Methaqualone

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  • Identifiers

    CAS number
    72-44-6

    Molecular formula
    C16H14N2O

    SMILES
    CC1=CC=CC=C1N2C(=NC3=CC=CC=C3C2=O)C

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Floral 49.97%
    Animal 43.73%
    Neroli 39.32%
    Sweet 35.77%
    Grape 34.3%
    Fruity 32.18%
    Phenolic 30.58%
    Bitter 29.76%
    Musty 28.81%
    Powdery 28.14%

    Scent© AI

  • Properties

    XLogP3-AA
    2.5

    Molecular weight
    250.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    479°C

    Melting point expt.

    • 120 °C

    Flash point est.
    194.72 ˚C

    Solubility expt.

    • PRACTICALLY INSOL IN WATER
    • Soluble 1 in 12 parts of alcohol, 1 in 1 part of chloroform, and 1 in 50 parts of ether.

  • Synonyms

    • METHAQUALONE
    • Metolquizolone
    • Quaalude
    • 72-44-6
    • Methaqualoneinone
    • Metaqualon
    • Ortonal
    • Metakvalon
    • Methaqualon
    • Tuazolone
    • Cateudyl
    • Melsomin
    • Tuazole
    • Aqual
    • Dormigoa
    • Dormogen
    • Dormutil
    • Dorsedin
    • Fadormir
    • Holodorm
    • Mollinox
    • Mozambin
    • Nobedorm
    • Noctilene
    • Optinoxan
    • Orthonal
    • Parminal
    • Rouqualone
    • Sindesvel
    • Somberol
    • Somnomed
    • Hyminal
    • Hypocol
    • Hyptor
    • Ipnofil
    • Melsed
    • Motolon
    • Roulone
    • Soverin
    • Torinal
    • Omnyl
    • Sonal
    • Sopor
    • Hyptor base
    • Normi-Nox
    • Methased
    • Citexal
    • Mequin
    • Revonal
    • Melsedin base
    • Pro-dorm
    • Dormigoa-Schlafmittel
    • MAOA
    • Methachalonum
    • Rorer 148
    • Rorer 714
    • Somnafac
    • 3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazoline
    • Nethaqualone
    • Metachalon
    • Metacualona
    • Methyl-o-tolylquinazolone
    • 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
    • 2-Methyl-3-o-tolyl-4-quinazolone
    • 2-Methyl-3-tolyl-4-oxybensdiazine
    • CN 38703
    • QZ 2
    • 2-Methyl-3-o-tolyl-4(3H)-quinazolinone
    • CI-705
    • Metaqualone
    • Methaqualonum
    • TR-495
    • Hypcol
    • 2-Methyl-3-(2-tolyl)quinazol-4-one
    • RIC 272
    • R-148
    • 2-Methyl-3-o-tolyl-4(3H)-chinazolone
    • 4(3H)-Quinazolinone, 2-methyl-3-(2-methylphenyl)-
    • QZ-2
    • 2-Methyl-3-(2-methylphenyl)-4-quinazolinone
    • 2-Methyl-3-(o-tolyl)-3,4-dihydro-4-quinazolinone
    • HSDB 3120
    • UNII-7ZKH8MQW6T
    • 2-Methyl-3-o-tolyl-4(3H)-chinazolinon
    • 7ZKH8MQW6T
    • EINECS 200-780-4
    • 4(3H)-Quinazolinone, 2-methyl-3-o-tolyl-
    • NSC 111388
    • NSC-111388
    • NSC-126877
    • NSC-631628
    • BRN 0211874
    • CHEBI:6821
    • DTXSID7023279
    • MTQ
    • TR 495
    • CN-38703
    • DTXCID403279
    • Methaqualone-d5
    • 5-24-03-00132 (Beilstein Handbook Reference)
    • 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
    • CI 705
    • NSC126877
    • NSC631628
    • 2-methyl-3-(o-tolyl)quinazolin-4-one
    • Metachalon [Czech]
    • NSC-111388-
    • NCGC00245236-02
    • METHAQUALONE (MART.)
    • METHAQUALONE [MART.]
    • Metacualona [INN-Spanish]
    • Methaqualonum [INN-Latin]
    • (2-Methyl-3-(o-tolyl)-3,4-dihydro-4-(quinazolinone)
    • METHAQUALONE (EP IMPURITY)
    • METHAQUALONE [EP IMPURITY]
    • Tuazol
    • CAS-72-44-6
    • WLN: T66 BVN ENJ CR B1& D1
    • 2-Methyl-3-o-tolyl-4(3H)-chinazolinon [German]
    • Reposil
    • DEA No. 2565
    • Methaqualone [USAN:USP:INN:BAN]
    • 1184966-71-9
    • A1ADG
    • METHAQUALONE [MI]
    • 2-Methyl-3-(o-tolyl)quinazolin-4(3H)-one
    • (.+/-.)-Methaqualone
    • METHAQUALONE [INN]

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.48
    methanol 13.52
    isopropanol 8.84
    water 0.02
    ethyl acetate 21.38
    n-propanol 13.65
    acetone 42.83
    n-butanol 13.91
    acetonitrile 17.01
    DMF 121.57
    toluene 20.32
    isobutanol 12.75
    1,4-dioxane 77.76
    methyl acetate 30.99
    THF 122.58
    2-butanone 45.62
    n-pentanol 14.35
    sec-butanol 9.8
    n-hexane 0.97
    ethylene glycol 2.96
    NMP 88.87
    cyclohexane 1.69
    DMSO 58.1
    n-butyl acetate 30.4
    n-octanol 8.63
    chloroform 144.01
    n-propyl acetate 27.3
    acetic acid 21.67
    dichloromethane 176.79
    cyclohexanone 85.48
    propylene glycol 2.81
    isopropyl acetate 14.97
    DMAc 104.25
    2-ethoxyethanol 25.91
    isopentanol 16.09
    n-heptane 1.03
    ethyl formate 26.77
    1,2-dichloroethane 134.12
    n-hexanol 18.62
    2-methoxyethanol 36.95
    isobutyl acetate 22.14
    tetrachloromethane 7.41
    n-pentyl acetate 25.59
    transcutol 41.47
    n-heptanol 12.64
    ethylbenzene 12.86
    MIBK 21.72
    2-propoxyethanol 40.15
    tert-butanol 11.0
    MTBE 12.0
    2-butoxyethanol 28.71
    propionic acid 15.52
    o-xylene 11.58
    formic acid 8.03
    diethyl ether 17.29
    m-xylene 11.39
    p-xylene 20.27
    chlorobenzene 40.96
    dimethyl carbonate 19.38
    n-octane 0.83
    formamide 18.64
    cyclopentanone 114.54
    2-pentanone 30.93
    anisole 23.83
    cyclopentyl methyl ether 31.89
    gamma-butyrolactone 103.61
    1-methoxy-2-propanol 21.21
    pyridine 94.51
    3-pentanone 28.28
    furfural 94.66
    n-dodecane 0.95
    diethylene glycol 28.08
    diisopropyl ether 4.2
    tert-amyl alcohol 11.64
    acetylacetone 38.78
    n-hexadecane 1.15
    acetophenone 31.76
    methyl propionate 24.31
    isopentyl acetate 30.68
    trichloroethylene 221.94
    n-nonanol 9.55
    cyclohexanol 15.29
    benzyl alcohol 25.42
    2-ethylhexanol 14.18
    isooctanol 11.59
    dipropyl ether 13.28
    1,2-dichlorobenzene 38.41
    ethyl lactate 13.26
    propylene carbonate 45.98
    n-methylformamide 34.96
    2-pentanol 7.44
    n-pentane 0.64
    1-propoxy-2-propanol 22.9
    1-methoxy-2-propyl acetate 29.17
    2-(2-methoxypropoxy) propanol 25.02
    mesitylene 6.34
    ε-caprolactone 56.12
    p-cymene 9.46
    epichlorohydrin 174.2
    1,1,1-trichloroethane 47.97
    2-aminoethanol 7.13
    morpholine-4-carbaldehyde 83.45
    sulfolane 100.54
    2,2,4-trimethylpentane 0.74
    2-methyltetrahydrofuran 54.91
    n-hexyl acetate 25.86
    isooctane 0.54
    2-(2-butoxyethoxy)ethanol 30.18
    sec-butyl acetate 17.34
    tert-butyl acetate 15.95
    decalin 1.8
    glycerin 7.45
    diglyme 61.52
    acrylic acid 18.2
    isopropyl myristate 11.73
    n-butyric acid 23.89
    acetyl acetate 16.04
    di(2-ethylhexyl) phthalate 17.17
    ethyl propionate 22.63
    nitromethane 47.57
    1,2-diethoxyethane 25.99
    benzonitrile 35.23
    trioctyl phosphate 10.8
    1-bromopropane 38.67
    gamma-valerolactone 122.16
    n-decanol 7.93
    triethyl phosphate 14.82
    4-methyl-2-pentanol 7.22
    propionitrile 22.01
    vinylene carbonate 48.89
    1,1,2-trichlorotrifluoroethane 60.55
    DMS 30.16
    cumene 9.49
    2-octanol 8.44
    2-hexanone 34.53
    octyl acetate 14.97
    limonene 10.62
    1,2-dimethoxyethane 67.71
    ethyl orthosilicate 14.2
    tributyl phosphate 13.02
    diacetone alcohol 22.92
    N,N-dimethylaniline 17.92
    acrylonitrile 34.23
    aniline 25.02
    1,3-propanediol 13.53
    bromobenzene 41.1
    dibromomethane 94.94
    1,1,2,2-tetrachloroethane 139.04
    2-methyl-cyclohexyl acetate 24.27
    tetrabutyl urea 19.14
    diisobutyl methanol 8.29
    2-phenylethanol 30.77
    styrene 14.28
    dioctyl adipate 17.37
    dimethyl sulfate 34.03
    ethyl butyrate 20.79
    methyl lactate 12.31
    butyl lactate 18.43
    diethyl carbonate 16.1
    propanediol butyl ether 14.98
    triethyl orthoformate 16.95
    p-tert-butyltoluene 7.77
    methyl 4-tert-butylbenzoate 27.73
    morpholine 68.09
    tert-butylamine 6.58
    n-dodecanol 6.53
    dimethoxymethane 54.06
    ethylene carbonate 39.84
    cyrene 33.35
    2-ethoxyethyl acetate 34.76
    2-ethylhexyl acetate 26.14
    1,2,4-trichlorobenzene 44.98
    4-methylpyridine 65.53
    dibutyl ether 12.47
    2,6-dimethyl-4-heptanol 8.29
    DEF 42.16
    dimethyl isosorbide 47.49
    tetrachloroethylene 83.36
    eugenol 34.12
    triacetin 21.89
    span 80 20.11
    1,4-butanediol 7.01
    1,1-dichloroethane 58.95
    2-methyl-1-pentanol 17.84
    methyl formate 32.92
    2-methyl-1-butanol 15.26
    n-decane 1.37
    butyronitrile 24.61
    3,7-dimethyl-1-octanol 9.91
    1-chlorooctane 7.75
    1-chlorotetradecane 3.94
    n-nonane 1.1
    undecane 1.13
    tert-butylcyclohexane 1.58
    cyclooctane 0.52
    cyclopentanol 19.72
    tetrahydropyran 58.94
    tert-amyl methyl ether 11.49
    2,5,8-trioxanonane 44.08
    1-hexene 7.21
    2-isopropoxyethanol 20.92
    2,2,2-trifluoroethanol 11.72
    methyl butyrate 34.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction