) Ietsw., fam. Lamiaceae (Labiatae) 0.08%