2,5-Dimethyl-3-methoxypyrazine

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    19846-22-1

    Molecular formula
    C7H10N2O

    SMILES
    CC1=CN=C(C(=N1)OC)C

    Retention indicies (RI)

    • DB5: 1050.0

  • Odor profile

    Nutty 66.1%
    Roasted 62.87%
    Earthy 61.76%
    Hazelnut 50.5%
    Cocoa 44.49%
    Musty 44.27%
    Potato 41.31%
    Burnt 40.5%
    Chocolate 40.22%
    Coffee 37.55%

    Scent© AI

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    4.43 (weak acid)

    Molecular weight
    138.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    214°C

    Flash point est.
    81.01 ˚C

  • Synonyms

    • 3-Methoxy-2,5-dimethylpyrazine
    • 19846-22-1
    • Pyrazine, 3-methoxy-2,5-dimethyl-
    • 2,5-dimethyl-3-methoxypyrazine
    • MFCD28162737
    • 2-METHOXY-3,6-DIMETHYLPYRAZINE,3-METHOXY-2,5-DIMETHYLPYRAZINE
    • 3-methoxyl-2,5-dimethylpyrazine
    • DMMP compound
    • CHEMBL94628
    • SCHEMBL4497174
    • AKOS026673956
    • DS-9921
    • SY126415
    • CS-0012597
    • Y10564

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 414.32
    methanol 659.01
    isopropanol 343.82
    water 18.89
    ethyl acetate 552.1
    n-propanol 366.76
    acetone 650.1
    n-butanol 323.29
    acetonitrile 562.22
    DMF 810.14
    toluene 224.36
    isobutanol 312.04
    1,4-dioxane 773.1
    methyl acetate 491.22
    THF 776.93
    2-butanone 470.77
    n-pentanol 269.35
    sec-butanol 358.68
    n-hexane 66.13
    ethylene glycol 195.94
    NMP 575.97
    cyclohexane 86.59
    DMSO 819.39
    n-butyl acetate 307.28
    n-octanol 150.17
    chloroform 1343.69
    n-propyl acetate 293.98
    acetic acid 608.9
    dichloromethane 1466.73
    cyclohexanone 582.25
    propylene glycol 176.63
    isopropyl acetate 264.89
    DMAc 597.44
    2-ethoxyethanol 491.03
    isopentanol 256.07
    n-heptane 46.94
    ethyl formate 476.78
    1,2-dichloroethane 783.41
    n-hexanol 231.52
    2-methoxyethanol 717.3
    isobutyl acetate 165.65
    tetrachloromethane 316.72
    n-pentyl acetate 199.87
    transcutol 475.84
    n-heptanol 134.98
    ethylbenzene 140.88
    MIBK 207.21
    2-propoxyethanol 378.59
    tert-butanol 407.62
    MTBE 398.7
    2-butoxyethanol 236.11
    propionic acid 371.48
    o-xylene 176.37
    formic acid 334.52
    diethyl ether 425.54
    m-xylene 168.31
    p-xylene 219.99
    chlorobenzene 377.53
    dimethyl carbonate 232.45
    n-octane 27.94
    formamide 348.09
    cyclopentanone 637.8
    2-pentanone 353.26
    anisole 264.68
    cyclopentyl methyl ether 402.98
    gamma-butyrolactone 819.69
    1-methoxy-2-propanol 433.86
    pyridine 500.77
    3-pentanone 329.34
    furfural 778.9
    n-dodecane 22.62
    diethylene glycol 308.42
    diisopropyl ether 129.25
    tert-amyl alcohol 378.65
    acetylacetone 408.26
    n-hexadecane 25.9
    acetophenone 249.3
    methyl propionate 419.04
    isopentyl acetate 243.87
    trichloroethylene 1394.81
    n-nonanol 121.82
    cyclohexanol 310.68
    benzyl alcohol 241.06
    2-ethylhexanol 154.42
    isooctanol 116.21
    dipropyl ether 188.38
    1,2-dichlorobenzene 371.17
    ethyl lactate 166.84
    propylene carbonate 461.51
    n-methylformamide 497.51
    2-pentanol 235.73
    n-pentane 61.75
    1-propoxy-2-propanol 254.18
    1-methoxy-2-propyl acetate 236.83
    2-(2-methoxypropoxy) propanol 167.0
    mesitylene 116.22
    ε-caprolactone 501.53
    p-cymene 104.52
    epichlorohydrin 878.82
    1,1,1-trichloroethane 767.26
    2-aminoethanol 256.14
    morpholine-4-carbaldehyde 639.98
    sulfolane 875.93
    2,2,4-trimethylpentane 48.25
    2-methyltetrahydrofuran 630.11
    n-hexyl acetate 258.12
    isooctane 29.07
    2-(2-butoxyethoxy)ethanol 222.78
    sec-butyl acetate 171.41
    tert-butyl acetate 249.23
    decalin 50.61
    glycerin 259.0
    diglyme 474.64
    acrylic acid 364.83
    isopropyl myristate 95.53
    n-butyric acid 454.68
    acetyl acetate 327.29
    di(2-ethylhexyl) phthalate 97.72
    ethyl propionate 268.04
    nitromethane 924.15
    1,2-diethoxyethane 262.46
    benzonitrile 341.92
    trioctyl phosphate 84.39
    1-bromopropane 442.18
    gamma-valerolactone 786.49
    n-decanol 93.45
    triethyl phosphate 122.4
    4-methyl-2-pentanol 127.92
    propionitrile 414.68
    vinylene carbonate 502.85
    1,1,2-trichlorotrifluoroethane 603.06
    DMS 224.81
    cumene 110.71
    2-octanol 120.7
    2-hexanone 266.73
    octyl acetate 129.43
    limonene 137.98
    1,2-dimethoxyethane 713.97
    ethyl orthosilicate 119.15
    tributyl phosphate 102.01
    diacetone alcohol 255.78
    N,N-dimethylaniline 194.86
    acrylonitrile 510.03
    aniline 269.26
    1,3-propanediol 346.36
    bromobenzene 405.92
    dibromomethane 926.39
    1,1,2,2-tetrachloroethane 1075.5
    2-methyl-cyclohexyl acetate 157.16
    tetrabutyl urea 118.98
    diisobutyl methanol 98.88
    2-phenylethanol 206.29
    styrene 166.08
    dioctyl adipate 129.89
    dimethyl sulfate 359.3
    ethyl butyrate 229.65
    methyl lactate 211.01
    butyl lactate 153.46
    diethyl carbonate 169.14
    propanediol butyl ether 202.19
    triethyl orthoformate 158.27
    p-tert-butyltoluene 102.88
    methyl 4-tert-butylbenzoate 193.7
    morpholine 660.49
    tert-butylamine 251.06
    n-dodecanol 73.73
    dimethoxymethane 566.54
    ethylene carbonate 428.57
    cyrene 211.06
    2-ethoxyethyl acetate 231.83
    2-ethylhexyl acetate 202.58
    1,2,4-trichlorobenzene 417.56
    4-methylpyridine 493.94
    dibutyl ether 172.4
    2,6-dimethyl-4-heptanol 98.88
    DEF 469.23
    dimethyl isosorbide 273.87
    tetrachloroethylene 814.7
    eugenol 198.64
    triacetin 202.9
    span 80 147.07
    1,4-butanediol 198.92
    1,1-dichloroethane 768.64
    2-methyl-1-pentanol 231.48
    methyl formate 531.1
    2-methyl-1-butanol 287.48
    n-decane 36.53
    butyronitrile 429.71
    3,7-dimethyl-1-octanol 126.53
    1-chlorooctane 126.34
    1-chlorotetradecane 51.63
    n-nonane 37.77
    undecane 28.13
    tert-butylcyclohexane 51.12
    cyclooctane 36.72
    cyclopentanol 365.7
    tetrahydropyran 565.64
    tert-amyl methyl ether 319.09
    2,5,8-trioxanonane 275.54
    1-hexene 166.47
    2-isopropoxyethanol 285.37
    2,2,2-trifluoroethanol 298.27
    methyl butyrate 361.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Premna serratifolia flower bud Premna serratifolia L. (P.obtusifolia Br.R., P.taitensis Sch.),Verbenaceae 0.8%