Urea

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  • Identifiers

    CAS number
    57-13-6

    Molecular formula
    CH4N2O

    SMILES
    C(=O)(N)N

  • Odor profile

    Odorless 68.67%
    Fishy 31.59%
    Cheesy 22.66%
    Pungent 21.96%
    Savory 21.37%
    Meaty 20.24%
    Cooked 16.49%
    Ripe 15.15%
    Sweet 15.01%
    Sulfurous 14.29%

    Scent© AI

  • Properties

    XLogP3-AA
    -1.4

    Molecular weight
    60.056 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 275 °F (NTP, 1992)
    • 132.7 °C
    • 132 °C to 135 °C
    • 132.70 °C
    • Ionization potential = 9 eV; Latent heat of fusion = 15.4 kJ/mol (at melting point); Latent heat of sublimation = 87.9 kJ/mol @ 25 °C; Heat of formation = -333.7 kJ/mol @ 25 °C; Decomposition temp = 135 °C
    • 132 °C
    • 132.7-135 °C

    Boiling point

    • Decomposes (NTP, 1992)
    • Decomposes

    Flash point est.
    114.8 ˚C

    Solubility expt.

    • >9 [ug/mL] (The mean of the results at pH 7.4)
    • Soluble (NTP, 1992)
    • 545000 mg/L (at 25 °C)
    • Very soluble in water; Soluble in ethanol
    • 10 ml 95% alc, 6 ml methanol, 1 ml boiling 95% alc, 20 ml abs alc, 2 ml glycerol; almost insol in chloroform, ether; sol in concn HCl
    • INSOL IN BENZENE; SOL IN ACETIC ACID
    • Sol in pyrimidine
    • In water, 5.45X10+5 mg/l @ 25 °C
    • 545.0 mg/mL
    • Solubility in water: miscible

  • Synonyms

    • urea
    • 57-13-6
    • carbamide
    • Isourea
    • Carbonyldiamide
    • Ureophil
    • Carbonyldiamine
    • Ureaphil
    • Carbamimidic acid
    • Urevert
    • Alphadrate
    • Aquadrate
    • Carbaderm
    • Keratinamin
    • Pseudourea
    • Carbonyl diamide
    • Calmurid
    • Pastaron
    • Urepearl
    • Carbamide resin
    • Ultra Mide
    • Varioform ii
    • Aqua Care
    • Harnstoff
    • Mocovina
    • Nutraplus
    • Prespersion, 75 urea
    • B-I-K
    • Supercel 3000
    • Aqua Care HP
    • basodexan
    • carmol
    • Ureacin-10 lotion
    • Ureacin-20
    • Ureacin-40 Creme
    • Caswell No. 902
    • Onychomal
    • Hyanit
    • NCI-C02119
    • Antisepsis bolus
    • Elaqua xx
    • Sterile Urea
    • Carbonyl Diamine
    • Keratinamin Kowa
    • CCRIS 989
    • HSDB 163
    • Benural 70
    • aminoketone
    • NSC 34375
    • uree
    • Isoharnstoff
    • Aquacare
    • Karbamid
    • Urepeal
    • EPA Pesticide Chemical Code 085702
    • Ureum
    • Carbamimic acid
    • Urea perhydrate
    • Bubber shet
    • Urepeal L
    • AI3-01202
    • 37955-36-5
    • EINECS 200-315-5
    • UR
    • NSC-34375
    • Pastaron 10
    • Pastaron 20
    • Pastaron 20 soft
    • INS NO.927A
    • E927b
    • INS-927A
    • DTXSID4021426
    • UNII-8W8T17847W
    • CHEBI:16199
    • Urea-18O
    • Urea [USP:JAN]
    • Carbamide;Carbonyldiamide
    • E-927A
    • MFCD00008022
    • 8W8T17847W
    • Azodicarboxylic acid-diamide
    • H2NC(O)NH2
    • H2N-C(OH)=NH
    • U-CORT COMPONENT UREA
    • H2N-C(=NH)-OH
    • HO-C(=NH)-NH2
    • (NH2)2CO
    • ALPHADERM COMPONENT UREA
    • DTXCID901426
    • 4744-36-9
    • CARMOL HC COMPONENT UREA
    • Urea, prilled
    • CHEBI:48376
    • CALMURID HC COMPONENT UREA
    • EC 200-315-5
    • NSC34375
    • NCGC00090892-01
    • Urea (USP:JAN)
    • UREA (USP-RS)
    • UREA [USP-RS]
    • UREA (II)
    • UREA (MART.)
    • UREA [II]
    • UREA [MART.]
    • Mocovina [Czech]
    • UREA (EP MONOGRAPH)
    • UREA (USP IMPURITY)
    • UREA [EP MONOGRAPH]
    • UREA [USP IMPURITY]
    • UREA (USP MONOGRAPH)
    • UREA [USP MONOGRAPH]
    • 3138-51-0
    • URE
    • Harnstoff [German]
    • Urea [JAN]
    • CAS-57-13-6
    • ALLANTOIN IMPURITY B (EP IMPURITY)
    • ALLANTOIN IMPURITY B [EP IMPURITY]
    • FLUOROURACIL IMPURITY G (EP IMPURITY)
    • FLUOROURACIL IMPURITY G [EP IMPURITY]
    • UREA, ACS
    • isoureas
    • Lanaphilic
    • Cerovel
    • Protexa
    • Uroderm
    • Vanamide
    • Uremol

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 43.98
    methanol 134.14
    isopropanol 20.64
    water 750.68
    ethyl acetate 9.73
    n-propanol 20.71
    acetone 29.99
    n-butanol 11.66
    acetonitrile 17.19
    DMF 283.81
    toluene 1.13
    isobutanol 11.99
    1,4-dioxane 28.21
    methyl acetate 19.62
    THF 28.95
    2-butanone 12.76
    n-pentanol 8.16
    sec-butanol 10.54
    n-hexane 0.77
    ethylene glycol 127.9
    NMP 87.19
    cyclohexane 0.5
    DMSO 95.06
    n-butyl acetate 6.34
    n-octanol 3.81
    chloroform 2.2
    n-propyl acetate 7.74
    acetic acid 72.13
    dichloromethane 2.75
    cyclohexanone 9.45
    propylene glycol 78.39
    isopropyl acetate 5.66
    DMAc 159.51
    2-ethoxyethanol 47.36
    isopentanol 7.28
    n-heptane 0.71
    ethyl formate 23.52
    1,2-dichloroethane 2.32
    n-hexanol 6.63
    2-methoxyethanol 111.99
    isobutyl acetate 4.71
    tetrachloromethane 1.3
    n-pentyl acetate 4.68
    transcutol 29.12
    n-heptanol 5.33
    ethylbenzene 0.62
    MIBK 4.51
    2-propoxyethanol 42.99
    tert-butanol 14.72
    MTBE 6.2
    2-butoxyethanol 24.87
    propionic acid 36.26
    o-xylene 1.24
    formic acid 210.98
    diethyl ether 7.17
    m-xylene 1.08
    p-xylene 1.0
    chlorobenzene 0.81
    dimethyl carbonate 28.21
    n-octane 0.31
    formamide 164.02
    cyclopentanone 19.17
    2-pentanone 7.82
    anisole 3.63
    cyclopentyl methyl ether 8.75
    gamma-butyrolactone 33.71
    1-methoxy-2-propanol 60.8
    pyridine 9.11
    3-pentanone 6.6
    furfural 40.78
    n-dodecane 0.23
    diethylene glycol 74.47
    diisopropyl ether 1.83
    tert-amyl alcohol 9.14
    acetylacetone 13.03
    n-hexadecane 0.24
    acetophenone 4.74
    methyl propionate 16.95
    isopentyl acetate 4.12
    trichloroethylene 3.02
    n-nonanol 3.49
    cyclohexanol 5.7
    benzyl alcohol 5.73
    2-ethylhexanol 2.94
    isooctanol 3.41
    dipropyl ether 5.49
    1,2-dichlorobenzene 0.81
    ethyl lactate 16.66
    propylene carbonate 17.26
    n-methylformamide 131.67
    2-pentanol 5.69
    n-pentane 0.77
    1-propoxy-2-propanol 22.81
    1-methoxy-2-propyl acetate 11.81
    2-(2-methoxypropoxy) propanol 15.06
    mesitylene 0.8
    ε-caprolactone 12.64
    p-cymene 0.94
    epichlorohydrin 16.53
    1,1,1-trichloroethane 1.43
    2-aminoethanol 90.37
    morpholine-4-carbaldehyde 99.06
    sulfolane 39.54
    2,2,4-trimethylpentane 0.35
    2-methyltetrahydrofuran 10.33
    n-hexyl acetate 4.96
