Humulene diepoxide

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    74282-08-9

  • Properties

  • Applications

    Humulene diepoxide (CAS 74282-08-9) is the diepoxide derivative of the sesquiterpene humulene with two highly reactive epoxide rings; in practice it serves as a bifunctional epoxide reagent for selective ring-opening to build diols, amino alcohols, and multifunctional scaffolds in organic synthesis and drug discovery; as an analytical reference standard for GC-MS, LC-MS, and NMR when identifying and quantifying humulene oxidation products in hop essential oil, terpene-rich botanicals, and food matrices; as a model compound in atmospheric chemistry to probe secondary organic aerosol formation from sesquiterpenes; and it has been explored as a bio-based epoxy monomer for flexible crosslinked networks at laboratory scale, as well as a substrate to evaluate catalyst/enzyme selectivity in epoxide ring-opening; note that it is a research chemical, not a therapeutic agent, and any reported biological activities (e.g., anti-inflammatory or cytotoxic effects) are mostly in vitro/preclinical and require further validation for safety and efficacy.

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IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Hop (Nugget cultivar) (USA) 8007-04-3 Humulus lupulus L., cultivar Nugget, fam. Cannabaceae 0.05%
Hop (Galena cultivar) (USA) 8007-04-3 Humulus lupulus L., cultivar Galena, fam. Cannabaceae 0.03%
Hop (Styrian cultivar) (USA) 8007-04-3 Humulus lupulus L., cultivar Styrian, fam. Cannabaceae 0.1%
Hop (Willamette cultivar) (USA) 8007-04-3 Humulus lupulus L., cultivar Willamette, fam. Cannabaceae 0.18%
Phoebe 2 Phoebe porsa Mez. (syn. Oreodaphne prosa Nees & Mart.), fam. Lauraceae 1.4%
Ocimum gratissimum (Tahiti) Ocimum gratissimum L., fam. Lamiaceae (Labiatae) 0.1%