gamma-Elemene

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  • Identifiers

    CAS number
    30824-67-0

    Molecular formula
    C15H24

    SMILES
    CC(=C1CC[C@@]([C@@H](C1)C(=C)C)(C)C=C)C

    Retention indicies (RI)

    • DB5: 1491.25
    • Carbowax: 1623.71

  • Odor profile

    Woody 83.6%
    Sweet 72.12%
    Herbal 65.62%
    Citrus 60.22%
    Terpenic 59.75%
    Green 55.62%
    Pine 47.85%
    Fresh 47.47%
    Spicy 46.35%
    Oily 43.12%

    Scent© AI

  • Properties

    XLogP3-AA
    5.4

    Molecular weight
    204.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    250°C

    Flash point est.
    97.84 ˚C

  • Synonyms

    • gamma-Elemene
    • (+)-gamma-elemene
    • gamma Elemene [WHO-DD]
    • 4J4Q7UH7EK
    • 30824-67-0
    • .gamma.-Elemene
    • (1S,2S)-1-ethenyl-1-methyl-4-propan-2-ylidene-2-prop-1-en-2-ylcyclohexane
    • Cyclohexane, 1-ethenyl-1-methyl-2-(1-methylethenyl)-4-(1-methylethylidene)-, (1S,2S)-
    • (1S,2S)-1-Ethenyl-1-methyl-2-(1-methylethenyl)-4-(1-methylethylidene)cyclohexane
    • (1S,2S)-1-Methyl-2-(prop-1-en-2-yl)-4-(propan-2-ylidene)-1-vinylcyclohexane
    • Cyclohexane, 1-ethenyl-1-methyl-2-(1-methylethenyl)-4-(1-methylethylidene)-, (1S-trans)-
    • starbld0002901
    • gamma-Elemene, (+)-
    • UNII-4J4Q7UH7EK
    • (+)-.GAMMA.-ELEMENE
    • BQSLMQNYHVFRDT-LSDHHAIUSA-N
    • CHEBI:132656
    • .GAMMA.-ELEMENE, (+)-
    • Q63392179
    • 2-Isopropenyl-1-methyl-4-(1-methylethylidene)-1-vinylcyclohexane
    • (1S,2S)-1-ethenyl-1-methyl-4-(propan-2-ylidene)-2-(prop-1-en-2-yl)cyclohexane

  • Applications

    gamma-Elemene (γ-elemene, CAS 30824-67-0) is a natural sesquiterpene found in zedoary/turmeric, ginger and other essential oils, used primarily in pharmaceutical and natural-products R&D as a potential antitumor scaffold: numerous in vitro and in vivo studies report antiproliferative activity, induction of apoptosis and autophagy, suppression of invasion/metastasis, chemo- and radiosensitization, and modulation of PI3K/Akt/mTOR, MAPK and NF-κB pathways; it has also been investigated for anti-inflammatory, antioxidant, antimicrobial/antifungal and antibiofilm effects, enabling exploration in drug-delivery systems (e.g., nanocarriers), botanical pesticide leads and biopreservation; in the fragrance sector, γ-elemene contributes a warm woody–herbal note to perfumery and may occur as a natural flavor component via essential oils, and it serves as an analytical reference standard for QC and chemotaxonomic profiling of oils; importantly, clinical evidence specific to γ-elemene remains limited (distinct from β-elemene–rich preparations), so any therapeutic use is investigational and not a substitute for standard care.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 224.5
    methanol 93.25
    isopropanol 227.17
    water 0.04
    ethyl acetate 458.0
    n-propanol 238.26
    acetone 266.26
    n-butanol 321.44
    acetonitrile 155.83
    DMF 220.82
    toluene 683.94
    isobutanol 191.33
    1,4-dioxane 919.32
    methyl acetate 268.5
    THF 1685.47
    2-butanone 415.57
    n-pentanol 191.05
    sec-butanol 242.99
    n-hexane 235.02
    ethylene glycol 7.36
    NMP 250.45
    cyclohexane 424.92
    DMSO 119.73
    n-butyl acetate 829.83
    n-octanol 225.85
    chloroform 755.71
    n-propyl acetate 260.72
    acetic acid 63.06
    dichloromethane 596.32
    cyclohexanone 595.84
    propylene glycol 25.8
    isopropyl acetate 394.02
    DMAc 273.61
    2-ethoxyethanol 135.16
    isopentanol 307.45
    n-heptane 358.88
    ethyl formate 140.4
    1,2-dichloroethane 398.0
    n-hexanol 582.61
    2-methoxyethanol 204.7
    isobutyl acetate 246.31
    tetrachloromethane 197.78
    n-pentyl acetate 324.73
    transcutol 908.87
    n-heptanol 227.58
    ethylbenzene 302.31
    MIBK 337.02
    2-propoxyethanol 437.4
    tert-butanol 383.8
    MTBE 794.17
    2-butoxyethanol 238.88
    propionic acid 78.71
    o-xylene 332.26
    formic acid 8.84
    diethyl ether 831.68
    m-xylene 454.23
    p-xylene 357.46
    chlorobenzene 420.37
    dimethyl carbonate 84.95
    n-octane 89.0
    formamide 20.24
    cyclopentanone 564.51
    2-pentanone 449.95
    anisole 411.89
    cyclopentyl methyl ether 771.65
    gamma-butyrolactone 386.17
    1-methoxy-2-propanol 241.83
    pyridine 618.94
    3-pentanone 345.9
    furfural 265.25
    n-dodecane 49.08
    diethylene glycol 110.52
    diisopropyl ether 355.65
    tert-amyl alcohol 329.71
    acetylacetone 323.92
    n-hexadecane 58.96
    acetophenone 273.02
    methyl propionate 264.16
    isopentyl acetate 710.62
    trichloroethylene 585.7
    n-nonanol 218.99
    cyclohexanol 339.69
    benzyl alcohol 167.44
    2-ethylhexanol 490.1
    isooctanol 199.98
    dipropyl ether 979.17
    1,2-dichlorobenzene 322.4
    ethyl lactate 68.96
    propylene carbonate 261.38
    n-methylformamide 64.66
    2-pentanol 274.33
    n-pentane 228.82
    1-propoxy-2-propanol 449.11
    1-methoxy-2-propyl acetate 562.36
    2-(2-methoxypropoxy) propanol 313.68
    mesitylene 296.19
    ε-caprolactone 460.05
    p-cymene 310.77
    epichlorohydrin 542.79
    1,1,1-trichloroethane 508.77
    2-aminoethanol 33.64
    morpholine-4-carbaldehyde 339.77
    sulfolane 288.12
    2,2,4-trimethylpentane 102.37
    2-methyltetrahydrofuran 1171.87
    n-hexyl acetate 452.83
    isooctane 106.55
    2-(2-butoxyethoxy)ethanol 390.28
    sec-butyl acetate 268.62
    tert-butyl acetate 471.68
    decalin 149.59
    glycerin 30.14
    diglyme 669.88
    acrylic acid 42.79
    isopropyl myristate 246.74
    n-butyric acid 234.8
    acetyl acetate 215.07
    di(2-ethylhexyl) phthalate 181.08
    ethyl propionate 254.05
    nitromethane 102.16
    1,2-diethoxyethane 763.33
    benzonitrile 256.22
    trioctyl phosphate 133.17
    1-bromopropane 558.62
    gamma-valerolactone 524.4
    n-decanol 168.08
    triethyl phosphate 173.98
    4-methyl-2-pentanol 220.99
    propionitrile 233.39
    vinylene carbonate 202.14
    1,1,2-trichlorotrifluoroethane 156.26
    DMS 222.89
    cumene 209.06
    2-octanol 164.03
    2-hexanone 317.47
    octyl acetate 275.54
    limonene 461.61
    1,2-dimethoxyethane 504.99
    ethyl orthosilicate 202.51
    tributyl phosphate 155.67
    diacetone alcohol 298.57
    N,N-dimethylaniline 286.17
    acrylonitrile 150.81
    aniline 342.34
    1,3-propanediol 89.03
    bromobenzene 525.56
    dibromomethane 512.08
    1,1,2,2-tetrachloroethane 485.7
    2-methyl-cyclohexyl acetate 412.21
    tetrabutyl urea 201.16
    diisobutyl methanol 273.72
    2-phenylethanol 337.68
    styrene 325.89
    dioctyl adipate 268.94
    dimethyl sulfate 82.87
    ethyl butyrate 514.47
    methyl lactate 65.84
    butyl lactate 152.64
    diethyl carbonate 261.78
    propanediol butyl ether 155.33
    triethyl orthoformate 364.52
    p-tert-butyltoluene 321.98
    methyl 4-tert-butylbenzoate 327.03
    morpholine 942.2
    tert-butylamine 367.62
    n-dodecanol 134.56
    dimethoxymethane 339.53
    ethylene carbonate 193.81
    cyrene 178.55
    2-ethoxyethyl acetate 375.13
    2-ethylhexyl acetate 653.53
    1,2,4-trichlorobenzene 343.57
    4-methylpyridine 667.15
    dibutyl ether 501.53
    2,6-dimethyl-4-heptanol 273.72
    DEF 356.29
    dimethyl isosorbide 595.17
    tetrachloroethylene 292.62
    eugenol 225.47
    triacetin 267.6
    span 80 296.39
    1,4-butanediol 25.43
    1,1-dichloroethane 446.12
    2-methyl-1-pentanol 219.6
    methyl formate 50.21
    2-methyl-1-butanol 258.41
    n-decane 96.93
    butyronitrile 375.27
    3,7-dimethyl-1-octanol 275.9
    1-chlorooctane 256.18
    1-chlorotetradecane 107.53
    n-nonane 99.74
    undecane 65.76
    tert-butylcyclohexane 144.85
    cyclooctane 180.67
    cyclopentanol 248.51
    tetrahydropyran 1379.81
    tert-amyl methyl ether 517.25
    2,5,8-trioxanonane 456.33
    1-hexene 470.45
    2-isopropoxyethanol 144.46
    2,2,2-trifluoroethanol 18.6
    methyl butyrate 276.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Ambrosia artemisiafolia Ambrosia artemisiafolia (Catinga de bode), fam. Asteraceae (Compositae) 10.3%
Shanqiu Anaphalis margaritacea (L.) Benth.et Hook.(Shanqiu),fam.Asteraceae (Comp.) 7.03%
Armoise flower 8008-93-3 Artemisia vulgaris L., fam. Asteraceae (Compositae) 1.53%
Basil (Nigeria) 2 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 0.15%
Blackcurrant bud, absolute 68606-81-5 Ribes nigrum L., fam. Grossulariaceae 0.83%
Blackcurrant bud 1 68606-81-5 Ribes nigrum L., fam. Grossulariaceae 0.25%
Caraway herb 8000-42-8 Carum carvi L., fam. Apiaceae (Umbelliferae) 0.1%
Caraway root 8000-42-8 Carum carvi L., fam. Apiaceae (Umbelliferae) 1.55%
Cedrela odorata Cedrela odorata L., fam. Meliaceae 0.12%
Eucalyptus citriodora (China) 1 8000-48-4 Eucalyptus citriodora Hook. f., fam. Myrtaceae 0.14%
Eupatorium maximilianii Eupatorium maximilianii (Erva de Sao Joao), fam. Asteraceae (Compositae) 6.24%
Hinoki leaf Chamaecyparis obtusa (Sieb. et Zucc.) Endl., fam. Cupressaceae 0.39%
Juniper berry 1 8012-91-7 Juniperus communis L., fam. Cupressaceae 1.6%
Dracocephalum kotschyi Dracocephalum kotschyi Boiss., fam. Lamiaceae (Labiatae) 0.3%
Ocimum micranthum (Brazil) Ocimum micranthum (common name: Alfavaca de campo), fam. Lamiaceae (Lab.) 3.57%
Stevia rebaudiana Stevia rebaudiana Bertoni, fam. Asteraceae (Compositae) 11.7%
Vanillosmopsis arborea leaf Vanillosmopsis arborea Baker, fam. Asteraceae (Compositae) 10.9%
Vassoura (Brazil) 1 Baccharis dracunculifolia DC., fam. Asteraceae (Compositae) 6.4%
Wedelia paludosa (Brazil) 1 Wedelia paludosa DC. (Mal-me-quer), fam. Asteraceae (Compositae) 2.4%
Xylopia aethiopica fruit (Cameroon) Xylopia aethiopica (Dunal) A. Richard, fam. Annonaceae 0.2%
Fingered Citron Citrus medica L., cultivar sarcodactylis (Noot.) Swingle, fam. Rutaceae 0.08%
Schinus molle berry 68917-52-2 Schinus molle L., fam. Anarcadiaceae 0.01%
Schinus molle leaf 68917-52-2 Schinus molle L., fam. Anarcadiaceae 0.02%
Cajuput (Vietnam) 2 8008-98-8 Melaleuca cajuputi Powell, var. cajuputi, fam. Myrtaceae 0.01%
Annual wormwood, leaf (U.S.A., Indiana) 1 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 0.4%
Annual wormwood, leaf (U.S.A., Indiana) 2 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 0.66%
Annual wormwood, flower (U.S.A., Indiana) 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 0.11%
Spilanthes acmella Spilanthes acmella Murr., fam. Asteraceae (Compositae) 3.06%
Vitex agnus-castus leaf (Finland) Vitex agnus-castus L., fam. Verbenaceae 0.1%
Croton adenocalyx (Marmeleiro) Croton adenocalyx A. DC., fam. Euphorbiaceae 10.57%
Trichostema dichotomum Trichostema dichotomum L., fam. Lamiaceae (Labiatae) 0.96%
Ageratum conyzoides flower (Fiji) 85480-32-6 Ageratum conyzoides L., fam. Asteraceae (Compositae) 0.1%
Ageratum conyzoides plant 1 (Fiji) 85480-32-6 Ageratum conyzoides L., fam. Asteraceae (Compositae) 0.25%
Ageratum conyzoides plant 2 (Fiji) 85480-32-6 Ageratum conyzoides L., fam. Asteraceae (Compositae) 0.4%
Seafennel 89997-98-8 Crithmum maritimum L., fam. Apiaceae (Umbelliferae) 0.79%
Synedrella nodiflora leaf (Fiji) Synedrella nodiflora (L.) 0.29%
Cascarilla 2 8007-06-5 Croton eluteria Bennett, fam. Euphorbiaceae 0.31%
Blackcurrant bud 2 68606-81-5 Ribes nigrum L., fam. Grossulariaceae 0.82%
Pistacia lentiscus (Spain) 1a leaf 90082-83-0 Pistacia lentiscus L., fam. Anacardiaceae 0.6%
Pistacia lentiscus (Spain) 1c ripe fruit 90082-83-0 Pistacia lentiscus L., fam. Anacardiaceae 0.02%
Tagetes 2 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.77%
Basil (Taiwan), leaf 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 0.01%
Basil (Taiwan), flower 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 0.08%
Basil (Taiwan), stem 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 0.23%
Basil (Taiwan), whole plant 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 0.05%
Basil (Taiwan) leaf & flower 8015-73-4 Ocimum basilicum L., fam. Lamiaceae (Labiatae) 0.04%
Star anise (China, Shangyou) 4 8007-70-3 Illicium verum Hooker fil., fam. Magnoliaceae (Illiciaceae) 0.5%
Ginger (China) 5 8007-08-7 Zingiber officinale Roscoe, fam. Zingiberaceae 0.05%
Juniper berry 4 8012-91-7 Juniperus communis L., fam. Cupressaceae 2.9%
Ageratum conyzoides (Ghana) 85480-32-6 Ageratum conyzoides L., fam. Asteraceae (Compositae) 0.67%