2-Acetyl-3-ethylpyrazine

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  • Identifiers

    CAS number
    32974-92-8

    Molecular formula
    C8H10N2O

    SMILES
    CCC1=NC=CN=C1C(=O)C

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1159.0

  • Odor profile

    Fragrance
    Nutty 83.75%
    Roasted 74.32%
    Popcorn 65.83%
    Hazelnut 58.83%
    Earthy 52.43%
    Potato 47.81%
    Musty 47.56%
    Cocoa 43.79%
    Coffee 41.61%
    Burnt 38.99%

     

    Flavor
    Nutty 76.47%
    Popcorn 58.3%
    Roast 54.87%
    Roasted 54.71%
    Earthy 50.4%
    Hazelnut 49.61%
    Potato 48.87%
    Corn 47.6%
    Chip 42.46%
    Coffee 38.82%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    5.72 (weak acid)

    Molecular weight
    150.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point

    • 220.00 to 221.00 °C. @ 760.00 mm Hg

    Flash point

    • 107.62 ˚C est.

    Solubility expt.

    • soluble in water, organic solvents, oils
    • miscible at room temperature (in ethanol)

  • Synonyms

    • 2-Acetyl-3-ethylpyrazine
    • 32974-92-8
    • 1-(3-ethylpyrazin-2-yl)ethanone
    • 1-(3-Ethylpyrazinyl)ethan-1-one
    • Ethanone, 1-(3-ethylpyrazinyl)-
    • 2-Acetyl-3-ethyl-1,4-diazine
    • 1-(3-Ethylpyrazinyl)ethanone
    • FEMA No. 3250
    • 1-(3-ethylpyrazin-2-yl)ethan-1-one
    • 1-(3-Ethyl-2-pyrazinyl)ethanone
    • 3-Ethyl-2-acetylpyrazine
    • UNII-AQ03N14XTL
    • 2-Ethyl-3-acetyl pyrazine
    • AQ03N14XTL
    • MFCD00038028
    • Pyrazine, 2-acetyl-3-ethyl
    • Ethanone, 1-(3-ethyl-2-pyrazinyl)-
    • EINECS 251-316-2
    • 1-(3-Ethylpyrazinyl)-Ethanone
    • DTXSID3067736
    • FEMA 3250
    • 1-(3-Ethyl-2-pyrazinyl)-Ethanone
    • 1-(3-Ethylpyrazinyl)ethanone, 9CI
    • 2-ACETYL-3-ETHYLPYRAZINE [FHFI]
    • Ethanone, 1-(ethylpyrazinyl)-
    • 2-acetyl-3-ethyl pyrazine
    • 2-ACETYL ETHYLPYRAZINE
    • SCHEMBL1532459
    • DTXCID6038617
    • CHEBI:173401
    • 3--Ethyl-2-pyrazinyl methyl ketone
    • AC8556
    • 1-(3-Ethyl-pyrazin-2-yl)-ethanone
    • 2-Acetyl-3-ethylpyrazine, 98%, FG
    • AKOS005256376
    • FS-1047
    • HY-W039157
    • PD158368
    • SY027477
    • DB-020324
    • A2003
    • CS-0096817
    • NS00022059
    • Q27274053

  • Applications

    2-Acetyl-3-ethylpyrazine, CAS 32974-92-8, is a roasted, nutty fragrance molecule widely employed as a flavor enhancer in confectionery, instant coffee, savory snacks, sauces, processed meat and seafood; it deepens “roasted” notes in BBQ sauces, dry rubs and low-calorie products; it is featured in tobacco and e-liquid flavor formulations, scented candles and personal-care fragrances; additionally, it serves as a reference compound in flavor analysis, sensory design and the development of plant-based food ingredients.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 143.89
    methanol 255.8
    isopropanol 92.85
    water 5.35
    ethyl acetate 250.82
    n-propanol 123.07
    acetone 304.32
    n-butanol 110.05
    acetonitrile 256.5
    DMF 569.68
    toluene 113.43
    isobutanol 97.71
    1,4-dioxane 404.02
    methyl acetate 207.03
    THF 417.72
    2-butanone 222.82
    n-pentanol 95.57
    sec-butanol 91.92
    n-hexane 16.46
    ethylene glycol 102.36
    NMP 567.36
    cyclohexane 19.6
    DMSO 590.85
    n-butyl acetate 133.72
    n-octanol 58.82
    chloroform 594.61
    n-propyl acetate 122.9
    acetic acid 261.91
    dichloromethane 747.73
    cyclohexanone 365.64
    propylene glycol 69.89
    isopropyl acetate 118.63
    DMAc 433.65
    2-ethoxyethanol 188.27
    isopentanol 94.48
    n-heptane 12.11
    ethyl formate 211.66
    1,2-dichloroethane 451.91
    n-hexanol 92.37
    2-methoxyethanol 343.33
    isobutyl acetate 72.63
    tetrachloromethane 103.39
    n-pentyl acetate 99.74
    transcutol 295.11
    n-heptanol 53.4
    ethylbenzene 70.37
    MIBK 110.82
    2-propoxyethanol 193.98
    tert-butanol 110.32
    MTBE 110.86
    2-butoxyethanol 106.88
    propionic acid 180.15
    o-xylene 88.1
    formic acid 156.25
    diethyl ether 149.34
    m-xylene 91.27
    p-xylene 94.06
    chlorobenzene 227.98
    dimethyl carbonate 123.05
    n-octane 7.41
    formamide 175.36
    cyclopentanone 469.31
    2-pentanone 194.57
    anisole 139.16
    cyclopentyl methyl ether 211.3
    gamma-butyrolactone 589.83
    1-methoxy-2-propanol 209.91
    pyridine 300.99
    3-pentanone 172.97
    furfural 543.91
    n-dodecane 7.36
    diethylene glycol 201.75
    diisopropyl ether 42.08
    tert-amyl alcohol 104.68
    acetylacetone 263.59
    n-hexadecane 8.68
    acetophenone 150.31
    methyl propionate 218.61
    isopentyl acetate 113.84
    trichloroethylene 810.78
    n-nonanol 49.88
    cyclohexanol 117.84
    benzyl alcohol 132.71
    2-ethylhexanol 67.6
    isooctanol 46.37
    dipropyl ether 66.78
    1,2-dichlorobenzene 227.82
    ethyl lactate 83.87
    propylene carbonate 285.87
    n-methylformamide 309.35
    2-pentanol 71.09
    n-pentane 14.22
    1-propoxy-2-propanol 119.18
    1-methoxy-2-propyl acetate 138.25
    2-(2-methoxypropoxy) propanol 99.61
    mesitylene 60.08
    ε-caprolactone 313.82
    p-cymene 51.31
    epichlorohydrin 563.63
    1,1,1-trichloroethane 342.6
    2-aminoethanol 116.63
    morpholine-4-carbaldehyde 468.74
    sulfolane 734.76
    2,2,4-trimethylpentane 12.67
    2-methyltetrahydrofuran 271.41
    n-hexyl acetate 136.67
    isooctane 9.48
    2-(2-butoxyethoxy)ethanol 123.34
    sec-butyl acetate 76.47
    tert-butyl acetate 116.21
    decalin 20.63
    glycerin 140.51
    diglyme 260.26
    acrylic acid 199.0
    isopropyl myristate 49.05
    n-butyric acid 202.19
    acetyl acetate 157.18
    di(2-ethylhexyl) phthalate 61.27
    ethyl propionate 129.92
    nitromethane 506.51
    1,2-diethoxyethane 120.85
    benzonitrile 221.85
    trioctyl phosphate 47.4
    1-bromopropane 192.32
    gamma-valerolactone 542.13
    n-decanol 38.32
    triethyl phosphate 66.05
    4-methyl-2-pentanol 48.22
    propionitrile 189.5
    vinylene carbonate 307.74
    1,1,2-trichlorotrifluoroethane 351.04
    DMS 148.15
    cumene 54.95
    2-octanol 44.77
    2-hexanone 122.31
    octyl acetate 66.36
    limonene 65.44
    1,2-dimethoxyethane 296.21
    ethyl orthosilicate 60.48
    tributyl phosphate 56.3
    diacetone alcohol 128.71
    N,N-dimethylaniline 106.56
    acrylonitrile 285.64
    aniline 143.84
    1,3-propanediol 151.83
    bromobenzene 254.82
    dibromomethane 444.68
    1,1,2,2-tetrachloroethane 546.59
    2-methyl-cyclohexyl acetate 83.97
    tetrabutyl urea 73.95
    diisobutyl methanol 41.36
    2-phenylethanol 118.51
    styrene 88.1
    dioctyl adipate 71.48
    dimethyl sulfate 257.7
    ethyl butyrate 98.94
    methyl lactate 129.14
    butyl lactate 81.25
    diethyl carbonate 79.38
    propanediol butyl ether 99.29
    triethyl orthoformate 72.21
    p-tert-butyltoluene 47.99
    methyl 4-tert-butylbenzoate 112.5
    morpholine 351.87
    tert-butylamine 69.71
    n-dodecanol 30.33
    dimethoxymethane 300.01
    ethylene carbonate 248.3
    cyrene 131.23
    2-ethoxyethyl acetate 133.04
    2-ethylhexyl acetate 92.87
    1,2,4-trichlorobenzene 255.94
    4-methylpyridine 300.43
    dibutyl ether 64.13
    2,6-dimethyl-4-heptanol 41.36
    DEF 282.28
    dimethyl isosorbide 188.08
    tetrachloroethylene 382.57
    eugenol 123.52
    triacetin 112.49
    span 80 82.5
    1,4-butanediol 83.9
    1,1-dichloroethane 336.85
    2-methyl-1-pentanol 91.68
    methyl formate 301.73
    2-methyl-1-butanol 100.19
    n-decane 10.87
    butyronitrile 190.71
    3,7-dimethyl-1-octanol 54.62
    1-chlorooctane 51.09
    1-chlorotetradecane 22.2
    n-nonane 10.55
    undecane 8.82
    tert-butylcyclohexane 19.68
    cyclooctane 9.0
    cyclopentanol 147.9
    tetrahydropyran 237.68
    tert-amyl methyl ether 101.2
    2,5,8-trioxanonane 162.02
    1-hexene 55.89
    2-isopropoxyethanol 115.69
    2,2,2-trifluoroethanol 137.36
    methyl butyrate 173.2

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Carob bean powder 2b roasted 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.01%