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Iso Muscone Aroma Chemical
CAS# 2550-52-9

Musk, Animal, Powdery, Amber, Dry

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Iso Muscone (also known commercially as Isomuscone) is a macrocyclic musk ketone, chemically identified as cyclohexadecanone (CAS 2550-52-9; molecular formula C16H30O). At room temperature it is typically a white crystalline solid and is valued as a base-note material that adds smoothness, depth, and a natural “skin-like” finish to a fragrance.

Olfactively, Iso Muscone delivers a pronounced musky character in the classic Tonkin-musk direction, with a soft powdery nuance and a subtly animalic facet that can still read clean and refined at appropriate dosage. It is often effective at low levels and can create strong synergy when combined with other macrocyclic musks, helping to round off the base and extend the overall drydown.

In application, Iso Muscone is broadly useful across many fragrance styles (chypre, fougère, oriental, leather, tobacco, gourmand), particularly when the goal is to increase substantivity and add a gentle musky aura behind the top and heart. Performance will depend on the finished product matrix, but it is commonly used in a wide range of personal-care formats; very strong oxidizing systems may reduce its performance.

Typical use levels vary widely by concept and product type, and can range from trace amounts up to several percent in the fragrance concentrate. As with any musk ingredient, ensure compliance by checking the current IFRA guidance and any applicable regulatory requirements for your specific product category before finalizing the formula.

Technical standards

Physical appearance Liquid Conform
Color Clear or cloudy liquid with precipitation Conform
Specific Gravity @20˚C 1.004 → 1.01 1.0084
Refractive Index @20˚C 1.486 → 1.492 1.4884
Flash point ≥ 100.0°C Conform

Solubility @25˚C

Solvent Solubility (g/L)
ethanol 250.66
methanol 166.03
isopropanol 343.16
water 0.03
ethyl acetate 1336.48
n-propanol 363.02
acetone 1095.51
n-butanol 387.8
acetonitrile 525.28
DMF 1372.71
toluene 828.45
isobutanol 341.39
1,4-dioxane 1365.04
methyl acetate 779.65
THF 2751.97
2-butanone 1083.87
n-pentanol 257.95
sec-butanol 368.25
n-hexane 322.28
ethylene glycol 24.75
NMP 1750.22
cyclohexane 827.93
DMSO 1025.08
n-butyl acetate 1289.35
n-octanol 255.88
chloroform 3707.17
n-propyl acetate 1064.76
acetic acid 393.75
dichloromethane 3117.07
cyclohexanone 2551.82
propylene glycol 77.48
isopropyl acetate 1143.38
DMAc 1127.68
2-ethoxyethanol 372.04
isopentanol 446.97
n-heptane 328.22
ethyl formate 574.23
1,2-dichloroethane 2086.78
n-hexanol 357.75
2-methoxyethanol 590.43
isobutyl acetate 738.97
tetrachloromethane 725.02
n-pentyl acetate 1104.01
transcutol 2131.76
n-heptanol 241.64
ethylbenzene 457.25
MIBK 878.12
2-propoxyethanol 574.71
tert-butanol 534.91
MTBE 877.21
2-butoxyethanol 519.45
propionic acid 488.04
o-xylene 522.74
formic acid 56.84
diethyl ether 982.18
m-xylene 536.49
p-xylene 626.1
chlorobenzene 1245.31
dimethyl carbonate 346.08
n-octane 106.95
formamide 131.24
cyclopentanone 2730.38
2-pentanone 1223.13
anisole 744.0
cyclopentyl methyl ether 1627.84
gamma-butyrolactone 2577.74
1-methoxy-2-propanol 638.01
pyridine 1846.3
3-pentanone 1030.4
furfural 1840.66
n-dodecane 56.18
diethylene glycol 244.04
diisopropyl ether 517.05
tert-amyl alcohol 479.44
acetylacetone 1471.19
n-hexadecane 70.72
acetophenone 781.0
methyl propionate 892.91
isopentyl acetate 1125.72
trichloroethylene 3586.49
n-nonanol 261.98
cyclohexanol 801.19
benzyl alcohol 428.69
2-ethylhexanol 407.34
isooctanol 263.68
dipropyl ether 1134.66
1,2-dichlorobenzene 1260.36
ethyl lactate 325.15
propylene carbonate 1497.53
n-methylformamide 441.86
2-pentanol 395.74
n-pentane 211.38
1-propoxy-2-propanol 675.42
1-methoxy-2-propyl acetate 975.34
2-(2-methoxypropoxy) propanol 487.25
mesitylene 411.2
ε-caprolactone 1906.27
p-cymene 361.51
epichlorohydrin 2227.55
1,1,1-trichloroethane 2396.12
2-aminoethanol 97.93
morpholine-4-carbaldehyde 1413.13
sulfolane 2842.19
2,2,4-trimethylpentane 107.33
2-methyltetrahydrofuran 1920.83
n-hexyl acetate 1088.72
isooctane 92.64
2-(2-butoxyethoxy)ethanol 712.58
sec-butyl acetate 818.81
tert-butyl acetate 1186.2
decalin 278.99
glycerin 124.42
diglyme 1552.25
acrylic acid 359.09
isopropyl myristate 451.89
n-butyric acid 1038.32
acetyl acetate 915.81
di(2-ethylhexyl) phthalate 286.48
ethyl propionate 950.09
nitromethane 943.86
1,2-diethoxyethane 1277.22
benzonitrile 844.85
trioctyl phosphate 226.01
1-bromopropane 1329.4
gamma-valerolactone 2624.34
n-decanol 185.6
triethyl phosphate 485.89
4-methyl-2-pentanol 283.8
propionitrile 693.86
vinylene carbonate 1154.75
1,1,2-trichlorotrifluoroethane 1339.73
DMS 749.04
cumene 313.54
2-octanol 234.19
2-hexanone 868.46
octyl acetate 495.75
limonene 616.33
1,2-dimethoxyethane 1157.44
ethyl orthosilicate 468.95
tributyl phosphate 333.58
diacetone alcohol 790.5
N,N-dimethylaniline 491.97
acrylonitrile 758.68
aniline 734.02
1,3-propanediol 234.09
bromobenzene 1583.42
dibromomethane 2180.22
1,1,2,2-tetrachloroethane 3204.41
2-methyl-cyclohexyl acetate 757.72
tetrabutyl urea 424.09
diisobutyl methanol 347.25
2-phenylethanol 418.85
styrene 608.01
dioctyl adipate 613.77
dimethyl sulfate 591.41
ethyl butyrate 1139.83
methyl lactate 335.94
butyl lactate 589.44
diethyl carbonate 658.89
propanediol butyl ether 385.55
triethyl orthoformate 798.59
p-tert-butyltoluene 342.35
methyl 4-tert-butylbenzoate 716.39
morpholine 1540.82
tert-butylamine 426.84
n-dodecanol 145.57
dimethoxymethane 825.18
ethylene carbonate 1127.65
cyrene 447.5
2-ethoxyethyl acetate 1017.89
2-ethylhexyl acetate 946.68
1,2,4-trichlorobenzene 1353.0
4-methylpyridine 1582.4
dibutyl ether 967.53
2,6-dimethyl-4-heptanol 347.25
DEF 1395.51
dimethyl isosorbide 1024.36
tetrachloroethylene 2136.87
eugenol 495.27
triacetin 971.29
span 80 550.72
1,4-butanediol 80.11
1,1-dichloroethane 2000.48
2-methyl-1-pentanol 297.61
methyl formate 337.08
2-methyl-1-butanol 387.72
n-decane 119.14
butyronitrile 797.46
3,7-dimethyl-1-octanol 355.89
1-chlorooctane 436.51
1-chlorotetradecane 160.24
n-nonane 127.22
undecane 76.26
tert-butylcyclohexane 209.95
cyclooctane 281.21
cyclopentanol 784.69
tetrahydropyran 1989.1
tert-amyl methyl ether 754.49
2,5,8-trioxanonane 901.67
1-hexene 611.89
2-isopropoxyethanol 368.19
2,2,2-trifluoroethanol 192.44
methyl butyrate 1276.97

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  • CAS NO.

    2550-52-9

  • OLFACTIVE FAMILY

    Musky

  • BRAND

    Symrise

Olfactory Pyramid

base

Notes

Musk
Animal
Powdery
Amber
Dry

IFRA standard 51

Recommendation
Restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0.25 % Category 7A
Rinse-off products applied to the hair with some hand contact
 7.4 %
Category 2
Products applied to the axillae
 0.23 % Category 7B
Leave-on products applied to the hair with some hand contact
 7.4 %
Category 3
Products applied to the face/body using fingertips
 4.4 % Category 8
Products with significant anogenital exposure
 0.37 %
Category 4
Products related to fine fragrance
 4.3 % Category 9
Products with body and hand exposure, primarily rinse off
 8.4 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 1.1 % Category 10A
Household care products with mostly hand contact
 0.98 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 1.1 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 13 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 1.1 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 0.37 %
Category 5D
Baby Creams, baby Oils and baby talc
 0.37 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 0.37 %
Category 6
Products with oral and lip exposure
 0.25 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

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  • All orders will be processed within 1-2 business days from the time the order is confirmed.
  • Free shipping is available for orders valued at $200 or more.
  • Delivery time is 1-3 business days for local areas, 3-7 days for suburban and nationwide deliveries, and 1-4 weeks for international orders.
  • You have 30 days from the date of receipt to initiate the return process.
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Certificates of Quality

  • Certificate of Analysis (COA)

    Provides information on the physical and chemical properties of the product.
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  • IFRA Certificate of Conformity

    Sets safety standards and guidelines for the product in manufacturing.
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  • Safety Data Sheet (SDS)

    Provides important safety guidelines for transporting, storing, and using the product.
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