Benzocaine

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  • Identifiers

    CAS number
    94-09-7

    Molecular formula
    C9H11NO2

    SMILES
    CCOC(=O)C1=CC=C(C=C1)N

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Floral 84.59%
    Grape 71.25%
    Fruity 69.17%
    Sweet 63.28%
    Neroli 49.06%
    Orange 44.72%
    Powdery 39.1%
    Cherry 33.89%
    Berry 32.71%
    Hawthorn 31.66%

    Scent© AI

  • Properties

    XLogP3-AA
    1.9

    Molecular weight
    165.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 92 °C

    Boiling point

    • 310 °C

    Flash point est.
    141.26 ˚C

    Solubility expt.

    • >24.8 [ug/mL] (The mean of the results at pH 7.4)
    • 1310 mg/L (at 30 °C)
    • One gram dissolves in about 5 ml alcohol, 2 ml chloroform, in about 4 ml ether, and in 30 to 50 ml of expressed almond oil or olive oil. Also sol in dil acids.
    • Soluble in acid
    • In water, 1,310 mg/L at 25 °C

  • Synonyms

    • benzocaine
    • Ethyl 4-aminobenzoate
    • 94-09-7
    • Ethyl aminobenzoate
    • Ethyl p-aminobenzoate
    • Parathesin
    • Norcaine
    • Americaine
    • Anaesthesin
    • Anesthesin
    • Parathesine
    • 4-Aminobenzoic acid ethyl ester
    • Amben ethyl ester
    • p-Carbethoxyaniline
    • Anaesthin
    • Anesthesine
    • Dermoplast
    • Ethoform
    • Hurricaine
    • Identhesin
    • Topcaine
    • Norcain
    • Baby Anbesol
    • Anaesthan-syngala
    • Ora-jel
    • Anestezin
    • Anesthone
    • Benzocainum
    • Keloform
    • Orthesin
    • Solu H
    • Dextran sulfate sodium
    • 4-Carbethoxyaniline
    • p-Ethoxycarboxylic aniline
    • Benzocaina
    • p-(Ethoxycarbonyl)aniline
    • Ethyl p-aminophenylcarboxylate
    • Benzoic acid, 4-amino-, ethyl ester
    • Ethyl PABA
    • 4-(Ethoxycarbonyl)aniline
    • Anaesthesinum
    • Ethoforme
    • Norcainum
    • Ethylis aminobenzoas
    • Aethoform
    • Otocain
    • Outgro
    • p-Aminobenzoic acid ethyl ester
    • Benzoic acid, p-amino-, ethyl ester
    • Aethylium paraminobenzoicum
    • Subcutin
    • 4-Aminobenzoic acid, ethyl ester
    • Caswell No. 430A
    • Benzocainum [INN-Latin]
    • Benzocaina [INN-Spanish]
    • Ethylester kyseliny p-aminobenzoove
    • Flavamed
    • HSDB 7225
    • p-Aminobenzoic acid, ethyl ester
    • 4-amino-benzoic acid ethyl ester
    • CHEBI:116735
    • UNII-U3RSY48JW5
    • NSC-4688
    • EINECS 202-303-5
    • ETHYL-P-AMINOBENZOATE
    • U3RSY48JW5
    • NSC 41531
    • NSC-41531
    • EPA Pesticide Chemical Code 097001
    • BRN 0638434
    • AR01
    • DTXSID8021804
    • AI3-02081
    • AR-01
    • MFCD00007892
    • Benzocaine [USP:INN:BAN]
    • DTXCID301804
    • 4-aminobenzoic acid-ethyl ester
    • Bensokain
    • 4-14-00-01129 (Beilstein Handbook Reference)
    • NSC41531
    • Dextran, hydrogen sulfate, sodium salt
    • CAS-94-09-7
    • NCGC00016352-01
    • Anestezin [Russian]
    • Chloraseptic
    • ETHYL4-AMINOBENZOATE
    • Benzocainum (INN-Latin)
    • Benzocaina (INN-Spanish)
    • WLN: ZR DVO2
    • aniline, 4-ethoxycarbonyl-
    • BENZOCAINE (MART.)
    • BENZOCAINE [MART.]
    • BENZOCAINE (USP-RS)
    • BENZOCAINE [USP-RS]
    • Benzocaine (USP:INN:BAN)
    • Ethyl aminobenzoate (VAN)
    • BENZOCAINE (EP MONOGRAPH)
    • BENZOCAINE [EP MONOGRAPH]
    • BENZOCAINE (USP MONOGRAPH)
    • BENZOCAINE [USP MONOGRAPH]
    • Finafta
    • Parathesin (TN)
    • SMR000059025
    • Ethylester kyseliny p-aminobenzoove [Czech]
    • Benzocaine (USP/INN)
    • SR-05000001573
    • p-Aminobenzoic ethyl ester
    • Desensitizer
    • Anesgerm
    • Anestenka
    • Athoforme
    • Benzoak
    • Benzocain
    • Benzodent
    • Chiggerex
    • Goodwinol
    • Preboost
    • Stallion
    • TopexRaspberry
    • TopexStrawberry
    • Topicale
    • Vagisil
    • Defend
    • Ioline
    • Iolite
    • Rexall
    • TopexCherry

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 313.53
    methanol 426.24
    isopropanol 212.3
    water 1.2
    ethyl acetate 166.51
    n-propanol 193.11
    acetone 492.99
    n-butanol 149.44
    acetonitrile 287.99
    DMF 916.05
    toluene 25.77
    isobutanol 108.11
    1,4-dioxane 319.89
    methyl acetate 183.01
    THF 435.81
    2-butanone 220.53
    n-pentanol 114.57
    sec-butanol 126.39
    n-hexane 1.75
    ethylene glycol 83.98
    NMP 535.8
    cyclohexane 1.73
    DMSO 1255.36
    n-butyl acetate 110.46
    n-octanol 53.04
    chloroform 248.52
    n-propyl acetate 109.34
    acetic acid 524.44
    dichloromethane 304.82
    cyclohexanone 267.14
    propylene glycol 123.96
    isopropyl acetate 82.78
    DMAc 479.89
    2-ethoxyethanol 209.23
    isopentanol 109.43
    n-heptane 1.61
    ethyl formate 162.31
    1,2-dichloroethane 198.06
    n-hexanol 78.69
    2-methoxyethanol 387.08
    isobutyl acetate 58.89
    tetrachloromethane 13.19
    n-pentyl acetate 61.88
    transcutol 580.21
    n-heptanol 44.58
    ethylbenzene 19.22
    MIBK 87.49
    2-propoxyethanol 154.69
    tert-butanol 236.24
    MTBE 94.62
    2-butoxyethanol 97.09
    propionic acid 215.19
    o-xylene 25.55
    formic acid 247.97
    diethyl ether 84.76
    m-xylene 26.29
    p-xylene 28.87
    chlorobenzene 77.09
    dimethyl carbonate 92.51
    n-octane 1.18
    formamide 441.33
    cyclopentanone 449.13
    2-pentanone 161.72
    anisole 87.58
    cyclopentyl methyl ether 112.94
    gamma-butyrolactone 551.22
    1-methoxy-2-propanol 237.03
    pyridine 206.87
    3-pentanone 94.94
    furfural 398.43
    n-dodecane 1.84
    diethylene glycol 167.35
    diisopropyl ether 17.76
    tert-amyl alcohol 135.23
    acetylacetone 215.89
    n-hexadecane 2.13
    acetophenone 102.81
    methyl propionate 140.49
    isopentyl acetate 88.17
    trichloroethylene 404.74
    n-nonanol 45.28
    cyclohexanol 91.06
    benzyl alcohol 93.98
    2-ethylhexanol 41.25
    isooctanol 36.52
    dipropyl ether 31.46
    1,2-dichlorobenzene 72.42
    ethyl lactate 70.51
    propylene carbonate 224.5
    n-methylformamide 414.38
    2-pentanol 79.71
    n-pentane 1.37
    1-propoxy-2-propanol 102.94
    1-methoxy-2-propyl acetate 106.0
    2-(2-methoxypropoxy) propanol 97.62
    mesitylene 17.02
    ε-caprolactone 212.07
    p-cymene 15.98
    epichlorohydrin 453.49
    1,1,1-trichloroethane 91.38
    2-aminoethanol 153.28
    morpholine-4-carbaldehyde 375.14
    sulfolane 627.87
    2,2,4-trimethylpentane 2.65
    2-methyltetrahydrofuran 217.61
    n-hexyl acetate 94.49
    isooctane 2.01
    2-(2-butoxyethoxy)ethanol 145.77
    sec-butyl acetate 56.27
    tert-butyl acetate 93.62
    decalin 3.25
    glycerin 188.21
    diglyme 266.65
    acrylic acid 244.69
    isopropyl myristate 31.78
    n-butyric acid 241.61
    acetyl acetate 112.06
    di(2-ethylhexyl) phthalate 41.19
    ethyl propionate 80.53
    nitromethane 899.97
    1,2-diethoxyethane 109.36
    benzonitrile 114.54
    trioctyl phosphate 31.13
    1-bromopropane 57.8
    gamma-valerolactone 438.21
    n-decanol 33.13
    triethyl phosphate 39.73
    4-methyl-2-pentanol 43.09
    propionitrile 137.4
    vinylene carbonate 207.95
    1,1,2-trichlorotrifluoroethane 286.61
    DMS 86.19
    cumene 17.0
    2-octanol 32.39
    2-hexanone 107.48
    octyl acetate 45.95
    limonene 23.79
    1,2-dimethoxyethane 291.09
    ethyl orthosilicate 36.0
    tributyl phosphate 38.46
    diacetone alcohol 143.69
    N,N-dimethylaniline 57.56
    acrylonitrile 219.76
    aniline 91.78
    1,3-propanediol 209.29
    bromobenzene 59.35
    dibromomethane 138.56
    1,1,2,2-tetrachloroethane 280.36
    2-methyl-cyclohexyl acetate 59.27
    tetrabutyl urea 52.27
    diisobutyl methanol 24.29
    2-phenylethanol 72.38
    styrene 27.02
    dioctyl adipate 53.29
    dimethyl sulfate 184.89
    ethyl butyrate 67.46
    methyl lactate 116.35
    butyl lactate 66.14
    diethyl carbonate 53.21
    propanediol butyl ether 124.36
    triethyl orthoformate 48.33
    p-tert-butyltoluene 15.97
    methyl 4-tert-butylbenzoate 79.61
    morpholine 356.49
    tert-butylamine 88.86
    n-dodecanol 23.78
    dimethoxymethane 266.55
    ethylene carbonate 162.54
    cyrene 119.78
    2-ethoxyethyl acetate 94.63
    2-ethylhexyl acetate 59.1
    1,2,4-trichlorobenzene 100.61
    4-methylpyridine 183.65
    dibutyl ether 42.08
    2,6-dimethyl-4-heptanol 24.29
    DEF 194.6
    dimethyl isosorbide 146.78
    tetrachloroethylene 138.23
    eugenol 88.38
    triacetin 98.16
    span 80 83.34
    1,4-butanediol 84.97
    1,1-dichloroethane 148.51
    2-methyl-1-pentanol 87.57
    methyl formate 302.22
    2-methyl-1-butanol 98.73
    n-decane 2.64
    butyronitrile 147.21
    3,7-dimethyl-1-octanol 42.83
    1-chlorooctane 20.27
    1-chlorotetradecane 8.34
    n-nonane 2.09
    undecane 2.16
    tert-butylcyclohexane 3.68
    cyclooctane 0.86
    cyclopentanol 131.38
    tetrahydropyran 174.98
    tert-amyl methyl ether 63.11
    2,5,8-trioxanonane 171.45
    1-hexene 14.12
    2-isopropoxyethanol 122.2
    2,2,2-trifluoroethanol 155.61
    methyl butyrate 123.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction