8-Cyclohexadecen-1-one

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    3100-36-5

    Molecular formula
    C16H28O

    SMILES
    C1CCCC=CCCCCCCC(=O)CCC1

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Musk 91.38%
    Animal 66.06%
    Powdery 64.78%
    Amber 51.44%
    Dry 46.14%
    Natural 41.59%
    Clean 39.07%
    Sweet 36.49%
    Balsamic 34.87%
    Floral 33.95%

    Scent© AI

  • Properties

    XLogP3-AA
    5.6

    Molecular weight
    236.39 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    325°C

    Flash point est.
    150.38 ˚C

  • Synonyms

    • 8-Cyclohexadecen-1-one
    • cyclohexadec-8-en-1-one
    • 8-Cyclohexadecenone
    • 3100-36-5
    • DTXSID0051994
    • EC 401-700-2
    • (8E)-cyclohexadec-8-en-1-one
    • DTXCID3030557
    • FC159812
    • DB-047947
    • Globanone

  • Applications

    8-Cyclohexadecen-1-one (CAS 3100-36-5) is an unsaturated macrocyclic ketone with a soft, clean, long-lasting musky–amber character, used primarily in fragrance applications as a musk base note and fixative in fine perfumery, laundry scents, soaps and detergents, and personal- and home-care products, where it enhances diffusion, boosts substantivity on skin and fabrics, and rounds floral, woody, amber, and fresh accords; owing to a more favorable environmental profile than nitro/polycyclic musks, macrocyclic ketones like this are often preferred in IFRA-compliant formulations; it is also used in olfactory research (structure–odor relationships, GC/MS reference standards), in fragrance delivery development (microencapsulation, solid carriers), and as a reference for macrocycle synthesis studies; technically, it shows good surfactant compatibility and heat/alkali stability in detergent matrices, although the C=C bond can oxidize so antioxidants are commonly co-used; it is not intended for flavor applications.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 360.61
    methanol 207.33
    isopropanol 449.14
    water 0.02
    ethyl acetate 1332.71
    n-propanol 438.53
    acetone 1308.84
    n-butanol 514.4
    acetonitrile 545.07
    DMF 1153.25
    toluene 905.17
    isobutanol 390.12
    1,4-dioxane 1484.36
    methyl acetate 760.75
    THF 2466.92
    2-butanone 1117.52
    n-pentanol 352.05
    sec-butanol 467.94
    n-hexane 448.83
    ethylene glycol 26.92
    NMP 1241.77
    cyclohexane 902.86
    DMSO 1060.56
    n-butyl acetate 1202.64
    n-octanol 267.97
    chloroform 3137.95
    n-propyl acetate 950.52
    acetic acid 387.5
    dichloromethane 2673.29
    cyclohexanone 2183.74
    propylene glycol 78.89
    isopropyl acetate 1065.77
    DMAc 999.8
    2-ethoxyethanol 408.89
    isopentanol 557.09
    n-heptane 336.81
    ethyl formate 474.34
    1,2-dichloroethane 1858.81
    n-hexanol 476.37
    2-methoxyethanol 599.12
    isobutyl acetate 671.77
    tetrachloromethane 540.48
    n-pentyl acetate 906.3
    transcutol 2887.15
    n-heptanol 262.02
    ethylbenzene 498.99
    MIBK 850.44
    2-propoxyethanol 676.74
    tert-butanol 648.75
    MTBE 1061.29
    2-butoxyethanol 520.07
    propionic acid 408.0
    o-xylene 531.59
    formic acid 47.93
    diethyl ether 1426.27
    m-xylene 561.91
    p-xylene 599.51
    chlorobenzene 1124.66
    dimethyl carbonate 288.9
    n-octane 100.83
    formamide 98.74
    cyclopentanone 2047.14
    2-pentanone 1292.38
    anisole 719.69
    cyclopentyl methyl ether 1516.51
    gamma-butyrolactone 1831.52
    1-methoxy-2-propanol 650.89
    pyridine 1703.63
    3-pentanone 1001.9
    furfural 1371.68
    n-dodecane 52.7
    diethylene glycol 268.8
    diisopropyl ether 588.18
    tert-amyl alcohol 555.29
    acetylacetone 1299.75
    n-hexadecane 65.77
    acetophenone 683.81
    methyl propionate 819.98
    isopentyl acetate 1039.61
    trichloroethylene 2941.59
    n-nonanol 263.7
    cyclohexanol 807.53
    benzyl alcohol 431.87
    2-ethylhexanol 456.57
    isooctanol 272.61
    dipropyl ether 1149.38
    1,2-dichlorobenzene 1045.28
    ethyl lactate 286.07
    propylene carbonate 1051.14
    n-methylformamide 319.63
    2-pentanol 515.64
    n-pentane 289.98
    1-propoxy-2-propanol 705.29
    1-methoxy-2-propyl acetate 904.56
    2-(2-methoxypropoxy) propanol 524.32
    mesitylene 407.79
    ε-caprolactone 1546.23
    p-cymene 318.07
    epichlorohydrin 1892.43
    1,1,1-trichloroethane 1900.72
    2-aminoethanol 100.22
    morpholine-4-carbaldehyde 1172.58
    sulfolane 1928.38
    2,2,4-trimethylpentane 117.18
    2-methyltetrahydrofuran 1879.87
    n-hexyl acetate 993.15
    isooctane 108.36
    2-(2-butoxyethoxy)ethanol 780.17
    sec-butyl acetate 732.46
    tert-butyl acetate 1051.5
    decalin 286.07
    glycerin 120.64
    diglyme 1504.8
    acrylic acid 283.64
    isopropyl myristate 406.9
    n-butyric acid 952.81
    acetyl acetate 753.18
    di(2-ethylhexyl) phthalate 265.39
    ethyl propionate 843.68
    nitromethane 774.98
    1,2-diethoxyethane 1399.73
    benzonitrile 748.97
    trioctyl phosphate 206.27
    1-bromopropane 1373.73
    gamma-valerolactone 2025.16
    n-decanol 189.84
    triethyl phosphate 382.61
    4-methyl-2-pentanol 339.31
    propionitrile 701.91
    vinylene carbonate 808.36
    1,1,2-trichlorotrifluoroethane 1084.8
    DMS 631.15
    cumene 317.14
    2-octanol 227.05
    2-hexanone 878.92
    octyl acetate 453.27
    limonene 569.13
    1,2-dimethoxyethane 1131.98
    ethyl orthosilicate 383.34
    tributyl phosphate 294.87
    diacetone alcohol 745.95
    N,N-dimethylaniline 472.87
    acrylonitrile 691.52
    aniline 757.21
    1,3-propanediol 243.34
    bromobenzene 1379.39
    dibromomethane 1965.03
    1,1,2,2-tetrachloroethane 2675.76
    2-methyl-cyclohexyl acetate 649.52
    tetrabutyl urea 378.28
    diisobutyl methanol 346.57
    2-phenylethanol 431.23
    styrene 658.81
    dioctyl adipate 556.72
    dimethyl sulfate 456.08
    ethyl butyrate 966.94
    methyl lactate 267.61
    butyl lactate 500.41
    diethyl carbonate 560.97
    propanediol butyl ether 406.15
    triethyl orthoformate 676.65
    p-tert-butyltoluene 300.43
    methyl 4-tert-butylbenzoate 611.86
    morpholine 1658.71
    tert-butylamine 526.14
    n-dodecanol 150.78
    dimethoxymethane 789.28
    ethylene carbonate 807.12
    cyrene 390.86
    2-ethoxyethyl acetate 926.87
    2-ethylhexyl acetate 853.44
    1,2,4-trichlorobenzene 1124.1
    4-methylpyridine 1514.86
    dibutyl ether 983.81
    2,6-dimethyl-4-heptanol 346.57
    DEF 1249.38
    dimethyl isosorbide 915.75
    tetrachloroethylene 1726.09
    eugenol 457.43
    triacetin 853.76
    span 80 550.59
    1,4-butanediol 84.58
    1,1-dichloroethane 1811.5
    2-methyl-1-pentanol 377.16
    methyl formate 252.52
    2-methyl-1-butanol 479.82
    n-decane 112.58
    butyronitrile 858.36
    3,7-dimethyl-1-octanol 371.09
    1-chlorooctane 403.65
    1-chlorotetradecane 148.15
    n-nonane 119.55
    undecane 72.37
    tert-butylcyclohexane 212.01
    cyclooctane 293.42
    cyclopentanol 670.04
    tetrahydropyran 2311.38
    tert-amyl methyl ether 799.65
    2,5,8-trioxanonane 926.66
    1-hexene 839.72
    2-isopropoxyethanol 409.68
    2,2,2-trifluoroethanol 134.27
    methyl butyrate 1062.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
Restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0.43 % Category 7A
Rinse-off products applied to the hair with some hand contact
 3.5 %
Category 2
Products applied to the axillae
 0.23 % Category 7B
Leave-on products applied to the hair with some hand contact
 3.5 %
Category 3
Products applied to the face/body using fingertips
 2.2 % Category 8
Products with significant anogenital exposure
 0.14 %
Category 4
Products related to fine fragrance
 4.3 % Category 9
Products with body and hand exposure, primarily rinse off
 8.4 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 1.1 % Category 10A
Household care products with mostly hand contact
 7.3 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 1.1 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 30 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0.43 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 0.14 %
Category 5D
Baby Creams, baby Oils and baby talc
 0.14 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 0.14 %
Category 6
Products with oral and lip exposure
 0.43 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Civet secretion (China) 68916-26-7 Viverra zibetha L., fam. Viverridae 0.85%