Butylated Hydroxytoluene

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  • Identifiers

    CAS number
    128-37-0

    Molecular formula
    C15H24O

    SMILES
    CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Phenolic 54.21%
    Leathery 49.64%
    Woody 47.37%
    Dry 37.77%
    Camphoreous 37.27%
    Burnt 33.36%
    Medicinal 31.8%
    Smoky 31.16%
    Animal 30.23%
    Spicy 30.18%

    Scent© AI

  • Properties

    XLogP3-AA
    5.3

    Molecular weight
    220.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 156 to 160 °F (NTP, 1992)
    • 70 °C
    • 71 °C
    • 158 °F

    Boiling point

    • 509 °F at 760 mmHg (NTP, 1992)
    • 265 °C
    • 265.00 °C. @ 760.00 mm Hg
    • 509 °F

    Flash point est.
    123.5 ˚C

    Flash point expt.

    • 260 °F (NTP, 1992)
    • 260 °F
    • 127.0 °C (260.6 °F) - closed cup
    • 260 °F (127 °C) open cup
    • 261 °F (127 °C) closed cup
    • 127 °C c.c.
    • 261 °F

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • Insoluble in water and propane- 1,2-diol; Freely soluble in ethanol
    • In water, 0.6 mg/L at 25 °C
    • In water, 0.4 mg/L at 20 °C
    • Insoluble in water
    • Freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% wt/wt; more sol in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil. Insoluble in propylene glycol
    • For more Solubility (Complete) data for 2,6-DI-T-BUTYL-P-CRESOL (6 total), please visit the HSDB record page.
    • 0.0006 mg/mL at 25 °C
    • Solubility in water, g/100ml at 25 °C: 0.00006
    • 0.00004%

  • Synonyms

    • 2,6-Di-tert-butyl-4-methylphenol
    • 128-37-0
    • Butylhydroxytoluene
    • 2,6-Di-tert-butyl-p-cresol
    • 2,6-Di-t-butyl-4-methylphenol
    • Ionol
    • DBPC
    • Stavox
    • BHT
    • Impruvol
    • Ionol CP
    • Dalpac
    • Deenax
    • Dibunol
    • Ionole
    • Kerabit
    • Topanol
    • Vianol
    • Antioxidant KB
    • Antioxidant 4K
    • Sumilizer BHT
    • Topanol O
    • Topanol OC
    • Vanlube PC
    • Antioxidant 29
    • Antioxidant 30
    • Antioxidant DBPC
    • Sustane BHT
    • Tenamene 3
    • Vanlube PCX
    • 2,6-ditert-butyl-4-methylphenol
    • Nonox TBC
    • Tenox BHT
    • Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
    • Chemanox 11
    • Agidol
    • Catalin CAO-3
    • Ionol 1
    • Advastab 401
    • 3,5-Di-tert-butyl-4-hydroxytoluene
    • BUKS
    • Parabar 441
    • Antrancine 8
    • Vulkanox KB
    • Catalin antioxydant 1
    • 2,6-Di-tert-butyl-4-cresol
    • Ionol (antioxidant)
    • Paranox 441
    • 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
    • Antioxidant MPJ
    • Antioxidant 4
    • Alkofen BP
    • AO 4K
    • CAO 1
    • CAO 3
    • Di-tert-butyl-p-cresol
    • Di-tert-butyl-p-methylphenol
    • Swanox BHT
    • Antox QT
    • Tenamen 3
    • Agidol 1
    • Antioxidant 264
    • Bht (food grade)
    • o-Di-tert-butyl-p-methylphenol
    • Antioxidant T 501
    • Ional
    • Nocrac 200
    • AO 29
    • NCI-C03598
    • 2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
    • 2,6-Di-tert-butyl-p-methylphenol
    • 2,6-Di-terc.butyl-p-kresol
    • Dbpc (technical grade)
    • 4-Hydroxy-3,5-di-tert-butyltoluene
    • FEMA No. 2184
    • 4-Methyl-2,6-tert-butylphenol
    • Butylhydroxytoluenum
    • Di-tert-butylcresol
    • AOX 4K
    • Dibutylhydroxytoluene
    • 2,6-ditert-butyl-4-methyl-phenol
    • Ionol CP-antioxidant
    • P 21
    • 2,6-DI-T-BUTYL-P-CRESOL
    • 4-Methyl-2,6-di-tert-butylphenol
    • AOX 4
    • Butyl hydroxy toluene
    • CCRIS 103
    • MFCD00011644
    • Popol
    • HSDB 1147
    • BHT 264
    • Bht(food grade)
    • NSC 6347
    • NSC-6347
    • 4-Methyl-2,6-di-terc. butylfenol
    • EINECS 204-881-4
    • Ionol BHT
    • Ralox BHT
    • 2,6-Di-tert-butyl-4-hydroxytoluene
    • 2,6-Di-tert-butyl-4-methyl-phenol
    • 1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene
    • 2,6-ditertiary-butyl-p-cresol
    • Dbpc(technical grade)
    • DTXSID2020216
    • E321
    • CHEBI:34247
    • 2,6-Di-tert-butyl-4-methylhydroxybenzene
    • AI3-19683
    • p-Cresol, 2,6-di-tert-butyl-
    • INS-321
    • 1P9D0Z171K
    • 2,6-bis(tert-butyl)-4-methylphenol
    • 2,6-Di-tert-butylcresol
    • CHEMBL146
    • Di-tert-Butyl-4-methylphenol
    • DTXCID20216
    • INS NO.321
    • E-321
    • FEMA 2184
    • NSC6347
    • 2,6-di-tert-butyl-4-methyl phenol
    • Phenol, 2,6-di-tert-butyl-4-methyl-
    • NCGC00091761-03
    • Tonarol
    • Toxolan P
    • Caswell No. 291A
    • Annulex BHT

  • Applications

    Butylated Hydroxytoluene (BHT, CAS 128-37-0) is a chain‑breaking phenolic antioxidant widely used to suppress oxidative rancidity and degradation in lipids, thereby extending shelf life and preserving product quality; in foods (additive E321) and animal feed it protects edible oils, ready‑to‑eat cereals, snacks, margarine and vitamin premixes at regulated use levels; in cosmetics/personal care it stabilizes fragrances and oils in creams, lipsticks and sunscreens; in pharmaceuticals it helps stabilize vitamin A, vitamin E, retinoids and oxidation‑sensitive tablet/ointment formulations; in industry it serves as a stabilizer for plastics, rubber, adhesives, inks and packaging materials, prevents oxidative breakdown in fuels, lubricants, hydraulic fluids and biodiesel, and inhibits peroxide formation in stored organic solvents; it is often used synergistically with BHA, propyl gallate or citric acid to enhance performance.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 175.14
    methanol 103.02
    isopropanol 249.42
    water 0.34
    ethyl acetate 287.63
    n-propanol 244.24
    acetone 364.71
    n-butanol 243.23
    acetonitrile 223.25
    DMF 544.85
    toluene 324.54
    isobutanol 248.54
    1,4-dioxane 516.88
    methyl acetate 305.64
    THF 1207.5
    2-butanone 439.34
    n-pentanol 214.4
    sec-butanol 300.69
    n-hexane 203.35
    ethylene glycol 38.01
    NMP 659.69
    cyclohexane 234.49
    DMSO 258.67
    n-butyl acetate 449.13
    n-octanol 277.74
    chloroform 838.38
    n-propyl acetate 269.89
    acetic acid 130.13
    dichloromethane 531.42
    cyclohexanone 686.87
    propylene glycol 110.03
    isopropyl acetate 246.03
    DMAc 471.72
    2-ethoxyethanol 168.57
    isopentanol 234.94
    n-heptane 214.19
    ethyl formate 226.88
    1,2-dichloroethane 338.05
    n-hexanol 483.04
    2-methoxyethanol 228.43
    isobutyl acetate 252.8
    tetrachloromethane 174.48
    n-pentyl acetate 300.78
    transcutol 228.06
    n-heptanol 294.91
    ethylbenzene 307.37
    MIBK 294.52
    2-propoxyethanol 392.82
    tert-butanol 356.44
    MTBE 387.65
    2-butoxyethanol 268.59
    propionic acid 196.49
    o-xylene 261.03
    formic acid 27.47
    diethyl ether 271.05
    m-xylene 298.25
    p-xylene 393.83
    chlorobenzene 351.84
    dimethyl carbonate 140.11
    n-octane 108.84
    formamide 48.99
    cyclopentanone 893.38
    2-pentanone 351.63
    anisole 345.87
    cyclopentyl methyl ether 564.99
    gamma-butyrolactone 775.43
    1-methoxy-2-propanol 286.75
    pyridine 447.48
    3-pentanone 298.23
    furfural 468.52
    n-dodecane 84.69
    diethylene glycol 160.21
    diisopropyl ether 171.11
    tert-amyl alcohol 365.73
    acetylacetone 313.16
    n-hexadecane 93.36
    acetophenone 301.44
    methyl propionate 292.29
    isopentyl acetate 432.43
    trichloroethylene 654.09
    n-nonanol 253.21
    cyclohexanol 386.35
    benzyl alcohol 225.99
    2-ethylhexanol 384.74
    isooctanol 248.97
    dipropyl ether 379.9
    1,2-dichlorobenzene 316.22
    ethyl lactate 171.21
    propylene carbonate 499.63
    n-methylformamide 193.06
    2-pentanol 252.28
    n-pentane 143.94
    1-propoxy-2-propanol 402.97
    1-methoxy-2-propyl acetate 341.05
    2-(2-methoxypropoxy) propanol 234.49
    mesitylene 227.82
    ε-caprolactone 534.49
    p-cymene 285.15
    epichlorohydrin 653.75
    1,1,1-trichloroethane 517.12
    2-aminoethanol 91.61
    morpholine-4-carbaldehyde 501.36
    sulfolane 804.61
    2,2,4-trimethylpentane 97.73
    2-methyltetrahydrofuran 755.71
    n-hexyl acetate 437.22
    isooctane 84.54
    2-(2-butoxyethoxy)ethanol 253.37
    sec-butyl acetate 223.5
    tert-butyl acetate 316.47
    decalin 163.59
    glycerin 94.21
    diglyme 386.95
    acrylic acid 143.32
    isopropyl myristate 244.91
    n-butyric acid 269.98
    acetyl acetate 173.5
    di(2-ethylhexyl) phthalate 185.11
    ethyl propionate 265.7
    nitromethane 253.36
    1,2-diethoxyethane 228.83
    benzonitrile 296.25
    trioctyl phosphate 177.6
    1-bromopropane 349.64
    gamma-valerolactone 731.86
    n-decanol 211.89
    triethyl phosphate 176.57
    4-methyl-2-pentanol 191.75
    propionitrile 293.47
    vinylene carbonate 367.95
    1,1,2-trichlorotrifluoroethane 319.27
    DMS 237.78
    cumene 250.99
    2-octanol 260.97
    2-hexanone 345.31
    octyl acetate 297.65
    limonene 374.79
    1,2-dimethoxyethane 407.21
    ethyl orthosilicate 173.98
    tributyl phosphate 167.58
    diacetone alcohol 325.05
    N,N-dimethylaniline 312.83
    acrylonitrile 262.3
    aniline 254.86
    1,3-propanediol 131.08
    bromobenzene 398.18
    dibromomethane 458.73
    1,1,2,2-tetrachloroethane 625.82
    2-methyl-cyclohexyl acetate 374.41
    tetrabutyl urea 243.17
    diisobutyl methanol 230.81
    2-phenylethanol 346.44
    styrene 277.79
    dioctyl adipate 272.89
    dimethyl sulfate 209.92
    ethyl butyrate 325.91
    methyl lactate 167.02
    butyl lactate 248.16
    diethyl carbonate 212.72
    propanediol butyl ether 245.62
    triethyl orthoformate 250.73
    p-tert-butyltoluene 313.47
    methyl 4-tert-butylbenzoate 363.54
    morpholine 564.21
    tert-butylamine 294.38
    n-dodecanol 179.9
    dimethoxymethane 327.89
    ethylene carbonate 320.9
    cyrene 319.71
    2-ethoxyethyl acetate 239.4
    2-ethylhexyl acetate 382.86
    1,2,4-trichlorobenzene 358.15
    4-methylpyridine 502.53
    dibutyl ether 293.26
    2,6-dimethyl-4-heptanol 230.81
    DEF 338.06
    dimethyl isosorbide 508.54
    tetrachloroethylene 313.74
    eugenol 286.74
    triacetin 251.75
    span 80 298.18
    1,4-butanediol 79.65
    1,1-dichloroethane 462.82
    2-methyl-1-pentanol 219.76
    methyl formate 190.71
    2-methyl-1-butanol 247.9
    n-decane 125.24
    butyronitrile 343.86
    3,7-dimethyl-1-octanol 253.09
    1-chlorooctane 269.98
    1-chlorotetradecane 142.47
    n-nonane 131.39
    undecane 100.65
    tert-butylcyclohexane 165.41
    cyclooctane 129.99
    cyclopentanol 467.19
    tetrahydropyran 678.5
    tert-amyl methyl ether 335.12
    2,5,8-trioxanonane 283.55
    1-hexene 335.97
    2-isopropoxyethanol 171.74
    2,2,2-trifluoroethanol 60.72
    methyl butyrate 345.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Artemisia waltonii (China) Artemisia waltonii J.R. Drumm. ex Pamp., fam. Asteraceae (Compositae) 1.42%
Asparagus officinalis (China) stem Asparagus officinalis L., fam. Liliaceae 0.28%
Oenothera odorata flower headspace (China) Oenothera odorata Jacq., fam. Onagraceae 0.92%
Luculia intermedia flower headspace (China) Luclia intermedia Hutch, fam. Rubiaceae 16.11%
Cymbidium sinense flower headspace (China) Cymbidium sinense (Andr.) Willd., fam. Orchidaceae 7.78%
Passion fruit (China) 2 Passiflora edulis Sims var. flavicarpa Dengener, fam. Passifloraceae 4.53%
Acacia confusa flower (China) Acacia confusa Merr., fam. Mimosaceae (Leguminosae) 3.85%
Chicory root, roasted 1a 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.22%
Chicory root, roasted 1b 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.38%