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Iso Ambrettolide alt. Scentolide Aroma Chemical
CAS# 28645-51-4 / 63286-42-0

Musk, Sweet, Animal, Fruity, Powdery

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Ambrettolide is one of the major achievements of modern aroma chemical science, offering an ideal substitute for costly natural ambrette seed extract. Developed in the mid-20th century, this synthetic macrocyclic musk appears as a clear, slightly viscous liquid with an exceptionally alluring odor structure. Its scent presents a beautiful interplay of warm musk, soft powdery floral nuances, and a delicate fruity sweetness reminiscent of juicy berries. Including this material in a production portfolio not only helps brands optimize costs and secure a stable supply, but also demonstrates a strong commitment to using ingredients that are more environmentally responsible.

Description

In the art of fragrance design, Ambrettolide belongs to the floral musk family and consistently plays a central role in the drydown thanks to its excellent substantivity and diffusion. Steffen Arctander described this group of materials as having a sweet floral-musky odor with outstanding fixative value. In a formula, it functions as an effective modifier, helping to smooth out sharper notes and create a soft, polished base. One blending technique that produces a particularly captivating olfactory effect is combining Ambrettolide with Hedione, rose, and other musks such as Ethylene Brassylate. To make this slightly viscous liquid easier to handle, professionals often dilute it in safe solvents such as DPG or IPM at levels of 10% to 50%, which makes weighing and dosing much more precise and convenient.

Applications

Ambrettolide is highly versatile and performs exceptionally well across a wide range of applications, from fine fragrance and scented candles to skincare products and soap. Thanks to its excellent stability, it is a preferred choice for creating long-lasting products without concerns about changes in color or structure. With a flexible recommended usage level of 0.5% to 5% under IFRA guidelines, along with a strong safety profile and no phototoxicity concerns, manufacturers can use it confidently across many types of projects. Its presence in globally recognized white musk fragrances is clear evidence of its appeal. Choosing Ambrettolide is a strategic decision that can elevate product quality, deliver a richer and more layered olfactory experience, and strongly support customer purchase decisions.

Technical standards

Physical appearance Transparent liquid Conform
Color Colorless to pale yellow Conform
Specific Gravity @20˚C 0.945 → 0.96 0.955
Refractive Index @20˚C 1.474 → 1.481 1.479
Acid value (mgKOH/g) ≤ 1.0 0.2
Purity ≥ 97.0% 97.8%

Solubility @25˚C

Solvent Solubility (g/L)
ethanol 665.09
methanol 484.54
isopropanol 715.44
water 0.02
ethyl acetate 1414.4
n-propanol 646.89
acetone 1662.82
n-butanol 707.65
acetonitrile 782.46
DMF 1399.67
toluene 996.61
isobutanol 561.23
1,4-dioxane 1543.5
methyl acetate 848.07
THF 2646.98
2-butanone 1239.12
n-pentanol 505.79
sec-butanol 652.48
n-hexane 364.37
ethylene glycol 47.47
NMP 1349.48
cyclohexane 739.57
DMSO 1798.04
n-butyl acetate 1150.68
n-octanol 300.53
chloroform 3707.6
n-propyl acetate 1028.41
acetic acid 653.68
dichloromethane 3465.0
cyclohexanone 2262.99
propylene glycol 131.15
isopropyl acetate 1016.9
DMAc 1128.79
2-ethoxyethanol 569.8
isopentanol 697.0
n-heptane 203.03
ethyl formate 572.64
1,2-dichloroethane 2241.0
n-hexanol 545.68
2-methoxyethanol 771.61
isobutyl acetate 673.6
tetrachloromethane 520.32
n-pentyl acetate 886.34
transcutol 3237.69
n-heptanol 282.83
ethylbenzene 492.49
MIBK 884.85
2-propoxyethanol 746.43
tert-butanol 852.37
MTBE 1082.12
2-butoxyethanol 563.05
propionic acid 563.49
o-xylene 514.85
formic acid 95.91
diethyl ether 1512.13
m-xylene 577.91
p-xylene 577.92
chlorobenzene 1257.01
dimethyl carbonate 318.57
n-octane 69.85
formamide 190.76
cyclopentanone 2196.67
2-pentanone 1380.98
anisole 732.84
cyclopentyl methyl ether 1493.92
gamma-butyrolactone 2069.68
1-methoxy-2-propanol 780.65
pyridine 2017.82
3-pentanone 970.79
furfural 1513.79
n-dodecane 43.3
diethylene glycol 343.03
diisopropyl ether 500.02
tert-amyl alcohol 705.23
acetylacetone 1290.06
n-hexadecane 52.27
acetophenone 714.27
methyl propionate 847.06
isopentyl acetate 942.1
trichloroethylene 3577.29
n-nonanol 273.59
cyclohexanol 988.98
benzyl alcohol 515.74
2-ethylhexanol 416.36
isooctanol 274.11
dipropyl ether 850.27
1,2-dichlorobenzene 1086.61
ethyl lactate 315.68
propylene carbonate 1112.34
n-methylformamide 489.75
2-pentanol 651.65
n-pentane 264.34
1-propoxy-2-propanol 713.27
1-methoxy-2-propyl acetate 842.16
2-(2-methoxypropoxy) propanol 529.66
mesitylene 387.49
ε-caprolactone 1641.28
p-cymene 268.56
epichlorohydrin 2190.12
1,1,1-trichloroethane 1944.15
2-aminoethanol 173.74
morpholine-4-carbaldehyde 1214.83
sulfolane 2305.49
2,2,4-trimethylpentane 99.99
2-methyltetrahydrofuran 2022.52
n-hexyl acetate 1001.19
isooctane 90.16
2-(2-butoxyethoxy)ethanol 831.73
sec-butyl acetate 714.03
tert-butyl acetate 981.61
decalin 220.87
glycerin 178.11
diglyme 1542.24
acrylic acid 403.53
isopropyl myristate 354.42
n-butyric acid 1179.66
acetyl acetate 772.92
di(2-ethylhexyl) phthalate 273.37
ethyl propionate 846.97
nitromethane 1148.47
1,2-diethoxyethane 1327.58
benzonitrile 852.92
trioctyl phosphate 204.37
1-bromopropane 1594.62
gamma-valerolactone 2119.9
n-decanol 191.86
triethyl phosphate 328.21
4-methyl-2-pentanol 366.11
propionitrile 814.37
vinylene carbonate 917.05
1,1,2-trichlorotrifluoroethane 1249.27
DMS 626.93
cumene 298.8
2-octanol 236.25
2-hexanone 925.73
octyl acetate 429.96
limonene 464.55
1,2-dimethoxyethane 1219.3
ethyl orthosilicate 315.76
tributyl phosphate 283.14
diacetone alcohol 774.08
N,N-dimethylaniline 476.03
acrylonitrile 870.72
aniline 871.71
1,3-propanediol 359.73
bromobenzene 1580.18
dibromomethane 2548.26
1,1,2,2-tetrachloroethane 3071.21
2-methyl-cyclohexyl acetate 576.79
tetrabutyl urea 364.45
diisobutyl methanol 291.22
2-phenylethanol 448.98
styrene 686.66
dioctyl adipate 518.79
dimethyl sulfate 514.31
ethyl butyrate 828.19
methyl lactate 327.64
butyl lactate 510.71
diethyl carbonate 514.16
propanediol butyl ether 497.86
triethyl orthoformate 550.8
p-tert-butyltoluene 254.81
methyl 4-tert-butylbenzoate 588.48
morpholine 1796.73
tert-butylamine 630.83
n-dodecanol 149.2
dimethoxymethane 912.08
ethylene carbonate 868.63
cyrene 436.26
2-ethoxyethyl acetate 931.2
2-ethylhexyl acetate 750.74
1,2,4-trichlorobenzene 1176.32
4-methylpyridine 1753.0
dibutyl ether 819.42
2,6-dimethyl-4-heptanol 291.22
DEF 1231.0
dimethyl isosorbide 901.01
tetrachloroethylene 1938.81
eugenol 493.36
triacetin 832.82
span 80 573.5
1,4-butanediol 139.11
1,1-dichloroethane 2175.21
2-methyl-1-pentanol 472.9
methyl formate 352.66
2-methyl-1-butanol 617.65
n-decane 86.66
butyronitrile 1048.12
3,7-dimethyl-1-octanol 353.82
1-chlorooctane 363.1
1-chlorotetradecane 127.0
n-nonane 90.7
undecane 57.71
tert-butylcyclohexane 161.25
cyclooctane 212.71
cyclopentanol 869.65
tetrahydropyran 2449.64
tert-amyl methyl ether 757.67
2,5,8-trioxanonane 955.04
1-hexene 836.11
2-isopropoxyethanol 504.61
2,2,2-trifluoroethanol 181.92
methyl butyrate 1145.47

Scent© AI

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  • CAS NUMBER

    28645-51-4
    63286-42-0

  • FAMILIES

    Musky

  • BRAND

    Sigma Aldrich

  • EVAPORATION RATE

    Ultra slow

  • Odor impact

    High est.

  • FLASH POINT

    160.51 ˚C est.

Olfactory Pyramid

base

Notes

Musk
Sweet
Animal
Fruity
Powdery

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Shipping & Returns

  • All orders will be processed within 1-2 business days from the time the order is confirmed.
  • Free shipping is available for orders valued at $500 or more.
  • Delivery time is 1-3 business days for local areas, 3-7 days for suburban and nationwide deliveries, and 1-4 weeks for international orders.
  • You have 30 days from the date of receipt to initiate the return process.
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Certificates of Quality

  • Certificate of Analysis (COA)

    Provides information on the physical and chemical properties of the product.
    Download  

  • IFRA Certificate of Conformity

    Sets safety standards and guidelines for the product in manufacturing.
    Download  

  • Safety Data Sheet (SDS)

    Provides important safety guidelines for transporting, storing, and using the product.
    Download  
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