Zoxamide

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  • Identifiers

    CAS number
    156052-68-5

    Molecular formula
    C14H16Cl3NO2

    SMILES
    CCC(C)(C(=O)CCl)NC(=O)C1=CC(=C(C(=C1)Cl)C)Cl

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 50.29%
    Cooling 29.57%
    Savory 27.26%
    Milky 23.36%
    Dry 23.24%
    Animal 21.75%
    Musk 21.33%
    Woody 21.2%
    Bitter 19.55%
    Mint 19.08%

     

    Flavor
    Bitter 67.79%
    Odorless 43.05%
    Bland 27.11%
    Mild 22.26%
    Sweet-like 20.58%
    Nitrile 19.44%
    Cedarleaf 18.93%
    Orange flower 18.74%
    Taco 18.68%
    Bread crust 18.61%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    6.88 (neutral)

    Molecular weight
    336.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    491°C

    Melting point expt.

    • 158-160 °C

    Flash point

    • 166.74 ˚C est.

    Solubility expt.

    • In water, 0.681 mg/L at 20 °C
    • In acetone = 0.0557 mg/L at 25 °C

  • Synonyms

    • Zoxamide
    • 156052-68-5
    • Zoxium
    • RH 7281
    • 3,5-Dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methylbenzamide
    • Zoxium 80W Agricultral Fungicide
    • Benzamide, 3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methyl-
    • F1XZW465PC
    • RH-7281
    • DTXSID9032581
    • DTXCID7012581
    • 3,5-Dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-p-toluamide
    • RH7281
    • RefChem:905395
    • CHEBI:82048
    • 3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzene-1-carboximidic acid
    • 605-037-1
    • 3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide
    • Zoxamid
    • Zoxamide [ISO]
    • Zoxium; RH 7281
    • Zoxamide 100 microg/mL in Acetone
    • MFCD03792722
    • HSDB 7278
    • UNII-F1XZW465PC
    • C14H16Cl3NO2
    • ZOXAMIDE [MI]
    • ZOXIUM [HSDB]
    • SCHEMBL70113
    • orb2278527
    • orb3024932
    • CHEMBL1893025
    • CHEBI:82853
    • MSK21236
    • Tox21_300943
    • NCGC00163809-01
    • NCGC00163809-02
    • NCGC00163809-03
    • NCGC00254845-01
    • DA-68871
    • HY-120921
    • CAS-156052-68-5
    • CS-0079642
    • NS00007053
    • Zoxamide, PESTANAL(R), analytical standard
    • C18903
    • G92483
    • Q19312105
    • (rs)-3,5-dichloro-N-(3-chloro-1-ethyl-1-methyl-2-oxopropyl)-4-methyl-benzamide
    • 3,5-dichloro-n-(3-chloro-1-ethyl-1-methyl-2-oxo-propyl)-4-methyl-benzamide
    • 3,5-DICHLORO-N-(3-CHLORO-1-ETHYL-1-METHYL-2-OXOPROPYL)-4- METHYLBENZAMIDE
    • 3,5-DICHLORO-N-(3-CHLORO-1-ETHYL-1-METHYL-2-OXOPROPYL)-P- TOLUAMIDE
    • BENZAMIDE, 3,5-DICHLORO-N-(3-CHLORO-1-ETHYL-1-METHYL-2- OXOPROPYL)-4-METHYL-
    • Pesticide4_Zoxamide_C14H16Cl3NO2_3,5-Dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide
    • 156052-68-5

  • Applications

    Zoxamide is a benzamide fungicide used in agriculture to protect crops from oomycete diseases; it is applied as foliar sprays or soil drenches and formulated as emulsifiable concentrates, suspension concentrates, or water-dispersible granules; it is used on crops such as grapes, potatoes, vegetables and ornamentals; applications cover both open-field and protected cultivation (greenhouses); it is commonly integrated into integrated pest management programs and may be tank-mixed with other fungicides to broaden disease control and manage resistance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 49.22
    methanol 37.91
    isopropanol 35.31
    water 0.02
    ethyl acetate 94.41
    n-propanol 44.37
    acetone 143.59
    n-butanol 39.35
    acetonitrile 23.98
    DMF 401.12
    toluene 44.81
    isobutanol 29.95
    1,4-dioxane 180.33
    methyl acetate 109.38
    THF 370.03
    2-butanone 152.91
    n-pentanol 38.75
    sec-butanol 41.04
    n-hexane 0.58
    ethylene glycol 6.43
    NMP 230.09
    cyclohexane 0.87
    DMSO 84.49
    n-butyl acetate 70.7
    n-octanol 12.62
    chloroform 314.19
    n-propyl acetate 70.43
    acetic acid 69.74
    dichloromethane 240.25
    cyclohexanone 189.0
    propylene glycol 15.25
    isopropyl acetate 67.24
    DMAc 567.02
    2-ethoxyethanol 126.46
    isopentanol 38.47
    n-heptane 0.68
    ethyl formate 49.11
    1,2-dichloroethane 108.46
    n-hexanol 36.59
    2-methoxyethanol 148.88
    isobutyl acetate 48.4
    tetrachloromethane 15.42
    n-pentyl acetate 51.54
    transcutol 262.57
    n-heptanol 24.62
    ethylbenzene 26.29
    MIBK 63.18
    2-propoxyethanol 127.97
    tert-butanol 48.03
    MTBE 61.56
    2-butoxyethanol 79.01
    propionic acid 38.24
    o-xylene 28.62
    formic acid 24.59
    diethyl ether 39.91
    m-xylene 26.57
    p-xylene 39.92
    chlorobenzene 57.7
    dimethyl carbonate 68.43
    n-octane 0.52
    formamide 60.26
    cyclopentanone 245.05
    2-pentanone 105.14
    anisole 96.68
    cyclopentyl methyl ether 88.71
    gamma-butyrolactone 222.83
    1-methoxy-2-propanol 113.8
    pyridine 166.64
    3-pentanone 77.25
    furfural 203.51
    n-dodecane 0.57
    diethylene glycol 84.1
    diisopropyl ether 10.76
    tert-amyl alcohol 51.4
    acetylacetone 158.97
    n-hexadecane 0.68
    acetophenone 106.14
    methyl propionate 94.25
    isopentyl acetate 70.97
    trichloroethylene 388.18
    n-nonanol 14.64
    cyclohexanol 43.54
    benzyl alcohol 89.69
    2-ethylhexanol 21.57
    isooctanol 21.73
    dipropyl ether 22.33
    1,2-dichlorobenzene 60.27
    ethyl lactate 41.35
    propylene carbonate 105.18
    n-methylformamide 85.45
    2-pentanol 26.76
    n-pentane 0.43
    1-propoxy-2-propanol 77.96
    1-methoxy-2-propyl acetate 112.16
    2-(2-methoxypropoxy) propanol 81.68
    mesitylene 13.11
    ε-caprolactone 159.97
    p-cymene 14.69
    epichlorohydrin 278.58
    1,1,1-trichloroethane 105.36
    2-aminoethanol 21.46
    morpholine-4-carbaldehyde 310.8
    sulfolane 172.97
    2,2,4-trimethylpentane 1.1
    2-methyltetrahydrofuran 160.83
    n-hexyl acetate 47.74
    isooctane 0.76
    2-(2-butoxyethoxy)ethanol 96.39
    sec-butyl acetate 54.9
    tert-butyl acetate 84.65
    decalin 1.54
    glycerin 26.9
    diglyme 215.93
    acrylic acid 40.05
    isopropyl myristate 20.51
    n-butyric acid 61.11
    acetyl acetate 64.93
    di(2-ethylhexyl) phthalate 31.61
    ethyl propionate 62.11
    nitromethane 168.55
    1,2-diethoxyethane 90.21
    benzonitrile 65.72
    trioctyl phosphate 18.47
    1-bromopropane 36.44
    gamma-valerolactone 362.23
    n-decanol 11.02
    triethyl phosphate 33.75
    4-methyl-2-pentanol 19.91
    propionitrile 33.45
    vinylene carbonate 104.48
    1,1,2-trichlorotrifluoroethane 182.55
    DMS 69.24
    cumene 16.45
    2-octanol 15.21
    2-hexanone 81.34
    octyl acetate 27.36
    limonene 18.02
    1,2-dimethoxyethane 217.69
    ethyl orthosilicate 32.39
    tributyl phosphate 21.79
    diacetone alcohol 100.72
    N,N-dimethylaniline 68.11
    acrylonitrile 53.16
    aniline 72.54
    1,3-propanediol 45.23
    bromobenzene 54.94
    dibromomethane 107.56
    1,1,2,2-tetrachloroethane 250.35
    2-methyl-cyclohexyl acetate 55.99
    tetrabutyl urea 37.13
    diisobutyl methanol 14.49
    2-phenylethanol 80.8
    styrene 35.01
    dioctyl adipate 39.37
    dimethyl sulfate 111.0
    ethyl butyrate 55.66
    methyl lactate 56.24
    butyl lactate 45.13
    diethyl carbonate 39.15
    propanediol butyl ether 57.2
    triethyl orthoformate 42.89
    p-tert-butyltoluene 14.79
    methyl 4-tert-butylbenzoate 77.31
    morpholine 237.65
    tert-butylamine 19.4
    n-dodecanol 8.22
    dimethoxymethane 210.53
    ethylene carbonate 75.98
    cyrene 114.4
    2-ethoxyethyl acetate 101.81
    2-ethylhexyl acetate 52.58
    1,2,4-trichlorobenzene 80.74
    4-methylpyridine 185.14
    dibutyl ether 18.39
    2,6-dimethyl-4-heptanol 14.49
    DEF 139.66
    dimethyl isosorbide 159.93
    tetrachloroethylene 139.39
    eugenol 83.58
    triacetin 72.98
    span 80 56.6
    1,4-butanediol 22.66
    1,1-dichloroethane 114.58
    2-methyl-1-pentanol 42.15
    methyl formate 74.95
    2-methyl-1-butanol 37.7
    n-decane 0.9
    butyronitrile 35.06
    3,7-dimethyl-1-octanol 17.45
    1-chlorooctane 7.07
    1-chlorotetradecane 3.0
    n-nonane 0.68
    undecane 0.69
    tert-butylcyclohexane 1.82
    cyclooctane 0.32
    cyclopentanol 49.1
    tetrahydropyran 114.32
    tert-amyl methyl ether 53.61
    2,5,8-trioxanonane 142.2
    1-hexene 7.03
    2-isopropoxyethanol 89.36
    2,2,2-trifluoroethanol 36.87
    methyl butyrate 86.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction