Methoxyacetic Acid

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  • Identifiers

    CAS number
    625-45-6

    Molecular formula
    C3H6O3

    SMILES
    COCC(=O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Caramellic 43.29%
    Sour 42.07%
    Buttery 38.17%
    Fruity 35.58%
    Ethereal 34.09%
    Odorless 32.32%
    Cheesy 32.18%
    Sharp 31.18%
    Milky 28.23%
    Dairy 27.92%

    Scent© AI

  • Properties

    XLogP3-AA
    -0.3

    Molecular weight
    90.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • 45.9 °F (NTP, 1992)
    • 7.7 °C

    Boiling point

    • 397 to 399 °F at 760 mmHg (NTP, 1992)

    Flash point est.
    82.36 ˚C

    Flash point expt.

    • greater than 235 °F (NTP, 1992)
    • Flash Point > 235 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
    • 1000 mg/mL at 20 °C

  • Synonyms

    • METHOXYACETIC ACID
    • 2-Methoxyacetic acid
    • 625-45-6
    • Acetic acid, methoxy-
    • Methoxyethanoic acid
    • Acetic acid, 2-methoxy-
    • CH3OCH2COOH
    • methoxy-acetic acid
    • CCRIS 6518
    • NSC 7300
    • EINECS 210-894-6
    • UNII-F11T1H7Q7W
    • BRN 0635800
    • F11T1H7Q7W
    • DTXSID1031591
    • AI3-24152
    • NSC-7300
    • DTXCID9011591
    • CHEBI:132098
    • EC 210-894-6
    • Methoxyacetic acid (ACD/Name 4.0)
    • Methoxyacetlc acid
    • CAS-625-45-6
    • 2-MethoxyaceticAcid
    • MFCD00004308
    • methoxyethanoate
    • 2methoxyacetic acid
    • methoxy acetic acid
    • acetic acid, methoxy
    • 2-methoxy acetic acid
    • 2-methoxy-acetic acid
    • (methyloxy)acetic acid
    • Acetic acid, 2methoxy
    • alpha-methoxyacetic acid
    • Methoxyacetic acid, 98%
    • METHYL GLYCOLIC ACID
    • CHEMBL1697714
    • NSC7300
    • AAA62545
    • HY-Y1009
    • STR04664
    • GLYCOLLIC ACID, METHYL ETHER
    • Tox21_201571
    • Tox21_303516
    • AKOS000119404
    • CCG-352130
    • CS-W020123
    • NCGC00090747-01
    • NCGC00090747-02
    • NCGC00090747-03
    • NCGC00257369-01
    • NCGC00259120-01
    • M0827
    • NS00009545
    • EN300-20233
    • D77874
    • Methoxyacetic acid, analytical reference material
    • Q20054532
    • F2191-0090
    • Z104477404
    • 210-894-6

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 309.29
    methanol 865.62
    isopropanol 107.08
    water 1475.14
    ethyl acetate 19.59
    n-propanol 151.0
    acetone 62.66
    n-butanol 81.04
    acetonitrile 59.33
    DMF 806.06
    toluene 1.03
    isobutanol 62.54
    1,4-dioxane 55.54
    methyl acetate 40.09
    THF 83.44
    2-butanone 30.26
    n-pentanol 29.15
    sec-butanol 61.22
    n-hexane 0.63
    ethylene glycol 820.31
    NMP 402.03
    cyclohexane 0.8
    DMSO 428.34
    n-butyl acetate 11.62
    n-octanol 17.26
    chloroform 5.34
    n-propyl acetate 13.68
    acetic acid 854.31
    dichloromethane 9.68
    cyclohexanone 39.85
    propylene glycol 452.68
    isopropyl acetate 8.06
    DMAc 339.45
    2-ethoxyethanol 202.7
    isopentanol 32.38
    n-heptane 1.59
    ethyl formate 54.56
    1,2-dichloroethane 9.59
    n-hexanol 27.27
    2-methoxyethanol 625.69
    isobutyl acetate 5.91
    tetrachloromethane 1.59
    n-pentyl acetate 8.51
    transcutol 225.51
    n-heptanol 14.75
    ethylbenzene 0.92
    MIBK 10.3
    2-propoxyethanol 119.85
    tert-butanol 87.99
    MTBE 10.75
    2-butoxyethanol 53.81
    propionic acid 237.95
    o-xylene 2.18
    formic acid 1638.97
    diethyl ether 10.48
    m-xylene 1.67
    p-xylene 1.19
    chlorobenzene 2.2
    dimethyl carbonate 26.21
    n-octane 0.56
    formamide 979.49
    cyclopentanone 63.32
    2-pentanone 19.25
    anisole 7.96
    cyclopentyl methyl ether 20.56
    gamma-butyrolactone 139.71
    1-methoxy-2-propanol 262.49
    pyridine 18.73
    3-pentanone 14.05
    furfural 134.91
    n-dodecane 0.57
    diethylene glycol 234.62
    diisopropyl ether 2.19
    tert-amyl alcohol 56.6
    acetylacetone 26.18
    n-hexadecane 0.57
    acetophenone 14.17
    methyl propionate 36.67
    isopentyl acetate 8.13
    trichloroethylene 13.29
    n-nonanol 14.92
    cyclohexanol 38.06
    benzyl alcohol 20.82
    2-ethylhexanol 10.64
    isooctanol 10.37
    dipropyl ether 10.23
    1,2-dichlorobenzene 3.72
    ethyl lactate 33.91
    propylene carbonate 48.18
    n-methylformamide 502.69
    2-pentanol 26.81
    n-pentane 1.05
    1-propoxy-2-propanol 63.79
    1-methoxy-2-propyl acetate 24.17
    2-(2-methoxypropoxy) propanol 64.58
    mesitylene 1.51
    ε-caprolactone 52.56
    p-cymene 2.67
    epichlorohydrin 68.06
    1,1,1-trichloroethane 3.09
    2-aminoethanol 674.13
    morpholine-4-carbaldehyde 322.31
    sulfolane 200.89
    2,2,4-trimethylpentane 0.72
    2-methyltetrahydrofuran 32.75
    n-hexyl acetate 16.39
    isooctane 0.45
    2-(2-butoxyethoxy)ethanol 91.62
    sec-butyl acetate 5.73
    tert-butyl acetate 10.52
    decalin 0.59
    glycerin 745.9
    diglyme 118.38
    acrylic acid 309.98
    isopropyl myristate 6.49
    n-butyric acid 120.27
    acetyl acetate 11.77
    di(2-ethylhexyl) phthalate 14.59
    ethyl propionate 13.01
    nitromethane 543.49
    1,2-diethoxyethane 17.87
    benzonitrile 10.72
    trioctyl phosphate 10.94
    1-bromopropane 2.98
    gamma-valerolactone 171.48
    n-decanol 11.0
    triethyl phosphate 9.82
    4-methyl-2-pentanol 10.67
    propionitrile 29.51
    vinylene carbonate 51.64
    1,1,2-trichlorotrifluoroethane 136.37
    DMS 18.71
    cumene 1.35
    2-octanol 7.95
    2-hexanone 10.95
    octyl acetate 11.61
    limonene 4.66
    1,2-dimethoxyethane 118.84
    ethyl orthosilicate 8.29
    tributyl phosphate 12.5
    diacetone alcohol 48.33
    N,N-dimethylaniline 10.45
    acrylonitrile 61.06
    aniline 11.98
    1,3-propanediol 470.17
    bromobenzene 1.08
    dibromomethane 4.51
    1,1,2,2-tetrachloroethane 10.74
    2-methyl-cyclohexyl acetate 12.15
    tetrabutyl urea 22.19
    diisobutyl methanol 6.06
    2-phenylethanol 16.14
    styrene 1.12
    dioctyl adipate 16.66
    dimethyl sulfate 64.8
    ethyl butyrate 11.48
    methyl lactate 92.14
    butyl lactate 22.01
    diethyl carbonate 8.24
    propanediol butyl ether 82.92
    triethyl orthoformate 10.2
    p-tert-butyltoluene 2.82
    methyl 4-tert-butylbenzoate 27.39
    morpholine 132.96
    tert-butylamine 27.08
    n-dodecanol 8.34
    dimethoxymethane 120.09
    ethylene carbonate 35.26
    cyrene 90.08
    2-ethoxyethyl acetate 17.12
    2-ethylhexyl acetate 6.1
    1,2,4-trichlorobenzene 5.25
    4-methylpyridine 13.64
    dibutyl ether 6.58
    2,6-dimethyl-4-heptanol 6.06
    DEF 71.09
    dimethyl isosorbide 86.44
    tetrachloroethylene 9.97
    eugenol 41.51
    triacetin 30.47
    span 80 62.44
    1,4-butanediol 160.03
    1,1-dichloroethane 3.94
    2-methyl-1-pentanol 15.41
    methyl formate 285.7
    2-methyl-1-butanol 37.95
    n-decane 0.82
    butyronitrile 20.07
    3,7-dimethyl-1-octanol 13.13
    1-chlorooctane 3.13
    1-chlorotetradecane 1.52
    n-nonane 0.76
    undecane 0.65
    tert-butylcyclohexane 0.69
    cyclooctane 0.4
    cyclopentanol 69.07
    tetrahydropyran 20.46
    tert-amyl methyl ether 12.04
    2,5,8-trioxanonane 104.5
    1-hexene 1.69
    2-isopropoxyethanol 72.06
    2,2,2-trifluoroethanol 339.16
    methyl butyrate 23.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction