Propylene Oxide

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  • Identifiers

    CAS number
    75-56-9

    Molecular formula
    C3H6O

    SMILES
    CC1CO1

    Safety labels

    Flammable
    Flammable

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Sweet 87.64%
    Ethereal 76.7%
    Solvent 62.03%
    Alcoholic 40.96%
    Musty 36.46%
    Caramellic 35.26%
    Fermented 34.38%
    Buttery 33.25%
    Rummy 32.37%
    Pungent 29.21%

    Scent© AI

    Odor threshold>

    • Odor Threshold Low: 10.0 [mmHg]. Odor Threshold High: 199.0 [mmHg]. Detection odor threshold from AIHA (mean = 45 ppm)
    • Inasmuch as the detectable odor concn of propylene oxide is reported to be as high as 200 ppm, its odor cannot be reliably used as a warning.
    • Odor detection in air= 9.90x10+0 ppm /Purity not specified/
    • Odor recognition in air= 3.50x10+1 ppm /Purity not specified/
    • Low: 24.7500 mg/cu m; High: 500.000 mg/cu m
    • Odor thresholds of 35 ppm, 44 ppm, and 200 ppm have been reported.

  • Properties

    XLogP3-AA
    0.0

    Molecular weight
    58.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -169.83 °F (EPA, 1998)
    • -112.13 °C
    • -111.9 °C
    • -112 °C
    • -170 °F

    Boiling point

    • 93.61 °F at 760 mmHg (EPA, 1998)
    • 34.23 °C
    • 34 °C
    • 94 °F

    Flash point est.
    -34.37 ˚C

    Flash point expt.

    • -35 °F (EPA, 1998)
    • -35 °F
    • -35 °F (closed cup); -20 °F (open cup)
    • -37 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
    • Solubility of water in propylene oxide is 12.8% by wt at 20 °C.
    • 40.5 wt% water @ 20 °C
    • MISCIBLE WITH ACETONE, BENZENE, CARBON TETRACHLORIDE, METHANOL, & ETHER
    • Soluble in alcohol and ether.
    • In water, 590,000 mg/l @ 25 °C
    • 590 mg/mL at 25 °C
    • Solubility in water, g/100ml at 20 °C: 40
    • 41%

  • Synonyms

    • Propylene oxide
    • 2-Methyloxirane
    • 75-56-9
    • 1,2-Epoxypropane
    • Methyloxirane
    • Oxirane, methyl-
    • Epoxypropane
    • Propyleneoxide
    • Propene oxide
    • 1,2-PROPYLENE OXIDE
    • Propylene epoxide
    • Methyl oxirane
    • 2,3-Epoxypropane
    • Methyloxacyclopropane
    • Methyl ethylene oxide
    • Propane, epoxy-
    • Oxyde de propylene
    • Epihydrin
    • oxirane, 2-methyl-
    • AD 6 (suspending agent)
    • Ethylene oxide, methyl-
    • Caswell No. 713A
    • 2-methyl-oxirane
    • Propane, 1,2-epoxy-
    • Methylethylene oxide
    • NCI-C50099
    • CCRIS 540
    • propeneoxide
    • HSDB 173
    • (+/-)-Propylene oxide
    • 2-Methyloxiran
    • UNII-Y4Y7NYD4BK
    • Y4Y7NYD4BK
    • 2-Methyl oxirane
    • EINECS 200-879-2
    • EPA Pesticide Chemical Code 042501
    • 1,2-epoxy-propane
    • BRN 0079763
    • AD 6
    • CHEBI:38685
    • AI3-07541
    • (+/-)-Methyloxirane
    • 3-Methyl-1,2-epoxypropane
    • DL-1,2-EPOXYPROPANE
    • (+/-)-1,2-Epoxypropane
    • DTXSID5021207
    • EC 200-879-2
    • 5-17-01-00017 (Beilstein Handbook Reference)
    • Propylene oxide (JAN)
    • PROPYLENE OXIDE [JAN]
    • PROPYLENE OXIDE (IARC)
    • PROPYLENE OXIDE [IARC]
    • PROPYLENE OXIDE (USP-RS)
    • PROPYLENE OXIDE [USP-RS]
    • propylenoxide
    • propene epoxide
    • Oxyde de propylene [French]
    • 1,2-epoxy propane
    • (+/-)-Propylene oxide, ReagentPlus(R), >=99%
    • UN1280
    • epoxy-propane
    • methyl-oxirane
    • proplyene oxide
    • 1,2-epoxipropane
    • rac-propylene oxide
    • 1,2-propylenoxide
    • (RS)-methyloxirane
    • MFCD00005126
    • S(-)-Methyloxirane
    • Caswell No 713A
    • Methyl-(S)-Oxirane
    • Methyl-Ethylene oxide
    • (rs)-propylene oxide
    • PROPANE, EPOXY
    • DL-PROPYLENE OXIDE
    • (.+/-.)-Methyloxirane
    • Propylene oxide [UN1280] [Flammable liquid]
    • (+-)-EPOXYPROPANE
    • (+-)-METHYLOXIRANE
    • PROPYLENE OXIDE [MI]
    • Propylene oxide (DOT:OSHA)
    • PROPYLENE OXIDE [FCC]
    • Pesticide Code: 042501.
    • DTXCID301207
    • (+-)-2-METHYLOXIRANE
    • (+/-)-1,2-Propylene oxide
    • CHEMBL2251584
    • (.+/-.)-1,2-Epoxypropane
    • (+/-)-Propylene oxide, 99%
    • (+/-)-1,2-Propylene-d6Oxide
    • (+-)-1,2-EPOXYPROPANE
    • (+/-)-Propylene oxide, 99.5%
    • 1,2-PROPYLENE OXIDE [HSDB]
    • BBL100026
    • STL511007
    • AKOS000121587
    • AKOS017283338
    • UN 1280
    • (+/-)-Propylene oxide, >=99.5%
    • DB-025383
    • DB-043223
    • (+/-)-Propylene oxide, analytical standard
    • E0016
    • NS00009434
    • EN300-22338
    • D09803
    • (+/-)-Propylene oxide, ReagentPlus(R), 99%
    • Propylene oxide [UN1280] [Flammable liquid]
    • Q727742
    • (+/-)-Propylene oxide, purum, >=99.0% (GC)
    • (R)-(+)-Methyloxirane; (R)-(+)-1,2-Epoxypropane
    • (S)-(-)-1,2-Epoxypropane; (S)-(-)-Methyloxirane
    • (+/-)-Propylene oxide, SAJ special grade, >=99.0%
    • F8880-5385
    • (+/-)-Propylene oxide, puriss. p.a., >=99.5% (GC)
    • Propylene oxide, United States Pharmacopeia (USP) Reference Standard
    • 200-879-2

