Camphor (synthetic)

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  • Identifiers

    CAS number
    464-49-3

    Molecular formula
    C10H16O

    SMILES
    C[C@@]12CC[C@@H](C1(C)C)CC2=O

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Herbal 81.9%
    Camphoreous 79.32%
    Woody 78.45%
    Mint 66.91%
    Pine 61.86%
    Fresh 58.18%
    Cooling 57.7%
    Green 57.07%
    Earthy 53.82%
    Spicy 44.09%

    Scent© AI

  • Properties

    XLogP3-AA
    2.2

    Molecular weight
    152.23 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Melting point expt.

    • 353.8 °F (NTP, 1992)
    • 176.00 to 177.00 °C. @ 760.00 mm Hg
    • 345 °F

    Boiling point

    • 399 °F at 760 mmHg (NTP, 1992)
    • 204.00 to 205.00 °C. @ 760.00 mm Hg
    • 399 °F

    Flash point est.
    62.39 ˚C

    Flash point expt.

    • 148 °F (NTP, 1992)
    • 150 °F

    Solubility expt.

    • less than 1 mg/mL at 59 °F (NTP, 1992)
    • 1600 mg/L @ 25 °C (exp)
    • Soluble in oils, water
    • Soluble (in ethanol)
    • Slightly soluble
    • Soluble (in ethanol)
    • Insoluble

  • Synonyms

    • (+)-Camphor
    • D-CAMPHOR
    • 464-49-3
    • (R)-(+)-Camphor
    • (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
    • (R)-Camphor
    • (1R)-(+)-Camphor
    • D(+)-Camphor
    • (+)-Bornan-2-one
    • DL-Camphor
    • Camphora
    • (1R,4R)-camphor
    • Camphor, Racemic
    • Camphor(D)
    • Camphor (synthetic)
    • Dextrocamphor
    • Camphor (1R)
    • (+)-2-Bornanone
    • Natural camphor
    • Camphor D-form
    • camphor (natural)
    • Camphor, dl-
    • Camphor, D-
    • FEMA No. 2230
    • Camphor, (+)-
    • Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R,4R)-
    • d-Camphor [JAN]
    • FEMA NO. 4513
    • NSC-755918
    • 5TJD82A1ET
    • Alcanfor
    • SYNTHETIC CAMPHOR
    • DTXSID4024721
    • CHEBI:15396
    • d-2-Bornanone
    • N20HL7Q941
    • Bicyclo(2.2.1)heptane-2-one, 1,7,7-trimethyl-
    • (1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
    • (1R)-Camphor
    • NCGC00090681-04
    • DTXCID804721
    • (1R,4R)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-one
    • Zang Qi
    • Camphor, (1R,4R)-(+)-
    • DL-Bornan-2-one
    • Camphor [USP]
    • Japanese camphor
    • Camphor USP
    • d-2-Camphanone
    • Caswell No. 155
    • CAMPHOR, RACEMIC (EP MONOGRAPH)
    • CAMPHOR, RACEMIC [EP MONOGRAPH]
    • CAS-464-49-3
    • Camphor, (+/-)-
    • UNII-5TJD82A1ET
    • HSDB 37
    • Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R)-
    • Camphorwood
    • Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R,4R)-
    • Laurus camphora
    • Camphor laurel
    • UNII-N20HL7Q941
    • d-Camphor; (1R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
    • EINECS 200-945-0
    • EINECS 244-350-4
    • Camphora camphora
    • D-(+)-Camphor;(1R)-(+)-Camphor
    • EPA Pesticide Chemical Code 015602
    • BRN 1907611
    • BRN 3196099
    • Cinnamonum camphora
    • Kampfer [German]
    • camphor-(+)
    • EINECS 207-355-2
    • ( S)-camphor
    • AI3-18783
    • UN2717
    • 2-Kamfanon [Czech]
    • (+-)-Camphor
    • Camphor, 96%
    • EC 200-945-0
    • CAMPHORA [HPUS]
    • 0-07-00-00135 (Beilstein Handbook Reference)
    • 4-07-00-00213 (Beilstein Handbook Reference)
    • CAMPHOR [HSDB]
    • AI3-01698
    • CAMPHOR [MI]
    • Spectrum2_000383
    • Spectrum3_000322
    • CAMPHOR [USP-RS]
    • CAMPHOR [WHO-DD]
    • D-CAMPHOR [FHFI]
    • DL-CAMPHOR [JAN]
    • (+)-Camphor (Standard)
    • Huile de camphre [French]
    • D-CAMPHOR [WHO-DD]
    • SCHEMBL16069
    • BSPBio_001923
    • CAMPHOR D-FORM [MI]
    • SPBio_000565
    • (+)-CAMPHOR [FCC]
    • D-Camphor, >=97%, FG
    • CHEMBL504760
    • (1R,4R)-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one
    • BDBM36263
    • HY-B1173R
    • KBio3_001143
    • D-CAMPHOR [EP MONOGRAPH]
    • D-Camphor, natural, 96%, FG
    • Pharmakon1600-01500156
    • (1R)-(+)-Camphor, 98%
    • (1R,4R)-(+)-CAMPHOR
    • HY-B1173
    • Tox21_110995
    • Tox21_202187
    • Tox21_303052
    • NSC755918
    • (+/-)-Camphor, >=95.5%
    • AKOS016001972
    • Tox21_110995_1
    • CS-4779
    • DB01744
    • NSC 755918
    • D-Camphor 1000 microg/mL in Methanol
    • D-Camphor, analytical reference material
    • NCGC00090681-01
    • NCGC00090681-02
    • NCGC00090681-06

  • Applications

    D-Camphor (CAS 464-49-3), the dextrorotatory isomer of camphor, is a natural bicyclic terpene with a strong aroma that is widely used in pharmaceuticals as a cooling, analgesic and decongestant ingredient in rubs, plasters and inhalants; in cosmetics, perfumes, soaps and shaving creams to impart its characteristic scent and cooling effect; in foods at trace levels as a flavoring for chewing gum and traditional sweets; in agriculture and household products as a natural insect repellent; in organic chemistry as a chiral auxiliary and precursor to camphor-10-sulfonic acid for asymmetric catalysis; and in polymer materials as a plasticizer for cellulose nitrate and a crystal-modifying additive that enhances mechanical properties and durability.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1092.77
    methanol 1415.08
    isopropanol 1018.54
    water 88.36
    ethyl acetate 1570.32
    n-propanol 923.56
    acetone 2031.17
    n-butanol 751.85
    acetonitrile 2189.84
    DMF 2418.11
    toluene 1001.91
    isobutanol 715.51
    1,4-dioxane 3091.16
    methyl acetate 1894.71
    THF 2193.78
    2-butanone 1452.46
    n-pentanol 433.46
    sec-butanol 731.68
    n-hexane 101.81
    ethylene glycol 473.85
    NMP 1136.25
    cyclohexane 200.04
    DMSO 1119.73
    n-butyl acetate 683.76
    n-octanol 274.78
    chloroform 4175.22
    n-propyl acetate 774.78
    acetic acid 1239.99
    dichloromethane 3036.71
    cyclohexanone 1351.17
    propylene glycol 506.42
    isopropyl acetate 1117.13
    DMAc 1564.9
    2-ethoxyethanol 962.34
    isopentanol 684.37
    n-heptane 69.9
    ethyl formate 1042.17
    1,2-dichloroethane 1782.34
    n-hexanol 519.25
    2-methoxyethanol 1710.5
    isobutyl acetate 544.31
    tetrachloromethane 1076.69
    n-pentyl acetate 476.05
    transcutol 2171.75
    n-heptanol 323.57
    ethylbenzene 662.46
    MIBK 813.88
    2-propoxyethanol 1136.34
    tert-butanol 1134.55
    MTBE 1134.04
    2-butoxyethanol 714.42
    propionic acid 989.8
    o-xylene 766.53
    formic acid 881.76
    diethyl ether 1136.94
    m-xylene 785.86
    p-xylene 1273.84
    chlorobenzene 1365.94
    dimethyl carbonate 895.91
    n-octane 38.9
    formamide 1869.37
    cyclopentanone 1681.9
    2-pentanone 1081.76
    anisole 1456.83
    cyclopentyl methyl ether 936.93
    gamma-butyrolactone 1982.44
    1-methoxy-2-propanol 1285.18
    pyridine 2022.12
    3-pentanone 904.29
    furfural 2046.23
    n-dodecane 31.15
    diethylene glycol 997.6
    diisopropyl ether 464.12
    tert-amyl alcohol 770.45
    acetylacetone 1704.69
    n-hexadecane 37.43
    acetophenone 1128.71
    methyl propionate 1191.82
    isopentyl acetate 688.95
    trichloroethylene 3511.79
    n-nonanol 270.61
    cyclohexanol 654.88
    benzyl alcohol 863.66
    2-ethylhexanol 293.52
    isooctanol 281.47
    dipropyl ether 442.91
    1,2-dichlorobenzene 1331.51
    ethyl lactate 395.92
    propylene carbonate 1246.19
    n-methylformamide 1726.93
    2-pentanol 569.29
    n-pentane 124.09
    1-propoxy-2-propanol 748.09
    1-methoxy-2-propyl acetate 1000.2
    2-(2-methoxypropoxy) propanol 636.71
    mesitylene 541.42
    ε-caprolactone 1180.44
    p-cymene 301.29
    epichlorohydrin 2242.22
    1,1,1-trichloroethane 2653.89
    2-aminoethanol 825.89
    morpholine-4-carbaldehyde 2001.79
    sulfolane 1392.97
    2,2,4-trimethylpentane 69.39
    2-methyltetrahydrofuran 1426.0
    n-hexyl acetate 610.1
    isooctane 75.08
    2-(2-butoxyethoxy)ethanol 790.54
    sec-butyl acetate 634.7
    tert-butyl acetate 1192.18
    decalin 129.91
    glycerin 639.83
    diglyme 1726.93
    acrylic acid 976.34
    isopropyl myristate 289.14
    n-butyric acid 1019.66
    acetyl acetate 1349.48
    di(2-ethylhexyl) phthalate 263.62
    ethyl propionate 759.71
    nitromethane 3096.8
    1,2-diethoxyethane 915.34
    benzonitrile 1235.35
    trioctyl phosphate 172.06
    1-bromopropane 789.03
    gamma-valerolactone 2329.75
    n-decanol 201.6
    triethyl phosphate 314.45
    4-methyl-2-pentanol 413.9
    propionitrile 1371.42
    vinylene carbonate 1412.93
    1,1,2-trichlorotrifluoroethane 1679.35
    DMS 903.92
    cumene 443.69
    2-octanol 224.87
    2-hexanone 717.21
    octyl acetate 328.75
    limonene 301.32
    1,2-dimethoxyethane 1710.78
    ethyl orthosilicate 314.96
    tributyl phosphate 226.15
    diacetone alcohol 1024.19
    N,N-dimethylaniline 846.16
    acrylonitrile 1846.86
    aniline 1224.12
    1,3-propanediol 997.61
    bromobenzene 1399.38
    dibromomethane 1726.9
    1,1,2,2-tetrachloroethane 2633.61
    2-methyl-cyclohexyl acetate 465.74
    tetrabutyl urea 247.71
    diisobutyl methanol 237.9
    2-phenylethanol 835.64
    styrene 788.08
    dioctyl adipate 358.12
    dimethyl sulfate 1032.11
    ethyl butyrate 606.16
    methyl lactate 673.71
    butyl lactate 396.38
    diethyl carbonate 494.2
    propanediol butyl ether 522.55
    triethyl orthoformate 435.58
    p-tert-butyltoluene 317.8
    methyl 4-tert-butylbenzoate 744.44
    morpholine 2414.95
    tert-butylamine 758.82
    n-dodecanol 153.83
    dimethoxymethane 1589.02
    ethylene carbonate 1132.1
    cyrene 539.81
    2-ethoxyethyl acetate 804.09
    2-ethylhexyl acetate 501.67
    1,2,4-trichlorobenzene 1441.6
    4-methylpyridine 1979.97
    dibutyl ether 337.24
    2,6-dimethyl-4-heptanol 237.9
    DEF 1031.41
    dimethyl isosorbide 1065.83
    tetrachloroethylene 2021.2
    eugenol 709.91
    triacetin 732.77
    span 80 483.79
    1,4-butanediol 376.36
    1,1-dichloroethane 2309.11
    2-methyl-1-pentanol 389.01
    methyl formate 1396.12
    2-methyl-1-butanol 574.71
    n-decane 52.65
    butyronitrile 1012.77
    3,7-dimethyl-1-octanol 299.92
    1-chlorooctane 208.19
    1-chlorotetradecane 95.0
    n-nonane 46.72
    undecane 39.3
    tert-butylcyclohexane 117.53
    cyclooctane 81.67
    cyclopentanol 788.76
    tetrahydropyran 1557.66
    tert-amyl methyl ether 649.81
    2,5,8-trioxanonane 1109.25
    1-hexene 318.18
    2-isopropoxyethanol 686.56
    2,2,2-trifluoroethanol 1046.81
    methyl butyrate 865.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction