2-Ethyl-5-methylpyrazine

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  • Identifiers

    CAS number
    13360-64-0

    Molecular formula
    C7H10N2

    SMILES
    CCC1=NC=C(N=C1)C

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Nutty 88.05%
    Roasted 81.58%
    Cocoa 71.26%
    Hazelnut 66.11%
    Earthy 65.6%
    Musty 62.95%
    Potato 60.17%
    Coffee 59.36%
    Chocolate 55.1%
    Green 53.84%

    Scent© AI

  • Properties

    XLogP3-AA
    1.0

    Molecular weight
    122.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    169°C

    Flash point est.
    66.85 ˚C

    Solubility expt.

    • soluble in water, organic solvents
    • miscible at room temperature (in ethanol)

  • Synonyms

    • 2-ETHYL-5-METHYLPYRAZINE
    • 13360-64-0
    • Pyrazine, 2-ethyl-5-methyl-
    • 2-Methyl-5-ethylpyrazine
    • 2-Ethyl-5-methyl pyrazine
    • FEMA No. 3154
    • 2,5-Methylethylpyrazine
    • BRN 0956719
    • 5-ethyl-2-methylpyrazine
    • EINECS 236-416-6
    • AI3-34443
    • W41R8X574D
    • 2-Ethyl-5-methyl-pyrazine
    • 2-Ethyl-5-methylpyrazine, 9CI, 8CI
    • Pyrazine, 5-ethyl-2-methyl
    • DTXSID6065422
    • FEMA 3154
    • 5-METHYL-2-ETHYLPYRAZINE
    • CHEBI:141542
    • ETHYL-5-METHYLPYRAZINE, 2-
    • 2-ETHYL-5-METHYLPYRAZINE [FHFI]
    • 2-Ethyl-5-methylpyrazine(contains 2-Ethyl-6-methylpyrazine)
    • UNII-W41R8X574D
    • CHEMBL94558
    • SCHEMBL110053
    • DTXCID9034157
    • MFCD09039261
    • AKOS006272101
    • AS-50066
    • NS00021609
    • E78081
    • Q27292273
    • 236-416-6

