Ethyl Salicylate

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    118-61-6

    Molecular formula
    C9H10O3

    SMILES
    CCOC(=O)C1=CC=CC=C1O

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1268.0
    • Carbowax: 1816.0

  • Odor profile

    Sweet 76.12%
    Floral 74.27%
    Fruity 71.95%
    Herbal 52.83%
    Green 51.27%
    Balsamic 45.02%
    Phenolic 40.92%
    Cherry 40.49%
    Anisic 39.15%
    Spicy 37.8%

    Scent© AI

  • Properties

    XLogP3-AA
    3.0

    Molecular weight
    166.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • 1.3 °C

    Boiling point

    • 233.00 to 235.00 °C. @ 760.00 mm Hg

    Flash point est.
    119.11 ˚C

    Solubility expt.

    • slightly soluble in water, glycerol; soluble in organic solvents, oils
    • miscible at room temperature (in ethanol)

  • Synonyms

    • Ethyl salicylate
    • ETHYL 2-HYDROXYBENZOATE
    • 118-61-6
    • Sal ethyl
    • Mesotol
    • Salotan
    • Salicylic ether
    • Ethyl o-hydroxybenzoate
    • Benzoic acid, 2-hydroxy-, ethyl ester
    • Salicylic acid, ethyl ester
    • Salicylic ethyl ester
    • 2-Hydroxybenzoic acid ethyl ester
    • o-(Ethoxycarbonyl)phenol
    • Sal ether
    • Salicyclic acid, ethyl ester
    • FEMA No. 2458
    • NSC 8209
    • EINECS 204-265-5
    • MFCD00002215
    • BRN 0907659
    • 555U6TZ2MV
    • DTXSID1021958
    • AI3-00513
    • NSC-8209
    • Benzoic acid, hydroxy-, ethyl ester
    • 2-ETHOXYCARBONYLPHENOL
    • ETHYL SALICYLATE [MI]
    • ETHYL SALICYLATE [FCC]
    • DTXCID601958
    • ETHYL SALICYLATE [FHFI]
    • CHEBI:88839
    • ETHYL SALICYLATE [MART.]
    • ETHYL SALICYLATE [WHO-DD]
    • 4-10-00-00149 (Beilstein Handbook Reference)
    • NCGC00181161-01
    • NCGC00181161-02
    • NCGC00181161-03
    • 1321-50-2
    • METHYL SALICYLATE IMPURITY F [EP IMPURITY]
    • ETHYL SALICYLATE (MART.)
    • CAS-118-61-6
    • METHYL SALICYLATE IMPURITY F (EP IMPURITY)
    • UNII-555U6TZ2MV
    • Salstan
    • Ethyl salicyclate
    • Ethyl ohydroxybenzoate
    • Ethyl 2hydroxybenzoate
    • o(Ethoxycarbonyl)phenol
    • Ethyl salicylate, 99%
    • 2-hydroxyethylbenzoic acid
    • Salicylic Acid Ethyl Ester
    • WLN: QR BVO2
    • SCHEMBL39622
    • 2Hydroxybenzoic acid ethyl ester
    • CHEMBL2251610
    • FEMA 2458
    • NSC8209
    • 2-hydroxy-benzoic acid ethyl ester
    • Tox21_112764
    • Tox21_113454
    • Benzoic acid, 2hydroxy, ethyl ester
    • Ethyl salicylate, analytical standard
    • STK397384
    • AKOS000120529
    • Tox21_112764_1
    • DB15576
    • DS-6424
    • Ethyl salicylate, >=99%, FCC, FG
    • CS-0016063
    • NS00012461
    • S0011
    • EN300-16108
    • D70269
    • Q408120
    • SR-01000944712
    • SR-01000944712-1
    • Z53833295
    • F0001-0297
    • 204-265-5

  • Applications

    Ethyl salicylate (CAS 118-61-6) is a fragrant ester of salicylic acid possessing the sweet minty aroma of wintergreen oil and is widely employed as a flavoring agent in chewing gum, toothpaste, beverages and cough syrups; it acts as a fixative and scent modifier in perfumes, shampoos, soaps, deodorants and sunscreen formulations thanks to its UV-absorbing salicylate core; in pharmaceuticals it functions both as a masking excipient and as a topical analgesic-anti-inflammatory ingredient in throat sprays, muscle rubs and dermatological creams; industrially it serves as a solvent for cellulose nitrate, an intermediate in the synthesis of flavors, dyes and pesticides, a reference standard in analytical chemistry, and a natural-tasting wintergreen surrogate in botanical and laboratory studies.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 510.06
    methanol 610.64
    isopropanol 368.24
    water 0.74
    ethyl acetate 218.13
    n-propanol 352.67
    acetone 542.95
    n-butanol 324.58
    acetonitrile 322.24
    DMF 1746.92
    toluene 56.67
    isobutanol 220.53
    1,4-dioxane 532.76
    methyl acetate 283.83
    THF 781.82
    2-butanone 327.22
    n-pentanol 220.13
    sec-butanol 283.29
    n-hexane 11.35
    ethylene glycol 189.44
    NMP 854.71
    cyclohexane 22.04
    DMSO 1398.7
    n-butyl acetate 156.01
    n-octanol 118.85
    chloroform 528.82
    n-propyl acetate 146.69
    acetic acid 422.71
    dichloromethane 602.96
    cyclohexanone 432.22
    propylene glycol 219.37
    isopropyl acetate 118.74
    DMAc 706.51
    2-ethoxyethanol 291.3
    isopentanol 209.68
    n-heptane 9.89
    ethyl formate 247.78
    1,2-dichloroethane 411.6
    n-hexanol 184.72
    2-methoxyethanol 724.19
    isobutyl acetate 81.36
    tetrachloromethane 39.65
    n-pentyl acetate 91.31
    transcutol 451.65
    n-heptanol 92.51
    ethylbenzene 50.84
    MIBK 145.02
    2-propoxyethanol 300.27
    tert-butanol 394.32
    MTBE 161.78
    2-butoxyethanol 166.94
    propionic acid 280.38
    o-xylene 54.88
    formic acid 140.54
    diethyl ether 165.42
    m-xylene 57.04
    p-xylene 66.24
    chlorobenzene 150.92
    dimethyl carbonate 165.31
    n-octane 6.75
    formamide 307.22
    cyclopentanone 604.37
    2-pentanone 263.71
    anisole 155.05
    cyclopentyl methyl ether 225.21
    gamma-butyrolactone 687.1
    1-methoxy-2-propanol 500.32
    pyridine 318.56
    3-pentanone 166.5
    furfural 515.58
    n-dodecane 10.36
    diethylene glycol 315.56
    diisopropyl ether 43.3
    tert-amyl alcohol 272.81
    acetylacetone 291.99
    n-hexadecane 11.66
    acetophenone 160.22
    methyl propionate 248.35
    isopentyl acetate 122.03
    trichloroethylene 659.39
    n-nonanol 99.06
    cyclohexanol 253.02
    benzyl alcohol 167.62
    2-ethylhexanol 91.83
    isooctanol 74.84
    dipropyl ether 77.51
    1,2-dichlorobenzene 141.13
    ethyl lactate 124.08
    propylene carbonate 352.02
    n-methylformamide 635.16
    2-pentanol 181.43
    n-pentane 10.87
    1-propoxy-2-propanol 191.53
    1-methoxy-2-propyl acetate 168.73
    2-(2-methoxypropoxy) propanol 163.75
    mesitylene 43.34
    ε-caprolactone 327.04
    p-cymene 42.43
    epichlorohydrin 661.68
    1,1,1-trichloroethane 234.75
    2-aminoethanol 283.97
    morpholine-4-carbaldehyde 563.97
    sulfolane 921.38
    2,2,4-trimethylpentane 10.01
    2-methyltetrahydrofuran 355.83
    n-hexyl acetate 161.7
    isooctane 9.36
    2-(2-butoxyethoxy)ethanol 240.23
    sec-butyl acetate 81.25
    tert-butyl acetate 143.32
    decalin 15.93
    glycerin 309.34
    diglyme 420.1
    acrylic acid 278.7
    isopropyl myristate 70.43
    n-butyric acid 331.38
    acetyl acetate 144.63
    di(2-ethylhexyl) phthalate 71.49
    ethyl propionate 131.92
    nitromethane 719.62
    1,2-diethoxyethane 139.51
    benzonitrile 191.97
    trioctyl phosphate 62.35
    1-bromopropane 172.27
    gamma-valerolactone 572.3
    n-decanol 77.4
    triethyl phosphate 71.5
    4-methyl-2-pentanol 91.9
    propionitrile 248.52
    vinylene carbonate 325.62
    1,1,2-trichlorotrifluoroethane 429.01
    DMS 141.92
    cumene 42.75
    2-octanol 73.95
    2-hexanone 162.91
    octyl acetate 92.06
    limonene 63.66
    1,2-dimethoxyethane 481.91
    ethyl orthosilicate 61.25
    tributyl phosphate 69.98
    diacetone alcohol 246.98
    N,N-dimethylaniline 108.36
    acrylonitrile 349.06
    aniline 153.23
    1,3-propanediol 404.98
    bromobenzene 137.16
    dibromomethane 366.96
    1,1,2,2-tetrachloroethane 525.56
    2-methyl-cyclohexyl acetate 98.95
    tetrabutyl urea 103.69
    diisobutyl methanol 61.86
    2-phenylethanol 139.97
    styrene 69.7
    dioctyl adipate 104.09
    dimethyl sulfate 298.29
    ethyl butyrate 115.77
    methyl lactate 217.89
    butyl lactate 104.81
    diethyl carbonate 93.1
    propanediol butyl ether 191.63
    triethyl orthoformate 79.96
    p-tert-butyltoluene 41.97
    methyl 4-tert-butylbenzoate 142.55
    morpholine 584.98
    tert-butylamine 183.93
    n-dodecanol 61.86
    dimethoxymethane 511.21
    ethylene carbonate 250.89
    cyrene 189.86
    2-ethoxyethyl acetate 121.97
    2-ethylhexyl acetate 90.06
    1,2,4-trichlorobenzene 172.0
    4-methylpyridine 263.04
    dibutyl ether 91.88
    2,6-dimethyl-4-heptanol 61.86
    DEF 367.63
    dimethyl isosorbide 242.54
    tetrachloroethylene 257.05
    eugenol 159.03
    triacetin 146.21
    span 80 148.9
    1,4-butanediol 156.09
    1,1-dichloroethane 326.79
    2-methyl-1-pentanol 152.68
    methyl formate 440.01
    2-methyl-1-butanol 195.78
    n-decane 14.03
    butyronitrile 254.55
    3,7-dimethyl-1-octanol 99.47
    1-chlorooctane 65.8
    1-chlorotetradecane 29.81
    n-nonane 12.52
    undecane 11.92
    tert-butylcyclohexane 15.45
    cyclooctane 6.89
    cyclopentanol 318.24
    tetrahydropyran 391.75
    tert-amyl methyl ether 128.69
    2,5,8-trioxanonane 307.43
    1-hexene 55.06
    2-isopropoxyethanol 179.66
    2,2,2-trifluoroethanol 131.1
    methyl butyrate 205.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Cassie absolute (blossom) 8023-82-3 Acacia farnesiana (L.) Willd., fam. Mimosaceae (Leguminosae) 0.09%
Easter Lily, Picked Flower Headspace A Lilium candidum L., fam. Liliaceae 0.1%
Easter Lily, Picked Flower Headspace B Lilium candidum L., fam. Liliaceae 0.4%
Narcissus tazetta absolute 2 8023-75-4 Narcissus tazetta L., fam. Amaryllidaceae 0.1%
Wintergreen (China) 68917-75-9 Gaultheria procumbens L., fam. Ericaceae 0.1%
Genet headspace 2 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.01%
Daphne tangutica flower concrete (China) Daphne tangutica Maxim., fam. Thymelaeaceae 0.14%
Couroupita guaianensis flower (Malaysia) Couroupita guianensis Auble, fam. Lecythidaceae 0.4%
Coleus aromaticus (Pakistan) 1 Coleus aromaticus Benth. (wild oregano), fam. Lamiaceae (Labiatae) 5.5%
Lawsonia inermis flower 1b Lawsonia inermis L. (syn. L. alba Lam.), fam. Lytraceae 0.1%
Acacia praecox flower (Argentina) Acacia praecox Gris., fam. Mimosaceae (Leguminosae) 1.1%
Tulip sylvestre headspace cv. "Lack van Rijn" Tulipa sylvestris L. cultivar "Lack van Rijn", fam. Liliaceae 0.1%
Cordia nitida fruit Cordia nitida Vahl., fam. Borraginaceae 0.5%
Alstonia scholaris Alstonia scholaris (L.) R.Br., fam. Apocynaceae 0.3%
Decalepis hamiltonii root (India) Decalepis hamiltonii (Wight & Arn), fam. Asclepiadaceae 0.04%
Viola etrusca (Italy) 1a hydrodistilled oil Viola etrusca Erben, fam. Violaceae 0.01%
Birch, Sweet (USA - Pennsylvania) Betula lenta L., fam. Betulaceae 0.12%