Methyl propionate

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  • Identifiers

    CAS number
    554-12-1

    Molecular formula
    C4H8O2

    SMILES
    CCC(=O)OC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fruity 94.44%
    Ethereal 87.21%
    Sweet 71.04%
    Rummy 70.3%
    Winey 55.39%
    Apple 54.89%
    Banana 45.16%
    Pungent 44.34%
    Pineapple 44.07%
    Fresh 43.39%

    Scent© AI

    Odor threshold>

    • THE PROBABLE HUMAN VALUES FOR ODOR AND FLAVOR THRESHOLDS IN WATER WERE REPORTED AS 100 AND 50 PPB, RESPECTIVELY.

  • Properties

    XLogP3-AA
    0.8

    Molecular weight
    88.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -125 °F (NTP, 1992)
    • -87.5 °C
    • -88 °C

    Boiling point

    • 175.5 °F at 760 mmHg (NTP, 1992)
    • 79.8 °C
    • 79.00 to 80.00 °C. @ 760.00 mm Hg
    • 80 °C

    Flash point est.
    -0.38 ˚C

    Flash point expt.

    • 28 °F (NTP, 1992)
    • 28 °F (-2 °C) (CLOSED CUP)
    • -2 °C c.c.

    Solubility expt.

    • 50 to 100 mg/mL at 72 °F (NTP, 1992)
    • COMPLETELY MISCIBLE WITH PROPYLENE GLYCOL
    • Soluble in most organic solvents.
    • Soluble in acetone; miscible in ethanol, ethyl ether.
    • In water, 62,370 mg/l @ 25 °C
    • 62.4 mg/mL at 25 °C
    • Solubility in water, g/100ml at 25 °C:
    • miscible with alcohol, ether, propylene glycol; soluble 1 ml in 16 ml water

  • Synonyms

    • METHYL PROPIONATE
    • Methyl propanoate
    • 554-12-1
    • Propanoic acid, methyl ester
    • Methyl propylate
    • Methylpropionate
    • Propionic acid, methyl ester
    • Propionate de methyle
    • PROPIONIC ACID METHYL ESTER
    • FEMA No. 2742
    • FEMA Number 2742
    • Propanoic acid methyl ester
    • Methyl Propionate (natural)
    • NSC 9375
    • HSDB 5688
    • formyl propionate
    • EINECS 209-060-4
    • UNII-NB21C0D33W
    • Methylester kyseliny propionove
    • BRN 1737628
    • NB21C0D33W
    • AI3-10621
    • NSC-9375
    • MFCD00009306
    • Methyl ester of propanoic acid
    • DTXSID7027201
    • CHEBI:89873
    • 4-02-00-00704 (Beilstein Handbook Reference)
    • WE(1:0/3:0)
    • Propionate de methyle [French]
    • UN1248
    • Methylester kyseliny propionove [Czech]
    • methyl proprionate
    • Methyl propionate, 99%
    • C2H5COOCH3
    • Propionic acid-methyl ester
    • WLN: 2VO1
    • METHYL PROPANOATE [MI]
    • DTXCID507201
    • CHEMBL3183973
    • METHYL PROPIONATE [FHFI]
    • METHYL PROPIONATE [HSDB]
    • FEMA 2742
    • NSC9375
    • Methyl propionate, >=98%, FG
    • Tox21_200730
    • LMFA07010410
    • Methyl propionate, analytical standard
    • AKOS008908807
    • UN 1248
    • NCGC00248813-01
    • NCGC00258284-01
    • CAS-554-12-1
    • DB-003724
    • Methyl propionate, purum, >=99.0% (GC)
    • NS00012985
    • P0508
    • S0301
    • EN300-70278
    • A830633
    • Methyl propionate [UN1248] [Flammable liquid]
    • Q418391
    • B64DF78F-37BE-4C30-A4DB-6EB6AD7FDD52
    • InChI=1/C4H8O2/c1-3-4(5)6-2/h3H2,1-2H
    • 209-060-4
    • 308065-15-8

  • Applications

    Methyl propionate (CAS 554-12-1) is a short-chain ester with a mild fruity aroma that enjoys wide industrial and laboratory use: thanks to its moderate volatility and balanced polarity it serves as a fast-drying solvent for automotive coatings, printing inks, acrylic adhesives, electronic component cleaning and natural-flavour extraction; in the flavour and fragrance sector it provides apple, pear and caramel notes to beverages, confectionery and tobacco; in organic synthesis it acts as an intermediate for manufacturing pharmaceuticals, agrochemicals, plasticizers, surfactants and polyester monomers; at process scale methyl propionate is also explored as an octane-boosting bio-fuel additive, a reaction medium for anionic polymerisation and a reference compound in gas chromatography, making it a versatile, cost-effective raw material that meets increasingly stringent safety and sustainability demands.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1520.12
    methanol 2548.31
    isopropanol 1053.53
    water 125.65
    ethyl acetate 665.44
    n-propanol 1032.26
    acetone 1147.75
    n-butanol 896.29
    acetonitrile 1705.02
    DMF 1445.83
    toluene 301.07
    isobutanol 814.73
    1,4-dioxane 1123.34
    methyl acetate 840.8
    THF 1178.84
    2-butanone 882.09
    n-pentanol 706.68
    sec-butanol 949.21
    n-hexane 157.34
    ethylene glycol 414.0
    NMP 1229.84
    cyclohexane 138.15
    DMSO 1363.11
    n-butyl acetate 317.85
    n-octanol 250.23
    chloroform 1858.85
    n-propyl acetate 405.81
    acetic acid 2260.45
    dichloromethane 2161.2
    cyclohexanone 802.43
    propylene glycol 355.75
    isopropyl acetate 337.23
    DMAc 1160.48
    2-ethoxyethanol 1179.07
    isopentanol 727.54
    n-heptane 64.3
    ethyl formate 685.91
    1,2-dichloroethane 1070.35
    n-hexanol 353.67
    2-methoxyethanol 1551.15
    isobutyl acetate 210.43
    tetrachloromethane 555.04
    n-pentyl acetate 277.6
    transcutol 1487.98
    n-heptanol 208.74
    ethylbenzene 198.28
    MIBK 338.97
    2-propoxyethanol 614.96
    tert-butanol 1234.66
    MTBE 841.85
    2-butoxyethanol 404.67
    propionic acid 995.12
    o-xylene 245.74
    formic acid 1503.04
    diethyl ether 772.26
    m-xylene 195.17
    p-xylene 317.9
    chlorobenzene 504.97
    dimethyl carbonate 179.57
    n-octane 36.15
    formamide 1790.83
    cyclopentanone 1018.13
    2-pentanone 596.61
    anisole 485.44
    cyclopentyl methyl ether 566.66
    gamma-butyrolactone 1111.16
    1-methoxy-2-propanol 852.11
    pyridine 1007.88
    3-pentanone 462.1
    furfural 1215.93
    n-dodecane 24.19
    diethylene glycol 514.08
    diisopropyl ether 194.1
    tert-amyl alcohol 1116.05
    acetylacetone 514.27
    n-hexadecane 26.43
    acetophenone 419.38
    methyl propionate 499.79
    isopentyl acetate 275.14
    trichloroethylene 1797.14
    n-nonanol 203.39
    cyclohexanol 610.69
    benzyl alcohol 504.96
    2-ethylhexanol 214.07
    isooctanol 179.19
    dipropyl ether 231.54
    1,2-dichlorobenzene 469.54
    ethyl lactate 181.12
    propylene carbonate 486.77
    n-methylformamide 1257.37
    2-pentanol 568.58
    n-pentane 144.5
    1-propoxy-2-propanol 342.63
    1-methoxy-2-propyl acetate 239.65
    2-(2-methoxypropoxy) propanol 321.39
    mesitylene 125.77
    ε-caprolactone 726.27
    p-cymene 114.68
    epichlorohydrin 1324.43
    1,1,1-trichloroethane 981.69
    2-aminoethanol 813.92
    morpholine-4-carbaldehyde 1101.26
    sulfolane 1065.97
    2,2,4-trimethylpentane 99.05
    2-methyltetrahydrofuran 1090.91
    n-hexyl acetate 367.14
    isooctane 47.19
    2-(2-butoxyethoxy)ethanol 451.47
    sec-butyl acetate 249.76
    tert-butyl acetate 349.75
    decalin 73.74
    glycerin 466.7
    diglyme 877.62
    acrylic acid 894.86
    isopropyl myristate 122.68
    n-butyric acid 1007.84
    acetyl acetate 381.65
    di(2-ethylhexyl) phthalate 146.68
    ethyl propionate 316.39
    nitromethane 2347.87
    1,2-diethoxyethane 503.95
    benzonitrile 669.49
    trioctyl phosphate 93.75
    1-bromopropane 689.1
    gamma-valerolactone 1147.49
    n-decanol 136.03
    triethyl phosphate 130.06
    4-methyl-2-pentanol 283.38
    propionitrile 964.38
    vinylene carbonate 490.97
    1,1,2-trichlorotrifluoroethane 931.37
    DMS 252.23
    cumene 156.76
    2-octanol 171.16
    2-hexanone 446.18
    octyl acetate 159.69
    limonene 163.52
    1,2-dimethoxyethane 1280.18
    ethyl orthosilicate 133.45
    tributyl phosphate 126.99
    diacetone alcohol 441.02
    N,N-dimethylaniline 347.5
    acrylonitrile 1152.97
    aniline 553.66
    1,3-propanediol 976.84
    bromobenzene 459.3
    dibromomethane 1292.54
    1,1,2,2-tetrachloroethane 1233.86
    2-methyl-cyclohexyl acetate 198.4
    tetrabutyl urea 164.15
    diisobutyl methanol 131.94
    2-phenylethanol 291.33
    styrene 281.5
    dioctyl adipate 177.42
    dimethyl sulfate 283.85
    ethyl butyrate 253.63
    methyl lactate 230.4
    butyl lactate 200.97
    diethyl carbonate 171.98
    propanediol butyl ether 319.65
    triethyl orthoformate 173.23
    p-tert-butyltoluene 107.7
    methyl 4-tert-butylbenzoate 283.18
    morpholine 1303.09
    tert-butylamine 816.01
    n-dodecanol 99.23
    dimethoxymethane 676.49
    ethylene carbonate 380.98
    cyrene 325.49
    2-ethoxyethyl acetate 368.18
    2-ethylhexyl acetate 213.5
    1,2,4-trichlorobenzene 546.26
    4-methylpyridine 980.68
    dibutyl ether 261.14
    2,6-dimethyl-4-heptanol 131.94
    DEF 765.29
    dimethyl isosorbide 468.76
    tetrachloroethylene 1045.11
    eugenol 309.75
    triacetin 294.64
    span 80 264.71
    1,4-butanediol 505.91
    1,1-dichloroethane 1152.67
    2-methyl-1-pentanol 632.76
    methyl formate 793.7
    2-methyl-1-butanol 771.09
    n-decane 42.48
    butyronitrile 925.83
    3,7-dimethyl-1-octanol 236.12
    1-chlorooctane 144.8
    1-chlorotetradecane 55.97
    n-nonane 44.91
    undecane 30.19
    tert-butylcyclohexane 81.17
    cyclooctane 47.22
    cyclopentanol 752.73
    tetrahydropyran 876.36
    tert-amyl methyl ether 656.93
    2,5,8-trioxanonane 557.08
    1-hexene 357.53
    2-isopropoxyethanol 660.06
    2,2,2-trifluoroethanol 771.44
    methyl butyrate 496.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction