Ethyl propionate

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  • Identifiers

    CAS number
    105-37-3

    Molecular formula
    C5H10O2

    SMILES
    CCC(=O)OCC

    Safety labels

    Flammable
    Flammable

    Retention indicies (RI)

    • DB5: 709.0
    • Carbowax: 943.33

  • Odor profile

    Fruity 96.06%
    Ethereal 85.14%
    Sweet 82.29%
    Rummy 69.59%
    Pineapple 59.35%
    Apple 58.5%
    Banana 56.62%
    Winey 55.2%
    Green 45.12%
    Pear 42.37%

    Scent© AI

  • Properties

    XLogP3-AA
    1.2

    Molecular weight
    102.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -99 °F (USCG, 1999)
    • -73.9 °C
    • -73 °C

    Boiling point

    • 210 °F at 760 mmHg (USCG, 1999)
    • 99.2 °C
    • 98.00 to 100.00 °C. @ 760.00 mm Hg

    Flash point est.
    6.29 ˚C

    Flash point expt.

    • 54 °F (USCG, 1999)
    • 12 °C (CLOSED CUP)

    Solubility expt.

    • SOLUBLE IN MOST ORGANIC SOLVENTS
    • Soluble in alcohol and ether
    • Miscible in ethanol and ethyl ether; soluble in acetone
    • In water, 19,200 mg/l @ 25 °C
    • 19.2 mg/mL at 20 °C
    • Soluble in most fixed oils and propylene glycol, soluble in water (1ml in 42ml)

  • Synonyms

    • ETHYL PROPIONATE
    • 105-37-3
    • Ethyl propanoate
    • Propanoic acid, ethyl ester
    • Propionic ether
    • Propionic ester
    • Propionic acid, ethyl ester
    • Ethylpropionate
    • Propionate d'ethyle
    • Propionic acid ethyl ester
    • Ethyl n-propionate
    • Propanoic acid ethyl ester
    • FEMA No. 2456
    • Ethyl propionate (natural)
    • NSC 8848
    • Ethylester kyseliny propionove
    • HSDB 5366
    • UNII-AT9K8FY49U
    • EINECS 203-291-4
    • AT9K8FY49U
    • MFCD00009308
    • BRN 0506287
    • DTXSID1040110
    • CHEBI:41330
    • AI3-24354
    • NSC-8848
    • Ethyl ester of propanoic acid
    • DTXCID9020110
    • 4-02-00-00705 (Beilstein Handbook Reference)
    • Ethyl Propionate(Propionic Acid Ethyl Ester)
    • Propionic acid-ethyl ester
    • WE(2:0/3:0)
    • ethylpropanoate
    • Propionate d'ethyle [French]
    • UN1195
    • Ethylester kyseliny propionove [Czech]
    • ethyl proprionate
    • n-Ethyl propanoate
    • Ethyl propionate, 99%
    • C2H5COOC2H5
    • propionic acid ethyl ester-
    • SCHEMBL16045
    • WLN: 2VO2
    • CHEMBL44115
    • ETHYL PROPIONATE [MI]
    • ETHYL PROPIONATE [FCC]
    • ETHYL PROPIONATE [FHFI]
    • FEMA 2456
    • MSK6712
    • NSC8848
    • HY-Y0812
    • Tox21_301081
    • Ethyl propionate, analytical standard
    • LMFA07010411
    • STL280279
    • AKOS003216229
    • AKOS008947789
    • Ethyl propionate, >=97%, FCC, FG
    • UN 1195
    • NCGC00248281-01
    • NCGC00254982-01
    • CAS-105-37-3
    • FE159333
    • LS-13076
    • DB-040613
    • NS00012457
    • P0505
    • EN300-16126
    • Ethyl propionate, natural, >=97%, FCC, FG
    • Ethyl propionate [UN1195] [Flammable liquid]
    • Q2740687
    • Ethyl propionate LBG-29964, LBG-29965 battery grade
    • F0001-0104
    • Propionic acid-ethyl ester 1000 microg/mL in Acetonitrile
    • InChI=1/C5H10O2/c1-3-5(6)7-4-2/h3-4H2,1-2H
    • 203-291-4

  • Applications

    Ethyl propionate (CAS 105-37-3) is a naturally occurring fruity ester found in durian, pineapple and wine, widely used as a flavouring agent in candies, baked goods and beverages, and as a medium-evaporation solvent for automotive coatings, printing inks, wood varnishes, adhesives and 3D-jet inks; in pharmaceuticals it acts as an excipient, drug-delivery carrier and extraction solvent for semisynthetic antibiotics, veterinary drugs and biopesticides; it is also employed as an analytical standard, intermediate for flavour-fragrance synthesis, food-grade protective coating, industrial cleaner, accelerator for curing agents in unsaturated polyesters, and gloss-enhancing additive in artificial leather manufacturing.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2245.63
    methanol 3718.2
    isopropanol 1690.37
    water 44.12
    ethyl acetate 2013.85
    n-propanol 1682.8
    acetone 3136.84
    n-butanol 1456.4
    acetonitrile 4189.73
    DMF 4178.69
    toluene 784.33
    isobutanol 1340.6
    1,4-dioxane 2692.07
    methyl acetate 2323.64
    THF 2645.4
    2-butanone 2484.1
    n-pentanol 1204.87
    sec-butanol 1655.14
    n-hexane 437.12
    ethylene glycol 705.87
    NMP 3746.3
    cyclohexane 378.24
    DMSO 3789.66
    n-butyl acetate 1224.93
    n-octanol 787.62
    chloroform 5115.54
    n-propyl acetate 1356.45
    acetic acid 3647.76
    dichloromethane 5932.59
    cyclohexanone 2657.27
    propylene glycol 702.0
    isopropyl acetate 1124.16
    DMAc 3475.85
    2-ethoxyethanol 1903.88
    isopentanol 1188.5
    n-heptane 181.08
    ethyl formate 1747.88
    1,2-dichloroethane 3367.6
    n-hexanol 897.43
    2-methoxyethanol 2935.59
    isobutyl acetate 711.65
    tetrachloromethane 1002.79
    n-pentyl acetate 1005.61
    transcutol 3591.31
    n-heptanol 491.32
    ethylbenzene 653.6
    MIBK 966.3
    2-propoxyethanol 1603.82
    tert-butanol 1817.72
    MTBE 1631.12
    2-butoxyethanol 945.29
    propionic acid 2052.61
    o-xylene 658.47
    formic acid 1621.66
    diethyl ether 1772.51
    m-xylene 565.55
    p-xylene 980.56
    chlorobenzene 1683.93
    dimethyl carbonate 711.04
    n-octane 107.84
    formamide 1836.42
    cyclopentanone 2997.79
    2-pentanone 1768.59
    anisole 1338.66
    cyclopentyl methyl ether 1425.16
    gamma-butyrolactone 3426.24
    1-methoxy-2-propanol 1891.99
    pyridine 2550.17
    3-pentanone 1530.32
    furfural 3581.6
    n-dodecane 94.27
    diethylene glycol 1159.77
    diisopropyl ether 523.32
    tert-amyl alcohol 1773.31
    acetylacetone 1991.24
    n-hexadecane 105.33
    acetophenone 1323.58
    methyl propionate 1517.14
    isopentyl acetate 957.37
    trichloroethylene 5505.29
    n-nonanol 597.68
    cyclohexanol 1315.8
    benzyl alcohol 1148.2
    2-ethylhexanol 590.39
    isooctanol 417.81
    dipropyl ether 740.36
    1,2-dichlorobenzene 1637.39
    ethyl lactate 615.22
    propylene carbonate 1775.46
    n-methylformamide 2686.5
    2-pentanol 1083.65
    n-pentane 314.54
    1-propoxy-2-propanol 990.35
    1-methoxy-2-propyl acetate 900.04
    2-(2-methoxypropoxy) propanol 872.38
    mesitylene 409.83
    ε-caprolactone 2377.05
    p-cymene 367.25
    epichlorohydrin 3466.01
