Acetone

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  • Identifiers

    CAS number
    67-64-1

    Molecular formula
    C3H6O

    SMILES
    CC(=O)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Retention indicies (RI)

    • Carbowax: 826.17

  • Odor profile

    Ethereal 79.52%
    Solvent 61.14%
    Pungent 47.57%
    Alcoholic 44.56%
    Camphoreous 42.27%
    Ketonic 41.44%
    Sweet 41.22%
    Fermented 39.67%
    Musty 38.65%
    Sharp 38.02%

    Scent© AI

    Odor threshold>

    • Odor Threshold Low: 3.6 [mmHg]. Odor Threshold High: 653.0 [mmHg]. Detection odor threshold from AIHA (mean = 62 ppm)
    • Water: 20 mg/L (or 20 ppm, w/v); air: 13 uL/L (or 13 ppm, v/v).
    • Odor low: 47.5 mg/cu m; Odor high: 1613.9 mg/cu m

  • Properties

    XLogP3-AA
    -0.1

    Molecular weight
    58.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -137 °F (NTP, 1992)
    • -94.9 °C
    • -94.8 °C
    • -95 °C
    • -137 °F
    • -140 °F

    Boiling point

    • 133 °F at 760 mmHg (NTP, 1992)
    • 56.08 °C
    • 56.00 to 57.00 °C. @ 760.00 mm Hg
    • 56 °C
    • 133 °F

    Flash point est.
    -24.41 ˚C

    Flash point expt.

    • 0 °F (NTP, 1992)
    • -18 °C
    • -16.99 °C (1.42 °F) - closed cup
    • -4 °F (-20 °C) (Closed cup)
    • 0 °F (closed cup)
    • -18 °C c.c.
    • 0 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)
    • Miscible with water
    • Miscible with benzene
    • Miscible with alcohol, dimethylformamide, ether
    • 1000 mg/mL at 25 °C
    • Solubility in water: miscible
    • miscible with water, alcohol, ether, chroroform and most fixed oils
    • Miscible

  • Synonyms

    • acetone
    • 2-propanone
    • 67-64-1
    • propanone
    • Dimethyl ketone
    • propan-2-one
    • Pyroacetic ether
    • Methyl ketone
    • Dimethylformaldehyde
    • beta-Ketopropane
    • Dimethylketal
    • Chevron acetone
    • Ketone propane
    • Aceton
    • Pyroacetic acid
    • Ketone, dimethyl
    • dimethylketone
    • Acetone (natural)
    • FEMA No. 3326
    • Dimethyl formaldehyde
    • RCRA waste number U002
    • Taimax
    • Caswell No. 004
    • HSDB 41
    • dimethylcetone
    • Dimethylketon
    • CCRIS 5953
    • Propanon
    • Azeton
    • NSC 135802
    • Aceton [German, Dutch, Polish]
    • EINECS 200-662-2
    • Ketone, dimethyl-
    • MFCD00008765
    • .beta.-Ketopropane
    • Acetone [NF]
    • EPA Pesticide Chemical Code 004101
    • NSC-135802
    • UNII-1364PS73AF
    • DTXSID8021482
    • CHEBI:15347
    • AI3-01238
    • 1364PS73AF
    • UN1090
    • (CH3)2CO
    • DTXCID101482
    • EC 200-662-2
    • Acetone (NF)
    • NSC135802
    • NCGC00091179-01
    • ACETONE (MART.)
    • ACETONE [MART.]
    • ACETONE (EP IMPURITY)
    • ACETONE [EP IMPURITY]
    • ACETONE (EP MONOGRAPH)
    • ACETONE [EP MONOGRAPH]
    • Acetona
    • Acetone, for HPLC, >=99.8%
    • Acetone, for HPLC, >=99.9%
    • Acetone, ACS reagent, >=99.5%
    • CAS-67-64-1
    • ISOFLURANE IMPURITY F (EP IMPURITY)
    • ISOFLURANE IMPURITY F [EP IMPURITY]
    • CHLOROBUTANOL IMPURITY B (EP IMPURITY)
    • CHLOROBUTANOL IMPURITY B [EP IMPURITY]
    • ACETONE (1,3-13C2, 99%)
    • ACETONE (1,1,1,3,3,3-D6)
    • RCRA waste no. U002
    • isopropanal
    • methylketone
    • Sasetone
    • methyl-ketone
    • 2propanone
    • b-Ketopropane
    • 2-propanal
    • Acetone ACS
    • Acetone (TN)
    • Acetone HPLC grade
    • methyl methyl ketone
    • Acetone, for HPLC
    • Acetone, ACS reagent
    • Acetone, HPLC Grade
    • TAK - Toxic Alcohols
    • ACETONE [VANDF]
    • ACETONE [FHFI]
    • ACETONE [HSDB]
    • Acetone ACS low benzene
    • ACETONE [FCC]
    • ACETONE [MI]
    • CH3COCH3
    • ACETONE [USP-RS]
    • ACETONE [WHO-DD]
    • Acetone, histological grade
    • Acetone, analytical standard
    • Acetone, Environmental Grade
    • Acetone, Semiconductor Grade
    • Acetone, LR, >=99%
    • Acetone, natural, >=97%
    • UN 1091 (Salt/Mix)
    • Aceton (GERMAN, POLISH)
    • Acetone, puriss., 99.0%
    • CHEMBL14253
    • WLN: 1V1
    • Acetone [for Spectrophotometry]
    • Acetone, AR, >=99.5%
    • Acetone (water < 1000 ppm)
    • Acetone, Spectrophotometric Grade
    • Acetone, >=99.5%, ACS reagent
    • Tox21_111096
    • Tox21_202480
    • c0556
    • LMFA12000057
    • Acetone 5000 microg/mL in Methanol
    • Acetone, purum, >=99.0% (GC)
    • AKOS000120890
    • ACETONE (2-13C, 99%)
    • Acetone 100 microg/mL in Acetonitrile
    • UN 1090
    • Acetone, SAJ first grade, >=99.0%
    • USEPA/OPP Pesticide Code: 044101
    • Acetone [UN1090] [Flammable liquid]
    • Acetone, for chromatography, >=99.8%
    • Acetone, histological grade, >=99.5%
    • Acetone, JIS special grade, >=99.5%
    • Acetone, Laboratory Reagent, >=99.5%
    • NCGC00260029-01
    • Acetone, for HPLC, >=99.8% (GC)
    • Acetone, UV HPLC spectroscopic, 99.8%

  • Applications

    Acetone (CAS 67-64-1) is a highly volatile, polar organic solvent whose versatility underpins many industries: in laboratories and chemical manufacturing it is used to rinse glassware, dilute or extract sparingly soluble compounds, act as a mobile phase additive in chromatography, and prepare samples for spectroscopic analysis; in coatings, inks, adhesives and plastics it rapidly dissolves polymers such as nitrocellulose, polystyrene and acrylics, enabling viscosity control, faster drying and effective surface cleaning before painting; as a chemical intermediate it feeds large-scale syntheses of methyl methacrylate and bisphenol A, precursors to PMMA, polycarbonate and epoxy resins; in cosmetics and personal care it is the active ingredient in nail-polish removers, false-eyelash glue solvents and pre-treatment degreasers for skin prior to makeup or tattooing; in pharmaceuticals it supports active-ingredient purification, steroid recrystallization and film-coating dehydration; additionally, acetone serves as a metal-degreasing agent in mechanical workshops, a secondary refrigerant in dry-ice baths, an auxiliary fuel for lamps and a rapid-penetrating fixative for biological specimens. Because it evaporates swiftly, is highly flammable and has a characteristic odor, its storage, transport and use require strict adherence to fire safety and ventilation regulations.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 778.19
    methanol 1308.44
    isopropanol 623.26
    water 525.2
    ethyl acetate 255.21
    n-propanol 542.91
    acetone 537.92
    n-butanol 405.45
    acetonitrile 455.98
    DMF 750.08
    toluene 79.24
    isobutanol 370.17
    1,4-dioxane 449.76
    methyl acetate 376.51
    THF 452.98
    2-butanone 342.29
    n-pentanol 229.15
    sec-butanol 462.14
    n-hexane 120.61
    ethylene glycol 634.42
    NMP 580.66
    cyclohexane 88.45
    DMSO 349.67
    n-butyl acetate 126.4
    n-octanol 213.33
    chloroform 606.32
    n-propyl acetate 130.63
    acetic acid 863.7
    dichloromethane 377.25
    cyclohexanone 257.68
    propylene glycol 675.27
    isopropyl acetate 149.43
    DMAc 737.62
    2-ethoxyethanol 378.59
    isopentanol 264.1
    n-heptane 77.43
    ethyl formate 200.75
    1,2-dichloroethane 183.68
    n-hexanol 281.74
    2-methoxyethanol 752.02
    isobutyl acetate 88.19
    tetrachloromethane 187.12
    n-pentyl acetate 110.92
    transcutol 659.23
    n-heptanol 162.86
    ethylbenzene 58.0
    MIBK 123.8
    2-propoxyethanol 459.17
    tert-butanol 591.08
    MTBE 299.49
    2-butoxyethanol 274.53
    propionic acid 550.08
    o-xylene 83.29
    formic acid 559.24
    diethyl ether 290.12
    m-xylene 70.0
    p-xylene 81.03
    chlorobenzene 92.48
    dimethyl carbonate 155.12
    n-octane 35.34
    formamide 444.12
    cyclopentanone 333.01
    2-pentanone 219.77
    anisole 144.5
    cyclopentyl methyl ether 219.57
    gamma-butyrolactone 385.64
    1-methoxy-2-propanol 557.84
    pyridine 231.4
    3-pentanone 211.9
    furfural 314.08
    n-dodecane 30.15
    diethylene glycol 456.75
    diisopropyl ether 98.68
    tert-amyl alcohol 447.14
    acetylacetone 212.14
    n-hexadecane 30.56
    acetophenone 129.21
    methyl propionate 277.33
    isopentyl acetate 105.5
    trichloroethylene 322.09
    n-nonanol 185.62
    cyclohexanol 284.51
    benzyl alcohol 148.8
    2-ethylhexanol 146.93
    isooctanol 114.99
    dipropyl ether 162.74
    1,2-dichlorobenzene 90.82
    ethyl lactate 154.15
    propylene carbonate 209.0
    n-methylformamide 499.77
    2-pentanol 285.65
    n-pentane 117.55
    1-propoxy-2-propanol 307.69
    1-methoxy-2-propyl acetate 158.76
    2-(2-methoxypropoxy) propanol 252.35
    mesitylene 49.09
    ε-caprolactone 256.36
    p-cymene 56.39
    epichlorohydrin 279.25
    1,1,1-trichloroethane 253.74
    2-aminoethanol 720.77
    morpholine-4-carbaldehyde 548.91
    sulfolane 330.42
    2,2,4-trimethylpentane 48.33
    2-methyltetrahydrofuran 317.43
    n-hexyl acetate 205.69
    isooctane 30.37
    2-(2-butoxyethoxy)ethanol 332.47
    sec-butyl acetate 96.76
    tert-butyl acetate 151.55
    decalin 39.95
    glycerin 739.15
    diglyme 445.75
    acrylic acid 527.01
    isopropyl myristate 95.66
    n-butyric acid 385.28
    acetyl acetate 172.07
    di(2-ethylhexyl) phthalate 95.08
    ethyl propionate 155.6
    nitromethane 667.03
    1,2-diethoxyethane 174.99
    benzonitrile 126.93
    trioctyl phosphate 76.39
    1-bromopropane 148.3
    gamma-valerolactone 408.15
    n-decanol 139.59
    triethyl phosphate 69.72
    4-methyl-2-pentanol 144.46
    propionitrile 291.11
    vinylene carbonate 197.86
    1,1,2-trichlorotrifluoroethane 439.41
    DMS 169.52
    cumene 52.9
    2-octanol 116.0
    2-hexanone 149.77
    octyl acetate 135.49
    limonene 86.27
    1,2-dimethoxyethane 405.3
    ethyl orthosilicate 72.68
    tributyl phosphate 84.69
    diacetone alcohol 252.21
    N,N-dimethylaniline 126.03
    acrylonitrile 329.75
    aniline 182.28
    1,3-propanediol 549.09
    bromobenzene 70.29
    dibromomethane 263.58
    1,1,2,2-tetrachloroethane 303.5
    2-methyl-cyclohexyl acetate 104.88
    tetrabutyl urea 114.69
    diisobutyl methanol 80.55
    2-phenylethanol 143.15
    styrene 68.63
    dioctyl adipate 125.1
    dimethyl sulfate 186.99
    ethyl butyrate 112.51
    methyl lactate 272.61
    butyl lactate 132.92
    diethyl carbonate 83.27
    propanediol butyl ether 311.45
    triethyl orthoformate 92.18
    p-tert-butyltoluene 60.15
    methyl 4-tert-butylbenzoate 162.93
    morpholine 507.86
    tert-butylamine 410.62
    n-dodecanol 110.05
    dimethoxymethane 365.42
    ethylene carbonate 164.1
    cyrene 196.38
    2-ethoxyethyl acetate 144.42
    2-ethylhexyl acetate 86.07
    1,2,4-trichlorobenzene 123.39
    4-methylpyridine 210.16
    dibutyl ether 141.96
    2,6-dimethyl-4-heptanol 80.55
    DEF 297.07
    dimethyl isosorbide 237.22
    tetrachloroethylene 253.02
    eugenol 178.51
    triacetin 206.58
    span 80 276.27
    1,4-butanediol 268.35
    1,1-dichloroethane 278.38
    2-methyl-1-pentanol 162.14
    methyl formate 341.93
    2-methyl-1-butanol 293.0
    n-decane 47.67
    butyronitrile 210.26
    3,7-dimethyl-1-octanol 161.55
    1-chlorooctane 100.46
    1-chlorotetradecane 49.68
    n-nonane 48.37
    undecane 36.23
    tert-butylcyclohexane 48.53
    cyclooctane 36.28
    cyclopentanol 347.35
    tetrahydropyran 303.84
    tert-amyl methyl ether 237.84
    2,5,8-trioxanonane 337.07
    1-hexene 164.63
    2-isopropoxyethanol 250.51
    2,2,2-trifluoroethanol 439.78
    methyl butyrate 172.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Carrot seed (France) 1 8015-88-1 Daucus carota L., fam. Apiaceae (Umbelliferae) 0.02%
Orange, bitter (Spain) 2 72968-50-4 Citrus aurantium L., ssp. amara Engl., fam. Rutaceae 0.05%
Truffle, black (Perigord) Tuber melanosporum, fam. Ascomycetae 8.0%
Satureja cuneifolia (Turkey) Satureja cuneifolia Ten. (S. pisidica Wettst.), fam. Lamiaceae (Labiatae) 0.1%
Artemisia judaica (Israel) 1 Artemisia judaica L. (Bat'aran), fam. Asteraceae (Compositae) 0.07%
Artemisia judaica (Egypt) 1 Artemisia judaica L. (Bat'aran), fam. Asteraceae (Compositae) 0.15%
Tagetes 2 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.03%
Annual wormwood (Yugoslavia) 84775-74-6 Artemisia annua L., fam. Asteraceae (Compositae) 0.03%
Rose (Bulgaria) 2 8007-01-0 Rosa damascena Mill., fam. Rosaceae 0.01%
Lavender (France) 6 8000-28-0 Lavandula angustifolia Mill., fam. Lamiaceae (Labiatae) 0.08%
Ageratum conyzoides (Ghana) 85480-32-6 Ageratum conyzoides L., fam. Asteraceae (Compositae) 0.01%
Micromeria myrtifolia (Turkey) Micromeria myrtifolia Boiss. et Hohen, fam. Lamiaceae (Labiatae) 0.03%
Calamintha nepeta (Turkey) 2 Calamintha nepeta (L.) Savi ssp. glandulosa (Req.) P.W.Ball, fam.Lamiaceae 0.01%
Thymus sibthorpii (Turkey) Thymus sibthorpii Bentham, fam. Lamiaceae (Labiatae) 0.01%
Grape flower 84929-27-1 Vitis vinifera L., ssp. Gruener Veltliner, fam. Vitaceae 2.1%
Lavandin (France) (Grosso) 2 8022-15-9 Lavandula x hybrida Rev. (L. x intermedia Emeric ex Loiesleur), Lamiaceae 0.01%
Lavandin (France) (Abrialis) 2 8022-15-9 Lavandula x hybrida Rev. (L. x intermedia Emeric ex Loiseleur), Lamiaceae 0.02%
Spike lavender 8016-78-2 Lavandula latifolia Medikus (L. spica D.C.), fam. Lamiaceae (Labiatae) 0.11%
Tagetes (Rwanda) 1 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.1%
Tagetes (France) 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.05%
Keora (India) 3 Pandanus odoratissimus L. (P. fascicularis Lam.), fam. Pandanaceae 0.1%
Rose (Turkey) 4 8007-01-7 Rosa damascena Mill., fam. Rosaceae 0.03%
Rose (Turkey) 5 8007-01-0 Rosa damascena Mill., fam. Rosaceae 0.01%
Tagetes (Cameroon) 1a leaf 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.1%
Tagetes (Cameroon) 1b flower 8016-84-0 Tagetes minuta L. (Marigold), fam. Asteraceae (Compositae) 0.01%
Bay, West Indian (Guadeloupe) 2a 8015-73-4 Pimenta racemosa var. racemosa (P. Miller) J.W. Moore, fam. Myrtaceae 0.01%
Lavender (France) 8 8000-28-0 Lavandula angustifolia Mill. (L. officinalis Chaix), fam. Lamiaceae 0.03%
Lavender (Bulgaria) 2 8000-28-0 Lavandula angustifolia Mill. (L. officinalis Chaix), fam. Lamiaceae 0.01%
Lavender (Ukraine) 8000-28-0 Lavandula angustifolia Mill., (L. officinalis Chaix), fam. Lamiaceae 0.01%
Lavender (Australia) 8000-28-0 Lavandula angustifolia Mill. (L. officinalis Chaix), fam. Lamiaceae 0.01%
Lavender (Moldova) 8000-28-0 Lavandula angustifolia Mill., (L. officinalis Chaix), fam. Lamiaceae 0.01%