1,4-Cineole

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    470-67-7

    Molecular formula
    C10H18O

    SMILES
    CC(C)C12CCC(O1)(CC2)C

    Safety labels

    Flammable
    Flammable

    Retention indicies (RI)

    • DB5: 1014.0
    • Carbowax: 1184.0

  • Odor profile

    Green 80.09%
    Herbal 72.65%
    Mint 68.14%
    Fresh 63.83%
    Cooling 60.05%
    Camphoreous 58.67%
    Woody 47.96%
    Earthy 46.51%
    Terpenic 44.56%
    Pine 43.84%

    Scent© AI

  • Properties

    XLogP3-AA
    2.5

    Molecular weight
    154.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Melting point expt.

    • 1 °C

    Boiling point

    • 173-174 °C
    • 65.00 °C. @ 16.00 mm Hg

    Flash point est.
    58.36 ˚C

    Solubility expt.

    • SLIGHTLY SOL IN WATER; SOL IN BENZENE, PETROLEUM ETHER; SOL IN ALL PROPORTION IN ETHER, ALC
    • Insoluble in water, soluble in oils
    • soluble (in ethanol)

  • Synonyms

    • 1,4-Cineole
    • 470-67-7
    • Isocineole
    • 1,4-Cineol
    • 1,4-EPOXY-P-MENTHANE
    • 1,4-Cineole (natural)
    • p-Menthane, 1,4-epoxy-
    • FEMA No. 3658
    • Isocineple
    • 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane
    • 1-Methyl-4-(1-methylethyl)-7-oxabicyclo(2.2.1)heptane
    • HSDB 5425
    • p-Menthane, 1,4-epoxy
    • EINECS 207-428-9
    • UNII-B55JTU839B
    • BRN 0104974
    • 1-Isopropyl-4-methyl-7-oxabicyclo(2.2.1)heptane
    • 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
    • CHEBI:80788
    • 1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane
    • 7-Oxabicyclo(2.2.1)heptane, 1-methyl-4-(1-methylethyl)-
    • 7-Oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl-
    • 1,4-CINEOLE [FHFI]
    • B55JTU839B
    • 7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-
    • DTXSID3047396
    • 1-METHYL-4-(1-METHYLETHYL)-7-OXABICYCLO[2.2.1]HEPTANE
    • 5-17-01-00273 (Beilstein Handbook Reference)
    • (+/-)-1,4-CINEOLE
    • 1,4-EPOXY-P-MENTHANE [HSDB]
    • 1-isopropyl-4-methylbicyclo[2.2.1]heptane
    • 4-isopropyl-1-methyl-7-oxabicyclo[2.2.1]heptane
    • (1s,4s)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane
    • 1-Methyl-4-(1-methylethyl)-7-oxabicyclo[2.2.1]heptane, 9CI
    • 1-Isopropyl-4-methylbicyclo(2.2.1)heptane
    • 1-methyl-4-propan-2-yl-7-oxabicyclo(2.2.1)heptane
    • 1-methyl-4-(propan-2-yl)-7-oxabicyclo(2.2.1)heptane
    • pCineole
    • 1-Methyl-4-(1-methylethyl)-7-oxabicyclo(2.2.1)heptane, 9ci
    • (1S,4S)-1-Methyl-4-(propan-2-yl)-7-oxabicyclo(2.2.1)heptane
    • 1,4Cineole
    • 1,4Cineol
    • MFCD00209502
    • pMenthane, 1,4epoxy
    • 1,4Cineole (natural)
    • 1,4-Cineole (Standard)
    • SCHEMBL231925
    • 1,4-Cineole, >=85%
    • CHEMBL2288022
    • SCHEMBL13180469
    • SCHEMBL15450554
    • SCHEMBL18993155
    • HY-N7117R
    • 1,4-Cineole, analytical standard
    • RFFOTVCVTJUTAD-AOOOYVTPSA-N
    • 7-Oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl- (6CI)
    • DTXCID201473981
    • 1,4-Cineole, >=95%, FG
    • HY-N7117
    • s5419
    • CCG-266250
    • AS-81210
    • DA-49175
    • 1ST159200
    • 1Isopropyl4methyl7oxabicyclo(2.2.1)heptane
    • C3652
    • CS-0066997
    • NS00012694
    • 7Oxabicyclo(2.2.1)heptane, 1isopropyl4methyl
    • C16909
    • F82275
    • 1Methyl4(1methylethyl)7oxabicyclo(2.2.1)heptane
    • 7Oxabicyclo(2.2.1)heptane, 1methyl4(1methylethyl)
    • 1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane #
    • 7Oxabicyclo(2.2.1)heptane, 1isopropyl4methyl (6CI)
    • Q12470088

  • Applications

    1,4-Cineole (CAS 470-67-7) is an oxygenated monoterpene with a fresh camphor-like aroma that is widely employed as a fragrance ingredient in perfumes, soaps, detergents and air fresheners; as a flavour enhancer in foods, beverages and chewing gum; as a bio-solvent for essential-oil extraction; as an active pharmaceutical agent in expectorant, respiratory antiseptic and topical analgesic formulations; and it is also being studied as a natural crop-protection compound and a green solvent in organic synthesis.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 975.77
    methanol 1192.19
    isopropanol 942.08
    water 16.97
    ethyl acetate 1239.24
    n-propanol 987.48
    acetone 1079.91
    n-butanol 923.67
    acetonitrile 1150.37
    DMF 1108.69
    toluene 844.53
    isobutanol 837.74
    1,4-dioxane 1657.44
    methyl acetate 1201.75
    THF 2121.89
    2-butanone 1070.2
    n-pentanol 640.5
    sec-butanol 848.22
    n-hexane 292.34
    ethylene glycol 359.37
    NMP 1028.11
    cyclohexane 349.16
    DMSO 718.64
    n-butyl acetate 867.88
    n-octanol 630.49
    chloroform 3792.77
    n-propyl acetate 683.73
    acetic acid 647.98
    dichloromethane 2753.6
    cyclohexanone 1353.77
    propylene glycol 532.93
    isopropyl acetate 931.99
    DMAc 989.5
    2-ethoxyethanol 904.25
    isopentanol 810.95
    n-heptane 212.54
    ethyl formate 715.09
    1,2-dichloroethane 1300.46
    n-hexanol 993.12
    2-methoxyethanol 1305.57
    isobutyl acetate 563.41
    tetrachloromethane 960.85
    n-pentyl acetate 683.03
    transcutol 1997.92
    n-heptanol 570.38
    ethylbenzene 490.38
    MIBK 746.85
    2-propoxyethanol 1447.2
    tert-butanol 941.4
    MTBE 1048.36
    2-butoxyethanol 884.02
    propionic acid 794.72
    o-xylene 587.15
    formic acid 311.17
    diethyl ether 1108.48
    m-xylene 658.98
    p-xylene 637.47
    chlorobenzene 1100.94
    dimethyl carbonate 515.0
    n-octane 112.45
    formamide 414.9
    cyclopentanone 1472.69
    2-pentanone 940.95
    anisole 899.84
    cyclopentyl methyl ether 1205.7
    gamma-butyrolactone 1557.7
    1-methoxy-2-propanol 1237.25
    pyridine 1252.24
    3-pentanone 824.81
    furfural 1411.82
    n-dodecane 103.14
    diethylene glycol 950.52
    diisopropyl ether 532.61
    tert-amyl alcohol 788.59
    acetylacetone 1106.24
    n-hexadecane 118.65
    acetophenone 720.05
    methyl propionate 960.51
    isopentyl acetate 790.69
    trichloroethylene 2284.44
    n-nonanol 539.7
    cyclohexanol 872.62
    benzyl alcohol 648.24
    2-ethylhexanol 552.81
    isooctanol 457.85
    dipropyl ether 682.96
    1,2-dichlorobenzene 1008.41
    ethyl lactate 409.77
    propylene carbonate 1022.2
    n-methylformamide 777.85
    2-pentanol 715.3
    n-pentane 277.61
    1-propoxy-2-propanol 1007.9
    1-methoxy-2-propyl acetate 985.4
    2-(2-methoxypropoxy) propanol 693.37
    mesitylene 475.61
    ε-caprolactone 1302.35
    p-cymene 371.34
    epichlorohydrin 1760.66
    1,1,1-trichloroethane 1807.28
    2-aminoethanol 649.77
    morpholine-4-carbaldehyde 1306.16
    sulfolane 1269.79
    2,2,4-trimethylpentane 167.26
    2-methyltetrahydrofuran 1483.97
    n-hexyl acetate 1014.7
    isooctane 156.11
    2-(2-butoxyethoxy)ethanol 884.11
    sec-butyl acetate 597.91
    tert-butyl acetate 918.49
    decalin 212.55
    glycerin 639.05
    diglyme 1549.6
    acrylic acid 643.9
    isopropyl myristate 431.63
    n-butyric acid 978.5
    acetyl acetate 930.93
    di(2-ethylhexyl) phthalate 340.65
    ethyl propionate 697.11
    nitromethane 1192.26
    1,2-diethoxyethane 856.37
    benzonitrile 877.69
    trioctyl phosphate 274.06
    1-bromopropane 1080.52
    gamma-valerolactone 1812.76
    n-decanol 384.14
    triethyl phosphate 338.79
    4-methyl-2-pentanol 524.29
    propionitrile 1072.15
    vinylene carbonate 1025.7
    1,1,2-trichlorotrifluoroethane 1110.72
    DMS 770.82
    cumene 402.14
    2-octanol 434.35
    2-hexanone 672.5
    octyl acetate 503.59
    limonene 460.26
    1,2-dimethoxyethane 1249.57
    ethyl orthosilicate 338.01
    tributyl phosphate 327.23
    diacetone alcohol 808.49
    N,N-dimethylaniline 594.71
    acrylonitrile 1122.55
    aniline 884.37
    1,3-propanediol 751.65
    bromobenzene 1202.05
    dibromomethane 1879.64
    1,1,2,2-tetrachloroethane 1962.04
    2-methyl-cyclohexyl acetate 537.58
    tetrabutyl urea 374.41
    diisobutyl methanol 360.66
    2-phenylethanol 749.54
    styrene 565.82
    dioctyl adipate 455.34
    dimethyl sulfate 625.21
    ethyl butyrate 605.63
    methyl lactate 562.42
    butyl lactate 496.57
    diethyl carbonate 445.72
    propanediol butyl ether 722.27
    triethyl orthoformate 480.95
    p-tert-butyltoluene 382.1
    methyl 4-tert-butylbenzoate 705.62
    morpholine 1577.6
    tert-butylamine 762.88
    n-dodecanol 290.78
    dimethoxymethane 1134.83
    ethylene carbonate 917.17
    cyrene 500.76
    2-ethoxyethyl acetate 887.93
    2-ethylhexyl acetate 659.67
    1,2,4-trichlorobenzene 1110.97
    4-methylpyridine 1351.76
    dibutyl ether 659.77
    2,6-dimethyl-4-heptanol 360.66
    DEF 860.96
    dimethyl isosorbide 985.7
    tetrachloroethylene 1353.36
    eugenol 610.17
    triacetin 800.89
    span 80 593.82
    1,4-butanediol 391.12
    1,1-dichloroethane 1758.03
    2-methyl-1-pentanol 572.09
    methyl formate 652.56
    2-methyl-1-butanol 778.17
    n-decane 167.0
    butyronitrile 969.65
    3,7-dimethyl-1-octanol 569.69
    1-chlorooctane 481.89
    1-chlorotetradecane 224.08
    n-nonane 169.05
    undecane 127.57
    tert-butylcyclohexane 226.07
    cyclooctane 182.89
    cyclopentanol 940.24
    tetrahydropyran 1425.77
    tert-amyl methyl ether 799.39
    2,5,8-trioxanonane 952.82
    1-hexene 608.5
    2-isopropoxyethanol 738.16
    2,2,2-trifluoroethanol 451.23
    methyl butyrate 760.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Bergamot (China) 1 8007-75-8 Citrus bergamia Risso et Poiteau, fam. Rutaceae 0.01%
Blackcurrant bud 1 68606-81-5 Ribes nigrum L., fam. Grossulariaceae 0.05%
Lime (Mexican, West Indian, Key) 1 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 0.01%
Lime (Mexican, West Indian, Key) 2 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 0.01%
Lime (Mexican, West Indian, Key) 3 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 1.0%
Lime (Persian) 1 90063-52-8 Citrus latifolia Tanaka, fam. Rutaceae 0.01%
Lime (Persian) 2 90063-52-8 Citrus latifolia Tanaka, fam. Rutaceae 1.0%
Lime (Mexican, West Indian, Key) 4 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 1.7%
Nutmeg (India) 2 8008-45-5 Myristica fragrans Houtt., fam. Myristicaceae 0.3%
Tea Tree (Australia) 1 68647-73-4 Melaleuca alternifolia (Maiden et Betche) Cheel, fam. Myrtaceae 0.01%
Yuzu (Japan) 2 Citrus junos Sieb. ex Tanaka, fam. Rutaceae 0.02%
Pistacia lentiscus (Spain) 1a leaf 90082-83-0 Pistacia lentiscus L., fam. Anacardiaceae 0.01%
Tea Tree (Australia) 7 68647-73-4 Melaleuca alternifolia (Maiden et Betche) Cheel, fam. Myrtaceae 0.01%
Hyptis suaveolens (India) 1 Hyptis suaveolens (L.) Poit., fam. Lamiaceae (Labiatae) 0.6%
Cedrus atlantica (Morocco) Cedrus atlantica Man., fam. Cupressaceae 0.01%
Lilac, White, Picked Flower Headspace 1 Syringa vulgaris L., fam. Oleaceae 0.17%
Laurel leaf (China) 8006-78-8 Laurus nobilis L., fam. Lauraceae 0.2%
Eucalyptus globulus (China) 1 8016-26-0 Eucalyptus globulus Labill., fam. Myrtaceae 0.8%
Terminalia bentzoe Terminalia bentzoe (L.) L.f.ssp.rodriguesensis Wickens, fam. Combretaceae 1.06%
Orange leaf, sweet (Mauritius) Citrus sinensis (L.) Osbeck, fam. Rutaceae 0.71%
Fir balsam 2b 8021-28-1 Abies balsamea (L.) Mill., fam. Pinaceae 0.09%
Citrus volkameriana (Colombia) Citrus volkameriana L., fam. Rutaceae 0.35%
Mandarin (Columbia) 8008-31-9 Citrus deliciosa Tenore (C. reticulata Blanco, cv.mandarin), fam. Rutaceae 0.08%
Heterotheca inuloides leaf (Mexico) Heterotheca inuloides Cass., fam. Asteraceae (Compositae) 0.23%
Tea Tree (Australia) 9 68647-73-4 Melaleuca alternifolia (Maiden et Betche) Cheel, fam. Myrtaceae 0.01%
Boldo leaf (Italy) Boldea fragrans Juss. (Peumus boldus Mol.) 0.92%
Boldo leaf (Chile) Boldea fragrans Juss. (Peumus boldus Mol.) 0.51%
Lime (Mexican, West Indian, Key) 5 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 2.32%
Lime (Mexican, West Indian, Key) (Peru) 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 3.52%
Lime (Mexican, West Indian, Key) (Ivory Coast) 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 3.72%
Lime (Mexican, West Indian, Key) 7 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 2.8%
Pistacia lentiscus (Spain) 3 whole plant 90082-83-0 Pistacia lentiscus L., fam. Anacardiaceae 0.01%
Port Orford Cedarwood Chamaecyparis lawsoniana (A. Murray) Parl., fam. Cupressaceae 1.3%
Bacuri fruit (Brazil) Platonia insignis M., fam. Guttiferae 0.3%
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.3%
Lime (Mexican, West Indian, Key) (Cuba) 8008-26-2 Citrus aurantifolia (Christm.) Swingle, fam. Rutaceae 2.0%
Lime (Persian) (Cuba) 90063-52-8 Citrus latifolia Tanaka, fam. Rutaceae 1.8%
Douglas fir (Bulgaria) Pseudotsuga menziesii (Mirbel) Franco, fam. Pinaceae 0.1%
Thymus fedtschenkoi (Iran) Thymus fedtschenkoi Ronniger, fam. Lamiaceae (Labiatae) 0.2%
Pinus canariensis (Spain-Tenerife) Pinus canariensis Sweet ex Sprengel, fam. Pinaceae 0.01%