Methyl isobutyl ketone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    108-10-1

    Molecular formula
    C6H12O

    SMILES
    CC(C)CC(=O)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

    Retention indicies (RI)

    • Carbowax: 1003.5

  • Odor profile

    Fruity 92.35%
    Sweet 75.92%
    Ketonic 67.78%
    Ethereal 66.55%
    Green 61.59%
    Herbal 59.49%
    Banana 54.42%
    Cheesy 53.63%
    Pungent 49.64%
    Fermented 46.49%

    Scent© AI

    Odor threshold

    • Odor Threshold Low: 0.1 [mmHg]. Odor Threshold High: 7.8 [mmHg]. Detection odor threshold from AIHA (mean = 0.88 ppm)
    • 0.10 ppm
    • Air: 0.68 ul/L; water: 1.3 mg/L
    • Odor detection limit in air: 9.70x10-6 g/L (gas).
    • /Range of odor thresholds reported in the literature:/ Methyl isobutyl keonte - 0.410 mg/cu m (odor low) 192.7 mg/cu m (odor high).
    • ... The mean odor detection threshold for MIBK was 10 ppm ... .

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    8.89 (weak base)

    Molecular weight
    100.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -120.5 °F (NTP, 1992)
    • -85 °C
    • -84 °C
    • -84.7 °C
    • -120 °F

    Boiling point

    • 243 to 244 °F at 760 mmHg (NTP, 1992)
    • 115.7 °C
    • 116.50 °C. @ 760.00 mm Hg
    • 117-118 °C
    • 242 °F

    Flash point est.
    16.09 ˚C

    Flash point expt.

    • 73 °F (NTP, 1992)
    • 23 °C
    • 64 °F (18 °C) (Closed cup)
    • 14 °C c.c.
    • 64 °F

    Solubility expt.

    • 1 to 5 mg/mL at 70 °F (NTP, 1992)
    • Water/air, blood/air, oil (olive oil)/air, oil/water, and oil/blood partition (or solubility) coefficients of methyl isobutyl ketone were measured by vial-equilibration in combination with gas chromatography. Partition coefficients for methyl isobutyl ketone: water/air: 79; blood/air: 90; oil/air: 926. The blood/air partition coefficients for ketones are almost in the same range as the water/air, irrespective of the oil/air partition coefficients.
    • In water, 19,000 mg/L at 25 °C
    • Slightly soluble in water
    • Miscible with ethanol, ether, acetone, benzene; soluble in chloroform
    • Miscible with most organic solvents
    • 19 mg/mL at 25 °C
    • Solubility in water, g/100ml at 20 °C: 1.91
    • miscible with alcohol, ether, and to 1 ml in 50 ml of water
    • 2%

  • Synonyms

    • 4-Methyl-2-pentanone
    • METHYL ISOBUTYL KETONE
    • 4-Methylpentan-2-one
    • 108-10-1
    • Isopropylacetone
    • Isobutyl methyl ketone
    • MIBK
    • Hexone
    • 2-Pentanone, 4-methyl-
    • 4-Methyl-2-oxopentane
    • Methylisobutylketon
    • Isohexanone
    • 2-Methyl-4-pentanone
    • Shell mibk
    • Metilisobutilchetone
    • Metyloizobutyloketon
    • Hexon
    • Isobutyl-methylketon
    • 2-Methylpropyl methyl ketone
    • Isopropyl acetone
    • Methyl-isobutyl-cetone
    • 4-Methyl-2-pentanon
    • 4-Metilpentan-2-one
    • Ketone, isobutyl methyl
    • 4-Methyl-pentan-2-on
    • Caswell No. 574AA
    • 4-Methyl-pentan-2-one
    • FEMA No. 2731
    • FEMA Number 2731
    • methylisobutylketone
    • Rcra waste number U161
    • NSC 5712
    • METHYL ISO-BUTYL KETONE
    • CCRIS 2052
    • HSDB 148
    • 4-Methyl-2-pentanone (natural)
    • UNII-U5T7B88CNP
    • EINECS 203-550-1
    • U5T7B88CNP
    • MFCD00008938
    • EPA Pesticide Chemical Code 044105
    • methyl isobutylketone
    • BRN 0605399
    • 2-Methyl-4-pentanal
    • Methyl I-butyl ketone
    • ethyl iso-butyl ketone
    • AI3-01229
    • NSC-5712
    • Methyl isobutyl ketone [NF]
    • DTXSID5021889
    • CHEBI:82344
    • EC 203-550-1
    • 4-01-00-03305 (Beilstein Handbook Reference)
    • Methyl isobutyl ketone (NF)
    • MIK
    • methylisobutyl ketone
    • 4-Methyl-2-pentanone, >=99%
    • METHYLISOBUTYLKETONE (USP-RS)
    • METHYLISOBUTYLKETONE [USP-RS]
    • METHYL ISOBUTYL KETONE (IARC)
    • METHYL ISOBUTYL KETONE [IARC]
    • METHYL ISOBUTYL KETONE (MART.)
    • METHYL ISOBUTYL KETONE [MART.]
    • METHYL ISOBUTYL KETONE (USP-RS)
    • METHYL ISOBUTYL KETONE [USP-RS]
    • Isobutyl-methylketon [Czech]
    • Metyloizobutyloketon [Polish]
    • isobutylmethyl ketone
    • Metilisobutilchetone [Italian]
    • 4-Methyl-2-pentanon [Czech]
    • Methyl-isobutyl-cetone [French]
    • 4-Metilpentan-2-one [Italian]
    • 4-methyl 2-pentanone
    • Methylisobutylketon [Dutch, German]
    • UN1245
    • RCRA waste no. U161
    • 4-Methyl-pentan-2-on [Dutch, German]
    • methylisobutyketone
    • isobutylmethylketone
    • methylisobutlyketone
    • i-BuCOMe
    • methylisobutyl keton
    • methylisobutyl-keton
    • Methylpentan-2-one
    • iso-butylmethylketone
    • methyl-isobutylketone
    • 4-methyl-2pentanone
    • methy isobutyl ketone
    • methyl isobutyl keton
    • methyl iso-butylketone
    • methyl-iso-butylketone
    • methyl-isobutyl ketone
    • 4-methylpentane-2-one
    • iso-C4H9COCH3
    • Methyl-2-pentanon,4-
    • 4-methyl- 2-pentanone
    • methyl 2-methylpropyl ketone
    • SCHEMBL15458
    • ISOPROPYLACETONE [MI]
    • CHEMBL285323
    • DTXCID701889
    • SCHEMBL13341539
    • NSC5712
    • Methyl isobutyl ketone, ACS grade
    • 4-Methyl-2-pentanone, HPLC Grade
    • Methylisobutylketon(DUTCH, GERMAN)
    • Tox21_201108
    • WLN: 1Y1 & 1V1
    • 4-METHYL-2-PENTANONE [FCC]
    • LMFA12000033
    • METHYL ISOBUTYL KETONE [HSDB]
    • 4-METHYL-2-PENTANONE [FHFI]
    • AKOS000118793
    • 4-Methyl-2-pentanone, AR, >=99%
    • 4-Methyl-2-pentanone, LR, >=99%
    • UN 1245
    • 4-Methyl-2-pentanone, >=99%, FCC
    • NCGC00091475-01
    • NCGC00091475-02
    • NCGC00258660-01
    • 4-Methyl-pentan-2-on(DUTCH, GERMAN)
    • BP-13453
    • CAS-108-10-1
    • 4-Methyl-2-pentanone, analytical standard
    • M0389
    • NS00009293
    • 4-Methyl-2-pentanone, technical grade, 95%
    • 4-Methyl-2-pentanone, for HPLC, >=99.5%

  • Applications

    4-Methyl-2-pentanone (MIBK, CAS 108-10-1) is a medium-evaporation industrial solvent prized for its ability to dissolve nitrocellulose, acrylic, alkyd, polyurethane and vinyl resins, making it essential in automotive paints, wood coatings, printing inks, adhesives, electroplating finishes and metal cleaners; it is also used for pharmaceutical extraction, dewaxing lubricating oils, azeotropic dehydration, semiconductor component rinsing, pesticide dilutions, and serves as a chemical intermediate in the manufacture of rubber additives, antioxidants, plasticizers and specialty fragrances.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1713.36
    methanol 2514.74
    isopropanol 1326.62
    water 41.96
    ethyl acetate 751.94
    n-propanol 1357.16
    acetone 1021.8
    n-butanol 1312.3
    acetonitrile 891.24
    DMF 725.62
    toluene 327.78
    isobutanol 1000.04
    1,4-dioxane 1359.99
    methyl acetate 726.88
    THF 1902.82
    2-butanone 780.93
    n-pentanol 720.74
    sec-butanol 1197.15
    n-hexane 707.46
    ethylene glycol 531.28
    NMP 1133.4
    cyclohexane 753.09
    DMSO 539.32
    n-butyl acetate 799.31
    n-octanol 737.2
    chloroform 1883.29
    n-propyl acetate 405.52
    acetic acid 2330.95
    dichloromethane 1143.3
    cyclohexanone 1295.12
    propylene glycol 675.92
    isopropyl acetate 463.64
    DMAc 670.11
    2-ethoxyethanol 596.39
    isopentanol 909.19
    n-heptane 521.15
    ethyl formate 525.79
    1,2-dichloroethane 666.34
    n-hexanol 1744.78
    2-methoxyethanol 1155.47
    isobutyl acetate 289.11
    tetrachloromethane 540.52
    n-pentyl acetate 461.47
    transcutol 1787.56
    n-heptanol 586.94
    ethylbenzene 221.69
    MIBK 444.71
    2-propoxyethanol 1365.63
    tert-butanol 1389.7
    MTBE 928.02
    2-butoxyethanol 611.27
    propionic acid 1309.04
    o-xylene 265.24
    formic acid 792.54
    diethyl ether 1015.26
    m-xylene 275.03
    p-xylene 293.37
    chlorobenzene 468.57
    dimethyl carbonate 191.07
    n-octane 145.13
    formamide 417.9
    cyclopentanone 1141.42
    2-pentanone 721.38
    anisole 317.31
    cyclopentyl methyl ether 1068.84
    gamma-butyrolactone 1290.57
    1-methoxy-2-propanol 808.58
    pyridine 694.18
    3-pentanone 535.96
    furfural 842.74
    n-dodecane 98.59
    diethylene glycol 837.6
    diisopropyl ether 370.53
    tert-amyl alcohol 1163.59
    acetylacetone 560.12
    n-hexadecane 106.04
    acetophenone 287.08
    methyl propionate 535.81
    isopentyl acetate 654.2
    trichloroethylene 1109.35
    n-nonanol 577.56
    cyclohexanol 1403.61
    benzyl alcohol 324.53
    2-ethylhexanol 859.35
    isooctanol 395.12
    dipropyl ether 719.43
    1,2-dichlorobenzene 402.88
    ethyl lactate 225.44
    propylene carbonate 738.85
    n-methylformamide 587.12
    2-pentanol 903.92
    n-pentane 541.34
    1-propoxy-2-propanol 966.9
    1-methoxy-2-propyl acetate 571.56
    2-(2-methoxypropoxy) propanol 507.43
    mesitylene 199.18
    ε-caprolactone 1100.33
    p-cymene 230.04
    epichlorohydrin 965.32
    1,1,1-trichloroethane 930.63
    2-aminoethanol 843.22
    morpholine-4-carbaldehyde 935.15
    sulfolane 1033.25
    2,2,4-trimethylpentane 195.85
    2-methyltetrahydrofuran 1616.52
    n-hexyl acetate 912.54
    isooctane 143.25
    2-(2-butoxyethoxy)ethanol 760.06
    sec-butyl acetate 292.9
    tert-butyl acetate 533.88
    decalin 219.26
    glycerin 726.79
    diglyme 943.6
    acrylic acid 956.29
    isopropyl myristate 305.25
    n-butyric acid 1373.68
    acetyl acetate 488.25
    di(2-ethylhexyl) phthalate 256.52
    ethyl propionate 352.94
    nitromethane 1292.82
    1,2-diethoxyethane 594.91
    benzonitrile 445.56
    trioctyl phosphate 217.82
    1-bromopropane 700.97
    gamma-valerolactone 1214.94
    n-decanol 395.39
    triethyl phosphate 186.43
    4-methyl-2-pentanol 442.91
    propionitrile 691.27
    vinylene carbonate 600.66
    1,1,2-trichlorotrifluoroethane 877.97
    DMS 398.37
    cumene 180.43
    2-octanol 430.02
    2-hexanone 524.75
    octyl acetate 409.96
    limonene 473.59
    1,2-dimethoxyethane 841.54
    ethyl orthosilicate 203.11
    tributyl phosphate 260.72
    diacetone alcohol 608.16
    N,N-dimethylaniline 232.6
    acrylonitrile 609.41
    aniline 452.9
    1,3-propanediol 877.44
    bromobenzene 413.98
    dibromomethane 969.95
    1,1,2,2-tetrachloroethane 1044.83
    2-methyl-cyclohexyl acetate 416.94
    tetrabutyl urea 321.44
    diisobutyl methanol 361.7
    2-phenylethanol 493.73
    styrene 228.53
    dioctyl adipate 353.87
    dimethyl sulfate 239.48
    ethyl butyrate 411.41
    methyl lactate 308.05
    butyl lactate 370.19
    diethyl carbonate 250.42
    propanediol butyl ether 681.59
    triethyl orthoformate 306.49
    p-tert-butyltoluene 226.52
    methyl 4-tert-butylbenzoate 388.98
    morpholine 1482.34
    tert-butylamine 1087.92
    n-dodecanol 286.39
    dimethoxymethane 530.87
    ethylene carbonate 540.7
    cyrene 357.97
    2-ethoxyethyl acetate 460.8
    2-ethylhexyl acetate 532.26
    1,2,4-trichlorobenzene 480.57
    4-methylpyridine 695.24
    dibutyl ether 606.32
    2,6-dimethyl-4-heptanol 361.7
    DEF 632.1
    dimethyl isosorbide 700.24
    tetrachloroethylene 804.33
    eugenol 369.47
    triacetin 508.24
    span 80 591.27
    1,4-butanediol 365.53
    1,1-dichloroethane 913.44
    2-methyl-1-pentanol 581.87
    methyl formate 457.27
    2-methyl-1-butanol 933.65
    n-decane 181.17
    butyronitrile 797.8
    3,7-dimethyl-1-octanol 594.27
    1-chlorooctane 448.41
    1-chlorotetradecane 173.44
    n-nonane 205.44
    undecane 126.73
    tert-butylcyclohexane 233.31
    cyclooctane 241.63
    cyclopentanol 1264.64
    tetrahydropyran 1669.95
    tert-amyl methyl ether 730.58
    2,5,8-trioxanonane 639.48
    1-hexene 970.95
    2-isopropoxyethanol 450.07
    2,2,2-trifluoroethanol 578.28
    methyl butyrate 463.6

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Myrrh gum (headspace) 8016-37-3 Commiphora myrrha (Nees) Engler, fam. Burseraceae 5.68%
Zizyphus jujuba fruit (Malaysia) Zizyphus jujuba Mill. var. inermis, fam. Rhamnaceae 0.02%
Tagetes (Rwanda) 1 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.5%
Tagetes (France) 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.05%
Tagetes (Zimbabwe) 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.1%
Pummelo (Shaddock) (India) peel 84696-38-8 Citrus maxima (J. Burman) Merrill. (C. grandis (L.) Osbeck), fam. Rutaceae 0.01%
Chicory root, roasted 1a 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.01%
Chicory root, roasted 1b 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.01%
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.05%
Ambarella fruit (Brazil) Spondias cytherea Sonnerat, fam. Anarcardiaceae 0.05%
Asafoetida (Pakistan) 2 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 0.01%