Ethyl Acetate

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  • Identifiers

    CAS number
    141-78-6

    Molecular formula
    C4H8O2

    SMILES
    CCOC(=O)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 605.0
    • Carbowax: 876.14

  • Odor profile

    Fruity 94.54%
    Ethereal 88.05%
    Sweet 84.18%
    Rummy 68.89%
    Winey 56.84%
    Banana 55.89%
    Solvent 50.57%
    Apple 48.3%
    Pear 45.68%
    Sharp 45.11%

    Scent© AI

    Odor threshold>

    • Odor Threshold Low: 6.4 [mmHg]. Odor Threshold High: 50.0 [mmHg]. Detection odor threshold from AIHA (mean = 18 ppm)
    • Ethyl acetate has a fruity odor and an odor threshold of 3.9 ppm.
    • Detection in air: 3.6-1.120 mg cu/m
    • 0.0196 mg/cu m (low odor); 665.0 mg/cu m (high odor); 350 mg/cu m (irritating concn)

  • Properties

    XLogP3-AA
    0.7

    Molecular weight
    88.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -118.5 °F (NTP, 1992)
    • -83.8 °C
    • -83.6 °C
    • -84 °C
    • 117 °F
    • -117 °F

    Boiling point

    • 171 °F at 760 mmHg (NTP, 1992)
    • 77.1 °C
    • Azeotropic mixture with water (6.1% wt/wt), bp: 70.4 °C; azeotropic mixture with water (7.8% wt/wt) and alcohol (9.0% wt/wt), bp: 70.3 °C; Slowly decomposed by moisture, then acquires acid reaction; absorbs water (up to 3.3% wt/wt)
    • 76.50 to 77.50 °C. @ 760.00 mm Hg
    • 77 °C
    • 171 °F

    Flash point est.
    -1.34 ˚C

    Flash point expt.

    • 24 °F (NTP, 1992)
    • 7.2 °C
    • -4 °C c.c.
    • 24 °F

    Solubility expt.

    • 50 to 100 mg/mL at 70 °F (NTP, 1992)
    • In water, 8.0X10+4 mg/L at 25 °C
    • Very soluble in water (64 g/L at 25 °C)
    • Miscible with ethanol, ethyl ether; very soluble in acetone, benzene
    • Miscible with chloroform
    • For more Solubility (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.
    • 80 mg/mL at 25 °C
    • Solubility in water, g/100ml at 20 °C: 8.7 (poor)
    • Slightly soluble in ethanol, ether, glycerol, fixed and volatile oils, soluble in water (1ml in 10ml)
    • (77 °F): 10%

  • Synonyms

    • ETHYL ACETATE
    • 141-78-6
    • Ethyl ethanoate
    • Acetic acid ethyl ester
    • Acetoxyethane
    • Vinegar naphtha
    • Acetic ether
    • Ethyl acetic ester
    • Acetic acid, ethyl ester
    • Ethylacetate
    • Acetidin
    • Essigester
    • EtOAc
    • Acetic ester
    • Aethylacetat
    • Ethylacetat
    • 1-acetoxyethane
    • AcOEt
    • RCRA waste number U112
    • Ethylacetaat
    • Octan etylu
    • FEMA No. 2414
    • Etile (acetato di)
    • Ethylazetat
    • Caswell No. 429
    • Ethyle (acetate d')
    • Acetate d'ethyle
    • Acetato de etilo
    • Ethyl acetate (natural)
    • Ethylester kyseliny octove
    • CHEBI:27750
    • Essigsaeureethylester
    • acetic-acid-ethylester
    • HSDB 83
    • NSC 70930
    • Ethylether
    • CCRIS 6036
    • acet-ethylester
    • acet-eth-ester
    • Ethyl ester of acetic acid
    • EINECS 205-500-4
    • MFCD00009171
    • NSC-70930
    • CH3-CO-O-CH3
    • EPA Pesticide Chemical Code 044003
    • UNII-76845O8NMZ
    • Ethyl acetate [NF]
    • DTXSID1022001
    • AI3-00404
    • 76845O8NMZ
    • DTXCID602001
    • EC 205-500-4
    • ETHYL ACETATE (1-13C)
    • NSC70930
    • Ethyl acetate (NF)
    • NCGC00091766-01
    • E1504
    • ETHYL ACETATE (II)
    • ETHYL ACETATE [II]
    • Ethyl acetate, ACS reagent
    • ETHYL ACETATE (MART.)
    • ETHYL ACETATE [MART.]
    • Ethyl acetate; Ethyl ethanoate
    • Essigester [German]
    • Ethylacetaat [Dutch]
    • Aethylacetat [German]
    • Octan etylu [Polish]
    • ethyl-acetate
    • ETHYL ACETATE (EP MONOGRAPH)
    • ETHYL ACETATE [EP MONOGRAPH]
    • acetic acid ethyl
    • Acetate d'ethyle [French]
    • Acetato de etilo [Spanish]
    • Ethyl acetate, ACS reagent, >=99.5%
    • CAS-141-78-6
    • Etile (acetato di) [Italian]
    • Ethyle (acetate d') [French]
    • Ethylester kyseliny octove [Czech]
    • UN1173
    • CH3COOC2H5
    • RCRA waste no. U112
    • ethylaceate
    • ethylactate
    • ethylacteate
    • Etylacetate
    • ehtyl acetate
    • ethanol acetate
    • ethly acetate
    • ethyl acteate
    • ethyl_acetate
    • ehyl acetate
    • ethl acetate
    • ethy acetate
    • ethyl aceate
    • ethyl actate
    • etyl acetate
    • Acetyl ester
    • 1-ethyl acetate
    • 2~ethyl acetate
    • acetic ethyl ester
    • Etile(acetato di)
    • Et-OAc
    • Ethyle(acetate d')
    • Caswell No 429
    • acetic acid ethylester
    • Ethyl Acetate, HPLC
    • CH3CO2Et
    • Ethyl acetate HPLC grade
    • Ethyl acetate, for HPLC
    • Ethyl acetate, 99.9%
    • Ethyl acetate, ACS grade
    • CH3CO2CH2CH3
    • Epitope ID:116868
    • ETHYL ACETATE [MI]
    • Ethyl acetate, HPLC Grade
    • CH3CO2C2H5
    • ETHYL ACETATE [FCC]
    • ETHYL ACETATE [FHFI]
    • ETHYL ACETATE [HSDB]
    • Ethyl acetate, >=99.5%
    • WLN: 2OV1
    • CHEMBL14152
    • ACETIC ACID,ETHYL ESTER
    • Ethyl acetate, AR, >=99%
    • Ethyl acetate, LR, >=99%
    • ETHYL ACETATE [USP-RS]
    • ETHYL ACETATE [WHO-DD]
    • Ethyl acetate, analytical standard

  • Applications

    Ethyl acetate (ethyl ethanoate, CAS 141-78-6) is a volatile organic solvent with a pleasant fruity odor that finds extensive use across industries: in coatings and varnishes it lowers viscosity, accelerates drying and yields smooth glossy finishes; in the manufacture of printing inks, adhesives, artificial leather and composite materials it efficiently dissolves nitrocellulose, acrylics, polyurethanes and other resins, ensuring uniform flow and strong adhesion; in pharmaceuticals and cosmetics it serves as an extraction medium, recrystallization solvent, perfume carrier and nail-polish remover; in food technology and flavor production it acts as a flavor carrier, decaffeination agent for coffee and aid in sugar and essential-oil purification; in laboratories it is part of chromatography solvent systems and insect preservation fluids; additionally it is regenerated as an electronics cleaner, automotive paint solvent, film-processing and bioplastic treatment solvent, and its rapid biodegradability and low toxicity make it compliant with stricter environmental regulations compared with many halogenated solvents.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 681.23
    methanol 968.44
    isopropanol 490.57
    water 82.24
    ethyl acetate 469.1
    n-propanol 447.02
    acetone 797.93
    n-butanol 376.35
    acetonitrile 880.54
    DMF 1334.42
    toluene 214.0
    isobutanol 311.87
    1,4-dioxane 812.4
    methyl acetate 536.39
    THF 842.34
    2-butanone 521.88
    n-pentanol 236.5
    sec-butanol 393.67
    n-hexane 73.7
    ethylene glycol 277.87
    NMP 1409.43
    cyclohexane 80.33
    DMSO 1096.18
    n-butyl acetate 132.66
    n-octanol 120.49
    chloroform 838.5
    n-propyl acetate 178.06
    acetic acid 1239.17
    dichloromethane 980.61
    cyclohexanone 588.64
    propylene glycol 258.7
    isopropyl acetate 229.28
    DMAc 1239.91
    2-ethoxyethanol 474.02
    isopentanol 266.52
    n-heptane 28.01
    ethyl formate 358.3
    1,2-dichloroethane 546.9
    n-hexanol 146.07
    2-methoxyethanol 977.47
    isobutyl acetate 92.38
    tetrachloromethane 149.63
    n-pentyl acetate 125.59
    transcutol 880.43
    n-heptanol 70.19
    ethylbenzene 100.49
    MIBK 180.01
    2-propoxyethanol 334.73
    tert-butanol 525.46
    MTBE 359.0
    2-butoxyethanol 153.45
    propionic acid 531.13
    o-xylene 149.5
    formic acid 751.4
    diethyl ether 416.5
    m-xylene 137.53
    p-xylene 137.09
    chlorobenzene 292.42
    dimethyl carbonate 164.77
    n-octane 13.55
    formamide 839.0
    cyclopentanone 724.65
    2-pentanone 380.33
    anisole 264.1
    cyclopentyl methyl ether 433.22
    gamma-butyrolactone 929.51
    1-methoxy-2-propanol 585.55
    pyridine 597.05
    3-pentanone 314.54
    furfural 977.72
    n-dodecane 13.94
    diethylene glycol 321.53
    diisopropyl ether 102.03
    tert-amyl alcohol 427.97
    acetylacetone 478.94
    n-hexadecane 15.11
    acetophenone 222.59
    methyl propionate 388.9
    isopentyl acetate 110.38
    trichloroethylene 879.51
    n-nonanol 102.01
    cyclohexanol 374.2
    benzyl alcohol 239.15
    2-ethylhexanol 83.82
    isooctanol 57.19
    dipropyl ether 108.92
    1,2-dichlorobenzene 258.13
    ethyl lactate 104.83
    propylene carbonate 389.79
    n-methylformamide 750.34
    2-pentanol 234.56
    n-pentane 70.62
    1-propoxy-2-propanol 184.15
    1-methoxy-2-propyl acetate 174.64
    2-(2-methoxypropoxy) propanol 213.83
    mesitylene 79.33
    ε-caprolactone 558.46
    p-cymene 50.99
    epichlorohydrin 878.64
    1,1,1-trichloroethane 474.14
    2-aminoethanol 402.07
    morpholine-4-carbaldehyde 1164.64
    sulfolane 987.52
    2,2,4-trimethylpentane 36.3
    2-methyltetrahydrofuran 718.59
    n-hexyl acetate 227.97
    isooctane 17.29
    2-(2-butoxyethoxy)ethanol 279.29
    sec-butyl acetate 120.0
    tert-butyl acetate 226.13
    decalin 40.38
    glycerin 400.52
    diglyme 473.21
    acrylic acid 548.31
    isopropyl myristate 77.78
    n-butyric acid 537.01
    acetyl acetate 318.55
    di(2-ethylhexyl) phthalate 83.55
    ethyl propionate 202.33
    nitromethane 1659.01
    1,2-diethoxyethane 214.24
    benzonitrile 324.04
    trioctyl phosphate 52.89
    1-bromopropane 320.75
    gamma-valerolactone 1093.25
    n-decanol 70.68
    triethyl phosphate 73.29
    4-methyl-2-pentanol 108.52
    propionitrile 462.81
    vinylene carbonate 415.38
    1,1,2-trichlorotrifluoroethane 588.82
    DMS 202.51
    cumene 75.73
    2-octanol 65.18
    2-hexanone 193.58
    octyl acetate 109.04
    limonene 82.28
    1,2-dimethoxyethane 655.49
    ethyl orthosilicate 68.08
    tributyl phosphate 76.59
    diacetone alcohol 284.21
    N,N-dimethylaniline 187.63
    acrylonitrile 606.76
    aniline 341.68
    1,3-propanediol 506.13
    bromobenzene 262.64
    dibromomethane 581.98
    1,1,2,2-tetrachloroethane 613.21
    2-methyl-cyclohexyl acetate 100.16
    tetrabutyl urea 107.78
    diisobutyl methanol 49.75
    2-phenylethanol 136.63
    styrene 142.18
    dioctyl adipate 126.23
    dimethyl sulfate 317.85
    ethyl butyrate 123.3
    methyl lactate 216.35
    butyl lactate 102.35
    diethyl carbonate 87.38
    propanediol butyl ether 183.81
    triethyl orthoformate 87.06
    p-tert-butyltoluene 50.96
    methyl 4-tert-butylbenzoate 174.42
    morpholine 911.23
    tert-butylamine 325.77
    n-dodecanol 53.27
    dimethoxymethane 543.21
    ethylene carbonate 313.36
    cyrene 212.04
    2-ethoxyethyl acetate 199.75
    2-ethylhexyl acetate 89.81
    1,2,4-trichlorobenzene 313.07
    4-methylpyridine 679.5
    dibutyl ether 130.95
    2,6-dimethyl-4-heptanol 49.75
    DEF 588.58
    dimethyl isosorbide 332.24
    tetrachloroethylene 398.18
    eugenol 172.58
    triacetin 238.55
    span 80 176.15
    1,4-butanediol 190.55
    1,1-dichloroethane 568.05
    2-methyl-1-pentanol 191.79
    methyl formate 512.02
    2-methyl-1-butanol 283.9
    n-decane 22.28
    butyronitrile 408.48
    3,7-dimethyl-1-octanol 107.41
    1-chlorooctane 79.06
    1-chlorotetradecane 33.19
    n-nonane 22.43
    undecane 16.83
    tert-butylcyclohexane 39.82
    cyclooctane 26.07
    cyclopentanol 460.65
    tetrahydropyran 569.16
    tert-amyl methyl ether 297.56
    2,5,8-trioxanonane 349.63
    1-hexene 163.89
    2-isopropoxyethanol 249.78
    2,2,2-trifluoroethanol 425.59
    methyl butyrate 267.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Aristolochia asclepiadifolia root Aristolochia asclepiadifolia, fam. Aristolochiaceae 0.9%
Genet absolute 1 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.14%
Ginger (Sri Lanka) 2 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 0.05%
Ginger (Sri Lanka) 4 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 0.05%
Orange, bitter (Spain) 2 72968-50-4 Citrus aurantium L., ssp. amara Engl., fam. Rutaceae 0.05%
Truffle, black (Perigord) Tuber melanosporum, fam. Ascomycetae 0.05%
Rosa rugosa Rosa rugosa Thunb., var. plena Regel, fam. Rosaceae 0.01%
Apple flower Malus arnoldiana (Rehd) Sarg. var. Redgold, fam. Rosaceae 0.01%
Osmanthus concentrate 1 (Sukhumi-Abkhasia) 68917-05-5 Osmanthus fragrans (Thunb.) Lour., fam. Oleaceae 0.06%
Osmanthus concentrate 2 (Sukhumi-Abkhasia) 68917-05-5 Osmanthus fragrans (Thunb.) Lour., fam. Oleaceae 0.06%
Clove leaf (Indonesia) 1 8000-34-8 Eugenia caryophyllus (Spreng.) Bullock & Harrison, fam. Myrtaceae 0.05%
Thyme 5 8007-46-3 Thymus vulgaris L., fam. Lamiaceae (Labiatae) 0.01%
Carrot seed (Japan) 8015-88-1 Daucus carota L., fam. Apiaceae (Umbelliferae) 0.22%
Mandrake fruit (Israel) Mandragora officinarum L., fam. Solanaceae 0.88%
Mustard seed (China) 1 8007-40-7 Brassica juncea (L.) Czern. et Coss., fam. Brassicaceae (Crucifereae) 3.79%
Grape flower 84929-27-1 Vitis vinifera L., ssp. Gruener Veltliner, fam. Vitaceae 2.3%
Jasmine sambac (China) headspace Jasminum sambac (L.) Aiton, fam. Oleaceae 0.22%
Osmanthus headspace (flowers) (China) 2 68917-05-5 Osmanthus fragrans (Thunb.) Lour., var. thunbergii Makino, fam. Oleaceae 0.5%
Michelia champaca flower headspace (China) Michelia champaca L., fam. Magnoliaceae 0.85%
Ylang Ylang (China) 2a 8006-81-5 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 57.93%
Styrax (China) 8024-01-9 Liquidamber formosana Hance, fam. Hamamelidaceae 0.63%
Fagraea berteriana flower Fagraea berteriana A. Gray ex Benth., fam. Potaliaceae 1.4%
Rhubarb root Rheum palmatum L., fam. Polygonaceae 1.0%
Bouea macrophylla fruit (Malaysia) Bouea macrophylla Grif. (B. gandaria Blume x Miq., fam. Anacardiaceae 6.4%
Aristolochia impudica leaf Aristolochia impudica J. Ortega, fam. Aristolochiaceae 1.2%
Rose (Turkey) 4 8007-01-7 Rosa damascena Mill., fam. Rosaceae 0.23%
Rose (Turkey) 5 8007-01-0 Rosa damascena Mill., fam. Rosaceae 0.1%
Keora (India) 2 Pandanus odoratissimus L. (P. fascicularis Lam.), fam. Pandanaceae 0.02%
Cyphomandra betacea fruit Cyphomandra betacea Sendtn., fam. Solanaceae (tree tomato, tamarillo) 0.01%
Aristolochia brevipes Aristolochia brevipes Benth., fam. Aristolochiaceae 0.1%
Colocasia esculenta (Taro) Colocasia esculenta (L.) Schott, fam. Araceae 2.6%
Psidium cattleianum fruit (R‚union Island) Psidium cattleianum Sabine, fam. Myrtaceae 6.0%
Shadberry fruit Amelanchier arborea Nutt., fam. Rosaceae 0.3%
Rollinia mucosa fruit Rollinia mucosa (Jacq.) Baill, fam. Annonaceae 3.0%
Chicory root, roasted 2 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.55%
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.01%
Truffle, Asian Tuber indicum Cooke et Mass. (T. himalayense Zhang-Minter),fam.Ascomycetae 3.0%
Cordia nitida fruit Cordia nitida Vahl., fam. Borraginaceae 10.8%
Pineapple pulp Ananas comosus (L.) Merr., fam. Bromeliaceae 5.95%
Soursop, fruit Annona muricata L., fam. Annonaceae 1.8%
Achillea serbica Achillea serbica Nym., fam. Asteraceae (Compositae) 3.4%
Daidai (Japan) Citrus aurantium L., cultivar cyathifera Y. Tanaka, fam. Rutaceae 0.3%
Geneps fruit (Cuba) Melicocca bijuga L., fam. Sapindaceae 9.7%
Baga fruit Annona glabra L., fam. Annonaceae 1.0%
Soursop, wild fruit Annona montana Macf., fam. Annonaceae 1.9%
Banana passa headspace extract (Brazil) 89957-82-4 Musa cavendishii cultivar nanica, fam. Musaceae 0.2%
Asafoetida (Pakistan) 2 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 0.01%
Mango (Cameroon) headspace of ripe fruit 90063-86-0 Mangifera indica L., fam. Anacardiaceae 4.51%
Papaya (Cameroon) headspace of ripe fruit Carica papaya L., 0.14%