Creosol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    93-51-6

    Molecular formula
    C8H10O2

    SMILES
    CC1=CC(=C(C=C1)O)OC

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1190.0
    • Carbowax: 1959.5

  • Odor profile

    Phenolic 86.97%
    Sweet 80.29%
    Spicy 76.45%
    Smoky 76.16%
    Vanilla 73.05%
    Woody 70.98%
    Medicinal 60.15%
    Clove 57.37%
    Burnt 46.7%
    Balsamic 46.05%

    Scent© AI

  • Properties

    XLogP3-AA
    1.3

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • 5.5 °C

    Boiling point

    • 221.00 to 222.00 °C. @ 760.00 mm Hg

    Flash point est.
    90.07 ˚C

    Solubility expt.

    • slightly soluble in water
    • miscible (in ethanol)

  • Synonyms

    • 2-METHOXY-4-METHYLPHENOL
    • 93-51-6
    • Creosol
    • 4-Methylguaiacol
    • Phenol, 2-methoxy-4-methyl-
    • 2-Methoxy-p-cresol
    • 4-Methyl guaiacol
    • p-Methylguaiacol
    • p-Creosol
    • Homoguaiacol
    • 2-Methoxy-4-cresol
    • p-Cresol, 2-methoxy-
    • 4-Hydroxy-3-methoxytoluene
    • 4-Methyl-2-methoxyphenol
    • Kreosol
    • Rohkcrsol
    • 2-methoxy-4-methyl-phenol
    • 3-Methoxy-4-hydroxytoluene
    • Cresolum drudum
    • 4-Hydroxy-3-methoxy-1-methylbenzene
    • Homocatechol monomethyl ether
    • Kreosol [German]
    • Valspice
    • 1-Hydroxy-2-methoxy-4-methylbenzene
    • FEMA No. 2671
    • NSC 4969
    • MFCD00002378
    • UNII-W9GW1KZG6N
    • W9GW1KZG6N
    • 2-Hydroxy-5-methylanisole
    • 2-methoxy-4-methyl phenol
    • EINECS 202-252-9
    • Phenol, 4-methyl-2-methoxy
    • BRN 1862340
    • DTXSID6047105
    • AI3-15891
    • NSC-4969
    • CREOSOL [MI]
    • DTXCID4027105
    • CHEBI:89886
    • NSC4969
    • 4-06-00-05878 (Beilstein Handbook Reference)
    • 2-METHOXY-4-METHYLPHENOL [FHFI]
    • 2-?Methoxy-?4-?methylphenol
    • 2-2-Methoxy-4-methylphenol
    • P-Methylguaicol
    • 4-Methylguiacol
    • Creosol (Standard)
    • Homocatechol methyl ester
    • 2-Methoxy-4-methylphenol (Methyl guaiacol)
    • 3-Methoxy-4-methyl-Phenol
    • SCHEMBL92236
    • 2-METHOXY-P- CRESOL
    • CHEMBL3182715
    • 2-Methoxy-4-methylphenol, 9CI
    • FEMA 2671
    • BCP19090
    • HY-W040971R
    • 2-Methoxy-4-methylphenol (creosol)
    • Tox21_302681
    • 2-Methoxy-4-methylphenol, >=98%
    • AKOS000120520
    • CS-W021711
    • FM36438
    • HY-W040971
    • CAS-93-51-6
    • NCGC00256731-01
    • 2-Methoxy-4-methylphenol, >=98%, FG
    • AS-15967
    • SY036778
    • 2-Methoxy-4-methylphenol (4-methylguaiacol)
    • 4-Methyl-2-methoxyphenol (4-methylguaiacol)
    • M0114
    • NS00012823
    • 2-Methoxy-4-methylphenol, analytical standard
    • EN300-18155
    • 2-Methoxy-4-methylphenol, natural, 97%, FG
    • D70655
    • Q403037
    • 2-Methoxy-p-cresol;Creosol;2-Methoxy-4-methylphenol
    • Z57234300
    • F0001-2237

  • Applications

    2-Methoxy-4-methylphenol (also known as p-Creosol or p-Methylguaiacol, CAS 93-51-6) is a pale yellow aromatic liquid with a broad range of applications across flavor-fragrance, pharmaceutical and technical chemical sectors: in flavoring it contributes smoky wood, mild vanilla and roasted coffee nuances to beverages, confectionery, perfumes and tobacco; in medicine it serves as a building block for expectorants, antimicrobial and antioxidant agents and is used as a flavor-masking enhancer in cough syrups or mouthwashes; in materials science it functions as a polymer stabilizer, a mild corrosion inhibitor for light metals and a component of heat-resistant synthetic resins; beyond these, p-Creosol is employed as an analytical reference standard in environmental biota studies and as an organic intermediate for eco-friendly agrochemicals, making it a versatile compound valued by multiple industries.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1071.22
    methanol 998.9
    isopropanol 780.37
    water 6.88
    ethyl acetate 753.75
    n-propanol 873.08
    acetone 1187.96
    n-butanol 510.8
    acetonitrile 1167.03
    DMF 949.84
    toluene 119.27
    isobutanol 493.25
    1,4-dioxane 1797.74
    methyl acetate 948.91
    THF 1624.6
    2-butanone 776.07
    n-pentanol 374.33
    sec-butanol 612.13
    n-hexane 46.42
    ethylene glycol 419.46
    NMP 424.5
    cyclohexane 52.0
    DMSO 1445.21
    n-butyl acetate 340.03
    n-octanol 207.52
    chloroform 909.76
    n-propyl acetate 445.09
    acetic acid 742.69
    dichloromethane 928.48
    cyclohexanone 608.42
    propylene glycol 414.98
    isopropyl acetate 321.66
    DMAc 388.77
    2-ethoxyethanol 774.07
    isopentanol 340.34
    n-heptane 40.38
    ethyl formate 556.96
    1,2-dichloroethane 687.62
    n-hexanol 372.12
    2-methoxyethanol 1186.6
    isobutyl acetate 232.41
    tetrachloromethane 155.13
    n-pentyl acetate 188.45
    transcutol 823.59
    n-heptanol 190.1
    ethylbenzene 99.39
    MIBK 284.36
    2-propoxyethanol 628.01
    tert-butanol 905.66
    MTBE 635.2
    2-butoxyethanol 344.92
    propionic acid 675.91
    o-xylene 104.26
    formic acid 331.87
    diethyl ether 693.6
    m-xylene 109.69
    p-xylene 132.85
    chlorobenzene 220.34
    dimethyl carbonate 248.74
    n-octane 26.28
    formamide 561.85
    cyclopentanone 873.88
    2-pentanone 512.75
    anisole 298.64
    cyclopentyl methyl ether 473.56
    gamma-butyrolactone 1104.89
    1-methoxy-2-propanol 745.77
    pyridine 438.43
    3-pentanone 344.0
    furfural 643.0
    n-dodecane 23.74
    diethylene glycol 615.14
    diisopropyl ether 160.66
    tert-amyl alcohol 621.46
    acetylacetone 531.33
    n-hexadecane 26.46
    acetophenone 219.31
    methyl propionate 531.8
    isopentyl acetate 264.42
    trichloroethylene 970.9
    n-nonanol 168.45
    cyclohexanol 344.38
    benzyl alcohol 220.58
    2-ethylhexanol 187.24
    isooctanol 150.76
    dipropyl ether 240.43
    1,2-dichlorobenzene 192.62
    ethyl lactate 207.61
    propylene carbonate 482.0
    n-methylformamide 753.71
    2-pentanol 340.52
    n-pentane 43.95
    1-propoxy-2-propanol 380.19
    1-methoxy-2-propyl acetate 303.54
    2-(2-methoxypropoxy) propanol 244.62
    mesitylene 83.26
    ε-caprolactone 506.84
    p-cymene 72.04
    epichlorohydrin 1234.0
    1,1,1-trichloroethane 592.52
    2-aminoethanol 589.11
    morpholine-4-carbaldehyde 669.56
    sulfolane 1003.65
    2,2,4-trimethylpentane 34.15
    2-methyltetrahydrofuran 946.29
    n-hexyl acetate 288.82
    isooctane 32.94
    2-(2-butoxyethoxy)ethanol 368.35
    sec-butyl acetate 226.78
    tert-butyl acetate 364.4
    decalin 37.82
    glycerin 469.38
    diglyme 670.5
    acrylic acid 513.26
    isopropyl myristate 119.47
    n-butyric acid 592.41
    acetyl acetate 326.36
    di(2-ethylhexyl) phthalate 91.97
    ethyl propionate 320.8
    nitromethane 1491.98
    1,2-diethoxyethane 341.57
    benzonitrile 245.08
    trioctyl phosphate 88.47
    1-bromopropane 368.05
    gamma-valerolactone 930.83
    n-decanol 134.22
    triethyl phosphate 113.96
    4-methyl-2-pentanol 182.08
    propionitrile 620.26
    vinylene carbonate 417.67
    1,1,2-trichlorotrifluoroethane 595.81
    DMS 231.9
    cumene 83.44
    2-octanol 150.4
    2-hexanone 388.88
    octyl acetate 158.03
    limonene 102.88
    1,2-dimethoxyethane 1028.13
    ethyl orthosilicate 105.09
    tributyl phosphate 96.28
    diacetone alcohol 418.41
    N,N-dimethylaniline 166.17
    acrylonitrile 690.31
    aniline 211.25
    1,3-propanediol 726.49
    bromobenzene 211.27
    dibromomethane 589.05
    1,1,2,2-tetrachloroethane 684.79
    2-methyl-cyclohexyl acetate 165.21
    tetrabutyl urea 109.67
    diisobutyl methanol 126.38
    2-phenylethanol 223.34
    styrene 117.61
    dioctyl adipate 150.44
    dimethyl sulfate 343.99
    ethyl butyrate 236.78
    methyl lactate 268.58
    butyl lactate 148.46
    diethyl carbonate 163.96
    propanediol butyl ether 296.41
    triethyl orthoformate 145.97
    p-tert-butyltoluene 78.68
    methyl 4-tert-butylbenzoate 196.16
    morpholine 1458.17
    tert-butylamine 422.28
    n-dodecanol 106.48
    dimethoxymethane 743.12
    ethylene carbonate 377.53
    cyrene 228.72
    2-ethoxyethyl acetate 258.52
    2-ethylhexyl acetate 187.89
    1,2,4-trichlorobenzene 216.21
    4-methylpyridine 363.62
    dibutyl ether 191.35
    2,6-dimethyl-4-heptanol 126.38
    DEF 410.28
    dimethyl isosorbide 354.13
    tetrachloroethylene 447.97
    eugenol 209.2
    triacetin 217.55
    span 80 203.21
    1,4-butanediol 316.81
    1,1-dichloroethane 682.58
    2-methyl-1-pentanol 260.21
    methyl formate 719.64
    2-methyl-1-butanol 336.12
    n-decane 37.2
    butyronitrile 512.6
    3,7-dimethyl-1-octanol 162.29
    1-chlorooctane 131.59
    1-chlorotetradecane 55.08
    n-nonane 37.97
    undecane 29.0
    tert-butylcyclohexane 44.13
    cyclooctane 24.58
    cyclopentanol 520.34
    tetrahydropyran 1039.31
    tert-amyl methyl ether 352.56
    2,5,8-trioxanonane 413.83
    1-hexene 168.9
    2-isopropoxyethanol 464.14
    2,2,2-trifluoroethanol 280.95
    methyl butyrate 431.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
Restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0.0085 % Category 7A
Rinse-off products applied to the hair with some hand contact
 0.096 %
Category 2
Products applied to the axillae
 0.0025 % Category 7B
Leave-on products applied to the hair with some hand contact
 0.096 %
Category 3
Products applied to the face/body using fingertips
 0.051 % Category 8
Products with significant anogenital exposure
 0.005 %
Category 4
Products related to fine fragrance
 0.047 % Category 9
Products with body and hand exposure, primarily rinse off
 0.092 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 0.012 % Category 10A
Household care products with mostly hand contact
 0.33 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 0.012 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 0.33 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0.012 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 0.18 %
Category 5D
Baby Creams, baby Oils and baby talc
 0.012 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 0.18 %
Category 6
Products with oral and lip exposure
 0.028 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Genet absolute 2 8023-80-1 Spartium junceum L., fam. Leguminosae (Papilionaceae) 0.01%
Jasmine polyanthum flower headspace Jasminum polyanthum L., fam. Oleaceae 3.59%
Jasmine (China) 1 8022-96-6 Jasminum officinale var. grandiflorum L., fam. Oleaceae 2.5%
Lawsonia inermis flower 1b Lawsonia inermis L. (syn. L. alba Lam.), fam. Lytraceae 0.2%
Tulip sylvestre (headspace) Tulipa sylvestris L., fam. Liliaceae 0.11%
Phalaenopsis veichiana headspace Phalaenopsis veitchiana, fam. Orchidaceae 6.4%