Methyl Salicylate

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  • Identifiers

    CAS number
    119-36-8

    Molecular formula
    C8H8O3

    SMILES
    COC(=O)C1=CC=CC=C1O

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Retention indicies (RI)

    • DB5: 1192.29
    • Carbowax: 1772.29

  • Odor profile

    Sweet 66.41%
    Phenolic 58.4%
    Fruity 57.36%
    Herbal 45.17%
    Floral 41.55%
    Mint 40.61%
    Aromatic 38.71%
    Medicinal 37.78%
    Cherry 37.77%
    Anisic 35.15%

    Scent© AI

  • Properties

    XLogP3-AA
    2.3

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • 16.5 °F (NTP, 1992)
    • -8.6 undefined
    • -8.6 °C
    • -8 °C

    Boiling point

    • 432 °F at 760 mmHg (NTP, 1992)
    • 220-224
    • 220-224 °C
    • 222.00 to 224.00 °C. @ 760.00 mm Hg
    • 223 °C

    Flash point est.
    108.63 ˚C

    Flash point expt.

    • 205 °F (NTP, 1992)
    • 205 °F (96 °C) (Closed cup)
    • 101 °C c.c.

    Solubility expt.

    • less than 1 mg/mL at 66 °F (NTP, 1992)
    • Slightly soluble
    • SOL IN CHLOROFORM, ETHER; MISCIBLE WITH ALC, GLACIAL ACETIC ACID
    • SOL IN DIETHYL ETHER
    • SOLUBLE IN MOST COMMON ORGANIC SOLVENTS
    • Sol in water: 0.74%w @ 30 °C
    • 0.7 mg/mL at 30 °C
    • Solubility in water, g/l at 30 °C: 0.74 (very slightly soluble)
    • slightly soluble in water; soluble in organic solvents, oils
    • miscible at room temperature (in ethanol)