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 187.41
    methanol 205.2
    isopropanol 130.96
    water 2.48
    ethyl acetate 97.65
    n-propanol 156.64
    acetone 128.04
    n-butanol 146.02
    acetonitrile 163.76
    DMF 222.65
    toluene 125.9
    isobutanol 132.92
    1,4-dioxane 204.34
    methyl acetate 112.39
    THF 272.21
    2-butanone 145.51
    n-pentanol 123.81
    sec-butanol 138.78
    n-hexane 28.71
    ethylene glycol 44.29
    NMP 245.25
    cyclohexane 51.69
    DMSO 246.12
    n-butyl acetate 161.64
    n-octanol 84.08
    chloroform 782.14
    n-propyl acetate 83.05
    acetic acid 204.04
    dichloromethane 724.41
    cyclohexanone 237.17
    propylene glycol 59.85
    isopropyl acetate 60.72
    DMAc 231.88
    2-ethoxyethanol 117.87
    isopentanol 119.64
    n-heptane 35.13
    ethyl formate 142.22
    1,2-dichloroethane 263.4
    n-hexanol 152.98
    2-methoxyethanol 171.42
    isobutyl acetate 61.98
    tetrachloromethane 162.32
    n-pentyl acetate 92.81
    transcutol 287.86
    n-heptanol 83.49
    ethylbenzene 73.92
    MIBK 63.24
    2-propoxyethanol 156.47
    tert-butanol 135.22
    MTBE 101.7
    2-butoxyethanol 114.19
    propionic acid 144.89
    o-xylene 92.45
    formic acid 77.99
    diethyl ether 88.69
    m-xylene 76.54
    p-xylene 116.89
    chlorobenzene 213.11
    dimethyl carbonate 43.25
    n-octane 16.11
    formamide 83.41
    cyclopentanone 240.55
    2-pentanone 95.34
    anisole 106.6
    cyclopentyl methyl ether 127.27
    gamma-butyrolactone 265.1
    1-methoxy-2-propanol 123.35
    pyridine 304.57
    3-pentanone 88.7
    furfural 337.1
    n-dodecane 15.3
    diethylene glycol 107.39
    diisopropyl ether 33.52
    tert-amyl alcohol 136.48
    acetylacetone 93.56
    n-hexadecane 16.89
    acetophenone 107.43
    methyl propionate 87.7
    isopentyl acetate 130.38
    trichloroethylene 550.94
    n-nonanol 69.3
    cyclohexanol 131.02
    benzyl alcohol 110.12
    2-ethylhexanol 107.83
    isooctanol 64.87
    dipropyl ether 92.67
    1,2-dichlorobenzene 197.77
    ethyl lactate 56.04
    propylene carbonate 193.33
    n-methylformamide 126.86
    2-pentanol 87.33
    n-pentane 29.18
    1-propoxy-2-propanol 126.59
    1-methoxy-2-propyl acetate 95.94
    2-(2-methoxypropoxy) propanol 105.88
    mesitylene 50.41
    ε-caprolactone 195.94
    p-cymene 74.94
    epichlorohydrin 285.43
    1,1,1-trichloroethane 295.58
    2-aminoethanol 87.9
    morpholine-4-carbaldehyde 205.16
    sulfolane 314.47
    2,2,4-trimethylpentane 22.23
    2-methyltetrahydrofuran 219.8
    n-hexyl acetate 122.54
    isooctane 12.37
    2-(2-butoxyethoxy)ethanol 129.81
    sec-butyl acetate 53.96
    tert-butyl acetate 63.58
    decalin 28.09
    glycerin 75.64
    diglyme 221.01
    acrylic acid 133.45
    isopropyl myristate 54.25
    n-butyric acid 181.46
    acetyl acetate 77.44
    di(2-ethylhexyl) phthalate 71.71
    ethyl propionate 68.02
    nitromethane 197.39
    1,2-diethoxyethane 125.56
    benzonitrile 207.41
    trioctyl phosphate 50.81
    1-bromopropane 197.66
    gamma-valerolactone 251.1
    n-decanol 55.14
    triethyl phosphate 61.21
    4-methyl-2-pentanol 52.58
    propionitrile 161.84
    vinylene carbonate 206.94
    1,1,2-trichlorotrifluoroethane 217.39
    DMS 82.73
    cumene 61.71
    2-octanol 59.57
    2-hexanone 95.59
    octyl acetate 72.54
    limonene 97.49
    1,2-dimethoxyethane 182.35
    ethyl orthosilicate 58.15
    tributyl phosphate 61.36
    diacetone alcohol 79.19
    N,N-dimethylaniline 93.27
    acrylonitrile 194.35
    aniline 149.28
    1,3-propanediol 112.36
    bromobenzene 240.22
    dibromomethane 484.46
    1,1,2,2-tetrachloroethane 432.93
    2-methyl-cyclohexyl acetate 95.37
    tetrabutyl urea 78.04
    diisobutyl methanol 55.44
    2-phenylethanol 128.8
    styrene 95.01
    dioctyl adipate 83.69
    dimethyl sulfate 76.07
    ethyl butyrate 112.1
    methyl lactate 62.24
    butyl lactate 82.65
    diethyl carbonate 84.26
    propanediol butyl ether 102.02
    triethyl orthoformate 80.77
    p-tert-butyltoluene 64.19
    methyl 4-tert-butylbenzoate 105.15
    morpholine 209.69
    tert-butylamine 102.41
    n-dodecanol 46.73
    dimethoxymethane 106.95
    ethylene carbonate 158.05
    cyrene 103.13
    2-ethoxyethyl acetate 102.64
    2-ethylhexyl acetate 111.74
    1,2,4-trichlorobenzene 227.54
    4-methylpyridine 263.95
    dibutyl ether 96.11
    2,6-dimethyl-4-heptanol 55.44
    DEF 142.1
    dimethyl isosorbide 173.74
    tetrachloroethylene 307.53
    eugenol 111.61
    triacetin 96.26
    span 80 106.96
    1,4-butanediol 62.73
    1,1-dichloroethane 283.74
    2-methyl-1-pentanol 116.62
    methyl formate 106.33
    2-methyl-1-butanol 129.0
    n-decane 22.01
    butyronitrile 192.0
    3,7-dimethyl-1-octanol 78.23
    1-chlorooctane 71.22
    1-chlorotetradecane 32.88
    n-nonane 22.0
    undecane 17.7
    tert-butylcyclohexane 26.97
    cyclooctane 17.45
    cyclopentanol 159.55
    tetrahydropyran 196.83
    tert-amyl methyl ether 85.69
    2,5,8-trioxanonane 162.2
    1-hexene 82.25
    2-isopropoxyethanol 85.88
    2,2,2-trifluoroethanol 70.66
    methyl butyrate 107.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Chicory root, roasted 1a 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.02%
Chicory root, roasted 1b 68650-43-1 Cichorium intybus L., fam. Asteraceae (Compositae) 0.06%
Mandarin (Italy) 8 8008-31-9 Citrus deliciosa Tenore (C. reticulata Blanco, cv.mandarin), fam. Rutaceae 0.01%