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 18.42
    sec-butyl acetate 3.71
    tert-butyl acetate 4.99
    decalin 0.28
    glycerin 161.29
    diglyme 39.97
    acrylic acid 51.99
    isopropyl myristate 1.86
    n-butyric acid 19.7
    acetyl acetate 7.28
    di(2-ethylhexyl) phthalate 3.92
    ethyl propionate 7.66
    nitromethane 98.35
    1,2-diethoxyethane 7.15
    benzonitrile 3.47
    trioctyl phosphate 3.16
    1-bromopropane 1.21
    gamma-valerolactone 48.99
    n-decanol 2.55
    triethyl phosphate 4.54
    4-methyl-2-pentanol 3.12
    propionitrile 8.7
    vinylene carbonate 18.52
    1,1,2-trichlorotrifluoroethane 41.61
    DMS 8.32
    cumene 0.7
    2-octanol 2.53
    2-hexanone 5.71
    octyl acetate 3.26
    limonene 1.21
    1,2-dimethoxyethane 52.87
    ethyl orthosilicate 4.02
    tributyl phosphate 3.49
    diacetone alcohol 11.93
    N,N-dimethylaniline 4.16
    acrylonitrile 15.79
    aniline 4.64
    1,3-propanediol 56.7
    bromobenzene 0.43
    dibromomethane 1.46
    1,1,2,2-tetrachloroethane 3.1
    2-methyl-cyclohexyl acetate 3.53
    tetrabutyl urea 5.68
    diisobutyl methanol 1.74
    2-phenylethanol 4.89
    styrene 0.74
    dioctyl adipate 3.85
    dimethyl sulfate 45.31
    ethyl butyrate 5.56
    methyl lactate 42.77
    butyl lactate 10.1
    diethyl carbonate 5.16
    propanediol butyl ether 23.97
    triethyl orthoformate 5.81
    p-tert-butyltoluene 0.96
    methyl 4-tert-butylbenzoate 8.04
    morpholine 34.96
    tert-butylamine 6.32
    n-dodecanol 1.92
    dimethoxymethane 74.05
    ethylene carbonate 15.01
    cyrene 18.54
    2-ethoxyethyl acetate 8.24
    2-ethylhexyl acetate 3.28
    1,2,4-trichlorobenzene 1.2
    4-methylpyridine 7.19
    dibutyl ether 2.25
    2,6-dimethyl-4-heptanol 1.74
    DEF 24.38
    dimethyl isosorbide 16.75
    tetrachloroethylene 3.19
    eugenol 11.92
    triacetin 8.98
    span 80 12.65
    1,4-butanediol 31.07
    1,1-dichloroethane 1.83
    2-methyl-1-pentanol 4.6
    methyl formate 106.18
    2-methyl-1-butanol 7.61
    n-decane 0.36
    butyronitrile 6.37
    3,7-dimethyl-1-octanol 2.27
    1-chlorooctane 0.77
    1-chlorotetradecane 0.42
    n-nonane 0.35
    undecane 0.28
    tert-butylcyclohexane 0.32
    cyclooctane 0.27
    cyclopentanol 11.54
    tetrahydropyran 8.46
    tert-amyl methyl ether 5.1
    2,5,8-trioxanonane 25.36
    1-hexene 1.55
    2-isopropoxyethanol 21.23
    2,2,2-trifluoroethanol 65.0
    methyl butyrate 10.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction