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Isobutyl Quinoline aka. Butyl Quinoline Secondary Aroma Chemical
CAS# 67634-06-4 / 65442-31-1

Earthy, Animal, Leathery, Green, Nutty

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Isobutyl Quinoline (and its isomer variations such as Pyralone or Butyl Quinoline Secondary) is a premium and iconic synthetic raw material in the perfumery industry. This compound is renowned for its ability to create extremely powerful leather, dry tobacco, and woody notes. Historically, Isobutyl Quinoline was the core ingredient in the famous Mousse de Saxe base created by the De Laire house, which shaped the golden era of classic leather and Chypre fragrances.

The product delivers a complex scent profile with high diffusion and vibrancy. The characteristic odor of Isobutyl Quinoline is described as a blend of tanned leather, damp earthy roots (similar to vetiver), oakmoss, and tobacco. Depending on the specific isomer, the olfactory nuances can vary slightly; for instance, Pyralone is generally finer, more aromatic, and more tobacco-like, with a less dry and earthy character compared to Butyl Quinoline Secondary. In the dry-down (base notes), this compound leaves a resinous layer and sometimes exhibits animalic or tarry facets.

One of the greatest advantages of Isobutyl Quinoline is its exceptionally high substantivity and its ability to act as an outstanding fixative. Its odor can last on a smelling blotter from 5 days up to over 160 hours. Due to its extreme odor strength, perfumers are often recommended to evaluate and use this product in a diluted form (such as 10% or 1% in DPG solvent) to fully appreciate its scent structure without being overwhelmed.
This chemical is a perfect choice for building depth in Chypre, Fougère, and Oriental perfume formulas, especially in premium masculine fragrances. The typical usage rate in fine fragrances usually ranges from minute traces up to a maximum of about 1% to 2% of the total composition.

Beyond fine fragrances, Isobutyl Quinoline is highly favored in consumer goods and home care products thanks to its excellent chemical stability. Due to its pyridine ring structure, which is highly resistant to hydrolysis and oxidation, this compound retains its scent exceptionally well across various harsh pH environments. The product demonstrates excellent performance in application bases such as acid cleaners, fabric conditioners, shampoos, antiperspirants, and bar soaps. It also provides great scent diffusion when used in candles or spatial diffusers.

26 total reviews

Technical standards

Solubility @25˚C

Solvent Solubility (g/L)
ethanol 360.77
methanol 186.66
isopropanol 284.87
water 0.07
ethyl acetate 876.0
n-propanol 380.36
acetone 1292.67
n-butanol 393.74
acetonitrile 641.42
DMF 1705.23
toluene 947.99
isobutanol 314.12
1,4-dioxane 1771.86
methyl acetate 844.98
THF 2035.32
2-butanone 1066.32
n-pentanol 298.28
sec-butanol 273.34
n-hexane 144.79
ethylene glycol 25.86
NMP 898.91
cyclohexane 264.2
DMSO 743.63
n-butyl acetate 1455.02
n-octanol 232.9
chloroform 2710.44
n-propyl acetate 662.71
acetic acid 292.02
dichloromethane 3860.47
cyclohexanone 1895.52
propylene glycol 34.85
isopropyl acetate 463.01
DMAc 774.75
2-ethoxyethanol 282.09
isopentanol 344.05
n-heptane 161.24
ethyl formate 709.85
1,2-dichloroethane 2775.98
n-hexanol 613.47
2-methoxyethanol 477.36
isobutyl acetate 483.4
tetrachloromethane 429.83
n-pentyl acetate 571.18
transcutol 1058.61
n-heptanol 256.86
ethylbenzene 409.09
MIBK 441.72
2-propoxyethanol 641.26
tert-butanol 293.74
MTBE 511.72
2-butoxyethanol 337.83
propionic acid 276.67
o-xylene 390.24
formic acid 35.09
diethyl ether 934.09
m-xylene 491.64
p-xylene 502.17
chlorobenzene 1031.42
dimethyl carbonate 271.3
n-octane 78.65
formamide 108.22
cyclopentanone 1894.45
2-pentanone 897.61
anisole 489.09
cyclopentyl methyl ether 952.97
gamma-butyrolactone 1729.7
1-methoxy-2-propanol 321.74
pyridine 1996.22
3-pentanone 713.78
furfural 1092.66
n-dodecane 48.02
diethylene glycol 222.15
diisopropyl ether 220.77
tert-amyl alcohol 263.27
acetylacetone 776.46
n-hexadecane 57.96
acetophenone 437.65
methyl propionate 656.78
isopentyl acetate 983.98
trichloroethylene 3879.41
n-nonanol 206.94
cyclohexanol 421.1
benzyl alcohol 313.93
2-ethylhexanol 414.22
isooctanol 199.6
dipropyl ether 662.43
1,2-dichlorobenzene 719.53
ethyl lactate 133.15
propylene carbonate 880.64
n-methylformamide 514.96
2-pentanol 231.37
n-pentane 119.03
1-propoxy-2-propanol 450.26
1-methoxy-2-propyl acetate 594.02
2-(2-methoxypropoxy) propanol 225.85
mesitylene 266.07
ε-caprolactone 1173.62
p-cymene 271.37
epichlorohydrin 2195.95
1,1,1-trichloroethane 1579.14
2-aminoethanol 72.8
morpholine-4-carbaldehyde 927.04
sulfolane 1149.6
2,2,4-trimethylpentane 45.06
2-methyltetrahydrofuran 1427.86
n-hexyl acetate 638.57
isooctane 39.05
2-(2-butoxyethoxy)ethanol 363.1
sec-butyl acetate 350.39
tert-butyl acetate 404.64
decalin 105.88
glycerin 46.76
diglyme 874.59
acrylic acid 213.17
isopropyl myristate 210.09
n-butyric acid 537.98
acetyl acetate 404.6
di(2-ethylhexyl) phthalate 158.33
ethyl propionate 463.26
nitromethane 730.36
1,2-diethoxyethane 910.28
benzonitrile 693.8
trioctyl phosphate 127.95
1-bromopropane 1433.19
gamma-valerolactone 1709.2
n-decanol 160.52
triethyl phosphate 189.21
4-methyl-2-pentanol 142.16
propionitrile 682.35
vinylene carbonate 809.73
1,1,2-trichlorotrifluoroethane 523.47
DMS 426.98
cumene 242.19
2-octanol 178.85
2-hexanone 664.45
octyl acetate 273.91
limonene 388.75
1,2-dimethoxyethane 1077.41
ethyl orthosilicate 192.07
tributyl phosphate 165.95
diacetone alcohol 313.68
N,N-dimethylaniline 308.06
acrylonitrile 787.41
aniline 551.73
1,3-propanediol 177.24
bromobenzene 1256.09
dibromomethane 2392.78
1,1,2,2-tetrachloroethane 2173.44
2-methyl-cyclohexyl acetate 389.27
tetrabutyl urea 234.69
diisobutyl methanol 192.22
2-phenylethanol 451.25
styrene 530.24
dioctyl adipate 259.17
dimethyl sulfate 310.0
ethyl butyrate 665.72
methyl lactate 119.57
butyl lactate 220.85
diethyl carbonate 375.43
propanediol butyl ether 198.95
triethyl orthoformate 348.4
p-tert-butyltoluene 228.01
methyl 4-tert-butylbenzoate 301.8
morpholine 1610.78
tert-butylamine 220.59
n-dodecanol 129.26
dimethoxymethane 956.46
ethylene carbonate 747.55
cyrene 216.24
2-ethoxyethyl acetate 616.85
2-ethylhexyl acetate 848.91
1,2,4-trichlorobenzene 729.09
4-methylpyridine 1701.08
dibutyl ether 528.36
2,6-dimethyl-4-heptanol 192.22
DEF 982.64
dimethyl isosorbide 521.14
tetrachloroethylene 1526.51
eugenol 269.59
triacetin 303.52
span 80 210.39
1,4-butanediol 73.41
1,1-dichloroethane 1956.52
2-methyl-1-pentanol 285.98
methyl formate 494.01
2-methyl-1-butanol 325.53
n-decane 84.16
butyronitrile 774.0
3,7-dimethyl-1-octanol 205.28
1-chlorooctane 321.25
1-chlorotetradecane 119.24
n-nonane 89.51
undecane 62.61
tert-butylcyclohexane 85.1
cyclooctane 92.69
cyclopentanol 417.92
tetrahydropyran 1958.57
tert-amyl methyl ether 349.52
2,5,8-trioxanonane 435.53
1-hexene 530.07
2-isopropoxyethanol 235.98
2,2,2-trifluoroethanol 85.28
methyl butyrate 722.96

Scent© AI

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  • CAS NUMBER

    67634-06-4
    65442-31-1

  • FAMILIES

    Animalic

  • BRAND

    Scent.vn

  • EVAPORATION RATE

    Very slow

  • Odor impact

    High est.

  • FLASH POINT

    118.97 ˚C est.

base
Earthy
Animal
Leathery
Green
Nutty
Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
No restriction
Category 2
Products applied to the axillae
No restriction Category 7B
Leave-on products applied to the hair with some hand contact
No restriction
Category 3
Products applied to the face/body using fingertips
No restriction Category 8
Products with significant anogenital exposure
No restriction
Category 4
Products related to fine fragrance
No restriction Category 9
Products with body and hand exposure, primarily rinse off
No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
No restriction Category 10A
Household care products with mostly hand contact
No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
No restriction
Category 5D
Baby Creams, baby Oils and baby talc
No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
No restriction
Category 6
Products with oral and lip exposure
No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
No restriction
  • All orders will be processed within 1-2 business days from the time the order is confirmed.
  • Free shipping is available for international retail orders valued at 500 USD or more.
  • Delivery time is 1-3 business days for local areas, 3-7 days for suburban and nationwide deliveries, and 1-4 weeks for international orders.
  • You have 30 days from the date of receipt to initiate the return process.
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  • Certificate of Analysis (COA)

    Provides information on the physical and chemical properties of the product.
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  • IFRA Certificate of Conformity

    Sets safety standards and guidelines for the product in manufacturing.
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  • Safety Data Sheet (SDS)

    Provides important safety guidelines for transporting, storing, and using the product.
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