    1,1,1-trichloroethane 2756.64
    2-aminoethanol 1137.77
    morpholine-4-carbaldehyde 3334.83
    sulfolane 3980.64
    2,2,4-trimethylpentane 215.14
    2-methyltetrahydrofuran 2430.24
    n-hexyl acetate 1552.78
    isooctane 130.48
    2-(2-butoxyethoxy)ethanol 1160.07
    sec-butyl acetate 816.12
    tert-butyl acetate 1100.33
    decalin 252.27
    glycerin 1011.58
    diglyme 2206.3
    acrylic acid 2100.79
    isopropyl myristate 471.64
    n-butyric acid 2155.12
    acetyl acetate 1415.37
    di(2-ethylhexyl) phthalate 471.15
    ethyl propionate 1183.83
    nitromethane 5398.06
    1,2-diethoxyethane 1392.22
    benzonitrile 2092.99
    trioctyl phosphate 341.91
    1-bromopropane 1898.25
    gamma-valerolactone 3626.83
    n-decanol 406.96
    triethyl phosphate 445.39
    4-methyl-2-pentanol 539.49
    propionitrile 2447.56
    vinylene carbonate 2021.62
    1,1,2-trichlorotrifluoroethane 2448.83
    DMS 1102.08
    cumene 486.59
    2-octanol 505.75
    2-hexanone 1438.95
    octyl acetate 660.92
    limonene 519.35
    1,2-dimethoxyethane 2997.88
    ethyl orthosilicate 405.92
    tributyl phosphate 511.06
    diacetone alcohol 1192.37
    N,N-dimethylaniline 941.03
    acrylonitrile 3347.95
    aniline 1171.77
    1,3-propanediol 1494.2
    bromobenzene 1726.13
    dibromomethane 3599.62
    1,1,2,2-tetrachloroethane 4077.02
    2-methyl-cyclohexyl acetate 666.48
    tetrabutyl urea 629.63
    diisobutyl methanol 340.49
    2-phenylethanol 820.18
    styrene 920.08
    dioctyl adipate 696.99
    dimethyl sulfate 1297.42
    ethyl butyrate 924.85
    methyl lactate 808.31
    butyl lactate 732.37
    diethyl carbonate 660.64
    propanediol butyl ether 1025.13
    triethyl orthoformate 560.13
    p-tert-butyltoluene 337.71
    methyl 4-tert-butylbenzoate 886.36
    morpholine 2870.96
    tert-butylamine 1233.31
    n-dodecanol 301.86
    dimethoxymethane 1837.86
    ethylene carbonate 1553.46
    cyrene 806.89
    2-ethoxyethyl acetate 1167.7
    2-ethylhexyl acetate 783.29
    1,2,4-trichlorobenzene 1786.85
    4-methylpyridine 2896.42
    dibutyl ether 895.1
    2,6-dimethyl-4-heptanol 340.49
    DEF 2470.3
    dimethyl isosorbide 1228.22
    tetrachloroethylene 2667.74
    eugenol 941.92
    triacetin 1204.16
    span 80 765.87
    1,4-butanediol 751.86
    1,1-dichloroethane 3154.14
    2-methyl-1-pentanol 1097.58
    methyl formate 1993.29
    2-methyl-1-butanol 1292.93
    n-decane 152.15
    butyronitrile 2200.51
    3,7-dimethyl-1-octanol 651.03
    1-chlorooctane 556.23
    1-chlorotetradecane 219.3
    n-nonane 164.92
    undecane 114.61
    tert-butylcyclohexane 271.23
    cyclooctane 138.52
    cyclopentanol 1553.68
    tetrahydropyran 2201.9
    tert-amyl methyl ether 1312.23
    2,5,8-trioxanonane 1359.07
    1-hexene 1045.61
    2-isopropoxyethanol 1199.19
    2,2,2-trifluoroethanol 1177.84
    methyl butyrate 1741.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Artabotrys hexapetalus flower headspace (China) Artabotrys hexapetalus (L.) f. Bhandari, fam. Annonaceae 0.37%
Guava fruit (Cuba) 91770-12-6 Psidium guajava L., fam. Myrtaceae 0.1%
Ambarella fruit (Brazil) Spondias cytherea Sonnerat, fam. Anarcardiaceae 0.5%