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 299.0
    methanol 378.9
    isopropanol 179.86
    water 15.2
    ethyl acetate 65.07
    n-propanol 176.14
    acetone 137.44
    n-butanol 132.13
    acetonitrile 130.78
    DMF 176.89
    toluene 18.74
    isobutanol 102.71
    1,4-dioxane 150.08
    methyl acetate 91.4
    THF 157.97
    2-butanone 88.02
    n-pentanol 83.29
    sec-butanol 121.45
    n-hexane 12.09
    ethylene glycol 192.18
    NMP 128.02
    cyclohexane 17.49
    DMSO 166.48
    n-butyl acetate 52.21
    n-octanol 45.87
    chloroform 183.18
    n-propyl acetate 40.76
    acetic acid 403.29
    dichloromethane 131.11
    cyclohexanone 80.68
    propylene glycol 215.11
    isopropyl acetate 32.81
    DMAc 143.5
    2-ethoxyethanol 143.46
    isopentanol 79.0
    n-heptane 16.05
    ethyl formate 50.87
    1,2-dichloroethane 64.73
    n-hexanol 97.35
    2-methoxyethanol 244.71
    isobutyl acetate 27.52
    tetrachloromethane 37.35
    n-pentyl acetate 28.72
    transcutol 311.99
    n-heptanol 42.29
    ethylbenzene 11.33
    MIBK 30.75
    2-propoxyethanol 172.1
    tert-butanol 137.74
    MTBE 61.51
    2-butoxyethanol 87.88
    propionic acid 173.58
    o-xylene 17.78
    formic acid 215.97
    diethyl ether 74.42
    m-xylene 14.36
    p-xylene 15.6
    chlorobenzene 30.38
    dimethyl carbonate 28.87
    n-octane 4.76
    formamide 159.83
    cyclopentanone 103.67
    2-pentanone 56.11
    anisole 38.19
    cyclopentyl methyl ether 57.94
    gamma-butyrolactone 108.31
    1-methoxy-2-propanol 157.28
    pyridine 95.46
    3-pentanone 48.77
    furfural 104.22
    n-dodecane 4.77
    diethylene glycol 196.61
    diisopropyl ether 18.14
    tert-amyl alcohol 95.33
    acetylacetone 54.8
    n-hexadecane 4.96
    acetophenone 35.41
    methyl propionate 60.32
    isopentyl acetate 40.94
    trichloroethylene 121.27
    n-nonanol 38.61
    cyclohexanol 82.9
    benzyl alcohol 46.54
    2-ethylhexanol 47.27
    isooctanol 29.6
    dipropyl ether 51.15
    1,2-dichlorobenzene 28.91
    ethyl lactate 40.51
    propylene carbonate 55.42
    n-methylformamide 118.92
    2-pentanol 73.13
    n-pentane 14.86
    1-propoxy-2-propanol 120.41
    1-methoxy-2-propyl acetate 57.87
    2-(2-methoxypropoxy) propanol 85.25
    mesitylene 9.96
    ε-caprolactone 71.15
    p-cymene 16.43
    epichlorohydrin 99.8
    1,1,1-trichloroethane 65.06
    2-aminoethanol 235.27
    morpholine-4-carbaldehyde 149.17
    sulfolane 111.94
    2,2,4-trimethylpentane 7.77
    2-methyltetrahydrofuran 101.3
    n-hexyl acetate 45.84
    isooctane 5.13
    2-(2-butoxyethoxy)ethanol 118.84
    sec-butyl acetate 25.97
    tert-butyl acetate 34.23
    decalin 6.86
    glycerin 236.5
    diglyme 161.61
    acrylic acid 184.39
    isopropyl myristate 20.74
    n-butyric acid 121.66
    acetyl acetate 47.09
    di(2-ethylhexyl) phthalate 27.24
    ethyl propionate 35.24
    nitromethane 223.7
    1,2-diethoxyethane 70.19
    benzonitrile 42.21
    trioctyl phosphate 19.47
    1-bromopropane 44.37
    gamma-valerolactone 125.45
    n-decanol 29.62
    triethyl phosphate 23.44
    4-methyl-2-pentanol 34.23
    propionitrile 84.06
    vinylene carbonate 52.72
    1,1,2-trichlorotrifluoroethane 157.91
    DMS 41.72
    cumene 10.36
    2-octanol 25.38
    2-hexanone 42.94
    octyl acetate 28.34
    limonene 26.31
    1,2-dimethoxyethane 127.2
    ethyl orthosilicate 23.67
    tributyl phosphate 22.94
    diacetone alcohol 64.51
    N,N-dimethylaniline 28.03
    acrylonitrile 97.64
    aniline 51.32
    1,3-propanediol 198.0
    bromobenzene 24.31
    dibromomethane 85.54
    1,1,2,2-tetrachloroethane 100.49
    2-methyl-cyclohexyl acetate 34.3
    tetrabutyl urea 28.77
    diisobutyl methanol 26.42
    2-phenylethanol 51.78
    styrene 16.03
    dioctyl adipate 34.05
    dimethyl sulfate 41.22
    ethyl butyrate 39.24
    methyl lactate 62.44
    butyl lactate 39.23
    diethyl carbonate 29.18
    propanediol butyl ether 107.28
    triethyl orthoformate 33.29
    p-tert-butyltoluene 16.27
    methyl 4-tert-butylbenzoate 39.4
    morpholine 181.21
    tert-butylamine 87.8
    n-dodecanol 24.11
    dimethoxymethane 80.1
    ethylene carbonate 43.21
    cyrene 63.7
    2-ethoxyethyl acetate 46.72
    2-ethylhexyl acetate 32.6
    1,2,4-trichlorobenzene 41.86
    4-methylpyridine 56.73
    dibutyl ether 34.39
    2,6-dimethyl-4-heptanol 26.42
    DEF 69.54
    dimethyl isosorbide 86.6
    tetrachloroethylene 82.53
    eugenol 46.84
    triacetin 58.86
    span 80 80.93
    1,4-butanediol 97.48
    1,1-dichloroethane 78.76
    2-methyl-1-pentanol 54.42
    methyl formate 75.19
    2-methyl-1-butanol 82.0
    n-decane 7.2
    butyronitrile 68.83
    3,7-dimethyl-1-octanol 42.06
    1-chlorooctane 19.8
    1-chlorotetradecane 9.98
    n-nonane 6.91
    undecane 5.61
    tert-butylcyclohexane 7.37
    cyclooctane 5.55
    cyclopentanol 105.07
    tetrahydropyran 106.09
    tert-amyl methyl ether 47.62
    2,5,8-trioxanonane 127.9
    1-hexene 28.36
    2-isopropoxyethanol 93.34
    2,2,2-trifluoroethanol 126.06
    methyl butyrate 41.68

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction