Ethyl Vanillin

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  • Identifiers

    CAS number
    121-32-4

    Molecular formula
    C9H10O3

    SMILES
    CCOC1=C(C=CC(=C1)C=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Vanilla 84.97%
    Sweet 80.18%
    Creamy 59.13%
    Spicy 54.86%
    Phenolic 49.38%
    Powdery 48.19%
    Balsamic 47.94%
    Caramellic 43.4%
    Floral 40.54%
    Smoky 39.04%

    Scent© AI

  • Properties

    XLogP3-AA
    1.6

    Molecular weight
    166.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 171 to 172 °F (NTP, 1992)
    • 76.7 °C
    • 76 - 78 °C

    Boiling point

    • 285 °C
    • 285.00 to 294.00 °C. @ 760.00 mm Hg

    Flash point est.
    130.72 ˚C

    Flash point expt.

    • 145 °C (293 °F) - closed cup

    Solubility expt.

    • Slightly soluble (NTP, 1992)
    • In water, 2,822 mg/L at 25 °C
    • Slightly soluble in water (1 g in 100 mL at 50 °C)
    • Soluble in ethanol, ether, benzene, chloroform
    • Freely soluble in ... solutions of alkali hydroxides; soluble in glycerol, propylene glycol
    • Solubility in 95% alcohol about 1 g/2 mL
    • 2.82 mg/mL at 25 °C
    • insoluble in water; soluble in organic solvents, oils
    • very soluble (1g in 2ml) (in ethanol)

  • Synonyms

    • 3-Ethoxy-4-hydroxybenzaldehyde
    • ETHYL VANILLIN
    • Ethylvanillin
    • 121-32-4
    • Ethylprotal
    • Bourbonal
    • Vanillal
    • Ethavan
    • Ethovan
    • Vanirom
    • Vanilal
    • Benzaldehyde, 3-ethoxy-4-hydroxy-
    • 4-Hydroxy-3-ethoxybenzaldehyde
    • Quantrovanil
    • Ethyl protal
    • Rhodiarome
    • Vanirome
    • Protocatechuic aldehyde ethyl ether
    • Vanillin, ethyl-
    • 2-Ethoxy-4-formylphenol
    • 3-Ethoxyprotocatechualdehyde
    • FEMA No. 2464
    • Arovanillon
    • Ethylprotocatechuic aldehyde
    • Vanbeenol
    • Ethyl vanillin (NF)
    • Ethyl vanillin [NF]
    • MFCD00006944
    • CCRIS 1346
    • HSDB 945
    • ethyl-vanillin
    • Ethylprotocatechualdehyde-3-ethyl ether
    • Vanillin,ethyl
    • 3-ETHOXY-4-HYDROXY-BENZALDEHYDE
    • UNII-YC9ST449YJ
    • NSC 1803
    • NSC-1803
    • EINECS 204-464-7
    • Ethyl protocatechuic aldehyde
    • YC9ST449YJ
    • NSC-67240
    • BRN 1073761
    • 3-ethoxy-4-hydroxy benzaldehyde
    • DTXSID5021968
    • CHEBI:48408
    • AI3-00786
    • Protocatechuic aldehyde 3-ethyl ether
    • J2.006K
    • ETHYL VANILLIN [II]
    • ETHYL VANILLIN [MI]
    • ETHYL VANILLIN [FCC]
    • ETHYL VANILLIN [FHFI]
    • ETHYL VANILLIN [HSDB]
    • VANILLIN,ETHYL [VANDF]
    • DTXCID901968
    • ETHYL VANILLIN [MART.]
    • ETHYL VANILLIN [USP-RS]
    • ETHYL VANILLIN [WHO-DD]
    • EC 204-464-7
    • NCGC00091583-02
    • WLN: VHR DQ CO2
    • ETHYL VANILLIN (II)
    • ETHYL VANILLIN (MART.)
    • ETHYL VANILLIN (USP-RS)
    • Quantrovanil, Vanillal
    • CAS-121-32-4
    • Aethylvanillin
    • Vanillin, ethyl
    • 2Ethoxy4formylphenol
    • BOUBONAL
    • Bourbonal ethyl protal
    • Ethyl vanillin, USAN?
    • FEMA Number 2464
    • Ethylvanillin (Standard)
    • Ethyl protocatechualdehyde
    • 3Ethoxyprotocatechualdehyde
    • 3Ethoxy4hydroxybenzaldehyde
    • 4Hydroxy3ethoxybenzaldehyde
    • SCHEMBL30247
    • 3ethoxy-4-hydroxybenzaldehyde
    • Benzaldehyde, 3ethoxy4hydroxy
    • MLS002454403
    • BIDD:ER0329
    • ETHYL VANILLIN [INCI]
    • 3-ethoxyl-4-hydroxybenzaldhyde
    • 5-ethoxy-4-hydroxybenzaldehyde
    • CHEMBL508676
    • Ethyl vanillin (Rhodiarome(R))
    • FEMA 2464
    • HY-B0940R
    • MSK3355
    • NSC1803
    • GLXC-10438
    • HMS2267D23
    • Ethyl vanillin, analytical standard
    • HY-B0940
    • NSC67240
    • Ethylprotocatechualdehyde3ethyl ether
    • Tox21_113535
    • Tox21_202125
    • Tox21_302903
    • BBL023011
    • s4568
    • STK353630
    • 3-(Ethoxy-d5)-4-hydroxybenzaldehyde
    • Ethyl vanillin, >=98%, FCC, FG
    • AKOS000119395
    • CCG-213720
    • CS-4409
    • FE34406
    • PS-4030
    • NCGC00091583-01
    • NCGC00091583-03
    • NCGC00091583-04
    • NCGC00256500-01
    • NCGC00259674-01
    • AC-10881
    • Ethyl proto-catechualdehyde-3-ethyl ether
    • NCI60_001511
    • SMR001252229
    • SY011364
    • DB-061895
    • E0050
    • NS00008588
    • EN300-18278
    • D01086
    • D70878
    • AB00949623_05

  • Applications

    Ethyl vanillin (CAS 121-32-4) is a powerful synthetic flavoring agent roughly three to four times stronger than natural vanillin, which explains its extensive use in food products such as chocolate, confectionery, baked goods, ice cream, breakfast cereals, beverages, condiments and many non-dairy formulations, where its heat and pH stability preserve the rich vanilla nuance during baking, pasteurization and extrusion; in pharmaceuticals, ethyl vanillin is added to cough syrups, chewable tablets and vitamin powders to mask unpleasant drug tastes; in the fragrance and cosmetic industry the molecule supplies a warm, sweet and persistent note in oriental perfumes, scented candles, soaps, shower gels, lipsticks, deodorants and e-cigarette liquids, helping to bridge woody, amber and caramel accords; additionally, ethyl vanillin functions as a chromatographic reference standard, an intermediate in drug synthesis, a palatability enhancer for premium animal feed and a scent-stabilizing additive in polymer packaging, thanks to its high purity, good solubility in ethanol, propylene glycol and oily carriers, and its GRAS safety status recognized by the FDA.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 583.12
    methanol 1273.76
    isopropanol 297.09
    water 1.32
    ethyl acetate 513.6
    n-propanol 230.19
    acetone 1396.56
    n-butanol 142.84
    acetonitrile 1012.16
    DMF 1271.48
    toluene 65.93
    isobutanol 118.91
    1,4-dioxane 586.75
    methyl acetate 875.27
    THF 823.29
    2-butanone 653.0
    n-pentanol 112.81
    sec-butanol 158.11
    n-hexane 4.54
    ethylene glycol 167.07
    NMP 664.19
    cyclohexane 9.7
    DMSO 2755.9
    n-butyl acetate 392.17
    n-octanol 63.09
    chloroform 398.6
    n-propyl acetate 436.23
    acetic acid 509.73
    dichloromethane 939.32
    cyclohexanone 505.76
    propylene glycol 87.16
    isopropyl acetate 171.09
    DMAc 691.25
    2-ethoxyethanol 369.65
    isopentanol 105.71
    n-heptane 7.5
    ethyl formate 491.88
    1,2-dichloroethane 720.27
    n-hexanol 108.69
    2-methoxyethanol 570.7
    isobutyl acetate 137.37
    tetrachloromethane 42.94
    n-pentyl acetate 123.17
    transcutol 747.95
    n-heptanol 46.03
    ethylbenzene 61.69
    MIBK 150.71
    2-propoxyethanol 250.0
    tert-butanol 284.07
    MTBE 202.35
    2-butoxyethanol 121.36
    propionic acid 297.2
    o-xylene 66.98
    formic acid 297.06
    diethyl ether 237.06
    m-xylene 56.31
    p-xylene 84.85
    chlorobenzene 167.81
    dimethyl carbonate 201.94
    n-octane 4.12
    formamide 890.6
    cyclopentanone 847.18
    2-pentanone 370.13
    anisole 208.91
    cyclopentyl methyl ether 197.15
    gamma-butyrolactone 1120.92
    1-methoxy-2-propanol 262.18
    pyridine 431.47
    3-pentanone 254.59
    furfural 732.83
    n-dodecane 4.74
    diethylene glycol 244.43
    diisopropyl ether 40.23
    tert-amyl alcohol 201.2
    acetylacetone 463.24
    n-hexadecane 5.49
    acetophenone 238.89
    methyl propionate 394.45
    isopentyl acetate 217.31
    trichloroethylene 970.96
    n-nonanol 53.16
    cyclohexanol 99.62
    benzyl alcohol 156.64
    2-ethylhexanol 69.01
    isooctanol 39.59
    dipropyl ether 100.31
    1,2-dichlorobenzene 161.64
    ethyl lactate 123.89
    propylene carbonate 428.28
    n-methylformamide 985.81
    2-pentanol 83.28
    n-pentane 4.43
    1-propoxy-2-propanol 155.87
    1-methoxy-2-propyl acetate 209.48
    2-(2-methoxypropoxy) propanol 138.69
    mesitylene 36.23
    ε-caprolactone 422.21
    p-cymene 42.67
    epichlorohydrin 1046.95
    1,1,1-trichloroethane 287.08
    2-aminoethanol 171.92
    morpholine-4-carbaldehyde 582.93
    sulfolane 1083.56
    2,2,4-trimethylpentane 5.35
    2-methyltetrahydrofuran 446.69
    n-hexyl acetate 162.98
    isooctane 3.97
    2-(2-butoxyethoxy)ethanol 191.19
    sec-butyl acetate 157.97
    tert-butyl acetate 159.19
    decalin 10.04
    glycerin 141.96
    diglyme 464.58
    acrylic acid 284.0
    isopropyl myristate 55.77
    n-butyric acid 250.49
    acetyl acetate 235.58
    di(2-ethylhexyl) phthalate 53.5
    ethyl propionate 258.55
    nitromethane 1855.13
    1,2-diethoxyethane 237.2
    benzonitrile 257.41
    trioctyl phosphate 42.34
    1-bromopropane 181.52
    gamma-valerolactone 747.58
    n-decanol 41.24
    triethyl phosphate 82.08
    4-methyl-2-pentanol 42.79
    propionitrile 389.96
    vinylene carbonate 397.36
    1,1,2-trichlorotrifluoroethane 386.56
    DMS 204.0
    cumene 42.02
    2-octanol 37.65
    2-hexanone 292.99
    octyl acetate 74.66
    limonene 62.71
    1,2-dimethoxyethane 649.81
    ethyl orthosilicate 63.95
    tributyl phosphate 59.5
    diacetone alcohol 194.4
    N,N-dimethylaniline 118.34
    acrylonitrile 651.46
    aniline 128.63
    1,3-propanediol 226.18
    bromobenzene 159.21
    dibromomethane 444.87
    1,1,2,2-tetrachloroethane 539.46
    2-methyl-cyclohexyl acetate 111.59
    tetrabutyl urea 81.93
    diisobutyl methanol 40.49
    2-phenylethanol 121.34
    styrene 88.55
    dioctyl adipate 91.24
    dimethyl sulfate 348.36
    ethyl butyrate 221.33
    methyl lactate 144.14
    butyl lactate 96.51
    diethyl carbonate 158.58
    propanediol butyl ether 131.58
    triethyl orthoformate 105.58
    p-tert-butyltoluene 37.3
    methyl 4-tert-butylbenzoate 122.38
    morpholine 594.07
    tert-butylamine 102.56
    n-dodecanol 31.63
    dimethoxymethane 509.14
    ethylene carbonate 316.53
    cyrene 153.45
    2-ethoxyethyl acetate 205.36
    2-ethylhexyl acetate 162.55
    1,2,4-trichlorobenzene 194.45
    4-methylpyridine 352.98
    dibutyl ether 88.49
    2,6-dimethyl-4-heptanol 40.49
    DEF 398.31
    dimethyl isosorbide 233.33
    tetrachloroethylene 323.57
    eugenol 124.09
    triacetin 176.79
    span 80 91.71
    1,4-butanediol 103.41
    1,1-dichloroethane 435.8
    2-methyl-1-pentanol 87.48
    methyl formate 945.11
    2-methyl-1-butanol 97.35
    n-decane 7.29
    butyronitrile 285.03
    3,7-dimethyl-1-octanol 59.96
    1-chlorooctane 41.11
    1-chlorotetradecane 17.0
    n-nonane 6.67
    undecane 5.74
    tert-butylcyclohexane 8.56
    cyclooctane 3.84
    cyclopentanol 161.21
    tetrahydropyran 351.16
    tert-amyl methyl ether 129.4
    2,5,8-trioxanonane 255.13
    1-hexene 34.21
    2-isopropoxyethanol 204.3
    2,2,2-trifluoroethanol 192.9
    methyl butyrate 425.76

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction