Triamterene

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  • Identifiers

    CAS number
    396-01-0

    Molecular formula
    C12H11N7

    SMILES
    C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Odorless 46.0%
    Burnt 28.45%
    Animal 27.56%
    Meaty 24.8%
    Roasted 23.89%
    Cooked 23.47%
    Bitter 22.26%
    Musty 22.19%
    Cheesy 21.48%
    Grape 19.6%

    Scent© AI

  • Properties

    XLogP3-AA
    1.0

    Molecular weight
    253.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    636°C

    Melting point expt.

    • 601 °F (NTP, 1992)
    • 316 °C
    • MP: 327 °C (crystals from dimethylformamide)

    Flash point est.
    342.95 ˚C

    Solubility expt.

    • less than 1 mg/mL at 68 °F (NTP, 1992)
    • Very slightly soluble in water (<0.1%)
    • Slightly soluble in water (1 in 1000)
    • In water, less than 0.1% at 50 °C
    • Slightly soluble in ethanol (1 in 3000), chloroform (1 in 4000)
    • Soluble in formic acid; sparingly soluble in methoxyethanol; very slightly soluble in acetic acid, dilute mineral acids
    • For more Solubility (Complete) data for Triamterene (7 total), please visit the HSDB record page.

  • Synonyms

    • triamterene
    • 396-01-0
    • 6-phenylpteridine-2,4,7-triamine
    • 2,4,7-Triamino-6-phenylpteridine
    • Dyrenium
    • Diurene
    • Noridil
    • Pterofen
    • Pterophene
    • Taturil
    • Teridin
    • Triamteren
    • Triamteril
    • Triteren
    • Ademin
    • Dytac
    • Jatropur
    • Triampur
    • Ademine
    • Noridyl
    • Teriam
    • Diren
    • Ditak
    • Dyren
    • Tri-Span
    • Urocaudal
    • Trispan
    • 6-Phenyl-2,4,7-pteridinetriamine
    • Diucelpin
    • Masuharmin
    • Triamizide
    • Triamthiazid
    • Amteren
    • Dinazide
    • Diutensat
    • Diuteren
    • Dyberzide
    • Dytenzide
    • Esiteren
    • Hidiurese
    • Hypertorr
    • Jenateren
    • Kalspare
    • Nephral
    • Renezide
    • Reviten
    • Tricilone
    • Triurene
    • Uretren
    • Anjal
    • Dazid
    • Diarol
    • Isobar
    • Trizid
    • Turfa
    • Apo-triazide
    • Thiazid Wolff
    • 2,4,7-Pteridinetriamine, 6-phenyl-
    • Ademin(e)
    • SK&F 8542
    • Triamterenum
    • Triamterena
    • Fluss 40
    • SALI-PUREN
    • 6-Phenyl-2,4,7-triaminopteridine
    • SKF 8542
    • Pteridine, 2,4,7-triamino-6-phenyl-
    • Triamterenum [INN-Latin]
    • Triamterena [INN-Spanish]
    • 2,4,7-Triamino-6-fenilpteridina
    • NSC 77625
    • NSC-77625
    • Triamtereno
    • CCRIS 5872
    • SK-8542
    • BRN 0266723
    • HSDB 3405
    • NCI C56042
    • EINECS 206-904-3
    • UNII-WS821Z52LQ
    • SK&F-8542
    • NSC 639359
    • WS821Z52LQ
    • DTXSID6021373
    • AI3-60017
    • Triamterene (Standard)
    • NCI-C56042
    • NSC77625
    • MFCD00006708
    • NSC-639359
    • CHEBI:9671
    • DTXCID001373
    • Hydrene
    • 5-26-17-00447 (Beilstein Handbook Reference)
    • DYAZIDE COMPONENT TRIAMTERENE
    • MAXZIDE COMPONENT TRIAMTERENE
    • NSC639359
    • Triamterene [USAN:USP:INN:BAN:JAN]
    • NCGC00016016-10
    • CAS-396-01-0
    • Triazide
    • TRIAMTERENE (IARC)
    • TRIAMTERENE [IARC]
    • Triamterenum (INN-Latin)
    • Triamterena (INN-Spanish)
    • TRIAMTERENE (MART.)
    • TRIAMTERENE [MART.]
    • TRIAMTERENE (USP-RS)
    • TRIAMTERENE [USP-RS]
    • TRIAMTERENE (EP MONOGRAPH)
    • TRIAMTERENE (USP IMPURITY)
    • TRIAMTERENE [EP MONOGRAPH]
    • TRIAMTERENE [USP IMPURITY]
    • TRIAMTERENE (USP MONOGRAPH)
    • TRIAMTERENE [USP MONOGRAPH]
    • Triamterene (USAN:USP:INN:BAN:JAN)
    • Dyrenium (TN)
    • Pteridine deriv. 11
    • 2,4,7-Triamino-6-fenilpteridina [Italian]
    • SR-01000002968
    • Triamterene?
    • Prestwick_480
    • Triamterene Capsules
    • Dyazide (Salt/Mix)
    • Triamterenum (Latin)
    • Spectrum_000508
    • Triamterene, >=99%
    • TRIAMTERENE [MI]

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.09
    methanol 0.45
    isopropanol 0.02
    water 0.02
    ethyl acetate 0.03
    n-propanol 0.05
    acetone 0.03
    n-butanol 0.04
    acetonitrile 0.04
    DMF 1.63
    toluene 0.01
    isobutanol 0.02
    1,4-dioxane 0.05
    methyl acetate 0.04
    THF 0.69
    2-butanone 0.05
    n-pentanol 0.05
    sec-butanol 0.02
    n-hexane 0.0
    ethylene glycol 1.06
    NMP 8.02
    cyclohexane 0.0
    DMSO 12.03
    n-butyl acetate 0.18
    n-octanol 0.02
    chloroform 0.01
    n-propyl acetate 0.08
    acetic acid 1.07
    dichloromethane 0.02
    cyclohexanone 0.2
    propylene glycol 1.2
    isopropyl acetate 0.03
    DMAc 2.13
    2-ethoxyethanol 1.63
    isopentanol 0.04
    n-heptane 0.0
    ethyl formate 0.21
    1,2-dichloroethane 0.02
    n-hexanol 0.08
    2-methoxyethanol 15.65
    isobutyl acetate 0.06
    tetrachloromethane 0.0
    n-pentyl acetate 0.09
    transcutol 1.85
    n-heptanol 0.06
    ethylbenzene 0.01
    MIBK 0.04
    2-propoxyethanol 2.33
    tert-butanol 0.03
    MTBE 0.01
    2-butoxyethanol 1.04
    propionic acid 0.35
    o-xylene 0.01
    formic acid 4.57
    diethyl ether 0.01
    m-xylene 0.01
    p-xylene 0.01
    chlorobenzene 0.01
    dimethyl carbonate 0.18
    n-octane 0.0
    formamide 4.17
    cyclopentanone 0.75
    2-pentanone 0.04
    anisole 0.03
    cyclopentyl methyl ether 0.07
    gamma-butyrolactone 2.13
    1-methoxy-2-propanol 3.2
    pyridine 0.19
    3-pentanone 0.03
    furfural 4.15
    n-dodecane 0.0
    diethylene glycol 6.48
    diisopropyl ether 0.0
    tert-amyl alcohol 0.03
    acetylacetone 0.16
    n-hexadecane 0.0
    acetophenone 0.13
    methyl propionate 0.09
    isopentyl acetate 0.18
    trichloroethylene 0.04
    n-nonanol 0.02
    cyclohexanol 0.04
    benzyl alcohol 0.15
    2-ethylhexanol 0.06
    isooctanol 0.05
    dipropyl ether 0.04
    1,2-dichlorobenzene 0.02
    ethyl lactate 0.56
    propylene carbonate 0.88
    n-methylformamide 1.29
    2-pentanol 0.01
    n-pentane 0.0
    1-propoxy-2-propanol 1.1
    1-methoxy-2-propyl acetate 0.53
    2-(2-methoxypropoxy) propanol 0.97
    mesitylene 0.01
    ε-caprolactone 0.39
    p-cymene 0.03
    epichlorohydrin 1.0
    1,1,1-trichloroethane 0.01
    2-aminoethanol 1.13
    morpholine-4-carbaldehyde 3.52
    sulfolane 10.25
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.12
    n-hexyl acetate 0.06
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.29
    sec-butyl acetate 0.04
    tert-butyl acetate 0.05
    decalin 0.0
    glycerin 10.9
    diglyme 2.12
    acrylic acid 0.93
    isopropyl myristate 0.03
    n-butyric acid 0.39
    acetyl acetate 0.05
    di(2-ethylhexyl) phthalate 0.21
    ethyl propionate 0.07
    nitromethane 1.29
    1,2-diethoxyethane 0.09
    benzonitrile 0.13
    trioctyl phosphate 0.12
    1-bromopropane 0.01
    gamma-valerolactone 3.75
    n-decanol 0.02
    triethyl phosphate 0.24
    4-methyl-2-pentanol 0.02
    propionitrile 0.05
    vinylene carbonate 0.63
    1,1,2-trichlorotrifluoroethane 4.9
    DMS 0.15
    cumene 0.01
    2-octanol 0.02
    2-hexanone 0.07
    octyl acetate 0.05
    limonene 0.02
    1,2-dimethoxyethane 0.99
    ethyl orthosilicate 0.18
    tributyl phosphate 0.14
    diacetone alcohol 0.52
    N,N-dimethylaniline 0.05
    acrylonitrile 0.17
    aniline 0.07
    1,3-propanediol 1.93
    bromobenzene 0.01
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.04
    2-methyl-cyclohexyl acetate 0.21
    tetrabutyl urea 0.23
    diisobutyl methanol 0.03
    2-phenylethanol 0.23
    styrene 0.01
    dioctyl adipate 0.11
    dimethyl sulfate 1.13
    ethyl butyrate 0.17
    methyl lactate 1.54
    butyl lactate 0.55
    diethyl carbonate 0.16
    propanediol butyl ether 0.91
    triethyl orthoformate 0.21
    p-tert-butyltoluene 0.02
    methyl 4-tert-butylbenzoate 0.4
    morpholine 0.2
    tert-butylamine 0.01
    n-dodecanol 0.02
    dimethoxymethane 0.75
    ethylene carbonate 0.33
    cyrene 2.73
    2-ethoxyethyl acetate 0.23
    2-ethylhexyl acetate 0.13
    1,2,4-trichlorobenzene 0.05
    4-methylpyridine 0.11
    dibutyl ether 0.01
    2,6-dimethyl-4-heptanol 0.03
    DEF 0.18
    dimethyl isosorbide 2.34
    tetrachloroethylene 0.04
    eugenol 0.76
    triacetin 0.24
    span 80 0.7
    1,4-butanediol 0.41
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.06
    methyl formate 0.8
    2-methyl-1-butanol 0.04
    n-decane 0.0
    butyronitrile 0.04
    3,7-dimethyl-1-octanol 0.02
    1-chlorooctane 0.0
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.11
    tetrahydropyran 0.02
    tert-amyl methyl ether 0.01
    2,5,8-trioxanonane 1.68
    1-hexene 0.0
    2-isopropoxyethanol 0.45
    2,2,2-trifluoroethanol 0.66
    methyl butyrate 0.15

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction