Nonivamide

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  • Identifiers

    CAS number
    2444-46-4

    Molecular formula
    C17H27NO3

    SMILES
    CCCCCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Spicy 39.72%
    Savory 38.87%
    Meaty 36.29%
    Odorless 36.09%
    Cooling 33.15%
    Herbal 30.83%
    Animal 24.62%
    Mint 23.64%
    Burnt 23.62%
    Pungent 23.23%

    Scent© AI

  • Properties

    XLogP3-AA
    4.2

    Molecular weight
    293.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 57 undefined
    • 124.00 to 128.00 °C. @ 760.00 mm Hg

    Boiling point

    • 492.7 undefined

    Flash point est.
    178.76 ˚C

    Solubility expt.

    • Soluble in water (slightly)
    • slightly
    • Slightly soluble in water
    • Soluble (in ethanol)

  • Synonyms

    • NONIVAMIDE
    • N-Vanillylnonanamide
    • 2444-46-4
    • Pseudocapsaicin
    • N-Vanillylnonamide
    • Pelargonic acid vanillylamide
    • N-Vanillylpelargonamide
    • N-(4-Hydroxy-3-methoxybenzyl)nonanamide
    • Nonanoic acid vanillylamide
    • N-Nonanoyl vanillylamide
    • Vanillyl pelargonic amide
    • Pelargonyl vanillylamide
    • Hydroxymethoxybenzyl pelargonamide
    • Vanillyl-N-nonylamide
    • Nonylic acid vanillylamide
    • Vanillyl n-nonoylamide
    • Nonivamida
    • Nonanamide, N-vanillyl-
    • Nonanoyl vanillylamide
    • Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-
    • FEMA No. 2787
    • Nonivamide [INN]
    • Nonivamidum
    • Nonylvanylamide
    • Hansaplast
    • desmethyldihydrocapsaicin
    • NSC 172795
    • Nonanoyl 4-hydroxy-3-methoxybenzylamide
    • N-Vanillylnonanoamide
    • N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
    • PAVA
    • Vanillyl n-Nonylamide
    • Nonylic acid vanillyamide
    • Nonivamidum [INN-Latin]
    • vanillylnonanamide
    • Nonivamida [INN-Spanish]
    • EINECS 219-484-1
    • NSC-172795
    • UNII-S846B891OR
    • BRN 2144300
    • N-vanillyl nonanamide
    • CHEBI:46936
    • S846B891OR
    • AH-23491X
    • N-((4-Hydroxy-3-methoxyphenyl)methyl)nonanamide
    • N-((Hydroxy-3-methoxyphenyl)methyl)4-nonanamide
    • CHEMBL75124
    • DTXSID1034769
    • Nonivamide (INN)
    • Nonanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-
    • NCGC00016089-05
    • Nonivamidum (INN-Latin)
    • Nonivamida (INN-Spanish)
    • NONIVAMIDE (MART.)
    • NONIVAMIDE [MART.]
    • DTXCID9014769
    • vanillylnonamide
    • Capsaicin synthetic
    • CAS-2444-46-4
    • 8-Nordihydrocapsaicin
    • N-vanillyl-nonanamide
    • Nonanoylvanillyl Amide
    • Capsaicin (Synthetic)
    • N-((4-Hydroxy-3-methoxyphenyl)methyl)-Nonanamide
    • N-[(4-Hydroxy-3-methoxyphenyl)methyl]-Nonanamide
    • N-Nonylvanylamide
    • Nonivamide; Pseudocapsaicin; PAVA; Pelargonic acid vallinylamide; Vanillyl N-nonylamide
    • PAVA spray
    • Hansaplast (TN)
    • Nonylic vanillamide
    • Synthetic capsaicin
    • Nonoyl vanillylamide
    • MFCD00017286
    • PSVA
    • Nonivamide (Standard)
    • Spectrum_000311
    • Pelargonoyl vanillylamide
    • SpecPlus_000799
    • N-Pelargonylvanillylamide
    • Spectrum2_001091
    • Spectrum4_000916
    • Spectrum5_001853
    • Lopac-V-9130
    • N-Vanillylnonanamide, 8CI
    • NONIVAMIDE [WHO-DD]
    • Lopac0_001218
    • SCHEMBL81939
    • KBioGR_001412
    • KBioSS_000791
    • MLS002153373
    • DivK1c_006895
    • SPECTRUM2300192
    • SPBio_001162
    • N-Pelargonic Acid Vanillylamide
    • FEMA 2787
    • KBio1_001839
    • KBio2_000791
    • KBio2_003359
    • KBio2_005927
    • HH 50
    • HMS2234E23
    • HMS3374K02
    • HMS3885C14
    • Pharmakon1600-01506172
    • ALBB-025790
    • Tox21_110302
    • Tox21_301218
    • BDBM50044767
    • CCG-39764
    • HY-17568R
    • NSC172795
    • NSC760391
    • s3935
    • AKOS001719931
    • N-Vanillylnonanamide, >=97%, powder
    • Tox21_110302_1
    • AC-4807
    • DB11324
    • FC71174
    • NSC-760391
    • N-Vanillylnonanamide, analytical standard
    • NCGC00016089-01
    • NCGC00016089-02
    • NCGC00016089-03
    • NCGC00016089-04
    • NCGC00016089-06
    • NCGC00094463-01
    • NCGC00094463-02