  • Synonyms

    • methyl salicylate
    • Methyl 2-hydroxybenzoate
    • 119-36-8
    • Analgit
    • Gaultheriaoel
    • Wintergruenoel
    • Flucarmit
    • Exagien
    • 2-Hydroxybenzoic acid methyl ester
    • 2-Carbomethoxyphenol
    • Methyl o-hydroxybenzoate
    • Betula
    • 2-(Methoxycarbonyl)phenol
    • BIRCH-ME
    • methylsalicylate
    • Betula Lenta
    • Salicylic acid, methyl ester
    • Benzoic acid, 2-hydroxy-, methyl ester
    • FEMA No. 2745
    • PredaLure
    • Caswell No. 577
    • Oils,wintergreen
    • Anthrapole ND
    • NSC 8204
    • o-Hydroxybenzoic acid, methyl ester
    • FEMA Number 2745
    • Flavor,wintergreen
    • MFCD00002214
    • Ben Gay
    • Salicylic Acid Methyl Ester
    • 90045-28-6
    • Metylester kyseliny salicylove
    • CCRIS 6259
    • HSDB 1935
    • NSC-8204
    • 2-Hydroxybenzoic acid, methyl ester
    • EINECS 204-317-7
    • Methyl salicylate
    • UNII-LAV5U5022Y
    • EPA Pesticide Chemical Code 076601
    • BRN 0971516
    • FEMA No. 2154
    • FEMA No. 3113
    • 1-O-methylsalicylate
    • LAV5U5022Y
    • DTXSID5025659
    • CHEBI:31832
    • AI3-00090
    • salicylate methyl ester
    • 2-Hydroxy-benzoic acid methyl ester
    • Methyl salicylate,synthetic
    • DTXCID805659
    • EC 204-317-7
    • 302912-49-8
    • 4-10-00-00143 (Beilstein Handbook Reference)
    • 135952-76-0
    • 8024-54-2
    • NCGC00091106-02
    • SALONPAS COMPONENT METHYL SALICYLATE
    • Methyl2-Hydroxybenzoate
    • METHYL SALICYLATE (II)
    • METHYL SALICYLATE [II]
    • METHYL SALICYLATE (MART.)
    • METHYL SALICYLATE [MART.]
    • Panalgesic
    • Theragesic
    • 2,4-Cyclohexadien-1-one,6-(hydroxymethoxymethylene)-(9CI)
    • METHYL SALICYLATE (USP-RS)
    • METHYL SALICYLATE [USP-RS]
    • Methyl salicylate [JAN]
    • METHYL SALICYLATE (EP IMPURITY)
    • METHYL SALICYLATE [EP IMPURITY]
    • METHYL SALICYLATE (EP MONOGRAPH)
    • Methyl salicylate (natural)
    • METHYL SALICYLATE [EP MONOGRAPH]
    • CAS-119-36-8
    • Benzoic acid, hydroxy-, methyl ester
    • Metylester kyseliny salicylove [Czech]
    • Methylester kyseliny salicylove [Czech]
    • Wintergreen
    • Methyl salicylate [JAN:NF]
    • Milagroso
    • Ubredol
    • Kofal
    • Methylester kyseliny salicylove
    • Kofal Original
    • Kofal Fuerte
    • methyl-salicylate
    • Zenol Cool
    • Bumooly-S
    • Methylis salicylas
    • Ted s Pain
    • Hyundai Moolpas F
    • FlexSport Roll On
    • La Flecha Japonesa
    • Germa Ubre Mastitis
    • Ling Nam Hung Far
    • Koong Yick Hung Fa
    • Mascura la Vaca Plus
    • Natralia Cramp Relief
    • 1335435-40-9
    • Aspi-RubPain Reliever
    • ReLeaf Arthritis Balm
    • Salonpas (Salt/Mix)
    • Methyl Salicylate 2%
    • XCEPTOR PAIN
    • Balsamo de UbreMascura
    • teds topical pain cream
    • Theragesic (Salt/Mix)
    • wintergreen leaf extract
    • Balsamo de Vaca Mascura
    • Methyl salicylate (TN)
    • Methyl Salicylate 10%
    • Methyl salicylate, 8CI
    • methyl-2-hydroxybenzoate
    • East Coast Joint Relief
    • Enamine_001611
    • Methyl salicylate, 98%
    • KRONA WART REMOVER
    • Abejas y Viboras Roll On
    • Germa Linimento Ubre Plus
    • Methyl salicylate, BioXtra
    • salicylic-acid methyl ester
    • WLN: QR BVO1
    • COATS ALOE ANALGESIC
    • WINTERGREEN [VANDF]
    • SCHEMBL5312
    • Methyl salicylate 100 microg/mL in Acetonitrile

  • Applications

    Methyl salicylate is a colorless, sweet-minty ester produced by esterifying salicylic acid with methanol or by extracting natural wintergreen leaves; pharmacologically it acts as a counter-irritant and topical analgesic in liniments, plasters, rubs, inhalants and cold-relief balms, while its refreshing aroma lends flavor to chewing gum, lozenges, toothpaste, mouthwash, confectionery and perfumery products; industrially it serves as a specialty solvent and plasticizer for nitrocellulose, acrylics, inks, lacquers, UV coatings and as an immersion liquid in optical and spectroscopic work, as an intermediate for dyes, antifungal agents and pesticides; in agriculture it functions as a semiochemical to lure aphids, stink bugs and other pests or as a plant defense elicitor; additionally, methyl salicylate is employed as a calibration standard in chromatography, NMR and IR analysis, as a leak-detector due to its penetrating odor and in quality control of rubber and polymer goods.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 313.46
    methanol 393.06
    isopropanol 225.39
    water 3.1
    ethyl acetate 155.45
    n-propanol 219.07
    acetone 311.23
    n-butanol 180.21
    acetonitrile 243.72
    DMF 1319.23
    toluene 50.24
    isobutanol 146.73
    1,4-dioxane 396.2
    methyl acetate 222.41
    THF 490.44
    2-butanone 226.31
    n-pentanol 145.88
    sec-butanol 182.45
    n-hexane 9.79
    ethylene glycol 262.77
    NMP 482.22
    cyclohexane 13.21
    DMSO 973.96
    n-butyl acetate 86.41
    n-octanol 100.02
    chloroform 350.47
    n-propyl acetate 116.03
    acetic acid 195.23
    dichloromethane 423.67
    cyclohexanone 238.25
    propylene glycol 170.46
    isopropyl acetate 91.69
    DMAc 567.62
    2-ethoxyethanol 293.2
    isopentanol 132.09
    n-heptane 12.58
    ethyl formate 211.07
    1,2-dichloroethane 275.52
    n-hexanol 138.37
    2-methoxyethanol 547.88
    isobutyl acetate 64.39
    tetrachloromethane 46.94
    n-pentyl acetate 73.85
    transcutol 248.97
    n-heptanol 90.15
    ethylbenzene 50.83
    MIBK 113.94
    2-propoxyethanol 263.2
    tert-butanol 266.28
    MTBE 123.05
    2-butoxyethanol 153.35
    propionic acid 176.94
    o-xylene 56.56
    formic acid 136.84
    diethyl ether 126.81
    m-xylene 58.46
    p-xylene 63.21
    chlorobenzene 96.94
    dimethyl carbonate 151.49
    n-octane 8.14
    formamide 318.33
    cyclopentanone 351.04
    2-pentanone 170.8
    anisole 139.26
    cyclopentyl methyl ether 155.81
    gamma-butyrolactone 395.78
    1-methoxy-2-propanol 365.66
    pyridine 185.17
    3-pentanone 123.54
    furfural 332.34
    n-dodecane 9.94
    diethylene glycol 301.68
    diisopropyl ether 38.32
    tert-amyl alcohol 192.85
    acetylacetone 210.9
    n-hexadecane 11.19
    acetophenone 127.52
    methyl propionate 186.91
    isopentyl acetate 73.96
    trichloroethylene 422.78
    n-nonanol 85.65
    cyclohexanol 143.57
    benzyl alcohol 137.36
    2-ethylhexanol 77.82
    isooctanol 70.16
    dipropyl ether 72.96
    1,2-dichlorobenzene 100.65
    ethyl lactate 110.34
    propylene carbonate 212.06
    n-methylformamide 542.94
    2-pentanol 116.89
    n-pentane 10.85
    1-propoxy-2-propanol 160.04
    1-methoxy-2-propyl acetate 119.22
    2-(2-methoxypropoxy) propanol 126.26
    mesitylene 44.36
    ε-caprolactone 186.27
    p-cymene 40.55
    epichlorohydrin 444.75
    1,1,1-trichloroethane 172.27
    2-aminoethanol 260.04
    morpholine-4-carbaldehyde 423.89
    sulfolane 601.5
    2,2,4-trimethylpentane 9.93
    2-methyltetrahydrofuran 233.31
    n-hexyl acetate 113.14
    isooctane 9.76
    2-(2-butoxyethoxy)ethanol 174.98
    sec-butyl acetate 65.57
    tert-butyl acetate 108.58
    decalin 14.03
    glycerin 253.54
    diglyme 302.24
    acrylic acid 183.01
    isopropyl myristate 55.81
    n-butyric acid 169.51
    acetyl acetate 96.92
    di(2-ethylhexyl) phthalate 54.2
    ethyl propionate 109.96
    nitromethane 447.96
    1,2-diethoxyethane 100.41
    benzonitrile 132.18
    trioctyl phosphate 52.37
    1-bromopropane 124.57
    gamma-valerolactone 364.49
    n-decanol 69.33
    triethyl phosphate 57.68
    4-methyl-2-pentanol 74.07
    propionitrile 186.75
    vinylene carbonate 210.25
    1,1,2-trichlorotrifluoroethane 321.28
    DMS 93.58
    cumene 42.89
    2-octanol 69.61
    2-hexanone 126.57
    octyl acetate 73.46
    limonene 55.64
    1,2-dimethoxyethane 415.14
    ethyl orthosilicate 49.83
    tributyl phosphate 51.39
    diacetone alcohol 185.19
    N,N-dimethylaniline 107.66
    acrylonitrile 277.28
    aniline 110.16
    1,3-propanediol 288.66
    bromobenzene 89.56
    dibromomethane 253.17
    1,1,2,2-tetrachloroethane 338.69
    2-methyl-cyclohexyl acetate 74.67
    tetrabutyl urea 80.62
    diisobutyl methanol 57.66
    2-phenylethanol 116.61
    styrene 60.16
    dioctyl adipate 76.78
    dimethyl sulfate 259.03
    ethyl butyrate 85.3
    methyl lactate 171.4
    butyl lactate 76.9
    diethyl carbonate 66.6
    propanediol butyl ether 143.21
    triethyl orthoformate 60.9
    p-tert-butyltoluene 41.09
    methyl 4-tert-butylbenzoate 127.58
    morpholine 396.09
    tert-butylamine 137.99
    n-dodecanol 56.39
    dimethoxymethane 443.89
    ethylene carbonate 163.52
    cyrene 162.0
    2-ethoxyethyl acetate 92.82
    2-ethylhexyl acetate 54.97
    1,2,4-trichlorobenzene 117.11
    4-methylpyridine 172.63
    dibutyl ether 67.99
    2,6-dimethyl-4-heptanol 57.66
    DEF 271.82
    dimethyl isosorbide 187.24
    tetrachloroethylene 197.74
    eugenol 138.22
    triacetin 106.48
    span 80 110.05
    1,4-butanediol 151.33
    1,1-dichloroethane 219.45
    2-methyl-1-pentanol 108.53
    methyl formate 426.28
    2-methyl-1-butanol 121.7
    n-decane 13.81
    butyronitrile 176.88
    3,7-dimethyl-1-octanol 80.89
    1-chlorooctane 58.34
    1-chlorotetradecane 26.78
    n-nonane 12.65
    undecane 11.6
    tert-butylcyclohexane 14.46
    cyclooctane 6.51
    cyclopentanol 183.94
    tetrahydropyran 213.98
    tert-amyl methyl ether 102.14
    2,5,8-trioxanonane 214.01
    1-hexene 40.85
    2-isopropoxyethanol 181.47
    2,2,2-trifluoroethanol 110.59
    methyl butyrate 158.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Cassie absolute (blossom) 8023-82-3 Acacia farnesiana (L.) Willd., fam. Mimosaceae (Leguminosae) 47.3%
Narcissus tazetta absolute 2 8023-75-4 Narcissus tazetta L., fam. Amaryllidaceae 0.1%
Wintergreen (China) 68917-75-9 Gaultheria procumbens L., fam. Ericaceae 90.0%
Ylang Ylang 4 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 0.56%
Apple flower Malus arnoldiana (Rehd) Sarg. var. Redgold, fam. Rosaceae 0.01%
Gaura drummondii flower Gaura drummondii L., fam. Oenotheraceae 2.2%
Tamarind 1 dried fruit Tamarindus indica L., fam. Leguminosae 0.06%
Hedychium coronarium flower (Japan) Hedychium coronarium Koenig, fam. Zingiberaceae 0.14%
Mandarin leaf (Petitgrain mandarin.) (Israel) 1 Citrus reticulata Blanco, cultivar Balady, fam. Rutaceae 1.0%
Mandarin leaf (Petitgrain mandarin.) (Israel) 7 Citrus reticulata Blanco, cultivar Nectarine, fam. Rutaceae 0.01%
Jasmine oil (Turkey) 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 4.2%
Jasmine absolute (Turkey) 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 0.94%
Jasmine absolute (France) 2 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 0.4%
Jasmine absolute (Italy) 2 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 1.05%
Jasmine absolute (India) 1 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 0.95%
Jasmine absolute (Morocco) 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 0.91%
Jasmine absolute (Egypt) 2 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 0.76%
Rose (Bulgaria) 2 8007-01-0 Rosa damascena Mill., fam. Rosaceae 0.01%
Origanum syriacum (Turkey) 2 Origanum syriacum L. var. bevanii (Holmes) Ietswaart, fam. Lamiaceae 0.03%
Daylily, Headspace Living Flower 1 Hemerocallis minor hybrid, fam. Liliaceae 1.96%
Hyacinth, living flower headspace 1a Hyacinthus orientalis L., fam. Liliaceae 0.1%
Hyacinth, picked flower headspace 1b Hyacinthus orientalis L., fam. Liliaceae 0.05%
Jasmine sambac (China) headspace Jasminum sambac (L.) Aiton, fam. Oleaceae 2.55%
Jasmine sambac headspace Jasminum sambac (L.) Aiton, fam. Oleaceae 1.7%
Lemon leaf (petitgrain) 2 84929-31-7 Citrus limon (L.) Burm. f., fam. Rutaceae 0.01%
Blumea brevipes Blumea brevipes (Oliv. & Hiern) Willd., fam. Asteraceae (Compositae) 0.05%
Ylang Ylang 2a 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 0.1%
Ylang Ylang 2b 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 0.3%
Ylang Ylang 2c 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 0.2%
Tuberose (China) flower headspace 8024-05-3 Polianthes tuberosa L., fam. Amaryllidaceae (Agavaceae) 11.29%
Genet absolute 2 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.01%
Genet headspace 2 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.03%
Daphne tangutica flower concrete (China) Daphne tangutica Maxim., fam. Thymelaeaceae 0.64%
Luculia intermedia flower headspace (China) Luclia intermedia Hutch, fam. Rubiaceae 2.26%
Clerodendrum fragrans flower (China) Clerodendrum fragrans Vent., fam. Verbenaceae 3.05%
Zanthoxylum nitidum (Vietnam) Zanthoxylum nitidum DC., fam Rutaceae 0.13%
Mimusops elengi flower headspace Mimusops elengi L., fam. Sapotaceae 0.48%
Tuberose 8024-05-3 Polianthes tuberosa L., fam. Amaryllidaceae (Agavaceae) 10.0%
Nepeta caesarea (Turkey) Nepeta caesarea Boiss, fam. Lamiaceae (Labiatae) 0.06%
Aerangis brachycarpa flower headspace Aerangis brachycarpa Rchb. f., fam. Orchidaceae 0.05%
Dendrobium beckleri flower headspace Dendrobium beckleri Sw., fam. Orchidaceae 2.4%
Plumeria rubra flower headspace (China) Plumeria rubra L. cultivar Acutifolia, fam. Apocynaceae 1.41%
Ylang Ylang (Colombia) 8006-81-3 Cananga odorata (Lamk.) Hook. f. et Thomson forma genuina, fam. Annonaceae 0.05%
Couroupita guaianensis flower (Malaysia) Couroupita guianensis Auble, fam. Lecythidaceae 0.05%
Tuberose living flower headspace 8024-05-3 Polianthes tuberosa L., fam. Amaryllidaceae (Agavaceae) 9.0%
Viburnum orientale leaf Viburnum orientale Pallas, fam. Caprifoliaceae 0.05%
Nicotiana forgetiana flower Nicotiana forgetiana Hort. ex Hensley (subgenus Petunioides), Solanaceae 0.94%
Lawsonia inermis flower 1a Lawsonia inermis L. (syn. L. alba Lam.), fam. Lythraceae 0.1%
Lawsonia inermis flower 1b Lawsonia inermis L. (syn. L. alba Lam.), fam. Lytraceae 1.8%
Betula alnoides (Vietnam) Betula alnoides Ham ex. D. Don, fam. Betulaceae 99.4%