Dimethyl tetrasulfide

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  • Identifiers

    CAS number
    5756-24-1

    Molecular formula
    C2H6S4

    SMILES
    CSSSSC

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1232.0
    • Carbowax: 1580.0

  • Odor profile

    Sulfurous 88.91%
    Onion 85.53%
    Garlic 80.75%
    Alliaceous 68.09%
    Cooked 56.23%
    Savory 55.79%
    Roasted 50.38%
    Pungent 49.31%
    Meaty 47.21%
    Cabbage 38.43%

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  • Properties

    XLogP3-AA
    1.8

    pKa est.
    1.39 (strong acid)

    Molecular weight
    158.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    255°C

    Flash point est.
    102.46 ˚C

  • Synonyms

    • Dimethyl tetrasulfide
    • 5756-24-1
    • Tetrasulfide, dimethyl
    • (methyltetrasulfanyl)methane
    • Dimethyl tetrasulphide
    • dimethyltetrasulfane
    • 1,4-Dimethyltetrasulfane
    • 2,3,4,5-Tetrathiahexane
    • 1,4-Dimethyltetrasulfide
    • EINECS 227-278-8
    • Methyl tetrasulfide, 8CI
    • DTXSID0063997
    • Dimethyltetrasulphane
    • 1,4-Dimethyltetrasulfane #
    • SCHEMBL565279
    • DTXCID1042231
    • methyldisulfanyldisulfanyl-methane
    • NS00022407
    • Q63398078
    • 227-278-8

  • Applications

    Dimethyl tetrasulfide (CAS 5756-24-1) is a polysulfide organosulfur compound with a strong sulfury odor; it is used mainly at trace levels as a flavor/aroma ingredient to impart onion–garlic, cabbage, seafood and cooked‑meaty notes; as a reference/standard in GC, GC–MS and GC–SCD for sulfur‑volatile analysis and sensory studies in foods, beverages and environmental odor work; as a sulfur‑transfer reagent and polysulfide‑bridge builder in organic synthesis and materials modification (installing extended S–S linkages, thiol/disulfide transformations) and as an intermediate to prepare sulfur‑rich ligands and polysulfide additives; it also serves as a model substrate in redox, biodegradation and off‑flavor formation research, and has been explored as an alternative sulfurization agent for hydrotreating catalysts in refining, subject to technical fit and safety regulations.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 206.54
    methanol 189.94
    isopropanol 225.47
    water 2.88
    ethyl acetate 873.17
    n-propanol 213.75
    acetone 1294.68
    n-butanol 239.84
    acetonitrile 636.62
    DMF 2252.19
    toluene 1033.07
    isobutanol 207.42
    1,4-dioxane 1869.77
    methyl acetate 843.41
    THF 2483.26
    2-butanone 868.77
    n-pentanol 183.22
    sec-butanol 223.39
    n-hexane 176.85
    ethylene glycol 116.96
    NMP 2662.45
    cyclohexane 528.72
    DMSO 1564.12
    n-butyl acetate 837.78
    n-octanol 309.17
    chloroform 2101.69
    n-propyl acetate 620.25
    acetic acid 403.85
    dichloromethane 1779.07
    cyclohexanone 2089.65
    propylene glycol 126.18
    isopropyl acetate 732.11
    DMAc 1477.49
    2-ethoxyethanol 399.35
    isopentanol 239.11
    n-heptane 261.66
    ethyl formate 578.12
    1,2-dichloroethane 1268.9
    n-hexanol 289.72
    2-methoxyethanol 638.9
    isobutyl acetate 492.96
    tetrachloromethane 787.34
    n-pentyl acetate 661.98
    transcutol 1057.17
    n-heptanol 243.57
    ethylbenzene 512.47
    MIBK 710.73
    2-propoxyethanol 587.89
    tert-butanol 399.62
    MTBE 607.59
    2-butoxyethanol 412.47
    propionic acid 354.94
    o-xylene 783.42
    formic acid 130.08
    diethyl ether 626.97
    m-xylene 884.93
    p-xylene 687.72
    chlorobenzene 1319.54
    dimethyl carbonate 780.67
    n-octane 157.91
    formamide 266.02
    cyclopentanone 2700.0
    2-pentanone 911.67
    anisole 1008.9
    cyclopentyl methyl ether 1513.33
    gamma-butyrolactone 2466.47
    1-methoxy-2-propanol 583.93
    pyridine 1360.32
    3-pentanone 848.94
    furfural 2467.28
    n-dodecane 128.17
    diethylene glycol 443.0
    diisopropyl ether 434.0
    tert-amyl alcohol 315.27
    acetylacetone 1785.85
    n-hexadecane 151.98
    acetophenone 1013.23
    methyl propionate 821.7
    isopentyl acetate 712.92
    trichloroethylene 2647.97
    n-nonanol 292.4
    cyclohexanol 565.97
    benzyl alcohol 517.01
    2-ethylhexanol 310.0
    isooctanol 227.22
    dipropyl ether 671.98
    1,2-dichlorobenzene 1500.64
    ethyl lactate 315.78
    propylene carbonate 1433.47
    n-methylformamide 652.58
    2-pentanol 238.89
    n-pentane 173.53
    1-propoxy-2-propanol 561.12
    1-methoxy-2-propyl acetate 996.72
    2-(2-methoxypropoxy) propanol 495.87
    mesitylene 806.91
    ε-caprolactone 1488.24
    p-cymene 480.8
    epichlorohydrin 2003.84
    1,1,1-trichloroethane 1926.12
    2-aminoethanol 147.52
    morpholine-4-carbaldehyde 2451.6
    sulfolane 3378.31
    2,2,4-trimethylpentane 132.92
    2-methyltetrahydrofuran 1555.06
    n-hexyl acetate 839.5
    isooctane 147.3
    2-(2-butoxyethoxy)ethanol 556.54
    sec-butyl acetate 487.71
    tert-butyl acetate 1069.6
    decalin 299.33
    glycerin 240.23
    diglyme 1322.58
    acrylic acid 390.43
    isopropyl myristate 482.08
    n-butyric acid 524.79
    acetyl acetate 997.51
    di(2-ethylhexyl) phthalate 353.31
    ethyl propionate 630.87
    nitromethane 1323.89
    1,2-diethoxyethane 813.95
    benzonitrile 1021.69
    trioctyl phosphate 304.01
    1-bromopropane 652.24
    gamma-valerolactone 2833.7
    n-decanol 240.16
    triethyl phosphate 490.28
    4-methyl-2-pentanol 199.12
    propionitrile 483.28
    vinylene carbonate 1408.52
    1,1,2-trichlorotrifluoroethane 1438.47
    DMS 909.02
    cumene 372.08
    2-octanol 239.16
    2-hexanone 629.84
    octyl acetate 516.59
    limonene 693.27
    1,2-dimethoxyethane 1044.86
    ethyl orthosilicate 464.56
    tributyl phosphate 355.17
    diacetone alcohol 804.04
    N,N-dimethylaniline 773.66
    acrylonitrile 702.66
    aniline 712.39
    1,3-propanediol 237.99
    bromobenzene 1651.96
    dibromomethane 1174.71
    1,1,2,2-tetrachloroethane 2112.96
    2-methyl-cyclohexyl acetate 640.04
    tetrabutyl urea 536.57
    diisobutyl methanol 315.93
    2-phenylethanol 558.19
    styrene 674.58
    dioctyl adipate 572.15
    dimethyl sulfate 1527.99
    ethyl butyrate 716.62
    methyl lactate 487.97
    butyl lactate 410.24
    diethyl carbonate 518.56
    propanediol butyl ether 370.28
    triethyl orthoformate 597.91
    p-tert-butyltoluene 545.98
    methyl 4-tert-butylbenzoate 922.79
    morpholine 1424.31
    tert-butylamine 282.15
    n-dodecanol 213.55
    dimethoxymethane 1296.4
    ethylene carbonate 1155.05
    cyrene 793.04
    2-ethoxyethyl acetate 809.58
    2-ethylhexyl acetate 686.67
    1,2,4-trichlorobenzene 1646.3
    4-methylpyridine 1485.95
    dibutyl ether 586.39
    2,6-dimethyl-4-heptanol 315.93
    DEF 1143.94
    dimethyl isosorbide 1366.76
    tetrachloroethylene 1436.01
    eugenol 679.61
    triacetin 885.6
    span 80 529.44
    1,4-butanediol 128.53
    1,1-dichloroethane 1182.7
    2-methyl-1-pentanol 183.03
    methyl formate 758.8
    2-methyl-1-butanol 212.75
    n-decane 186.02
    butyronitrile 520.72
    3,7-dimethyl-1-octanol 330.42
    1-chlorooctane 449.07
    1-chlorotetradecane 253.53
    n-nonane 193.57
    undecane 150.14
    tert-butylcyclohexane 249.44
    cyclooctane 351.82
    cyclopentanol 610.16
    tetrahydropyran 1362.39
    tert-amyl methyl ether 572.29
    2,5,8-trioxanonane 993.08
    1-hexene 292.26
    2-isopropoxyethanol 346.34
    2,2,2-trifluoroethanol 311.41
    methyl butyrate 752.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Onion 8002-72-0 Allium cepa L., fam. Liliaceae 0.5%
Onion, welsh 8002-72-0 Allium fistulosum L. var. Maichuon, fam. Liliaceae 2.15%
Scallion Allium fistulosum L. var. Caespitosum, fam. Liliaceae 0.85%
Scallion (Cuba) Allium fistulosum L., fam. Liliaceae 0.5%
Asafoetida (Pakistan) 2 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 0.19%
Asafoetida (Iran) 1 9000-04-8 Ferula assafoetida L., fam. Apiaceae (Umbelliferae) 0.01%