Chamazulene

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  • Identifiers

    CAS number
    529-05-5

    Molecular formula
    C14H16

    SMILES
    CCC1=CC2=C(C=CC2=C(C=C1)C)C

    Retention indicies (RI)

    • DB5: 1723.5
    • Carbowax: 2395.0

  • Odor profile

    Woody 45.52%
    Spicy 42.42%
    Leathery 42.25%
    Herbal 41.72%
    Phenolic 40.47%
    Animal 39.26%
    Earthy 37.26%
    Sweet 30.61%
    Tobacco 30.27%
    Musty 29.63%

    Scent© AI

  • Properties

    XLogP3-AA
    4.4

    Molecular weight
    184.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • < 25 °C

    Boiling point

    • 159.00 °C. @ 11.00 mm Hg

    Flash point est.
    109.06 ˚C

  • Synonyms

    • Chamazulene
    • Chamazulen
    • 529-05-5
    • 7-Ethyl-1,4-dimethylazulene
    • Camazulene
    • Dimethulene
    • Dimethulen
    • 1,4-Dimethyl-7-ethylazulene
    • Azulene, 7-ethyl-1,4-dimethyl-
    • BA 2784
    • EINECS 208-449-6
    • UNII-Z439UH6E5F
    • BRN 1306577
    • 7-ethyl-1,4-dimethyl-azulene
    • Z439UH6E5F
    • AZULENE, 1,4-DIMETHYL-7-ETHYL-
    • CHEBI:3573
    • DTXSID70200939
    • 4-05-00-01736 (Beilstein Handbook Reference)
    • BA-2784
    • dimethylene
    • Dimethwlen
    • Lindazulene
    • CHAMAZULENE [MI]
    • CHAMAZULENE [WHO-DD]
    • CHEMBL495665
    • 1,4-Dimethyl-7-ethyl-Azulene
    • Chamazulene, analytical standard
    • GXGJIOMUZAGVEH-UHFFFAOYSA-
    • DTXCID50123430
    • MFCD00800984
    • AKOS040744437
    • FC74879
    • LMPR0103410002
    • DA-72140
    • FS-10668
    • HY-121038
    • NS00013451
    • CHAMAZULENE (CONSTITUENT OF CHAMOMILE)
    • C09633
    • G89287
    • Q909088
    • CHAMAZULENE (CONSTITUENT OF CHAMOMILE) [DSC]
    • 208-449-6
    • InChI=1/C14H16/c1-4-12-7-5-10(2)13-8-6-11(3)14(13)9-12/h5-9H,4H2,1-3H3

  • Applications

    Chamazulene (CAS 529-05-5) is an azulene-type sesquiterpene responsible for the deep blue color of German chamomile and yarrow oils, formed from matricin during steam distillation, and it is applied for its reported anti-inflammatory and antioxidant activities: soothing erythema, post-sun/razor irritation, and sensitive skin in creams, serums, and facial oils; providing mild antimicrobial support and barrier comfort in redness- or blemish-prone formulations; serving as a visible marker and an analytical QC target in essential-oil profiling by GC/MS (used as a reference standard); contributing to perfumery and aromatherapy as part of “blue chamomile oil”; being investigated as an azulene scaffold for dermocosmetic actives, radical scavengers, and potential 5‑lipoxygenase/COX inhibitors; and acting as a model in spectroscopy/photochemistry due to azulene’s unusual electronic properties; practical use calls for attention to light/oxygen sensitivity, dose control, safety assessment, and compliance with local regulations.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 186.76
    methanol 78.0
    isopropanol 179.5
    water 0.05
    ethyl acetate 703.62
    n-propanol 224.53
    acetone 1009.88
    n-butanol 232.12
    acetonitrile 383.38
    DMF 1303.51
    toluene 888.31
    isobutanol 196.69
    1,4-dioxane 1559.29
    methyl acetate 704.68
    THF 2314.34
    2-butanone 1027.48
    n-pentanol 205.21
    sec-butanol 206.1
    n-hexane 313.14
    ethylene glycol 20.07
    NMP 916.56
    cyclohexane 353.58
    DMSO 474.12
    n-butyl acetate 1517.85
    n-octanol 309.98
    chloroform 1825.53
    n-propyl acetate 667.21
    acetic acid 107.03
    dichloromethane 2555.73
    cyclohexanone 1514.54
    propylene glycol 37.82
    isopropyl acetate 489.97
    DMAc 858.68
    2-ethoxyethanol 218.06
    isopentanol 212.9
    n-heptane 453.04
    ethyl formate 495.72
    1,2-dichloroethane 1769.66
    n-hexanol 530.01
    2-methoxyethanol 268.45
    isobutyl acetate 571.77
    tetrachloromethane 429.21
    n-pentyl acetate 658.13
    transcutol 580.7
    n-heptanol 280.5
    ethylbenzene 650.2
    MIBK 483.88
    2-propoxyethanol 493.71
    tert-butanol 251.77
    MTBE 643.2
    2-butoxyethanol 304.7
    propionic acid 172.58
    o-xylene 507.92
    formic acid 10.9
    diethyl ether 876.0
    m-xylene 557.24
    p-xylene 811.78
    chlorobenzene 833.1
    dimethyl carbonate 326.56
    n-octane 211.19
    formamide 43.31
    cyclopentanone 1828.94
    2-pentanone 841.09
    anisole 734.32
    cyclopentyl methyl ether 1016.59
    gamma-butyrolactone 1400.19
    1-methoxy-2-propanol 242.51
    pyridine 1463.06
    3-pentanone 810.39
    furfural 800.29
    n-dodecane 139.61
    diethylene glycol 151.54
    diisopropyl ether 311.0
    tert-amyl alcohol 255.69
    acetylacetone 792.74
    n-hexadecane 164.7
    acetophenone 597.27
    methyl propionate 593.29
    isopentyl acetate 1075.63
    trichloroethylene 2443.04
    n-nonanol 286.64
    cyclohexanol 308.02
    benzyl alcohol 295.08
    2-ethylhexanol 487.53
    isooctanol 231.14
    dipropyl ether 1162.45
    1,2-dichlorobenzene 698.04
    ethyl lactate 170.99
    propylene carbonate 695.19
    n-methylformamide 309.82
    2-pentanol 182.16
    n-pentane 177.34
    1-propoxy-2-propanol 444.39
    1-methoxy-2-propyl acetate 689.7
    2-(2-methoxypropoxy) propanol 286.55
    mesitylene 381.13
    ε-caprolactone 981.32
    p-cymene 488.63
    epichlorohydrin 1635.82
    1,1,1-trichloroethane 1296.52
    2-aminoethanol 49.18
    morpholine-4-carbaldehyde 944.6
    sulfolane 1009.59
    2,2,4-trimethylpentane 93.01
    2-methyltetrahydrofuran 1445.14
    n-hexyl acetate 816.31
    isooctane 80.74
    2-(2-butoxyethoxy)ethanol 346.65
    sec-butyl acetate 452.3
    tert-butyl acetate 530.99
    decalin 229.83
    glycerin 40.01
    diglyme 854.28
    acrylic acid 124.76
    isopropyl myristate 384.55
    n-butyric acid 285.71
    acetyl acetate 419.91
    di(2-ethylhexyl) phthalate 240.06
    ethyl propionate 588.35
    nitromethane 367.8
    1,2-diethoxyethane 942.44
    benzonitrile 548.8
    trioctyl phosphate 208.7
    1-bromopropane 1168.86
    gamma-valerolactone 1350.02
    n-decanol 243.06
    triethyl phosphate 294.43
    4-methyl-2-pentanol 136.84
    propionitrile 458.83
    vinylene carbonate 632.18
    1,1,2-trichlorotrifluoroethane 369.48
    DMS 592.9
    cumene 420.22
    2-octanol 247.53
    2-hexanone 727.99
    octyl acetate 452.82
    limonene 640.87
    1,2-dimethoxyethane 1003.92
    ethyl orthosilicate 290.19
    tributyl phosphate 244.98
    diacetone alcohol 315.82
    N,N-dimethylaniline 537.44
    acrylonitrile 461.78
    aniline 409.85
    1,3-propanediol 95.02
    bromobenzene 1153.18
    dibromomethane 1695.51
    1,1,2,2-tetrachloroethane 1558.91
    2-methyl-cyclohexyl acetate 547.28
    tetrabutyl urea 384.68
    diisobutyl methanol 276.92
    2-phenylethanol 461.26
    styrene 698.64
    dioctyl adipate 426.49
    dimethyl sulfate 390.36
    ethyl butyrate 895.81
    methyl lactate 135.55
    butyl lactate 249.89
    diethyl carbonate 526.12
    propanediol butyl ether 183.19
    triethyl orthoformate 477.78
    p-tert-butyltoluene 446.2
    methyl 4-tert-butylbenzoate 460.21
    morpholine 1253.68
    tert-butylamine 206.92
    n-dodecanol 209.15
    dimethoxymethane 889.74
    ethylene carbonate 590.09
    cyrene 293.65
    2-ethoxyethyl acetate 657.63
    2-ethylhexyl acetate 1032.1
    1,2,4-trichlorobenzene 715.88
    4-methylpyridine 1270.98
    dibutyl ether 794.05
    2,6-dimethyl-4-heptanol 276.92
    DEF 818.1
    dimethyl isosorbide 670.93
    tetrachloroethylene 971.2
    eugenol 342.39
    triacetin 448.06
    span 80 266.59
    1,4-butanediol 57.82
    1,1-dichloroethane 1309.82
    2-methyl-1-pentanol 213.77
    methyl formate 335.23
    2-methyl-1-butanol 208.67
    n-decane 224.84
    butyronitrile 528.84
    3,7-dimethyl-1-octanol 271.37
    1-chlorooctane 535.66
    1-chlorotetradecane 239.11
    n-nonane 238.55
    undecane 174.48
    tert-butylcyclohexane 210.75
    cyclooctane 184.24
    cyclopentanol 361.85
    tetrahydropyran 1631.97
    tert-amyl methyl ether 487.73
    2,5,8-trioxanonane 540.25
    1-hexene 698.7
    2-isopropoxyethanol 222.93
    2,2,2-trifluoroethanol 47.93
    methyl butyrate 781.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Chamomile, german (Argentina) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 1.05%
Chamomile, german (Bulgaria) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 17.64%
Chamomile, german (Hungary) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 8.0%
Eucalyptus globulus (Hungary) fruit 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 0.45%
Wormwood (Mugwort) 1 8008-93-3 Artemisia absinthium L., fam. Asteraceae (Compositae) 1.2%
Yarrow (Canada) 1 84082-83-7 Achillea millefolium L., fam. Asteraceae (Compositae) 1.7%
Abies sibirica 2 Abies sibirica Ledeb., fam. Pinaceae 1.5%
Pinus sylvestris 2 8023-99-2 Pinus sylvestris L. (Scotch pine), fam. Pinaceae 1.7%
Roman chamomile (Italy) 4 8015-92-7 Anthemis nobilis L., fam. Asteraceae (Compositae) 3.47%
Roman chamomile (Egypt) 8015-92-7 Anthemis nobilis L., fam. Asteraceae (Compositae) 2.07%
Roman chamomile (England) 8015-92-7 Anthemis nobilis L., fam. Asteraceae (Compositae) 4.39%
Wormwood (Mugwort) (U.S.A.) 2 8008-93-3 Artemisia absinthium L., fam. Asteraceae (Compositae) 0.11%
Wormwood (Mugwort) (U.S.A.) 4 8008-93-3 Artemisia absinthium L., var. 'Powis Castle', fam. Asteraceae (Compositae) 3.61%
Wormwood (Mugwort) (U.S.A.) 5 8008-93-3 Artemisia absinthium L., var. 'Powis Castle', fam. Asteraceae (Compositae) 2.22%
Artemisia arborescens (U.S.A.) Artemisia arborescens L., fam. Asteraceae (Compositae) 21.39%
Chamomile, german (Brazil) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 8.19%
Chamomile, german (Germany) 1 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 23.35%
Artemisia argentea (Madeira) Artemisia argentea L'Her., fam. Asteraceae (Compositae) 0.01%
Chamomile, german (Egypt) 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 3.43%
Chamomile, german (Italy) 1 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 10.0%
Chamomile, german (Italy) 2 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 3.52%
Yarrow (Hungary) 84082-83-7 Achillea millefolium L., fam. Asteraceae (Compositae) 12.5%
Yarrow (Poland) 84082-83-7 Achillea millefolium L., fam. Asteraceae (Compositae) 13.0%
Yarrow (Canada) 2 84082-83-7 Achillea millefolium L., fam. Asteraceae (Compositae) 20.0%
Wormwood (Mugwort) (Cuba) 8008-93-3 Artemisia absinthium L., fam. Asteraceae (Compositae) 0.26%
Chamomile, german (Greece) 1a 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 1.1%
Chamomile, german (Greece) 1b 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 1.2%
Chamomile, german (India) 1 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 8.0%
Wormwood (Mugwort) Spain 2a leaf 8008-93-3 Artemisia absinthium L., fam. Asteraceae (Compositae) 0.05%
Wormwood (Mugwort) Spain 2b flowering top 8008-93-3 Artemisia absinthium L., fam. Asteraceae (Compositae) 0.7%
Tansy, moroccan (Morocco) 1 Tanacetum annuum L., fam. Asteraceae (Compositae) 28.0%
Tansy, moroccan (Morocco) 2 Tanacetum annuum L., fam. Asteraceae (Compositae) 2.8%
Chamomile, german (India) 2a whole flower 8002-66-2 Chamomilla recutita (L.) Rausch.(Matricaria chamomilla L.), fam.Asteraceae 2.9%
Yarrow (Estonia) 1a flower 84082-83-7 Achillea millefolium L., fam. Asteraceae (Compositae) 16.0%
Yarrow (Estonia) 1b leaf 84082-83-7 Achillea millefolium L., fam. Asteraceae (Compositae) 3.4%
Yarrow (Estonia) 1c stem 84082-83-7 Achillea millefolium L., fam. Asteraceae (Compositae) 2.0%
Argyranthemum adauctum ssp. adauctum Argyranthemum adauctum ssp.adauctum Humphries, fam.Asteraceae (Compositae) 4.4%
Argyranthemum adauctum ssp. gracile Argyranthemum adauctum ssp.gracile Humphries, fam. Asteraceae (Compositae) 7.8%