Triethylene Glycol

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  • Identifiers

    CAS number
    112-27-6

    Molecular formula
    C6H14O4

    SMILES
    C(COCCOCCO)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Odorless 60.55%
    Alcoholic 40.2%
    Ethereal 25.95%
    Fishy 21.32%
    Solvent 17.69%
    Sweet 14.85%
    Oily 14.48%
    Clean 13.99%
    Fresh 12.84%
    Musty 10.94%

    Scent© AI

  • Properties

    XLogP3-AA
    -1.6

    Molecular weight
    150.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 24.3 °F (NTP, 1992)
    • -7 °C
    • -5 - -7 °C

    Boiling point

    • 545 °F at 760 mmHg (NTP, 1992)
    • 285 °C; 165 °C at 14 mm Hg
    • 285 °C

    Flash point est.
    150.75 ˚C

    Flash point expt.

    • 330 °F (NTP, 1992)
    • 165 °C
    • 350 °F (177 °C) (Open cup)

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Miscible with alcohol, benzene, toluene; sparingly sol in ether; practically insol in petroleum ether
    • Soluble in oxygenated solvents.
    • Slightly soluble in ethyl ether, chloroform; insoluble in petroleum ether
    • In water, miscible
    • Solubility in water: very good

  • Synonyms

    • TRIETHYLENE GLYCOL
    • 112-27-6
    • Triglycol
    • 2,2'-(Ethane-1,2-diylbis(oxy))diethanol
    • 2,2'-Ethylenedioxydiethanol
    • 2-[2-(2-Hydroxyethoxy)ethoxy]ethanol
    • Trigen
    • Triethylenglykol
    • Triethyleneglycol
    • 1,2-Bis(2-hydroxyethoxy)ethane
    • 2,2'-Ethylenedioxybis(ethanol)
    • 3,6-Dioxaoctane-1,8-diol
    • 2,2'-(Ethylenedioxy)diethanol
    • 2,2'-Ethylenedioxyethanol
    • Di-beta-hydroxyethoxyethane
    • Triethylene glcol
    • Glycol bis(hydroxyethyl) ether
    • Trigol
    • 2,2'-[ethane-1,2-diylbis(oxy)]diethanol
    • Caswell No. 888
    • Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-
    • Ethylene glycol dihydroxydiethyl ether
    • TEG
    • Bis(2-hydroxyethoxyethane)
    • Ethanol, 2,2'-(ethylenedioxy)di-
    • 2,2'-(1,2-Ethanediylbis(oxy))bisethanol
    • NSC 60758
    • HSDB 898
    • Ethylene glycol-bis-(2-hydroxyethyl ether)
    • 119438-10-7
    • EINECS 203-953-2
    • EPA Pesticide Chemical Code 083501
    • BRN 0969357
    • CCRIS 8926
    • 2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHANOL
    • DTXSID4021393
    • UNII-3P5SU53360
    • CHEBI:44926
    • AI3-01453
    • NSC-60758
    • MACROGOL 150
    • 3P5SU53360
    • PEG-3
    • 3,6-Dioxa-1,8-octanediol
    • Di-.beta.-hydroxyethoxyethane
    • DTXCID601393
    • Ethanol, 2,2'-(1,2-ethanediylbis(oxy))bis-
    • EC 203-953-2
    • 4-01-00-02400 (Beilstein Handbook Reference)
    • 2,2'-(ethane-1,2-diylbis(oxy))bis(ethan-1-ol)
    • NCGC00163798-03
    • 2-[2-(2-hydroxyethoxy)ethoxy]ethan-1-ol
    • 103734-98-1
    • 122784-99-0
    • 137800-98-7
    • 145112-98-7
    • TRIETHYLENE GLYCOL (USP-RS)
    • TRIETHYLENE GLYCOL [USP-RS]
    • Triethylenglykol [Czech]
    • MFCD00081839
    • 2-(2-(2-hydroxyethoxy)ethoxy)ethanol
    • 203-953-2
    • CAS-112-27-6
    • 2-(2-(2-HYDROXY-ETHOXY)-ETHOXY)-ETHANOL
    • OH-PEG3-OH
    • Trigenos
    • triethylenglycol
    • triethylene-glycol
    • Triethyleneglycol,
    • Tri-ethylene glycol
    • MFCD00002880
    • 3,8-diol
    • TEG (GLYCOL)
    • Triethylene glycol, puriss.
    • SCHEMBL14929
    • WLN: Q2O2O2Q
    • Triethylene glycol (Standard)
    • Ethanol,2'-(ethylenedioxy)di-
    • TRIETHYLENE GLYCOL [MI]
    • CHEMBL1235259
    • 1,8-dihydroxy-3,6-dioxaoctane
    • TRIETHYLENE GLYCOL [HSDB]
    • TRIETHYLENE GLYCOL DIMALEATE
    • HY-W017440R
    • NSC60758
    • STR02345
    • TRIETHYLENE GLYCOL [WHO-DD]
    • Tox21_112073
    • Tox21_202440
    • Tox21_300306
    • MFCD01779596
    • MFCD01779599
    • MFCD01779601
    • MFCD01779603
    • MFCD01779605
    • MFCD01779609
    • MFCD01779611
    • MFCD01779612
    • MFCD01779614
    • MFCD01779615
    • MFCD01779616
    • STL282716
    • AKOS000120013
    • CS-W018156
    • DB02327
    • FT15207
    • HY-W017440
    • USEPA/OPP Pesticide Code: 083501
    • NCGC00163798-01
    • NCGC00163798-02
    • NCGC00163798-04
    • NCGC00163798-05
    • NCGC00163798-06
    • NCGC00254097-01
    • NCGC00259989-01
    • 1,2-DI(BETA-HYDROXYETHOXY)ETHANE
    • 2-[2-(2-Hydroxyethoxy)ethoxy]ethanol #
    • BP-21036
    • DA-78612
    • Triethylene glycol, ReagentPlus(R), 99%
    • Ethanol,2'-[1,2-ethanediylbis(oxy)]bis-
    • NS00002182
    • T0428
    • EN300-19916
    • 2,2'-(1,2-Ethanediyl bis (oxy))-bisethanol
    • F71165
    • SBI-0653903.0001
    • ETHYLENE GLYCOL-BIS(2-HYDROXYETHYL)ETHER

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 110.67
    methanol 325.46
    isopropanol 45.73
    water 72.88
    ethyl acetate 17.38
    n-propanol 70.16
    acetone 35.06
    n-butanol 41.94
    acetonitrile 35.67
    DMF 308.73
    toluene 2.95
    isobutanol 32.73
    1,4-dioxane 69.38
    methyl acetate 29.78
    THF 83.11
    2-butanone 21.3
    n-pentanol 20.01
    sec-butanol 31.68
    n-hexane 1.76
    ethylene glycol 168.4
    NMP 259.51
    cyclohexane 7.07
    DMSO 591.27
    n-butyl acetate 13.83
    n-octanol 10.25
    chloroform 49.16
    n-propyl acetate 12.63
    acetic acid 327.55
    dichloromethane 59.47
    cyclohexanone 50.38
    propylene glycol 92.33
    isopropyl acetate 7.7
    DMAc 183.61
    2-ethoxyethanol 90.8
    isopentanol 18.61
    n-heptane 3.6
    ethyl formate 34.95
    1,2-dichloroethane 39.15
    n-hexanol 15.9
    2-methoxyethanol 208.86
    isobutyl acetate 6.54
    tetrachloromethane 11.68
    n-pentyl acetate 8.48
    transcutol 133.68
    n-heptanol 9.38
    ethylbenzene 2.15
    MIBK 5.35
    2-propoxyethanol 57.01
    tert-butanol 39.14
    MTBE 10.67
    2-butoxyethanol 29.28
    propionic acid 117.01
    o-xylene 4.63
    formic acid 442.23
    diethyl ether 13.32
    m-xylene 2.61
    p-xylene 3.39
    chlorobenzene 8.15
    dimethyl carbonate 14.73
    n-octane 1.34
    formamide 434.6
    cyclopentanone 67.99
    2-pentanone 11.19
    anisole 9.57
    cyclopentyl methyl ether 22.98
    gamma-butyrolactone 123.96
    1-methoxy-2-propanol 86.28
    pyridine 47.37
    3-pentanone 13.42
    furfural 133.47
    n-dodecane 1.1
    diethylene glycol 99.88
    diisopropyl ether 2.63
    tert-amyl alcohol 28.64
    acetylacetone 18.41
    n-hexadecane 1.18
    acetophenone 15.74
    methyl propionate 24.9
    isopentyl acetate 10.13
    trichloroethylene 57.53
    n-nonanol 9.51
    cyclohexanol 42.4
    benzyl alcohol 19.41
    2-ethylhexanol 9.55
    isooctanol 7.11
    dipropyl ether 13.41
    1,2-dichlorobenzene 12.71
    ethyl lactate 22.99
    propylene carbonate 47.98
    n-methylformamide 205.62
    2-pentanol 13.9
    n-pentane 2.58
    1-propoxy-2-propanol 34.95
    1-methoxy-2-propyl acetate 18.25
    2-(2-methoxypropoxy) propanol 36.6
    mesitylene 2.58
    ε-caprolactone 53.11
    p-cymene 4.66
    epichlorohydrin 67.66
    1,1,1-trichloroethane 15.27
    2-aminoethanol 175.2
    morpholine-4-carbaldehyde 186.0
    sulfolane 238.51
    2,2,4-trimethylpentane 1.5
    2-methyltetrahydrofuran 36.1
    n-hexyl acetate 12.58
    isooctane 0.65
    2-(2-butoxyethoxy)ethanol 44.03
    sec-butyl acetate 5.95
    tert-butyl acetate 8.46
    decalin 2.08
    glycerin 201.86
    diglyme 88.88
    acrylic acid 153.78
    isopropyl myristate 5.84
    n-butyric acid 74.61
    acetyl acetate 16.53
    di(2-ethylhexyl) phthalate 10.91
    ethyl propionate 11.94
    nitromethane 236.86
    1,2-diethoxyethane 19.69
    benzonitrile 16.66
    trioctyl phosphate 7.63
    1-bromopropane 13.09
    gamma-valerolactone 113.15
    n-decanol 6.88
    triethyl phosphate 16.08
    4-methyl-2-pentanol 5.7
    propionitrile 27.81
    vinylene carbonate 52.69
    1,1,2-trichlorotrifluoroethane 167.31
    DMS 18.01
    cumene 2.55
    2-octanol 5.34
    2-hexanone 8.83
    octyl acetate 8.24
    limonene 7.86
    1,2-dimethoxyethane 88.46
    ethyl orthosilicate 13.56
    tributyl phosphate 10.59
    diacetone alcohol 20.99
    N,N-dimethylaniline 11.84
    acrylonitrile 50.33
    aniline 19.83
    1,3-propanediol 127.73
    bromobenzene 5.56
    dibromomethane 32.44
    1,1,2,2-tetrachloroethane 59.27
    2-methyl-cyclohexyl acetate 14.44
    tetrabutyl urea 18.22
    diisobutyl methanol 6.3
    2-phenylethanol 14.53
    styrene 3.19
    dioctyl adipate 15.35
    dimethyl sulfate 49.59
    ethyl butyrate 14.69
    methyl lactate 43.22
    butyl lactate 17.93
    diethyl carbonate 12.77
    propanediol butyl ether 35.35
    triethyl orthoformate 16.54
    p-tert-butyltoluene 4.84
    methyl 4-tert-butylbenzoate 22.22
    morpholine 115.62
    tert-butylamine 20.29
    n-dodecanol 5.61
    dimethoxymethane 56.92
    ethylene carbonate 39.13
    cyrene 50.0
    2-ethoxyethyl acetate 14.68
    2-ethylhexyl acetate 8.33
    1,2,4-trichlorobenzene 17.29
    4-methylpyridine 21.49
    dibutyl ether 9.27
    2,6-dimethyl-4-heptanol 6.3
    DEF 47.42
    dimethyl isosorbide 57.53
    tetrachloroethylene 55.47
    eugenol 27.13
    triacetin 27.77
    span 80 34.9
    1,4-butanediol 49.99
    1,1-dichloroethane 16.04
    2-methyl-1-pentanol 11.28
    methyl formate 100.69
    2-methyl-1-butanol 22.53
    n-decane 1.85
    butyronitrile 19.07
    3,7-dimethyl-1-octanol 8.82
    1-chlorooctane 5.2
    1-chlorotetradecane 2.4
    n-nonane 1.75
    undecane 1.36
    tert-butylcyclohexane 1.45
    cyclooctane 2.12
    cyclopentanol 62.85
    tetrahydropyran 39.22
    tert-amyl methyl ether 10.35
    2,5,8-trioxanonane 73.02
    1-hexene 3.73
    2-isopropoxyethanol 34.79
    2,2,2-trifluoroethanol 153.77
    methyl butyrate 20.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction