Isodamascone Aroma Chemical
CAS# 39872-57-6

Isodamascone (CAS 39872-57-6) is a premium synthetic fragrance ingredient belonging to the rose ketone family. In its physical form, it appears as a clear, colorless to pale yellow liquid. With the molecular formula C13H20O, Isodamascone acts as a highly important heart note in perfumery, distinguished by its powerful diffusion and impressive substantivity. When tested on a smelling strip at a 100% concentration, its scent can last for up to 128 hours.

The olfactory profile of Isodamascone is complex, radiant, and multifaceted. Its most defining characteristic is a vibrant combination of fruity and floral notes, capturing the essence of fresh raspberry, a sizzling dew-covered rose, and slightly spicy plum or prunes. Additionally, it features a warm, dry tobacco leaf nuance that adds depth and a masculine touch. What uniquely separates Isodamascone from other damascone isomers is its specific 2,4,4-trimethyl substitution, which imparts a distinctive "isonoid" facet with subtle metallic or violet-like nuances.

In the fragrance and cosmetics industry, Isodamascone is widely used to create modern feminine fragrances and realistic rose-fruit accords. Due to its immense olfactory strength, it is typically evaluated in a 10% solution or less, and it can dramatically enhance a blend's freshness even when used in trace amounts between 0.05% and 0.1%. The compound is hydrophobic (lipophilic) with a LogP of approximately 3.59, meaning it is insoluble in water but highly soluble in alcohol. It demonstrates excellent stability in various products such as body lotions, shampoos, soaps, and antiperspirant roll-ons. However, it is highly unstable in chlorine bleach, where it rapidly degrades.

Regarding safety and sustainability, Isodamascone is a vegan, non-GMO ingredient that is also Halal-compliant. However, because its α,β-unsaturated ketone structure can be chemically reactive and potentially cause skin sensitization or allergic reactions, its use is strictly regulated. The International Fragrance Association (IFRA) restricts the concentration of rose ketones in consumer products to ensure safety, with the European Union limiting their total concentration to 0.02% in cosmetics. For optimal quality, it should be stored at room temperature (not exceeding 25°C) in well-filled, hermetically sealed aluminum or HDPE containers, protected from light and air, ensuring a safe shelf life of up to 24 months.