Methionol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    505-10-2

    Molecular formula
    C4H10OS

    SMILES
    CSCCCO

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 962.0
    • Carbowax: 1723.0

  • Odor profile

    Sulfurous 83.58%
    Vegetable 71.14%
    Meaty 63.39%
    Onion 62.15%
    Cabbage 56.07%
    Garlic 55.99%
    Potato 55.74%
    Cheesy 54.69%
    Sweet 54.41%
    Alliaceous 51.52%

    Scent© AI

  • Properties

    XLogP3-AA
    0.5

    Molecular weight
    106.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point

    • 89.00 to 90.00 °C. @ 13.00 mm Hg

    Flash point est.
    72.1 ˚C

    Solubility expt.

    • slightly soluble in water; soluble in alcohol, propylene glycol and oils

  • Synonyms

    • Methionol
    • 505-10-2
    • 3-methylthiopropanol
    • 3-(Methylthio)-1-propanol
    • 3-(METHYLTHIO)PROPANOL
    • 1-Propanol, 3-(methylthio)-
    • 3-Hydroxypropyl methyl sulfide
    • 3-(methylthio)propan-1-ol
    • 3-(methylsulfanyl)propan-1-ol
    • 3-Methylmercapto-1-propanol
    • 3-Methylthio-1-propanol
    • 3-methylsulfanylpropan-1-ol
    • gamma-Methylmercaptopropyl alcohol
    • 3-(Methylsulfanyl)-1-propanol
    • 4-Thiapentan-1-ol
    • 3-(Methylthio)propyl alcohol
    • methylmercaptopropanol
    • 3-Methyl thiopropaol
    • NSC 2859
    • Methyl 3-hydroxypropylsulfide
    • FEMA No. 3415
    • gamma-Hydroxypropyl methyl sulfide
    • 3-methylsulfanyl-1-propanol
    • H1E1U441XX
    • CHEBI:49019
    • NSC-2859
    • .gamma.-Methylmercaptopropyl alcohol
    • EINECS 208-004-6
    • MFCD00036560
    • 3-Methylthiopropyl alcohol
    • 3-(Methylsulfanyl)propanol
    • 3-methylsulfanyl-propan-1-ol
    • 3-Methylmercaptopropyl Alcohol
    • AI3-17420
    • DTXSID7060128
    • 3-(METHYLTHIO)PROPANOL [FHFI]
    • 3-Hydroxypropyl methyl sulfide; 3-Methylmercapto-1-propanol; 4-Thiapentan-1-ol
    • UNII-H1E1U441XX
    • 3-(methylthio)propane-1-ol
    • C4H10OS
    • SCHEMBL101773
    • 3-(Methylmercapto)propan-1-ol
    • CHEMBL332887
    • DTXCID4040846
    • FEMA 3415
    • NSC2859
    • 3-(Methylsulfanyl)-1-propanol #
    • O,O-Diphenyl, methanedisulIfonate-
    • 3-(Methylthio)-1-propanol, 98%
    • AKOS005255124
    • 3-(Methylsulfanyl)propanol (methionol)
    • FM25962
    • SB17653
    • AS-59057
    • 3-(Methylthio)-1-propanol, >=98%, FG
    • DB-003422
    • CS-0015993
    • M0735
    • NS00022250
    • laquo gammaRaquo -methylmercaptopropyl alcohol
    • EN300-112112
    • Q11343729
    • 3-Methylsulfanyl-propan-1-ol;3-Methylmercapto-propan-1-ol
    • InChI=1/C4H10OS/c1-6-4-2-3-5/h5H,2-4H2,1H
    • 208-004-6

  • Applications

    3-(Methylthio)-1-propanol, also known as methionol, is a valuable organosulfur compound widely applied in the flavor and fragrance industry for imparting cooked onion, garlic, roasted meat and matured wine notes, and is simultaneously employed as an analytical standard for GC-MS calibration, as a precursor for sulfide or phosphorous-containing derivatives, for probing aroma-formation mechanisms during beer and wine fermentation, for quality control of roasted coffee, for Maillard reaction studies in food science, for tailoring sensory profiles of non-alcoholic beverages, for simulating human body odor in deodorant evaluations, and for isotope-labeling experiments that trace methionine metabolism; moreover, thanks to its good solubility in organic solvents and convenient boiling point, this molecule is exploited as a niche reaction medium and methylthio-transfer reagent in pharmaceutical synthesis laboratories.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1247.69
    methanol 1743.64
    isopropanol 830.03
    water 15.69
    ethyl acetate 212.29
    n-propanol 828.47
    acetone 595.76
    n-butanol 700.18
    acetonitrile 297.18
    DMF 749.77
    toluene 90.55
    isobutanol 483.35
    1,4-dioxane 638.74
    methyl acetate 220.12
    THF 979.8
    2-butanone 315.59
    n-pentanol 357.84
    sec-butanol 461.7
    n-hexane 27.51
    ethylene glycol 503.9
    NMP 536.24
    cyclohexane 59.69
    DMSO 1348.01
    n-butyl acetate 312.25
    n-octanol 157.73
    chloroform 528.81
    n-propyl acetate 186.13
    acetic acid 788.72
    dichloromethane 357.18
    cyclohexanone 640.08
    propylene glycol 449.85
    isopropyl acetate 121.74
    DMAc 304.9
    2-ethoxyethanol 466.64
    isopentanol 402.46
    n-heptane 58.43
    ethyl formate 258.55
    1,2-dichloroethane 245.76
    n-hexanol 492.63
    2-methoxyethanol 947.89
    isobutyl acetate 119.32
    tetrachloromethane 139.88
    n-pentyl acetate 160.66
    transcutol 845.12
    n-heptanol 204.71
    ethylbenzene 42.07
    MIBK 154.87
    2-propoxyethanol 649.94
    tert-butanol 680.16
    MTBE 205.38
    2-butoxyethanol 343.91
    propionic acid 508.25
    o-xylene 65.61
    formic acid 444.62
    diethyl ether 213.25
    m-xylene 74.37
    p-xylene 60.12
    chlorobenzene 158.68
    dimethyl carbonate 63.95
    n-octane 17.57
    formamide 420.55
    cyclopentanone 721.68
    2-pentanone 292.03
    anisole 121.86
    cyclopentyl methyl ether 326.5
    gamma-butyrolactone 651.45
    1-methoxy-2-propanol 553.85
    pyridine 437.21
    3-pentanone 149.53
    furfural 599.73
    n-dodecane 12.69
    diethylene glycol 608.51
    diisopropyl ether 58.09
    tert-amyl alcohol 354.83
    acetylacetone 266.76
    n-hexadecane 13.89
    acetophenone 133.07
    methyl propionate 167.07
    isopentyl acetate 215.82
    trichloroethylene 474.82
    n-nonanol 129.24
    cyclohexanol 472.44
    benzyl alcohol 176.13
    2-ethylhexanol 231.18
    isooctanol 148.81
    dipropyl ether 224.21
    1,2-dichlorobenzene 137.21
    ethyl lactate 115.3
    propylene carbonate 279.25
    n-methylformamide 539.93
    2-pentanol 335.05
    n-pentane 32.65
    1-propoxy-2-propanol 486.72
    1-methoxy-2-propyl acetate 217.41
    2-(2-methoxypropoxy) propanol 218.42
    mesitylene 53.69
    ε-caprolactone 420.19
    p-cymene 64.39
    epichlorohydrin 472.95
    1,1,1-trichloroethane 242.38
    2-aminoethanol 721.86
    morpholine-4-carbaldehyde 613.6
    sulfolane 757.68
    2,2,4-trimethylpentane 16.49
    2-methyltetrahydrofuran 551.38
    n-hexyl acetate 181.98
    isooctane 16.76
    2-(2-butoxyethoxy)ethanol 337.01
    sec-butyl acetate 91.86
    tert-butyl acetate 139.61
    decalin 21.14
    glycerin 558.78
    diglyme 573.1
    acrylic acid 445.7
    isopropyl myristate 72.6
    n-butyric acid 620.03
    acetyl acetate 120.23
    di(2-ethylhexyl) phthalate 88.79
    ethyl propionate 109.75
    nitromethane 638.92
    1,2-diethoxyethane 251.76
    benzonitrile 235.89
    trioctyl phosphate 76.88
    1-bromopropane 150.21
    gamma-valerolactone 797.5
    n-decanol 95.4
    triethyl phosphate 73.69
    4-methyl-2-pentanol 143.85
    propionitrile 276.17
    vinylene carbonate 290.16
    1,1,2-trichlorotrifluoroethane 489.64
    DMS 101.31
    cumene 39.26
    2-octanol 118.52
    2-hexanone 206.97
    octyl acetate 97.36
    limonene 111.04
    1,2-dimethoxyethane 513.5
    ethyl orthosilicate 77.54
    tributyl phosphate 83.14
    diacetone alcohol 267.78
    N,N-dimethylaniline 91.33
    acrylonitrile 365.51
    aniline 213.58
    1,3-propanediol 812.22
    bromobenzene 129.93
    dibromomethane 259.15
    1,1,2,2-tetrachloroethane 409.47
    2-methyl-cyclohexyl acetate 137.44
    tetrabutyl urea 117.06
    diisobutyl methanol 120.08
    2-phenylethanol 211.34
    styrene 59.18
    dioctyl adipate 111.83
    dimethyl sulfate 125.89
    ethyl butyrate 174.97
    methyl lactate 160.32
    butyl lactate 162.44
    diethyl carbonate 95.02
    propanediol butyl ether 321.2
    triethyl orthoformate 129.23
    p-tert-butyltoluene 65.74
    methyl 4-tert-butylbenzoate 153.02
    morpholine 796.71
    tert-butylamine 350.79
    n-dodecanol 75.29
    dimethoxymethane 319.03
    ethylene carbonate 233.23
    cyrene 203.08
    2-ethoxyethyl acetate 178.47
    2-ethylhexyl acetate 159.63
    1,2,4-trichlorobenzene 158.34
    4-methylpyridine 341.57
    dibutyl ether 129.34
    2,6-dimethyl-4-heptanol 120.08
    DEF 274.92
    dimethyl isosorbide 315.88
    tetrachloroethylene 344.5
    eugenol 188.89
    triacetin 152.04
    span 80 263.24
    1,4-butanediol 309.62
    1,1-dichloroethane 266.34
    2-methyl-1-pentanol 214.7
    methyl formate 315.95
    2-methyl-1-butanol 352.86
    n-decane 21.31
    butyronitrile 356.1
    3,7-dimethyl-1-octanol 136.22
    1-chlorooctane 73.09
    1-chlorotetradecane 31.21
    n-nonane 21.54
    undecane 15.54
    tert-butylcyclohexane 23.89
    cyclooctane 18.72
    cyclopentanol 603.51
    tetrahydropyran 641.78
    tert-amyl methyl ether 132.17
    2,5,8-trioxanonane 402.88
    1-hexene 90.62
    2-isopropoxyethanol 281.94
    2,2,2-trifluoroethanol 229.22
    methyl butyrate 187.48

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Mandrake fruit (Israel) Mandragora officinarum L., fam. Solanaceae 4.44%
Averrhoa bilimbi fruit (Malaysia) Averrhoa bilimbi L., fam. Oxalidaceae 0.1%