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 815.39
    methanol 1902.78
    isopropanol 300.39
    water 0.22
    ethyl acetate 686.79
    n-propanol 358.01
    acetone 1395.98
    n-butanol 229.15
    acetonitrile 330.63
    DMF 639.94
    toluene 36.81
    isobutanol 164.82
    1,4-dioxane 478.23
    methyl acetate 439.2
    THF 655.47
    2-butanone 454.2
    n-pentanol 123.24
    sec-butanol 157.05
    n-hexane 0.41
    ethylene glycol 72.82
    NMP 252.47
    cyclohexane 2.64
    DMSO 2124.3
    n-butyl acetate 151.63
    n-octanol 32.31
    chloroform 352.97
    n-propyl acetate 212.14
    acetic acid 704.27
    dichloromethane 483.8
    cyclohexanone 489.09
    propylene glycol 147.72
    isopropyl acetate 278.37
    DMAc 587.52
    2-ethoxyethanol 418.27
    isopentanol 159.37
    n-heptane 0.71
    ethyl formate 271.12
    1,2-dichloroethane 412.32
    n-hexanol 73.51
    2-methoxyethanol 1021.1
    isobutyl acetate 119.39
    tetrachloromethane 30.23
    n-pentyl acetate 99.38
    transcutol 853.3
    n-heptanol 39.69
    ethylbenzene 20.17
    MIBK 165.85
    2-propoxyethanol 252.02
    tert-butanol 357.1
    MTBE 206.72
    2-butoxyethanol 138.16
    propionic acid 286.34
    o-xylene 31.21
    formic acid 248.45
    diethyl ether 124.06
    m-xylene 30.33
    p-xylene 30.89
    chlorobenzene 89.19
    dimethyl carbonate 116.8
    n-octane 0.98
    formamide 515.38
    cyclopentanone 606.6
    2-pentanone 389.68
    anisole 81.44
    cyclopentyl methyl ether 141.16
    gamma-butyrolactone 619.29
    1-methoxy-2-propanol 459.72
    pyridine 234.78
    3-pentanone 176.46
    furfural 393.65
    n-dodecane 1.59
    diethylene glycol 253.79
    diisopropyl ether 23.09
    tert-amyl alcohol 196.88
    acetylacetone 572.5
    n-hexadecane 1.8
    acetophenone 113.81
    methyl propionate 321.0
    isopentyl acetate 138.18
    trichloroethylene 599.35
    n-nonanol 32.39
    cyclohexanol 139.86
    benzyl alcohol 105.69
    2-ethylhexanol 35.2
    isooctanol 35.95
    dipropyl ether 27.63
    1,2-dichlorobenzene 90.09
    ethyl lactate 91.15
    propylene carbonate 271.27
    n-methylformamide 425.53
    2-pentanol 87.17
    n-pentane 0.39
    1-propoxy-2-propanol 143.21
    1-methoxy-2-propyl acetate 186.2
    2-(2-methoxypropoxy) propanol 119.06
    mesitylene 19.89
    ε-caprolactone 366.3
    p-cymene 16.47
    epichlorohydrin 653.28
    1,1,1-trichloroethane 205.73
    2-aminoethanol 225.53
    morpholine-4-carbaldehyde 347.44
    sulfolane 637.54
    2,2,4-trimethylpentane 2.11
    2-methyltetrahydrofuran 258.9
    n-hexyl acetate 104.12
    isooctane 1.5
    2-(2-butoxyethoxy)ethanol 187.35
    sec-butyl acetate 122.72
    tert-butyl acetate 251.47
    decalin 2.89
    glycerin 200.1
    diglyme 406.86
    acrylic acid 205.92
    isopropyl myristate 34.37
    n-butyric acid 527.66
    acetyl acetate 293.43
    di(2-ethylhexyl) phthalate 45.3
    ethyl propionate 147.86
    nitromethane 1364.09
    1,2-diethoxyethane 182.64
    benzonitrile 109.58
    trioctyl phosphate 31.36
    1-bromopropane 79.72
    gamma-valerolactone 752.46
    n-decanol 24.11
    triethyl phosphate 49.81
    4-methyl-2-pentanol 49.97
    propionitrile 148.31
    vinylene carbonate 218.89
    1,1,2-trichlorotrifluoroethane 399.85
    DMS 116.4
    cumene 16.96
    2-octanol 25.87
    2-hexanone 151.21
    octyl acetate 46.69
    limonene 22.55
    1,2-dimethoxyethane 487.38
    ethyl orthosilicate 46.87
    tributyl phosphate 40.97
    diacetone alcohol 289.16
    N,N-dimethylaniline 49.71
    acrylonitrile 221.57
    aniline 96.06
    1,3-propanediol 432.46
    bromobenzene 78.94
    dibromomethane 214.43
    1,1,2,2-tetrachloroethane 466.27
    2-methyl-cyclohexyl acetate 73.85
    tetrabutyl urea 53.23
    diisobutyl methanol 25.64
    2-phenylethanol 84.0
    styrene 27.89
    dioctyl adipate 64.99
    dimethyl sulfate 200.85
    ethyl butyrate 98.61
    methyl lactate 147.23
    butyl lactate 97.31
    diethyl carbonate 71.91
    propanediol butyl ether 130.48
    triethyl orthoformate 65.89
    p-tert-butyltoluene 16.52
    methyl 4-tert-butylbenzoate 105.3
    morpholine 601.61
    tert-butylamine 84.27
    n-dodecanol 18.47
    dimethoxymethane 456.42
    ethylene carbonate 215.01
    cyrene 123.65
    2-ethoxyethyl acetate 196.34
    2-ethylhexyl acetate 86.88
    1,2,4-trichlorobenzene 108.53
    4-methylpyridine 178.64
    dibutyl ether 38.72
    2,6-dimethyl-4-heptanol 25.64
    DEF 284.9
    dimethyl isosorbide 197.09
    tetrachloroethylene 264.61
    eugenol 107.52
    triacetin 144.65
    span 80 97.21
    1,4-butanediol 120.07
    1,1-dichloroethane 270.4
    2-methyl-1-pentanol 100.51
    methyl formate 315.19
    2-methyl-1-butanol 125.95
    n-decane 2.29
    butyronitrile 167.46
    3,7-dimethyl-1-octanol 38.36
    1-chlorooctane 16.93
    1-chlorotetradecane 7.12
    n-nonane 1.72
    undecane 1.84
    tert-butylcyclohexane 2.74
    cyclooctane 0.8
    cyclopentanol 142.99
    tetrahydropyran 306.8
    tert-amyl methyl ether 98.54
    2,5,8-trioxanonane 240.86
    1-hexene 5.41
    2-isopropoxyethanol 219.09
    2,2,2-trifluoroethanol 180.11
    methyl butyrate 229.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction