Galaxolide

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  • Identifiers

    CAS number
    1222-05-5

    Molecular formula
    C18H26O

    SMILES
    CC1COCC2=CC3=C(C=C12)C(C(C3(C)C)C)(C)C

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Musk 71.01%
    Sweet 54.77%
    Powdery 47.71%
    Amber 47.31%
    Floral 45.97%
    Woody 42.74%
    Dry 37.73%
    Animal 34.43%
    Fruity 30.68%
    Leathery 26.78%

    Scent© AI

  • Properties

    XLogP3-AA
    4.8

    Molecular weight
    258.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 57-58 °C
    • MP: -10 to 0 °C (mixture of isomers)

    Boiling point

    • BP: 128 °C at 0.8 mm Hg

    Flash point est.
    146.51 ˚C

    Solubility expt.

    • In water, 1.75 mg/L at 25 °C
    • In water, 1.65-1.99 mg/L at 25 °C and pH 5-9[ECHA; Search for Chemicals. 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexmethylindeno

  • Synonyms

    • Galaxolide
    • 1222-05-5
    • Abbalide
    • Galoxolide
    • Pearlide
    • 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene
    • Galaxolide White
    • HHCB
    • Cyclopenta[g]-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-
    • hexamethylindanopyran
    • Hexahydrohexamethyl cyclopentabenzopyran
    • 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran
    • 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran
    • EINECS 214-946-9
    • CCRIS 8402
    • CHEBI:83784
    • 4,6,6,7,8,8-hexamethyl-1,3,4,7-tetrahydrocyclopenta[g]isochromene
    • HSDB 7514
    • GALAXOLIDE [HSDB]
    • 14170060AT
    • Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran
    • EC 214-946-9
    • 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylindeno(5,6-c)pyran
    • 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta(g)-2-benzopyran
    • Cyclopenta(g)-2-benzopyran, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-
    • 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran
    • HHCB cpd
    • 4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta(g)isochromene
    • Galaxolide 1
    • UNII-14170060AT
    • Galaxolide 1+2
    • 4-(2-Aminoethyl)-5-nitropyrocatechol; 4-(2-Aminoethyl)-5-nitro-1,2-benzenediol; 4-(2-Aminoethyl)-5-nitrobenzene-1,2-diol
    • hexahydro-hexamethylcyclopenta-benzopyran
    • HHCB [MI]
    • SCHEMBL115118
    • CHEMBL1883305
    • DTXSID8027373
    • HEXAMETHYLINDANOPYRAN [INCI]
    • MFCD00072199
    • Galaxolide - Mixture of Diastereomers
    • AKOS016010343
    • FG23642
    • FG45940
    • s12385
    • NCGC00164416-01
    • NCGC00164416-02
    • 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (ca. 50% in Diethyl Phthalate)
    • CS-0152668
    • G0415
    • NS00008760
    • Galaxolide solution, 50% in diethyl phthalate
    • A891175
    • Q2268349
    • Hexahydro4,6,6,7,8,8hexamethylcyclopentagamma2benzopyran
    • 6-Oxa-1,1,2,3,3,8-hexamethyl-2,3,5,6,7,8-hexahydro-1H-benz
    • 1,3,4,6,7,8Hexahydro4,6,6,7,8,8hexamethylcyclopenta(g)2benzopyran
    • 1,3,4,6,7,8Hexahydro4,6,6,7,8,8hexamethylcyclopentagamma2benzopyran
    • 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene #
    • 4,6,6,7,8,8-hexamethyl-1H,3H,4H,6H,7H,8H-indeno[5,6-c]pyran
    • Cyclopenta(g)2benzopyran, 1,3,4,6,7,8hexahydro4,6,6,7,8,8hexamethyl
    • 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta[G]-2-benzopyran
    • 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran;1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-b enzopyrane;Abbalide
    • 214-946-9
    • 4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene, ca. 48-52% in diethyl phthalate

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 289.17
    methanol 229.97
    isopropanol 197.09
    water 2.16
    ethyl acetate 690.19
    n-propanol 352.36
    acetone 670.28
    n-butanol 331.94
    acetonitrile 509.34
    DMF 861.85
    toluene 1029.5
    isobutanol 275.29
    1,4-dioxane 1649.22
    methyl acetate 610.2
    THF 1521.5
    2-butanone 614.83
    n-pentanol 192.45
    sec-butanol 186.68
    n-hexane 87.93
    ethylene glycol 46.71
    NMP 801.48
    cyclohexane 266.03
    DMSO 266.42
    n-butyl acetate 647.24
    n-octanol 125.85
    chloroform 2156.27
    n-propyl acetate 428.91
    acetic acid 292.67
    dichloromethane 1899.97
    cyclohexanone 1106.69
    propylene glycol 55.13
    isopropyl acetate 500.66
    DMAc 647.14
    2-ethoxyethanol 310.14
    isopentanol 308.12
    n-heptane 80.23
    ethyl formate 424.28
    1,2-dichloroethane 1229.23
    n-hexanol 346.02
    2-methoxyethanol 449.53
    isobutyl acetate 388.5
    tetrachloromethane 550.99
    n-pentyl acetate 430.45
    transcutol 911.36
    n-heptanol 195.35
    ethylbenzene 420.78
    MIBK 412.78
    2-propoxyethanol 578.2
    tert-butanol 235.52
    MTBE 476.44
    2-butoxyethanol 354.24
    propionic acid 291.01
    o-xylene 496.94
    formic acid 98.8
    diethyl ether 719.32
    m-xylene 638.15
    p-xylene 535.4
    chlorobenzene 1054.71
    dimethyl carbonate 385.17
    n-octane 28.87
    formamide 193.45
    cyclopentanone 1121.38
    2-pentanone 562.21
    anisole 619.48
    cyclopentyl methyl ether 865.2
    gamma-butyrolactone 1161.72
    1-methoxy-2-propanol 309.31
    pyridine 1340.95
    3-pentanone 548.23
    furfural 1047.31
    n-dodecane 17.5
    diethylene glycol 313.75
    diisopropyl ether 291.77
    tert-amyl alcohol 184.28
    acetylacetone 664.8
    n-hexadecane 21.99
    acetophenone 514.79
    methyl propionate 568.68
    isopentyl acetate 657.23
    trichloroethylene 2132.56
    n-nonanol 125.82
    cyclohexanol 394.77
    benzyl alcohol 383.32
    2-ethylhexanol 252.46
    isooctanol 166.55
    dipropyl ether 406.79
    1,2-dichlorobenzene 910.69
    ethyl lactate 175.94
    propylene carbonate 747.28
    n-methylformamide 394.91
    2-pentanol 197.67
    n-pentane 101.65
    1-propoxy-2-propanol 360.87
    1-methoxy-2-propyl acetate 668.7
    2-(2-methoxypropoxy) propanol 271.13
    mesitylene 402.81
    ε-caprolactone 944.33
    p-cymene 277.98
    epichlorohydrin 1355.79
    1,1,1-trichloroethane 1187.11
    2-aminoethanol 121.42
    morpholine-4-carbaldehyde 1060.62
    sulfolane 796.17
    2,2,4-trimethylpentane 58.84
    2-methyltetrahydrofuran 1050.18
    n-hexyl acetate 457.65
    isooctane 53.09
    2-(2-butoxyethoxy)ethanol 348.38
    sec-butyl acetate 357.12
    tert-butyl acetate 516.9
    decalin 118.97
    glycerin 81.35
    diglyme 793.92
    acrylic acid 264.81
    isopropyl myristate 186.01
    n-butyric acid 431.39
    acetyl acetate 537.88
    di(2-ethylhexyl) phthalate 201.25
    ethyl propionate 407.39
    nitromethane 636.22
    1,2-diethoxyethane 557.76
    benzonitrile 657.89
    trioctyl phosphate 138.29
    1-bromopropane 679.37
    gamma-valerolactone 1463.73
    n-decanol 89.54
    triethyl phosphate 258.04
    4-methyl-2-pentanol 163.01
    propionitrile 475.1
    vinylene carbonate 876.49
    1,1,2-trichlorotrifluoroethane 654.31
    DMS 504.77
    cumene 263.71
    2-octanol 113.43
    2-hexanone 379.62
    octyl acetate 214.32
    limonene 306.3
    1,2-dimethoxyethane 753.01
    ethyl orthosilicate 262.03
    tributyl phosphate 169.17
    diacetone alcohol 327.2
    N,N-dimethylaniline 403.58
    acrylonitrile 531.61
    aniline 649.66
    1,3-propanediol 202.51
    bromobenzene 1244.13
    dibromomethane 1245.04
    1,1,2,2-tetrachloroethane 1485.22
    2-methyl-cyclohexyl acetate 424.29
    tetrabutyl urea 194.97
    diisobutyl methanol 166.8
    2-phenylethanol 488.86
    styrene 506.77
    dioctyl adipate 264.38
    dimethyl sulfate 408.52
    ethyl butyrate 446.92
    methyl lactate 196.67
    butyl lactate 270.89
    diethyl carbonate 352.16
    propanediol butyl ether 203.59
    triethyl orthoformate 397.94
    p-tert-butyltoluene 273.7
    methyl 4-tert-butylbenzoate 401.78
    morpholine 1429.2
    tert-butylamine 212.26
    n-dodecanol 67.97
    dimethoxymethane 781.44
    ethylene carbonate 773.22
    cyrene 352.46
    2-ethoxyethyl acetate 607.9
    2-ethylhexyl acetate 590.15
    1,2,4-trichlorobenzene 993.59
    4-methylpyridine 1289.16
    dibutyl ether 223.98
    2,6-dimethyl-4-heptanol 166.8
    DEF 616.51
    dimethyl isosorbide 645.51
    tetrachloroethylene 1105.65
    eugenol 367.53
    triacetin 419.64
    span 80 258.12
    1,4-butanediol 84.41
    1,1-dichloroethane 1027.15
    2-methyl-1-pentanol 194.52
    methyl formate 362.4
    2-methyl-1-butanol 281.31
    n-decane 33.9
    butyronitrile 503.14
    3,7-dimethyl-1-octanol 141.76
    1-chlorooctane 143.85
    1-chlorotetradecane 58.47
    n-nonane 31.18
    undecane 23.24
    tert-butylcyclohexane 91.6
    cyclooctane 111.69
    cyclopentanol 340.71
    tetrahydropyran 1401.65
    tert-amyl methyl ether 329.97
    2,5,8-trioxanonane 478.63
    1-hexene 222.8
    2-isopropoxyethanol 247.52
    2,2,2-trifluoroethanol 189.63
    methyl butyrate 465.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction