Chavibetol

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    501-19-9

    Molecular formula
    C10H12O2

    SMILES
    COC1=C(C=C(C=C1)CC=C)O

  • Odor profile

    Spicy 85.71%
    Phenolic 71.06%
    Sweet 65.87%
    Woody 63.26%
    Smoky 59.8%
    Clove 57.91%
    Medicinal 42.18%
    Warm 41.77%
    Herbal 35.78%
    Vanilla 35.38%

    Scent© AI

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    8.89 (weak base)

    Molecular weight
    164.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    250°C

    Flash point est.
    110.49 ˚C

  • Synonyms

    • Chavibetol
    • 501-19-9
    • m-Eugenol
    • 5-Allyl-2-methoxyphenol
    • 2-methoxy-5-prop-2-enyl-phenol
    • 2-methoxy-5-prop-2-enylphenol
    • Phenol, 5-allyl-2-methoxy-
    • 2-methoxy-5-(prop-2-en-1-yl)phenol
    • UNII-OE7NQ16G4D
    • OE7NQ16G4D
    • 3-hydroxy-4-methoxyallylbenzene
    • 2-Methoxy-5-(2-propenyl)phenol
    • 3-Allyl-6-methoxyphenol
    • Phenol, 2-methoxy-5-(2-propenyl)-
    • DTXSID70198206
    • 3-ALLYL-6-METHOXY PHENOL
    • 1-METHOXY-2-HYDROXY-4-ALLYLBENZENE
    • 5-allyl-2-methoxy-phenol
    • 5-Allyl-2-methoxyphenol #
    • phenol, 3-allyl-6-methoxy-
    • SCHEMBL901503
    • CHEMBL259093
    • DTXCID60120697
    • CHEBI:167418
    • BBL028696
    • STL371291
    • AKOS006243252
    • VS-08911
    • CS-0331965
    • NS00123832
    • Q2961728
    • Z56778513

  • Applications

    Chavibetol (CAS 501-19-9), also known as hydroxychavicol/allylpyrocatechol, is a natural phenolic from Piper betle with multiple applications and prospects: used in flavors and personal care for its warm-spicy note and antioxidant capacity, investigated as a bio-based preservative that suppresses bacteria, yeasts, and biofilms in food; in biomedicine, in vitro/in vivo studies report oral-antimicrobial effects (e.g., antiplaque, S. mutans, Candida), synergy with antibiotics, anti-inflammatory and redox-modulating actions, and anticancer potential via apoptosis in certain cell lines, suggesting use in mouthwashes, dental materials, and oral-care products; it is also explored as an eco-friendly insecticidal/larvicidal agent, an antimicrobial additive for packaging, coatings, and hydrogels, and as an analytical standard and synthetic intermediate in pharma–fragrance chemistry; any therapeutic deployment requires toxicology, stability evaluation, and regulatory compliance before commercialization.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1891.43
    methanol 2244.14
    isopropanol 942.97
    water 0.42
    ethyl acetate 1904.22
    n-propanol 1289.19
    acetone 1505.28
    n-butanol 864.86
    acetonitrile 1651.11
    DMF 1126.29
    toluene 211.68
    isobutanol 610.35
    1,4-dioxane 1964.23
    methyl acetate 1399.86
    THF 2101.48
    2-butanone 1051.56
    n-pentanol 451.2
    sec-butanol 678.79
    n-hexane 26.48
    ethylene glycol 264.04
    NMP 502.14
    cyclohexane 73.57
    DMSO 1916.0
    n-butyl acetate 683.63
    n-octanol 137.5
    chloroform 997.63
    n-propyl acetate 566.05
    acetic acid 1095.68
    dichloromethane 1337.07
    cyclohexanone 886.5
    propylene glycol 322.84
    isopropyl acetate 514.92
    DMAc 442.25
    2-ethoxyethanol 783.71
    isopentanol 505.07
    n-heptane 34.04
    ethyl formate 764.59
    1,2-dichloroethane 1055.22
    n-hexanol 507.6
    2-methoxyethanol 1745.06
    isobutyl acetate 237.67
    tetrachloromethane 122.44
    n-pentyl acetate 197.99
    transcutol 1852.87
    n-heptanol 143.58
    ethylbenzene 93.26
    MIBK 349.7
    2-propoxyethanol 795.35
    tert-butanol 1081.72
    MTBE 803.43
    2-butoxyethanol 286.2
    propionic acid 669.06
    o-xylene 103.56
    formic acid 388.09
    diethyl ether 1550.78
    m-xylene 139.05
    p-xylene 100.36
    chlorobenzene 316.44
    dimethyl carbonate 307.45
    n-octane 13.14
    formamide 911.6
    cyclopentanone 1058.38
    2-pentanone 926.48
    anisole 290.06
    cyclopentyl methyl ether 699.07
    gamma-butyrolactone 1343.85
    1-methoxy-2-propanol 910.86
    pyridine 813.16
    3-pentanone 557.33
    furfural 762.84
    n-dodecane 11.9
    diethylene glycol 606.69
    diisopropyl ether 182.18
    tert-amyl alcohol 663.85
    acetylacetone 695.48
    n-hexadecane 13.83
    acetophenone 228.49
    methyl propionate 1039.49
    isopentyl acetate 428.65
    trichloroethylene 1502.34
    n-nonanol 120.54
    cyclohexanol 508.84
    benzyl alcohol 239.02
    2-ethylhexanol 214.28
    isooctanol 112.79
    dipropyl ether 315.79
    1,2-dichlorobenzene 239.78
    ethyl lactate 172.14
    propylene carbonate 560.82
    n-methylformamide 1020.72
    2-pentanol 478.43
    n-pentane 38.96
    1-propoxy-2-propanol 444.36
    1-methoxy-2-propyl acetate 466.65
    2-(2-methoxypropoxy) propanol 262.96
    mesitylene 83.82
    ε-caprolactone 715.61
    p-cymene 70.21
    epichlorohydrin 1689.37
    1,1,1-trichloroethane 659.9
    2-aminoethanol 534.6
    morpholine-4-carbaldehyde 712.11
    sulfolane 976.53
    2,2,4-trimethylpentane 22.83
    2-methyltetrahydrofuran 1283.22
    n-hexyl acetate 268.68
    isooctane 23.17
    2-(2-butoxyethoxy)ethanol 419.78
    sec-butyl acetate 261.18
    tert-butyl acetate 433.39
    decalin 28.55
    glycerin 370.55
    diglyme 791.92
    acrylic acid 468.33
    isopropyl myristate 103.58
    n-butyric acid 943.38
    acetyl acetate 523.52
    di(2-ethylhexyl) phthalate 87.97
    ethyl propionate 418.82
    nitromethane 1953.96
    1,2-diethoxyethane 651.87
    benzonitrile 301.01
    trioctyl phosphate 72.41
    1-bromopropane 511.93
    gamma-valerolactone 1118.81
    n-decanol 93.18
    triethyl phosphate 115.69
    4-methyl-2-pentanol 185.12
    propionitrile 877.26
    vinylene carbonate 476.61
    1,1,2-trichlorotrifluoroethane 664.83
    DMS 246.65
    cumene 62.65
    2-octanol 90.72
    2-hexanone 421.83
    octyl acetate 129.25
    limonene 118.16
    1,2-dimethoxyethane 1077.63
    ethyl orthosilicate 116.93
    tributyl phosphate 95.95
    diacetone alcohol 475.02
    N,N-dimethylaniline 134.07
    acrylonitrile 921.18
    aniline 346.3
    1,3-propanediol 781.96
    bromobenzene 298.06
    dibromomethane 828.98
    1,1,2,2-tetrachloroethane 950.35
    2-methyl-cyclohexyl acetate 180.3
    tetrabutyl urea 113.22
    diisobutyl methanol 119.58
    2-phenylethanol 235.47
    styrene 131.72
    dioctyl adipate 141.08
    dimethyl sulfate 330.78
    ethyl butyrate 354.95
    methyl lactate 266.1
    butyl lactate 150.66
    diethyl carbonate 217.71
    propanediol butyl ether 251.31
    triethyl orthoformate 195.61
    p-tert-butyltoluene 68.67
    methyl 4-tert-butylbenzoate 164.94
    morpholine 2206.07
    tert-butylamine 536.75
    n-dodecanol 71.99
    dimethoxymethane 1168.61
    ethylene carbonate 457.53
    cyrene 214.3
    2-ethoxyethyl acetate 357.7
    2-ethylhexyl acetate 294.08
    1,2,4-trichlorobenzene 265.7
    4-methylpyridine 586.15
    dibutyl ether 214.41
    2,6-dimethyl-4-heptanol 119.58
    DEF 654.4
    dimethyl isosorbide 408.51
    tetrachloroethylene 583.19
    eugenol 176.23
    triacetin 241.13
    span 80 192.11
    1,4-butanediol 218.65
    1,1-dichloroethane 923.09
    2-methyl-1-pentanol 301.96
    methyl formate 856.83
    2-methyl-1-butanol 459.09
    n-decane 19.51
    butyronitrile 794.68
    3,7-dimethyl-1-octanol 142.32
    1-chlorooctane 93.76
    1-chlorotetradecane 37.0
    n-nonane 18.91
    undecane 14.69
    tert-butylcyclohexane 26.72
    cyclooctane 22.59
    cyclopentanol 559.79
    tetrahydropyran 1776.95
    tert-amyl methyl ether 400.59
    2,5,8-trioxanonane 484.51
    1-hexene 138.58
    2-isopropoxyethanol 425.38
    2,2,2-trifluoroethanol 249.22
    methyl butyrate 529.92

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Mentha sylvestris var. incana Mentha sylvestris var. incana, fam Lamiacae (Labiatae) 1.82%
Chervil (France) 8000-44-0 Anthriscus cerefolium (L.) Hoffm. (Cerefolium sativum Lam.), fam. Apiaceae 0.1%
Betel leaf Bangla (India) Piper betle L. var. Bangla, fam. Piperaceae 0.5%