Dipropylene Glycol

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  • Identifiers

    CAS number
    25265-71-8

    Molecular formula
    C12H28O6

    SMILES
    CC(CO)OC(C)CO.CC(COCC(C)O)O

    Safety labels

  • Odor profile

    Fragrance
    Fruity 42.77%
    Alcoholic 39.96%
    Odorless 39.6%
    Buttery 32.22%
    Ethereal 31.2%
    Sweet 25.23%
    Oily 23.96%
    Solvent 22.86%
    Fermented 20.78%
    Milky 20.36%

     

    Flavor
    Odorless 42.56%
    Fruity 36.29%
    Alcoholic 36.14%
    Bitter 33.45%
    Onion 33.24%
    Musty 29.0%
    Creamy 28.8%
    Buttery 26.95%
    Sweet 26.56%
    Fruit 26.28%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    8.13 (weak base)

    Molecular weight
    268.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • -40 °F (NTP, 1992)
    • Supercools
    • -40 °C

    Boiling point

    • 444 to 450 °F at 760 mmHg (NTP, 1992)
    • 231 °C
    • 232 °C

    Flash point

    • 114.62 ˚C est.
    • 280 °F (NTP, 1992)
    • 120 °C
    • 250 °F (121 °C) (open cup)
    • 120 °C (closed cup)
    • 138 °C (280 °F) - closed cup
    • 138 °C o.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 75 °F (NTP, 1992)
    • Miscible with water
    • Miscible with ethanol
    • Soluble in toluene
    • Solubility in water: miscible

  • Synonyms

    • Oxybispropanol
    • Dipropylenglykol
    • 4-Oxa-2,6-heptandiol
    • E107L85C40
    • EPA Pesticide Chemical Code 068604
    • RefChem:57330
    • Abelia seaweed refining mask
    • Abelia green tea energy mask
    • Abelia cucumber soothing mask
    • Abelia lemon brightening mask
    • Abelia collagen amplifying mask
    • DTXSID0027856
    • Professional Level Brighting Pen
    • Abelia pomegranate bounce up mask
    • Abelia royal jelly nutrition mask
    • Abelia aloe vera moisturizing mask
    • DTXCID501769096
    • 246-770-3
    • 25265-71-8
    • Dipropylene Glycol
    • Dipropyleneglycol
    • NSC-8688
    • Propanol, oxybis-
    • Dowanol DPG
    • Caswell No. 399E
    • DPG-FC
    • DPG-RF
    • ADK DPG-RF
    • CCRIS 475
    • SCHEMBL21638767
    • UNII-E107L85C40
    • HSDB 2658
    • EINECS 246-770-3
    • EC 246-770-3
    • 25265-71-8

  • Applications

    Dipropylene Glycol (CAS 25265-71-8) is a versatile solvent and humectant used across multiple industries. Common applications include: solvent and carrier in cosmetics and personal care products (emollient, fragrance delivery, and active-ingredient transport); solvent for fragrances and flavor ingredients in perfumery and flavors; solvent, co-solvent, and processing aid in coatings, paints, and inks; plasticizer and processing aid for polymers and plastics; humectant and solvent in cleaning, household, and industrial products; and an excipient/solvent in pharmaceutical formulations. Applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 200.52
    methanol 449.92
    isopropanol 127.49
    water 83.66
    ethyl acetate 33.02
    n-propanol 156.02
    acetone 57.93
    n-butanol 113.69
    acetonitrile 65.47
    DMF 226.79
    toluene 9.1
    isobutanol 92.69
    1,4-dioxane 165.8
    methyl acetate 45.53
    THF 161.91
    2-butanone 44.94
    n-pentanol 63.22
    sec-butanol 101.48
    n-hexane 5.87
    ethylene glycol 204.02
    NMP 262.55
    cyclohexane 14.26
    DMSO 321.02
    n-butyl acetate 31.86
    n-octanol 40.31
    chloroform 105.02
    n-propyl acetate 25.38
    acetic acid 245.04
    dichloromethane 132.83
    cyclohexanone 100.23
    propylene glycol 145.34
    isopropyl acetate 18.16
    DMAc 185.55
    2-ethoxyethanol 130.98
    isopentanol 59.9
    n-heptane 11.71
    ethyl formate 58.94
    1,2-dichloroethane 66.06
    n-hexanol 65.98
    2-methoxyethanol 252.75
    isobutyl acetate 18.15
    tetrachloromethane 25.68
    n-pentyl acetate 26.46
    transcutol 145.19
    n-heptanol 40.68
    ethylbenzene 9.09
    MIBK 16.76
    2-propoxyethanol 120.87
    tert-butanol 116.36
    MTBE 46.13
    2-butoxyethanol 73.43
    propionic acid 135.96
    o-xylene 15.54
    formic acid 257.78
    diethyl ether 37.83
    m-xylene 9.81
    p-xylene 12.76
    chlorobenzene 23.8
    dimethyl carbonate 17.41
    n-octane 5.04
    formamide 161.44
    cyclopentanone 118.74
    2-pentanone 27.98
    anisole 27.58
    cyclopentyl methyl ether 51.21
    gamma-butyrolactone 164.0
    1-methoxy-2-propanol 122.13
    pyridine 61.42
    3-pentanone 28.15
    furfural 151.14
    n-dodecane 4.15
    diethylene glycol 153.92
    diisopropyl ether 9.88
    tert-amyl alcohol 94.12
    acetylacetone 35.32
    n-hexadecane 4.48
    acetophenone 32.99
    methyl propionate 37.62
    isopentyl acetate 28.79
    trichloroethylene 93.76
    n-nonanol 34.99
    cyclohexanol 90.57
    benzyl alcohol 42.7
    2-ethylhexanol 38.79
    isooctanol 31.08
    dipropyl ether 33.5
    1,2-dichlorobenzene 31.13
    ethyl lactate 38.28
    propylene carbonate 87.3
    n-methylformamide 143.56
    2-pentanol 50.71
    n-pentane 8.54
    1-propoxy-2-propanol 82.15
    1-methoxy-2-propyl acetate 37.67
    2-(2-methoxypropoxy) propanol 66.23
    mesitylene 9.11
    ε-caprolactone 103.54
    p-cymene 15.52
    epichlorohydrin 116.66
    1,1,1-trichloroethane 37.98
    2-aminoethanol 213.7
    morpholine-4-carbaldehyde 223.7
    sulfolane 242.14
    2,2,4-trimethylpentane 6.76
    2-methyltetrahydrofuran 98.86
    n-hexyl acetate 38.25
    isooctane 3.59
    2-(2-butoxyethoxy)ethanol 77.32
    sec-butyl acetate 15.14
    tert-butyl acetate 21.95
    decalin 6.86
    glycerin 229.22
    diglyme 142.84
    acrylic acid 144.33
    isopropyl myristate 19.93
    n-butyric acid 102.83
    acetyl acetate 26.51
    di(2-ethylhexyl) phthalate 29.29
    ethyl propionate 24.67
    nitromethane 159.25
    1,2-diethoxyethane 41.92
    benzonitrile 40.81
    trioctyl phosphate 24.62
    1-bromopropane 36.79
    gamma-valerolactone 173.24
    n-decanol 26.59
    triethyl phosphate 28.56
    4-methyl-2-pentanol 22.81
    propionitrile 57.6
    vinylene carbonate 87.3
    1,1,2-trichlorotrifluoroethane 160.35
    DMS 31.22
    cumene 10.56
    2-octanol 26.1
    2-hexanone 25.34
    octyl acetate 26.25
    limonene 25.5
    1,2-dimethoxyethane 147.95
    ethyl orthosilicate 27.74
    tributyl phosphate 25.94
    diacetone alcohol 44.85
    N,N-dimethylaniline 28.31
    acrylonitrile 71.66
    aniline 35.05
    1,3-propanediol 194.95
    bromobenzene 18.17
    dibromomethane 77.83
    1,1,2,2-tetrachloroethane 89.48
    2-methyl-cyclohexyl acetate 37.25
    tetrabutyl urea 37.2
    diisobutyl methanol 24.33
    2-phenylethanol 39.01
    styrene 10.44
    dioctyl adipate 36.12
    dimethyl sulfate 47.45
    ethyl butyrate 31.25
    methyl lactate 56.61
    butyl lactate 39.99
    diethyl carbonate 24.24
    propanediol butyl ether 73.54
    triethyl orthoformate 34.92
    p-tert-butyltoluene 16.26
    methyl 4-tert-butylbenzoate 46.25
    morpholine 174.93
    tert-butylamine 71.87
    n-dodecanol 21.5
    dimethoxymethane 69.97
    ethylene carbonate 74.68
    cyrene 79.15
    2-ethoxyethyl acetate 34.0
    2-ethylhexyl acetate 24.38
    1,2,4-trichlorobenzene 40.48
    4-methylpyridine 48.63
    dibutyl ether 26.49
    2,6-dimethyl-4-heptanol 24.33
    DEF 76.41
    dimethyl isosorbide 98.23
    tetrachloroethylene 69.56
    eugenol 54.61
    triacetin 48.03
    span 80 65.18
    1,4-butanediol 100.12
    1,1-dichloroethane 43.35
    2-methyl-1-pentanol 46.15
    methyl formate 96.63
    2-methyl-1-butanol 70.79
    n-decane 6.43
    butyronitrile 53.15
    3,7-dimethyl-1-octanol 33.37
    1-chlorooctane 19.8
    1-chlorotetradecane 9.21
    n-nonane 6.41
    undecane 4.91
    tert-butylcyclohexane 6.69
    cyclooctane 5.71
    cyclopentanol 127.94
    tetrahydropyran 98.72
    tert-amyl methyl ether 40.26
    2,5,8-trioxanonane 108.6
    1-hexene 13.47
    2-isopropoxyethanol 73.41
    2,2,2-trifluoroethanol 103.32
    methyl butyrate 39.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction