Choline Chloride

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  • Identifiers

    CAS number
    67-48-1

    Molecular formula
    C5H14ClNO

    SMILES
    C[N+](C)(C)CCO.[Cl-]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fermented 55.46%
    Alcoholic 45.9%
    Solvent 41.81%
    Ethereal 41.03%
    Cheesy 39.43%
    Oily 37.04%
    Musty 34.04%
    Fruity 33.78%
    Fishy 33.32%
    Pungent 31.64%

    Scent© AI

  • Properties

    Molecular weight
    139.62 g/mol

    Melting point expt.

    • 577 to 581 °F (Decomposes) (NTP, 1992)
    • 305 °C (decomposes)
    • 305 °C

    Flash point est.
    -56.16 ˚C

    Solubility expt.

    • Very soluble (NTP, 1992)
    • Very sol in water and alcohol
    • Solubility in water: miscible
    • Soluble in water
    • Soluble (in ethanol)

  • Synonyms

    • CHOLINE CHLORIDE
    • 67-48-1
    • Hepacholine
    • Lipotril
    • Paresan
    • 2-Hydroxy-N,N,N-trimethylethanaminium chloride
    • Hormocline
    • (2-Hydroxyethyl)trimethylammonium chloride
    • Biocolina
    • Biocoline
    • Luridin chloride
    • Choline hydrochloride
    • Neocolina
    • Bilineurin chloride
    • Cholinium chloride
    • Choline, chloride
    • Chloride de choline
    • Choline chlorhydrate
    • Cholini chloridum
    • Cloruro de colina
    • CHOLINE (CL)
    • Chlorure de choline
    • Colina cloruro
    • Choline chloride [INN]
    • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
    • Choline (chloride)
    • 2-Hydroxyethyl(trimethyl)azanium;chloride
    • Trimethyl(2-hydroxyethyl)ammonium chloride
    • CCRIS 3716
    • HSDB 984
    • (beta-Hydroxyethyl)trimethylammonium chloride
    • EINECS 200-655-4
    • MFCD00011721
    • NSC 402838
    • NSC-402838
    • 2-Hydroxy-N,N,N,-trimethylethanaminium chloride
    • (2-hydroxyethyl)trimethylazanium chloride
    • DTXSID4020325
    • FEMA NO. 4500
    • UNII-45I14D8O27
    • AI3-18302
    • Cloruro de colina [INN-Spanish]
    • CHEBI:133341
    • Chlorure de choline [INN-French]
    • Ammonium, (2-hydroxyethyl)trimethyl-, chloride
    • 45I14D8O27
    • DTXCID20325
    • CHEMBL282468
    • EC 200-655-4
    • 2-Hydroxy-N,N,N-trimethylethanaminium chloride (1:1)
    • Choline chloride - 99%
    • (2-H2-Hydroxyethyl)trimethylammonium chloride
    • CHOLINE CHLORIDE (MART.)
    • CHOLINE CHLORIDE [MART.]
    • Cloruro de colina (INN-Spanish)
    • CHOLINE CHLORIDE (USP-RS)
    • CHOLINE CHLORIDE [USP-RS]
    • Chlorure de choline (INN-French)
    • Colina cloruro [DCIT]
    • Chloride de choline [French]
    • Cholini chloridum [INN-Latin]
    • NSC402838
    • SR-01000075745
    • 2-hydroxyethyl(trimethyl)azanium chloride
    • cholinii chloridum
    • Chloride, Choline
    • cholinium chloratum
    • 2-hydroxyethyl(trimethyl)ammonium chloride
    • SCHEMBL14957
    • CHOLINE CHLORIDE [MI]
    • SPECTRUM1503428
    • Choline (chloride) (Standard)
    • CHOLINE CHLORIDE [FCC]
    • CHOLINE CHLORIDE [HSDB]
    • CHOLINE CHLORIDE [VANDF]
    • HMS500F09
    • HY-B1337R
    • CHOLINE CHLORIDE [WHO-DD]
    • HMS1922E20
    • HMS2093G05
    • HMS3652D05
    • HMS3885F09
    • Pharmakon1600-01503428
    • Choline chloride [HOEtN1,1,1]Cl
    • HY-B1337
    • Tox21_200492
    • CCG-39465
    • NSC758473
    • s4171
    • AKOS015903458
    • Choline chloride - 75% water solution
    • CS-4855
    • FC01179
    • FS-3795
    • NSC-758473
    • CAS-67-48-1
    • WLN: Q2K1&1&1 &Q &G
    • NCGC00095059-01
    • NCGC00095059-02
    • NCGC00258046-01
    • FC157132
    • FC179365
    • DB-055035
    • NS00076292
    • SW219165-1
    • (.beta.-Hydroxyethyl)trimethylammonium chloride
    • D70213
    • EN300-102823
    • AB01568267_01
    • 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride
    • A835769
    • Q2964153
    • SR-01000075745-3
    • SR-01000075745-5
    • 1CDEFBD7-7905-4D2C-BEA8-44A54D9787D3
    • F8889-3032
    • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
    • 200-655-4

  • Applications

    Choline chloride (CAS 67-48-1) is an essential nutrient often grouped with the B-complex vitamins and finds broad use: as a feed additive for poultry, swine, ruminants and aquaculture it donates methyl groups, prevents fatty liver, accelerates growth, improves egg production, feed conversion and immune response; in pharmaceuticals and dietary supplements it serves as a precursor of acetylcholine for cognitive health, a hepatoprotective agent, a prenatal nutrient and a homocysteine-lowering factor; in biotechnology it is a component of cell-culture media and a protein stabilizer; in agriculture foliar sprays of choline chloride enhance germination and stress tolerance to drought and salinity; in cosmetics it acts as a humectant and antistatic agent for hair care; additionally, this quaternary ammonium salt is a key building block for deep eutectic solvents, electrolytes, corrosion inhibitors, demulsifiers in petroleum processing, catalysts for organic synthesis and hydrometallurgical recycling, valued for its biodegradability, low toxicity and cost effectiveness.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 182.93
    methanol 647.57
    isopropanol 22.89
    water 2745.03
    ethyl acetate 1.17
    n-propanol 56.94
    acetone 1.98
    n-butanol 26.78
    acetonitrile 2.62
    DMF 26.26
    toluene 0.12
    isobutanol 14.89
    1,4-dioxane 10.37
    methyl acetate 2.85
    THF 8.39
    2-butanone 1.78
    n-pentanol 8.87
    sec-butanol 14.46
    n-hexane 0.32
    ethylene glycol 610.23
    NMP 51.13
    cyclohexane 0.49
    DMSO 28.51
    n-butyl acetate 1.41
    n-octanol 4.0
    chloroform 5.92
    n-propyl acetate 1.45
    acetic acid 328.21
    dichloromethane 5.68
    cyclohexanone 2.75
    propylene glycol 202.95
    isopropyl acetate 0.32
    DMAc 22.53
    2-ethoxyethanol 73.07
    isopentanol 4.71
    n-heptane 0.55
    ethyl formate 8.0
    1,2-dichloroethane 2.55
    n-hexanol 9.98
    2-methoxyethanol 217.46
    isobutyl acetate 0.66
    tetrachloromethane 3.08
    n-pentyl acetate 1.46
    transcutol 45.27
    n-heptanol 9.13
    ethylbenzene 0.13
    MIBK 0.21
    2-propoxyethanol 42.37
    tert-butanol 7.56
    MTBE 0.78
    2-butoxyethanol 32.14
    propionic acid 59.68
    o-xylene 0.25
    formic acid 1777.77
    diethyl ether 2.08
    m-xylene 0.13
    p-xylene 0.19
    chlorobenzene 0.28
    dimethyl carbonate 0.94
    n-octane 0.22
    formamide 832.02
    cyclopentanone 4.09
    2-pentanone 0.58
    anisole 0.51
    cyclopentyl methyl ether 1.6
    gamma-butyrolactone 12.0
    1-methoxy-2-propanol 32.17
    pyridine 3.38
    3-pentanone 0.77
    furfural 18.92
    n-dodecane 0.11
    diethylene glycol 107.32
    diisopropyl ether 0.19
    tert-amyl alcohol 7.67
    acetylacetone 0.48
    n-hexadecane 0.11
    acetophenone 0.89
    methyl propionate 2.09
    isopentyl acetate 0.84
    trichloroethylene 3.75
    n-nonanol 3.41
    cyclohexanol 7.94
    benzyl alcohol 2.89
    2-ethylhexanol 2.61
    isooctanol 4.25
    dipropyl ether 1.61
    1,2-dichlorobenzene 0.47
    ethyl lactate 5.3
    propylene carbonate 4.0
    n-methylformamide 84.31
    2-pentanol 4.28
    n-pentane 0.49
    1-propoxy-2-propanol 14.96
    1-methoxy-2-propyl acetate 2.06
    2-(2-methoxypropoxy) propanol 10.77
    mesitylene 0.12
    ε-caprolactone 6.36
    p-cymene 0.42
    epichlorohydrin 7.82
    1,1,1-trichloroethane 0.79
    2-aminoethanol 521.39
    morpholine-4-carbaldehyde 44.91
    sulfolane 18.68
    2,2,4-trimethylpentane 0.15
    2-methyltetrahydrofuran 3.67
    n-hexyl acetate 1.83
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 19.31
    sec-butyl acetate 0.43
    tert-butyl acetate 0.31
    decalin 0.12
    glycerin 437.38
    diglyme 24.32
    acrylic acid 81.56
    isopropyl myristate 0.45
    n-butyric acid 21.58
    acetyl acetate 0.64
    di(2-ethylhexyl) phthalate 1.97
    ethyl propionate 0.94
    nitromethane 49.37
    1,2-diethoxyethane 2.39
    benzonitrile 0.84
    trioctyl phosphate 1.53
    1-bromopropane 1.17
    gamma-valerolactone 16.78
    n-decanol 2.08
    triethyl phosphate 1.46
    4-methyl-2-pentanol 0.86
    propionitrile 2.15
    vinylene carbonate 4.99
    1,1,2-trichlorotrifluoroethane 62.17
    DMS 1.56
    cumene 0.19
    2-octanol 2.6
    2-hexanone 0.8
    octyl acetate 1.05
    limonene 0.58
    1,2-dimethoxyethane 15.51
    ethyl orthosilicate 1.57
    tributyl phosphate 1.33
    diacetone alcohol 1.93
    N,N-dimethylaniline 0.77
    acrylonitrile 3.72
    aniline 1.71
    1,3-propanediol 267.39
    bromobenzene 0.15
    dibromomethane 3.29
    1,1,2,2-tetrachloroethane 3.95
    2-methyl-cyclohexyl acetate 1.66
    tetrabutyl urea 1.96
    diisobutyl methanol 0.74
    2-phenylethanol 3.48
    styrene 0.12
    dioctyl adipate 1.28
    dimethyl sulfate 2.31
    ethyl butyrate 1.18
    methyl lactate 8.13
    butyl lactate 5.58
    diethyl carbonate 0.93
    propanediol butyl ether 24.89
    triethyl orthoformate 1.62
    p-tert-butyltoluene 0.44
    methyl 4-tert-butylbenzoate 3.17
    morpholine 29.43
    tert-butylamine 3.38
    n-dodecanol 1.31
    dimethoxymethane 6.91
    ethylene carbonate 3.38
    cyrene 16.58
    2-ethoxyethyl acetate 3.04
    2-ethylhexyl acetate 0.82
    1,2,4-trichlorobenzene 0.8
    4-methylpyridine 1.02
    dibutyl ether 0.69
    2,6-dimethyl-4-heptanol 0.74
    DEF 3.42
    dimethyl isosorbide 9.95
    tetrachloroethylene 7.18
    eugenol 7.58
    triacetin 3.34
    span 80 13.52
    1,4-butanediol 83.19
    1,1-dichloroethane 0.85
    2-methyl-1-pentanol 2.9
    methyl formate 29.13
    2-methyl-1-butanol 8.85
    n-decane 0.21
    butyronitrile 1.49
    3,7-dimethyl-1-octanol 1.37
    1-chlorooctane 0.56
    1-chlorotetradecane 0.21
    n-nonane 0.2
    undecane 0.15
    tert-butylcyclohexane 0.12
    cyclooctane 0.16
    cyclopentanol 14.26
    tetrahydropyran 3.72
    tert-amyl methyl ether 0.96
    2,5,8-trioxanonane 15.31
    1-hexene 0.55
    2-isopropoxyethanol 17.28
    2,2,2-trifluoroethanol 168.53
    methyl butyrate 1.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction