Methyl Salicylate Aroma Chemical
CAS# 119-36-8
Sweet, Phenolic, Fruity, Herbal, Floral
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Methyl Salicylate, widely known as wintergreen oil or oil of wintergreen, is a long-established material with remarkably broad practical applications. First isolated in 1843 by the chemist Auguste André Thomas Cahours, it is a nature-identical substance originally found in wintergreen leaves and the bark of sweet birch. Today, however, it is produced mainly through inexpensive industrial synthesis, which has almost entirely replaced costly natural extraction.
Description
Presenting as a clear to pale yellow liquid, this material gives off a cool, sweet aroma with the unmistakable medicinal character associated with topical pain-relief liniments. Belonging to the medicinal-minty odor family, Methyl Salicylate is extremely powerful in the top note, with very high diffusion, although its substantivity is only short to moderate. In perfumery, it serves as a highly effective modifier. Perfumers typically use only trace amounts to recreate the slightly green, natural-rubbery nuance found in tuberose, ylang-ylang, or acacia, and it pairs especially well with Eugenol or Benzyl Salicylate. Because its odor is so strong and can easily evoke the impression of a dental clinic, it must be diluted in safe solvents such as DPG or TEC at 1% or 0.1% to allow accurate dosage control.
Applications
In terms of applications, Methyl Salicylate is widely used in pharmaceuticals, toothpaste, chewing gum, root beer-style soft drinks, and to a lesser extent in soap and perfume. Under IFRA safety standards, its use is strictly limited because of the risk of skin sensitization and systemic toxicity, with permitted levels in fine fragrance typically being very low. Users should take particular care to store this material safely and out of reach of children, as it is highly toxic if swallowed in significant amounts and may cause a burning sensation on the skin when used neat. Despite these safety concerns, Methyl Salicylate remains a signature component in familiar products such as Salonpas patches and Listerine mouthwash, and it also lends a distinctive accent to the legendary tuberose fragrance Fracas by Robert Piguet.
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Technical standards
Technical standards
Solubility @25˚C
Solubility @25˚C
| Solvent | Solubility (g/L) |
|---|---|
| ethanol | 313.46 |
| methanol | 393.06 |
| isopropanol | 225.39 |
| water | 3.1 |
| ethyl acetate | 155.45 |
| n-propanol | 219.07 |
| acetone | 311.23 |
| n-butanol | 180.21 |
| acetonitrile | 243.72 |
| DMF | 1319.23 |
| toluene | 50.24 |
| isobutanol | 146.73 |
| 1,4-dioxane | 396.2 |
| methyl acetate | 222.41 |
| THF | 490.44 |
| 2-butanone | 226.31 |
| n-pentanol | 145.88 |
| sec-butanol | 182.45 |
| n-hexane | 9.79 |
| ethylene glycol | 262.77 |
| NMP | 482.22 |
| cyclohexane | 13.21 |
| DMSO | 973.96 |
| n-butyl acetate | 86.41 |
| n-octanol | 100.02 |
| chloroform | 350.47 |
| n-propyl acetate | 116.03 |
| acetic acid | 195.23 |
| dichloromethane | 423.67 |
| cyclohexanone | 238.25 |
| propylene glycol | 170.46 |
| isopropyl acetate | 91.69 |
| DMAc | 567.62 |
| 2-ethoxyethanol | 293.2 |
| isopentanol | 132.09 |
| n-heptane | 12.58 |
| ethyl formate | 211.07 |
| 1,2-dichloroethane | 275.52 |
| n-hexanol | 138.37 |
| 2-methoxyethanol | 547.88 |
| isobutyl acetate | 64.39 |
| tetrachloromethane | 46.94 |
| n-pentyl acetate | 73.85 |
| transcutol | 248.97 |
| n-heptanol | 90.15 |
| ethylbenzene | 50.83 |
| MIBK | 113.94 |
| 2-propoxyethanol | 263.2 |
| tert-butanol | 266.28 |
| MTBE | 123.05 |
| 2-butoxyethanol | 153.35 |
| propionic acid | 176.94 |
| o-xylene | 56.56 |
| formic acid | 136.84 |
| diethyl ether | 126.81 |
| m-xylene | 58.46 |
| p-xylene | 63.21 |
| chlorobenzene | 96.94 |
| dimethyl carbonate | 151.49 |
| n-octane | 8.14 |
| formamide | 318.33 |
| cyclopentanone | 351.04 |
| 2-pentanone | 170.8 |
| anisole | 139.26 |
| cyclopentyl methyl ether | 155.81 |
| gamma-butyrolactone | 395.78 |
| 1-methoxy-2-propanol | 365.66 |
| pyridine | 185.17 |
| 3-pentanone | 123.54 |
| furfural | 332.34 |
| n-dodecane | 9.94 |
| diethylene glycol | 301.68 |
| diisopropyl ether | 38.32 |
| tert-amyl alcohol | 192.85 |
| acetylacetone | 210.9 |
| n-hexadecane | 11.19 |
| acetophenone | 127.52 |
| methyl propionate | 186.91 |
| isopentyl acetate | 73.96 |
| trichloroethylene | 422.78 |
| n-nonanol | 85.65 |
| cyclohexanol | 143.57 |
| benzyl alcohol | 137.36 |
| 2-ethylhexanol | 77.82 |
| isooctanol | 70.16 |
| dipropyl ether | 72.96 |
| 1,2-dichlorobenzene | 100.65 |
| ethyl lactate | 110.34 |
| propylene carbonate | 212.06 |
| n-methylformamide | 542.94 |
| 2-pentanol | 116.89 |
| n-pentane | 10.85 |
| 1-propoxy-2-propanol | 160.04 |
| 1-methoxy-2-propyl acetate | 119.22 |
| 2-(2-methoxypropoxy) propanol | 126.26 |
| mesitylene | 44.36 |
| ε-caprolactone | 186.27 |
| p-cymene | 40.55 |
| epichlorohydrin | 444.75 |
| 1,1,1-trichloroethane | 172.27 |
| 2-aminoethanol | 260.04 |
| morpholine-4-carbaldehyde | 423.89 |
| sulfolane | 601.5 |
| 2,2,4-trimethylpentane | 9.93 |
| 2-methyltetrahydrofuran | 233.31 |
| n-hexyl acetate | 113.14 |
| isooctane | 9.76 |
| 2-(2-butoxyethoxy)ethanol | 174.98 |
| sec-butyl acetate | 65.57 |
| tert-butyl acetate | 108.58 |
| decalin | 14.03 |
| glycerin | 253.54 |
| diglyme | 302.24 |
| acrylic acid | 183.01 |
| isopropyl myristate | 55.81 |
| n-butyric acid | 169.51 |
| acetyl acetate | 96.92 |
| di(2-ethylhexyl) phthalate | 54.2 |
| ethyl propionate | 109.96 |
| nitromethane | 447.96 |
| 1,2-diethoxyethane | 100.41 |
| benzonitrile | 132.18 |
| trioctyl phosphate | 52.37 |
| 1-bromopropane | 124.57 |
| gamma-valerolactone | 364.49 |
| n-decanol | 69.33 |
| triethyl phosphate | 57.68 |
| 4-methyl-2-pentanol | 74.07 |
| propionitrile | 186.75 |
| vinylene carbonate | 210.25 |
| 1,1,2-trichlorotrifluoroethane | 321.28 |
| DMS | 93.58 |
| cumene | 42.89 |
| 2-octanol | 69.61 |
| 2-hexanone | 126.57 |
| octyl acetate | 73.46 |
| limonene | 55.64 |
| 1,2-dimethoxyethane | 415.14 |
| ethyl orthosilicate | 49.83 |
| tributyl phosphate | 51.39 |
| diacetone alcohol | 185.19 |
| N,N-dimethylaniline | 107.66 |
| acrylonitrile | 277.28 |
| aniline | 110.16 |
| 1,3-propanediol | 288.66 |
| bromobenzene | 89.56 |
| dibromomethane | 253.17 |
| 1,1,2,2-tetrachloroethane | 338.69 |
| 2-methyl-cyclohexyl acetate | 74.67 |
| tetrabutyl urea | 80.62 |
| diisobutyl methanol | 57.66 |
| 2-phenylethanol | 116.61 |
| styrene | 60.16 |
| dioctyl adipate | 76.78 |
| dimethyl sulfate | 259.03 |
| ethyl butyrate | 85.3 |
| methyl lactate | 171.4 |
| butyl lactate | 76.9 |
| diethyl carbonate | 66.6 |
| propanediol butyl ether | 143.21 |
| triethyl orthoformate | 60.9 |
| p-tert-butyltoluene | 41.09 |
| methyl 4-tert-butylbenzoate | 127.58 |
| morpholine | 396.09 |
| tert-butylamine | 137.99 |
| n-dodecanol | 56.39 |
| dimethoxymethane | 443.89 |
| ethylene carbonate | 163.52 |
| cyrene | 162.0 |
| 2-ethoxyethyl acetate | 92.82 |
| 2-ethylhexyl acetate | 54.97 |
| 1,2,4-trichlorobenzene | 117.11 |
| 4-methylpyridine | 172.63 |
| dibutyl ether | 67.99 |
| 2,6-dimethyl-4-heptanol | 57.66 |
| DEF | 271.82 |
| dimethyl isosorbide | 187.24 |
| tetrachloroethylene | 197.74 |
| eugenol | 138.22 |
| triacetin | 106.48 |
| span 80 | 110.05 |
| 1,4-butanediol | 151.33 |
| 1,1-dichloroethane | 219.45 |
| 2-methyl-1-pentanol | 108.53 |
| methyl formate | 426.28 |
| 2-methyl-1-butanol | 121.7 |
| n-decane | 13.81 |
| butyronitrile | 176.88 |
| 3,7-dimethyl-1-octanol | 80.89 |
| 1-chlorooctane | 58.34 |
| 1-chlorotetradecane | 26.78 |
| n-nonane | 12.65 |
| undecane | 11.6 |
| tert-butylcyclohexane | 14.46 |
| cyclooctane | 6.51 |
| cyclopentanol | 183.94 |
| tetrahydropyran | 213.98 |
| tert-amyl methyl ether | 102.14 |
| 2,5,8-trioxanonane | 214.01 |
| 1-hexene | 40.85 |
| 2-isopropoxyethanol | 181.47 |
| 2,2,2-trifluoroethanol | 110.59 |
| methyl butyrate | 158.98 |
Scent© AI

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CAS NUMBER
119-36-8
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FAMILIES
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BRAND
Scent.vn
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EVAPORATION RATE
Moderate
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Odor impact
High est.
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FLASH POINT
108.63 ˚C est.
Olfactory Pyramid
Notes
| Sweet |
| Phenolic |
| Fruity |
| Herbal |
| Floral |
| Maximum acceptable concentrations in the finished product (%) | |||
|---|---|---|---|
|
Category 1
Products applied to the lips
|
No restriction |
Category 7A
Rinse-off products applied to the hair with some hand contact
|
No restriction |
|
Category 2
Products applied to the axillae
|
No restriction |
Category 7B
Leave-on products applied to the hair with some hand contact
|
No restriction |
|
Category 3
Products applied to the face/body using fingertips
|
No restriction |
Category 8
Products with significant anogenital exposure
|
No restriction |
|
Category 4
Products related to fine fragrance
|
No restriction |
Category 9
Products with body and hand exposure, primarily rinse off
|
No restriction |
|
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
|
No restriction |
Category 10A
Household care products with mostly hand contact
|
No restriction |
|
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
|
No restriction |
Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
|
No restriction |
|
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
|
No restriction |
Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
|
No restriction |
|
Category 5D
Baby Creams, baby Oils and baby talc
|
No restriction |
Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
|
No restriction |
|
Category 6
Products with oral and lip exposure
|
No restriction |
Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
|
No restriction |
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Certificates of Quality
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Certificate of Analysis (COA)
Provides information on the physical and chemical properties of the product.Download -
IFRA Certificate of Conformity
Sets safety standards and guidelines for the product in manufacturing.Download -
Safety Data Sheet (SDS)
Provides important safety guidelines for transporting, storing, and using the product.Download